Proteinuria and lipid signalling in the kidney

The presence of protein in the urine of patients with renal disease is an adverse prognostic feature. Those patients with proteinuria are much more likely to develop progressive renal scarring and eventual renal failure than those without proteinuria. My research examines the effect of albumin, and lipids bound to albumin, on proximal tubular cell growth and survival as well as other cellular functions. The effect of albumin on growth related signalling pathways is being studied. In addition lysophosphatidic acid signalling and transcriptional factor regulation in the kidney proximal tubule is a major focus of research. 

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