Professor Chris Brightling

Image of Prof Chris BrightlingNIHR Senior Investigator and Clinical Professor in Respiratory Medicine

Contact details

Secretary: Yvonne Docherty

Respiratory Sciences Biomedical Research Centre, Glenfield Hospital

Telephone: (+44) (0)116 258 3998

Email: ceb17@le.ac.uk

Personal details

I am a National Institute for Health Research Senior Investigator, Fellow of the Academy of Medical Sciences, Respiratory Theme Lead for Leicester NIHR Biomedical Research Centre, Director Institute for Lung Health and Honorary Consultant Respiratory Physician, Leicester, UK. I am the Coordinator for the European Union Consortium AirPROM, MRC/ABPI COPD (COPDMAP) Consortium, the MRC Molecular Pathology Node EMBER and Respiratory lead for the IMI 3TR. I am the founding Director of the European Respiratory Society Clinical Research Collaborations, Chair-elect of the ERS Science Council and Director of the NIHR Translational Research Collaboration. My research focusses on improving the clinical management and understanding the immunopathogenesis of the airway diseases asthma, chronic cough and COPD. I have published over 370 peer-reviewed articles and have an h-index of 95 (google scholar). I am a member of the American College of Chest Physicians’ Cough Guidelines, the British Thoracic Society, American Thoracic Society/European Respiratory Society Severe Asthma guidelines and I'm on the scientific committee for the Global INitiative for Asthma - GINA.

Research

  • Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease (COPD) and chronic cough;
  • Current projects include understanding the interactions between mast cells and airway smooth muscle cells in the development of the asthmatic phenotype, airway smooth muscle migration and remodelling in asthma and COPD.

Selected Publications

KF Chung, SE Wenzel, JL Brozek, A Bush, M Castro, PJ Sterk, IM Adcock...... C Brightling et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European respiratory journal 2014 43 (2), 343-373

M Bafadhel, S McKenna, S Terry, V Mistry, C Reid, P Haldar, M McCormick, K Haldar, T Kebadze, A Duvoix, K Lindblad, H Patel, P Rugman, P Dodson, M Jenkins, M Saunders, P Newbold, RH Green, P Venge, DA Lomas, MR Barer, SL Johnston, ID Pavord, CE Brightling. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. American journal of respiratory and critical care medicine 2011 184 (6), 662-671

MF Moffatt, IG Gut, F Demenais, DP Strachan, E Bouzigon, S Heath E von Mutius, M Farrall, M Lathrop, WOCM Cookson, GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. New England Journal of Medicine 2010 363 (13), 1211-1221

J Bousquet, E Mantzouranis, AA Cruz, N Aït-Khaled, CE Baena-Cagnani, ER Bleecker, CE Brightling. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. Journal of Allergy and Clinical Immunology 2010 126 (5), 926-938

P Haldar, CE Brightling, B Hargadon, S Gupta, W Monteiro, A Sousa et al. Mepolizumab and exacerbations of refractory eosinophilic asthmaNew England Journal of Medicine 2009 360 (10), 973-984

P Haldar, ID Pavord, DE Shaw, MA Berry, M Thomas, CE Brightling et al. Cluster analysis and clinical asthma phenotypes. American journal of respiratory and critical care medicine 2008 178 (3), 218-224

RS Irwin, MH Baumann, DC Bolser, LP Boulet, SS Braman, CE Brightling et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest 2006 129 (1), 1S-23S

MA Berry, B Hargadon, M Shelley, D Parker, DE Shaw, RH Green, P Bradding, CE Brightling, AJ Wardlaw, ID Pavord. Evidence of a role of tumor necrosis factor α in refractory asthma. New England Journal of Medicine 2006 354 (7), 697-708

RH Green, CE Brightling, S McKenna, B Hargadon, D Parker, P Bradding et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trialThe Lancet 2002 360 (9347), 1715-1721

CE Brightling, P Bradding, FA Symon, ST Holgate, AJ Wardlaw, ID Pavord. Mast-cell infiltration of airway smooth muscle in asthma. New England Journal of Medicine 2002 346 (22), 1699-1705

RH Green, CE Brightling, G Woltmann, D Parker, AJ Wardlaw, ID Pavord. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002 57 (10), 875-879

Recent publications (2017 - 2019)

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