Professor Mike Barer

Professor of Clinical Microbiology and Honorary Consultant Microbiologist

Contact detailsProfessor M Barer

Personal Assistant: TBC

Office: 136b, MSB

Telephone: +44 (0)116 252 2951/2933



We work at the interface between bacterial physiology and human infection concentrating on Tuberculosis and gastrointestinal infections.

Themes include:

  • The physiology of M. tuberculosis during infection;
  • TB genomics applied to public health and strain characterisation in real time;
  • The nature of bacterial viability and its practical detection;
  • The biological properties of enteric bacteria that underpin their transmission;
  • Methods to determine the properties of bacteria in their natural environments;
  • Culture-independent approaches to determining the aetiology and pathogenesis of bacterial diseases.


2011 2010 2009 2008 2007 2001-2006

Our work is mainly funded by the UK Medical Research Council.


Bafadhel M, Clark TW, Reid C, Medina, MJ, Batham S, Barer MR, Nicholson KG, Brightling CE. Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest 2011;139(6):1410-8


Cheah ES, Malkin J, Free RC, Lee SM, Perera N, Woltmann G, Patel H, Kimmitt PT, Smith RJ, Rajakumar K, Barer MR. A two-tube combined TaqMan/SYBR Green assay to identify microbacteria and detect single global lineage-defining polymorphisms in Mycobacterium tuberculosis. J Mol Diagn 2010;12(2):250-6

Mukamolova GV, Turapov O, Malkin J, Woltmann G, Barer M. Resuscitation-promoting factors reveal an occult population of tubercle Baccilli in sputum. Am J Respir Crit Care Med 2010;181(2):174-80


Pardini M, Niemann S, Varaine F, Iona E, Meacci F, Orru G, Yesilkaya H, Jarosz T, Andrew P, Barer M, Checchi F, Rinder H, Orefici G, Rusch-Gerdes S, Fattorini L, Oggioni MR, Bonnet M. Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe. Tuberculosis (Edinb) 2009;89:317-24.

Mukamolova GV, Turapov O, Malkin J, Woltmann G, Barer MR, Resuscitation promoting factors reveal an occult population of tubercle bacilli in sputum. Am J Respir Crit Care Med 2009 epub online.

Malkin J, Shrimpton A, Wiselka M, Barer MR, Duddridge M, Perera N. Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behcet's disease. J Med Microbiol 2009;59(3):371-3


Garton NJ, Waddell SJ, Sherratt AL, Lee SM, Smith RJ, Senner C, Hinds J, Rajakumar K, Adegbola RA, Besra GS, Butcher PB,Barer MRCytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med 2008;5(4):e75.


Stanley EC, Mole RJ, Smith RJ, Glenn SM, Barer MR, McGowan M, Rees CE, Development of a new, combined rapid method using phage and PCR for detection and identification of viable Mycobacterium paratuberculosis bacteria within 48 hours. Appl Environ Microbiol 2007;73(6):1851-7.

Ou HY, Ju CT, Thong KL, Ahmad N, Deng Z, Barer MR, Rajakumar K. Translational genomics to develop a salmonella enterica serovar paratyphi A multiplex polymerase chain reaction assay. J Mol Diagn 2007;9(5):624-30.

Ou HY, He X, Harrison EM, Kulasekara BR, Thani AB, Kadioglu A, Lory S, Hinton JC, Barer MR, Deng Z, Rajakumar K. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res 2007;35(Web Server issue): W97-W104.


Yesilkaya H, Meacci F, Niemann S, Hillemann D, Rusch -Gerdes S, Barer MR, Andrew PW, Oggioni MR. Evaluation of molecular-beacon, TaqMan and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed mycobacterium tuberculosis DNA extracts. J Clin Microbiol 2006;44(10):3826-9.

Yesilkaya H, Forbes KJ, Shafi J, Smith R, Dale JW, Rajakumar K, Barer MR, Andrew PW. The genetic portrait of an outbreak strain. Tuberculosis (Edinb) 2006;86(5):357-62.

Ou HY, Chen LL, Lonnen J, Chaudhuri RR, Thani AB, Smith R, Garton NJ, Hinton J, Pallen M, Barer MR, Rajakumar K. A novel strategy for the identification of genomic islands by comparative analysis of the contents and contexts of tRNA sites in closely related bacteria. Nucleic Acids Res 2006;34(1):e3.

Newton SM, Smith RJ, Wilkinson KA, Nicol MP, Garton NJ, Staples KJ, Stewart GR, Wain JR, Martineau AR, Fandrich S, Smallie T, Foxwell B, Al-Obaidi A, Shafi J, Rajakumar K, Kampmann B, Andrew PW, Ziegler-Heitbrock L, Barer MR, Wilkinson RJ. A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. Proc Natl Acad Sci USA 2006;103(42):15594-8.

Rowan AK, Davenport RJ, Snape JR, Fearnside D, Barer MR, Curtis TP, Head IM. Development of a rapid assay for determining the relative abundance of bacteria. Appl Environ Microbiol 2005;71(12):8481-90.

Ou HY, Smith R, Lucchini S, Hinton J, Chaudhuri RR, Pallen M, Barer MR, Rajakumar K. ArrayOme: a program for estimating the sizes of microarray-visualized bacterial genomes. Nucleic Acids Res 2005;33(1):e3.

Marei A, Ghaemmaghami A, Renshaw P, Wiselka M, Barer M, Carr M, Ziegler-Heitbrock L. Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. Int Immunol 2005;17:1439-46.

Barer MR, Bogosian G. The viable but nonculturable concept, bacteria in urine samples, and Occam's razor. J Clin Microbiol 2004;42(11):5434

Yesilkaya H, Barer MR, Andrew PW. Antibiotic resistance may affect alkali decontamination of specimens containing mycobacteria. Diagn Microbiol Infec Dis 2004;50(2):153-5

Rajakumar K, Shafi J, Smith RJ, Stabler RA, Andrew PW, Modha D, Bryant G, Monk P, Hinds J, Butcher PD, Barer MRUse of genome level-informed PCR as a new investigational approach for analysis of outbreak-associated Mycobacterium tuberculosis isolates. J Clin Microbiol 2004;42(5):1890-6.

Kehoe SC, Barer MR, Devlin LO, McGuigan KG. Batch process solar disinfection is an efficient means of disinfecting drinking water contaminated with Shigella dysenteriae type I. Lett Appl Microbiol 2004;38(5):410-4.

Rowan AK, Moser G, Gray N, Snape JR, Fearnside D, Curtis TP, Barer MR, Head IM. A comparitive study of ammonia-oxidizing bacteria in lab-scale industrial wastewater treatment reactors. Water Sci Technol 2003;48(3):17-24.

Prytz I, Sanden AM, Nystrom T, Farewell A, Wahlstrom A, Forberg C, Pragai Z, Barer M, Harwood C,Larsson G. Fed-batch production of recombinant beta-galactosidase using the universal stress promoters uspA and uspB in high cell density cultivations. Biotechnol Bioeng 2003;83:595-603.

Pantos O, Cooney RP, Le Tissier MD, Barer M, O'Donnell AG, Bythell JC. The bacterial ecology of a plague-like disease affecting the Caribbean coral Montastrea annularis. Environ Microbiol 2003;5(5):370-82.

Smith RJ, Newton AT, Harwood CR, Barer MR. Active but nonculturable cells of Salmonella enterica serovar Typhimurium do not infect or colonize mice. Microbiology 2002;148(9):2717-26.

Shafi J, Andrew PW, Barer MR. Microarrays for public health: genomic epidemiology of tuberculosis. Comp Funct Genomics 2002;3(4):362-5.

Rowan AK, Snape JR, Fearnside D, Curtis TP, Barer MR, Head IM. A comparison of autotrophic ammonia-oxidizing bacteria in full- and laboratory-scale wastewater treatment reactors. Water Sci Technol 2002;46(1-2):319-22.

Lyon HO, Schulte EK, Prento P, Barer MR, Bene MC. Standardized staining methods: Feulgen-Rossenbeck reaction for desoxyribonucleic acid and periodic acid-Schiff (PAS) procedure. Biotech Histochem 2002;77(3):121-5

Garton NJ, Christensen H, Minnikin DE, Adegbola RA, Barer MRIntracellular lipophilic inclusions of mycobacteria in vitro and in sputum. Microbiology 2002;148(10):2951-8.

Cooney RP, Pantos, Le Tissier M, Barer M, O'Donnell AG, Bythell JC. Characterization of the bacterial consortium associated with black band disease in coral using molecular microbiological techniques. Environ Microbiol 2002;4(7):401-13.

Bythell JC, Barer MR, Cooney RP, Guest JR, O'Donnell AG, Pantos O, Le Tissier MD. Histopathological methods for the investigation of microbial communities associated with disease lesions in reef corals. Lett Appl Microbiol 2002;34(5):359-64.

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Contact Details

Department of Respiratory Sciences
Maurice Shock Medical Sciences Building
University Road
Leicester LE1 9HN

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951