Professor Peter Bradding

Clinical Professor in Respiratory Medicine

Contact details

Secretary: Jeanette Garnett

Office: CS061, Respiratory Medicine, Glenfield Hospital

Telephone: (+44) (0)116 258 3998

Email: jeanette.garnett@uhl-tr.nhs.uk

Research

  • The pathophysiology of asthma, with a particular focus on airway inflammation, ion channels and mast cell-airway smooth muscle interactions.
  • The pathophysiology of idiopathic pulmonary fibrosis focussing on ion channel regulation of fibroblast biology.

Teaching

  • Undergraduate and postgraduate teaching, clinical and non clinical
  • Associate Fellow of the Higher Education Academy

Publications

  • Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham Anderson J, Hargadon B, Arron JR, Wardlaw A, Brightling CE, Heaney LG, Bradding P. Airway pathological heterogeneity in asthma: visualisation of disease micro-clusters using topological data analysis. J Allergy Clin Immunol, 2018; 142:1457-1468.
  • Chachi, L, Alzahrani A, Biddle M, Bagadood R, Koziol-White C, Panettieri R, Bradding P*, Amrani Y*. Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors. Clin Exp Immunol 2018; 194(2):253-258. *Joint senior author
  • Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord I, Lindsay JT, Costello RW; Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK). Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma. Am J Respir Crit Care Med 2019; 15;199:454-464.
  • Roach KM, Sutcliffe A, Matthews L, Elliott G, Newby C, Amrani Y, Bradding P. A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis. Sci Rep 2018; 8:342. doi: 10.1038/s41598-017-18555-9
  • Bilocca D, Hargadon B, Pavord ID, Green RH, Brightling CE, Bradding P, Wardlaw AJ, Martin N, Murphy AC, Siddiqui S. The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma. Chron Respir Dis 2018 Feb;15(1):85-87.
  • Woolnough KF, Richardson M, Newby C, Craner M, Bourne M, Monteiro W, Siddiqui S, Bradding P, Pashley CH, Wardlaw AJ. The relationship between biomarkers of fungal allergy and lung damage in asthma. Clin Exp Allergy 2017; 47:48-56.
  • Organ L, Bacci B, Koumoundouros E, Kimpton W, Samuel C, Nowell C, Bradding P, Roach K, Westall G, Jaffar J, Snibson K. Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosis in a large animal model. Am J Respir Cell Mol Biol 2017; 56:539-550.
  • Gangwar RS, Minai-Fleminger Y, Seaf M, Gutgold A, Shikotra A, Barber C, Chauhan A, Holgate S, Bradding P, Howarth P, Eliashar R, Berkman N, Levi-Schaffer F. CD48 on blood leukocytes and in serum of asthma patients varies with severity. Allergy 2017; 72:888-895.
  • Shikotra A, Choy DF, Siddiqui S, Arthur G, Nagarkar DR, Jia G, Wright AKA, Ohri CM, Doran E, Butler CA, Hargadon B, Abbas AR, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P. A CEACAM6-high airway neutrophil phenotype and CEACAM6-high epithelial cells are features of severe asthma. J Immunol 2017; 198:3307–3317.
  • Natarajan S, Free RC, Bradding P, McGarvey L, Siddiqui S. The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma. Respir Res 2017; 18:44. doi: 10.1186/s12931-017-0520-2.
  • Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE. Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling. Eur Respir J 2017; 49. pii: 1601507. doi: 10.1183/13993003.01507-2016.
  • Welsh KG, Rousseau K, Fisher G, Bonser LR, Bradding P, Brightling CE, Thornton DJ, Gaillard EA. MUC5AC and a glycosylated variant of MUC5B alter mucin composition in children with acute asthma. Chest 2017; 152:771-779..
  • Lal N, Willcox CR, Beggs A, Taniere P, Shikotra A, Bradding P, Adams R, Fisher D, Middleton G, Tselepis C, Willcox BE. Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q. J Pathol Clin Res. 2017;3:155-170. doi: 10.1002/cjp2.70.

 

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