Professor Nigel Brunskill

Professor of Renal Medicine

Contact details

Personal Assistant: Jane Gilbert (+44 (0)116 258 8043)

Lab: 228, MSB / Office: 237, MSB

Telephone: +44 (0)116 252 3078



  • Investigations into the mechanisms of progressive renal disease and diabetic nephropathy.
  • Study of the cell biological and signalling importance of Cpeptide in the proximal tubule.
  • Study of microparticles as novel markers of cardiovascular disease in uraemia.
  • Urinary proteomics and advanced urinary diagnostics.
  • Clinical studies into renal disease and its complications in pregnancy

Proteinuria and lipid signalling in the kidney

The presence of protein in the urine of patients with renal disease is an adverse prognostic feature. Those patients with proteinuria are much more likely to develop progressive renal scarring and eventual renal failure than those without proteinuria. My research examines the effect of albumin, and lipids bound to albumin, on proximal tubular cell growth and survival as well as other cellular functions. The effect of albumin on growth related signalling pathways is being studied. In addition lysophosphatidic acid signalling and transcriptional factor regulation in the kidney proximal tubule is a major focus of research.

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