Publications (2017 - 2019)

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Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum. MA Ghebre, PH Pang, D Desai, B Hargadon, C Newby, J Woods, ... BMC pulmonary medicine 2019 19 (1), 1-10

Neutrophil elastase as a biomarker for bacterial infection in COPD. SJ Thulborn, V Mistry, CE Brightling, KL Moffitt, D Ribeiro, M Bafadhel Respiratory research 2019 20 (1), 170

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma. L George, AR Taylor, A Esteve‐Codina, M Soler Artigas, GA Thun, ... Allergy 2019

The ERS fellowship portfolio: fostering excellence and diversity. RE Morty, LE Donnelly, D Stolz, N Roche, T Welte, KA Forrest, ... European Respiratory Journal 2019 54 (3), 1901503

Small airways dysfunction: is there any involvement in patients with atopy?–Authors' reply. M Kraft, C Brightling, D Postma The Lancet Respiratory Medicine 2019 7 (9), e27

Non-typeable Haemophilus influenzae protein vaccine in adults with COPD: A phase 2 clinical trial. TMA Wilkinson, S Schembri, C Brightling, ND Bakerly, K Lewis, ... Vaccine (2019)

The impact of the prostaglandin D2 receptor 2 and its downstream effects on the pathophysiology of asthma. CE Brightling, G Brusselle, P Altman Allergy (2019)

Cough and eosinophilia. S Diver, RJ Russell, CE Brightling The Journal of Allergy and Clinical Immunology: In Practice 2019 7 (6), 1740-1747

Breath analysis by two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection–Method optimisation and integration within a large-scale … MJ Wilde, RL Cordell, D Salman, B Zhao, W Ibrahim, L Bryant, ... Journal of Chromatography 2019 A 1594, 160-172

Imaging modalities. S Siddiqui, M Castro, CE Brightling Severe Asthma 2019 84, 113

Mepolizumab does not alter the blood basophil count in severe asthma. AKA Wright, S Diver, J McCarthy, A Marvin, M Soares, T Thornton, ... Wiley (2019).

Lung computational models and the role of the small airways in asthma. BH Foy, M Soares, R Bordas, M Richardson, A Bell, A Singapuri, ... American journal of respiratory and critical care medicine (2019)

Outpatients With Acute Cough Urgent Need to Implement Streamlining of Antibiotic and Antiviral Treatments Response. AT Hill, PM Gold, AA El Solh, JP Metlay, B Ireland, RS Irwin, TM Adams, ... Chest 2019 155 (5), 1082-1083

Benralizumab for the Prevention of COPD Exacerbations. GJ Criner, BR Celli, CE Brightling, A Agusti, A Papi, D Singh, DD Sin, ... The New England journal of medicine (2019)

T2 biologics for chronic obstructive pulmonary disease. A Yousuf, W Ibrahim, NJ Greening, CE Brightling The Journal of Allergy and Clinical Immunology: In Practice 2019 7 (5), 1405-1416

Benralizumab for Chronic Obstructive Pulmonary Disease: Results of the Phase III GALATHEA Trial. GJ Criner, BR Celli, CE Brightling, A Agusti, A Papi, FC Sciurba, DD Sin, ... B15. IMMUNOTHERAPY FOR LUNG DISEASE, A2626-A2626 (2019)

Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma. M Ketelaar, MA Portelli, FN Dijk, A Faiz, N Shrine, J Hankinson, S Bhaker, ... B62. ASTHMA MECHANISMS, A3800-A3800 (2019)

Exhaled Breath Analysis by Real-Time Mass Spectrometry. L Bryant, R Cordell, MJ Wilde, L Carr, W Ibrahim, M Richardson, ... C44. ASTHMA EPIDEMIOLOGY, A4906-A4906 (2019

Optimising the Discovery of Breath-Based Biomarkers for Phenotyping Acute Exacerbations of Asthma and COPD. M Wilde, R Cordell, M Richardson, W Ibrahim, B Zhao, D Salman, ... A31. ASTHMA: CLINICAL STUDIES I, A1292-A1292 (2019)

Assessment of Severe Cardio-Respiratory Exacerbations Using the Forced Oscillation Technique. W Ibrahim, S Natarajan, B Zhao, M Richardson, T Suzuki, LL Ng, ... A68. NEW TECHNIQUES, METHODOLOGIES, AND MATHEMATICAL MODELING, A2240-A2240 (2019)

Comparative Feasibility of Sputum and Exhaled Breath VOCs Sampling in Patients with Severe Exacerbations of Airways Disease. W Ibrahim, MJ Wilde, R Cordell, L Bryant, RC Free, B Zhao, M Richardson, ... A32. ASTHMA: CLINICAL STUDIES II, A1339-A1339 (2019)

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study. DS Postma, C Brightling, S Baldi, M Van den Berge, LM Fabbri, ... The Lancet Respiratory Medicine 2019 7 (5), 402-416

Characterisation of Exacerbations of Severe Eosinophilic Asthma on Mepolizumab Compared to Placebo. R Shrimanker, O Keene, DJ Bratton, S Yancey, L Heaney, ID Pavord B21. SEVERE ASTHMA: CLINICAL AND MECHANISTIC STUDIES, A2671-A2671 (2019)

Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. O Khorfan, S Alsamman, H Abbas, A Sankari, AT Hastie, FJ Martinez, ... American Journal of Respiratory and Critical Care Medicine 2019 199 (7), 913-916

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study E Menditto, E Costa, L Midão, S Bosnic‐Anticevich, E Novellino, S Bialek, ... Clinical & Experimental Allergy 2019 49 (4), 442-460

Guidance to 2018 good practice. J Bousquet, A Bedbrook, W Czarlewski, GL Onorato, S Arnavielhe, ... Clinical and Translational Allergy (2019)

Bacterial colonization at stable disease influences exacerbation severity in COPD. W Tew, J Mar, C Holweg, R Shrimanker, V Mistry, C Brightling, ... ERJ Open Research 5 (suppl 2), PP218 (2019)

Comparison of CT ventilation imaging and hyperpolarised gas MRI: effects of breathing manoeuvre. BA Tahir, H Marshall, PJC Hughes, CE Brightling, G Collier, RH Ireland, ... Physics in Medicine & Biology 2019 64 (5), 055013


Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study. W Ibrahim, M Wilde, R Cordell, D Salman, D Ruszkiewicz, L Bryant, ... BMJ open 2019 9 (3), e025486

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. P Sakornsakolpat, D Prokopenko, M Lamontagne, NF Reeve, AL Guyatt, ... Nature genetics 2019 51 (3), 494

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Bousquet, PW Hellings, I Agache, F Amat, I Annesi-Maesano, ... Journal of Allergy and Clinical Immunology 2019 143 (3), 864-879

DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment. R Saunders, H Kaul, R Berair, S Gonem, A Singapuri, AJ Sutcliffe, ... Science translational medicine 2019 11 (479), eaao6451

Response to Huisstede et al. Increased eosinophil uptake in the lungs of obese asthmatics–to correct for obesity compare to obese controls. N Farahi, C Summers, C Loutsios, N Tregay, A Wright, R Berair, ... (2019)

Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma. AJ Bell, BH Foy, M Richardson, A Singapuri, E Mirkes, M van den Berge, ... Journal of Allergy and Clinical Immunology (2019)

ERS/EAACI Statement on severe exacerbations in asthma in adult: facts, priorities and key research questions. A Bourdin, L Bjermer, C Brightling, G Brusselle, P Chanez, F Chung, ... European respiratory journal, 1900900 (2019)

Computational modelling prediction and clinical validation of impact of benralizumab on airway smooth muscle mass in asthma. L Chachi, S Diver, H Kaul, MC Rebelatto, A Boutrin, P Nisa, P Newbold, ... European Respiratory Journal, 1900930 (2019)

Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab. L George, A Wright, V Mistry, A Sutcliffe, L Chachi, K Haldar, ... International Journal of Chronic Obstructive Pulmonary Disease 2019 14, 1177

Airway inflammation in COPD-progress to precision medicine. C Brightling, N Greening European Respiratory Journal, 1900651 (2019)

Prostaglandin D2 type 2 receptor antagonism reduces airway smooth muscle mass in asthma: mechanistic insights from in vitro and computational models. R Saunders, H Kaul, R Berair, S Gonem, A Singapuri, A Sutcliffe, C Latifa, ... Science Translational Medicine 2019 11 (479)

Cohort profile: Extended Cohort for E-health, Environment and DNA (EXCEED). C John, NF Reeve, RC Free, AT Williams, AE Farmaki, J Bethea, ... bioRxiv, 422782 (2019)

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. N Shrine, MA Portelli, C John, MS Artigas, N Bennett, R Hall, J Lewis, ... The Lancet Respiratory Medicine 7 (1), 20-34

Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. MT Vashi, JL Willoughby, SJ Quinn, BT Tran, VL Kim, NA Coombs, ... American Journal of Respiratory and Critical Care Medicine 2019 199 (1), 110-112

Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report. A Moore, A Harnden, CC Grant, S Patel, RS Irwin, KW Altman, E Azoulay, ... Chest 2019 155 (1), 147-154

Adult outpatients with acute cough due to suspected pneumonia or influenza: CHEST Guideline and Expert Panel Report. AT Hill, PM Gold, AA El Solh, JP Metlay, B Ireland, RS Irwin, TM Adams, ... Chest 2019 155 (1), 155-167

Spread the Word About CHEST in 2019: Innovations, Introductions, and Farewells. RS Irwin, JE Heffner, L Maxwell, CL French, N Augustyn, ... Chest 2019 155 (1), 1-4

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