Publications

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Publications for Last 10 years only 

2013  2012  2011  2010  2009  2003-2008 

2013

Melo J, Schrama D, Andrew PW, Faleiro ML. Proteomic analysis shows that individual Listeria monocytogenes strains use different strategies in response to gastric stress. Foodborne Pathog Dis 2013;10(2):107-19

Yesilkaya H, Andisi VF, Andrew PW, Bijlsma JJ. Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals. Trends Microbiol 2013;21(4):187-95

Wisby L, Fernandes VE, Neill DR, Kadioglu A, Andrew PW, Denny P. Spir2: a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice. BMC Genomics 2013;14(1):242

Melo J, Schrama D, Hussey S, Andrew PW, Faleiro ML. Listeria monocytogenes dairy isolates show a different proteome response to sequential exposure to gastric and intestinal fluids. Int J Food Microbiol 2013;162(2-3):51-63

Smith CM, Kulkarni H, Radhakrishnan P, Rutman A, Bankart MJ, Williams G, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. Ciliary dyskinesia is an early feature of respiratory syncytial virus infection. Eur Respir J 2013;Mar 21 [epub ahead of print]

Melo J, Andrew PW, Faleiro ML. Different assembly of acid and salt tolerance response in two dairy Listeria monocytogenes wild strains. Arch Microbiol 2013;195(5):339-48

2012

Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, Strickland N, Gordon SB, Denny P, Kadioglu A, Andrew PW. T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice. PLoS Pathog 2012;8(7):e1002660

Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog 2012;8(7):e1002793

Smith CM, Djakow J, Free RC, Djakow P, Lonnen R, Williams G, Pohunek P, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. ciliaFA: a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software. Cilia 2012;1(1):14 [epub ahead of print]

Hajaj B, Yesilkaya H, Benisty R, David M, Andrew PW, Porat N. Thiol peroxidase is an important component of Streptococcus pneumoniae in oxygenated environments. Infect Immun 2012;80(12):4333-43

2011

Corbett D, Schuler S, Glenn S, Andrew PW, Cavet JS, Roberts IS. The combined actions of the copper-responsive repressor CsoR and copper-metallochaperone CopZ modulate CopA-mediated copper efflux in the intracellular pathogen Listeria monocytogenes. Mol Microbiol 2011;81(2):457-72

Smith CM, Bradding P, Neill DR, Baxendale H, Felici F, Andrew PW. Novel immunogenic peptides elicit systemic anaphylaxis in mice: implications for peptide vaccines. J Immunol 2011;187(3):1201-6

Shafeeq S, Yesilkaya H, Kloosterman TG, Narayanan G, Wandel M, Andrew PW, Huipers OP, Morrissey JA. The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae. Mol Microbiol 2011;81(5):1255-70

Bonnet M, Pardini M, Meacci F, Orru G, Yesilkaya H, Jarosz T, Andrew PW, Barer M, Checchi F, Rinder H, Orefici G, Rusch-Gerdes S, Fattorini L, Oggioni MR, Melzer J, Niemann S, Varaine F. Treatment of tuberculosis in a region with high drug resistance: outcomes, drug resistance amplification and re-infection. PLoS One 2011;6(8):e23081

Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gomez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M. Invariant natural killer cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 2011;12(10):966-74

Ahmad AF, Lonnen J, Andrew PW, Kilvington S. Development of a rapid DNA extraction method and one-step nested PCR for the detection of Naegleria fowleri from the environment. Water Res 2011;45(16):5211-7

Kadioglu A, De Filippo K, Bangert M, Fernandes VE, Richards L, Jones K, Andrew PW, Hogg N. The integrins Mac-1 and (alpha)4(beta) perform crucial roles in neutrophil and T-cell recruitment to lungs during Streptococcus pneumoniae infection. J Immunol 2011;186(10):5907-15

Ahmad AF, Andrew PW, Kilvington S. Development of a nested PCR for environmental detection of the pathogen free-living amoeba Balamuthia mandrillaris. J Eukaryot Microbiol 2011;58(3):269-71

Xu G, Kiefel MJ, Wilson JC, Andrew PW, Oggioni MR, Taylor GL. Three Streptococcus pneumoniae Sialidases: three different products. J Am Chem Soc 2011;133(6):1718-21

Smith CM, Hirst RA, Bankart MJ, Jones DW, Easton A, Andrew PW, O'Callaghan C. Cooling of cilia allows functional analysis of beat pattern for diagnostic testing. Chest 2011;140(1):186-90

Kadioglu A, Cuppone AM, Trappetti C, List T, Spreafico A, Pozzi G, Andrew PW, Oggioni MR. Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice. J Infect Dis 2011;204(12):1971-9

2010

McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreria D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerals KA, Tschopp J, Petrilli V, Andrew PW, Kadioglu A, Lavelle EC. Pneumolysin activates the MLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 2010;11(6):e1001191

Tellabati A, Fernandes VE, Teichert F, Singh R, Rylance J, Gordon S, Andrew PW, Grigg J. Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia. Part Fibre Toxicol 2010;7:30

Cruse G, Fernandes VE, de Salort J, Pankhania D, Marinas MS, Brewin H, Andrew PW, Bradding P, Kadioglu A. Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol 2010;184(12):7108-15

Fadaee-Shohada M, Hirst RA, Rutman A, Roberts IS, O'Callaghan C, Andrew PW. The behaviour of both listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture. PLoS One 2010;5(5):e10450

Heaselgrave W, Andrew PW, Kilvington S. Acidified nitrite enhances hydrogen peroxide disinfection of Ananthamoeba, bacteria and fungi. J Antimicrob Chemother 2010;65(6):1207-14

Richards L, Ferreira DM, Miyaji EN, Andrew PW, Kadioglu A. The immunising effect of pneumococcal nasopharyngeal colonisation: protection against future colonisation and fatal invasive disease.  Immunobiology 2010;215(4):251-63

Terra VS, Homer KA, Rao SG, Andrew PW, Yesilkaya H. Characterization of novel beta-galactodisase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae. Infect Immun 2010;78(1):348-57

2009

Bortoni ME, Terra CS, Hinds J, Andrew PW, Yesilkaya H. The pneumococcal response to oxidative stress includes a role for Rgg.  Microbiology 2009;155(12):4123-34

Croucher NJ, Walker D, Romero P, Lennard N, Paterson GK, Bason NC, Mitchell AM, Quail MA, Andrew PW, Parkhill J, Bentley SD, Mitchell TJ. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. J Bacteriol 2009;191(5):1480-9

Yesilkaya H, Spissu F, Carvalho SM, Terra VS, Homer KA, Benisty R, Porat N, Neves AR, Andrew PW. Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence. Infect Immun 2009;77(12):5418-27

Trappetti C, Kadioglu A, Carter M, Hayre J, Iannelli F, Pozzi G, Andrew PW, Oggioni MR. Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host. J Infect Dis 2009;199(10):1497-1505

Croucher NJ, Walker D, Romero P, Lennard N, Paterson GK, Bason NC, Mitchell AM, Quail MA, Andrew PW, Parkhill J, Bentley SD, Mitchell TJ. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae (Spain23F) ST81. J Bacteriol 2009;191:1480-9

Smith CM, Lo Passo C, Scuderi A, Kolberg J, Baxendale H, Goldblatt D, Oggioni MR, Felici F, Andrew PWPeptide mimics of two pneumococcal capsular polysaccharide serotypes (6B and 9V) protect mice from a lethal challenge with Streptococcus pneumoniae. Eur J Immunol 2009;39(6):1527-35

2003-2008

Yesilkaya H, Manco S, Kadioglu A, Terra VS, Andrew PW. The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae. FEMS Microbiol Lett 2008;278(2):231-5

Hirst RA, Gosai B, Rutman A, Guerin CJ, Nicotera P, Andrew PW, O’Callaghan C.  Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis. J Infect Dis 2008;197(5):744-51

El-Rachkidy RG, Davies NW, Andrew PW. Pneumolysin generates multiple conductance pores in the membrane of nucleated cells. Biochem Biophys Res Comm 2008;368(3):786-92

Kadioglu A, Weiser JN, Paton JC, Andrew PW. The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Rev Microbiol 2008;6(4):288-301

Adriao A, Vieira M, Fernandes I, Barbosa M, Sol M, Tenreiro RP, Chambel L, Barata B, Zilhao I, Shama G, Perni S, Jordan SJ, Andrew PW, Faleiro ML. Marked intra-strain variation in response of Listeria monocytogenes dairy isolates to acid or salt stress and the effect of acid or salt adaptation on adherence to abiotic surfaces. Int J Food Microbiol 2008;123:142-50

Sonnen AF, Rowe AJ, Andrew PW, Gilbert RJ. Oligomerisation of pneumolysin on cholesterol crystals: similarities to the behaviour of polyene antibiotics. Toxicon 2008;51(8):1554-9

Jordan SJ, Perni S, Glenn S, Fernedes I, Barbosa M, Sol M, Teneiro RP, Chambel L, Barata B, Zilhao I, Aldsworth TG, Adriao A, Faleiro ML, Shama G, Andrew PW.  Listeria monocytogenes biofilm-associated protein (BapL) may contribute to surface attachment of L. monocytogenes but is absent from many field isolates. Appl Environ Microbiol 2008;74(17):5451-6

Xu G, Li X, Andrew PW, Taylor GL. Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008;64(9):772-5

Xu G, Potter JA, Russell RJ, Oggioni MR, Andrew PW, Taylor GL. Crystal structure of the NanB sialidase from Streptococcus pneumoniae. J Mol Biol 2008;384(2):436-49

Chambel L, Sol M, Fernandes I, Barbosa M, Zilhao I, Barata B, Jordan S, Perni S, Shama G, Adriao A, Faleiro L, Requena T, Pelaez C, Andrew PW, Tenreiro R.  Occurrence and persistence of Listeria spp. in the environment of ewe and cow's milk cheese dairies in Portugal unveiled by an integrated analysis of identification, typing and spatial-temporal mapping along the production cycle. Int J Food Microbiol 2007;116(1):52-63

Perni S, Aldsworth TG, Jordan SJ, Fernandes I, Barbosa M, Sol M, Tenreiro RP, Chambel L, Zilhao I, Barata B, Adriao A, Faleiro ML, Andrew PW, Shama, G. The resistance to detachment of dairy strains of Listeria monocytogenes from stainless steel by shear stress is related to the fluid dynamic characteristics of the location of isolation. Intern J Food Microbiol 2007;116(3):384-90

Bennett HJ, Pearce DM, Glenn S, Taylor CM, Kuhn M, Sonenshein AL, Andrew PW, Roberts IS. Characterization of relA and codY mutants of Listeria monocytogenes identification of the CodY regulon and its role in virulence. Mol Microbiol 2007;63(5):1453-67

Manco S, Hernon F, Yesilkaya H, Paton JC, Andrew PW, Kadioglu A.  Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. Infect Immun 2006;74(7):4014-20

Perni S, Jordan SJ, Andrew PW, Sharma Gl. Biofilm development by Listeria innocua in turbulent flow regimes. Food Control 2006;17:875-83

Yesilkaya H, Soma-Haddrick S, Crennell SJ, Andrew PW. Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A. Res Microbiol 2006;157(6):569-74

Yesilkaya H, Forbes KJ, Shafi J, Smith R, Dale JW, Rajakumar K, Barer MR, Andrew PW. The genetic portrait of an outbreak strain. Tuberculosis (Edinb) 2006;86(5):357-62

Oggioni MR, Trappetti C, Kadioglu A, Cassone M, Iannelli F, Ricci S, Andrew PW, Pozzi G. Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. Mol Microbiol 2006;61(5):1196-210.

Newton SM, Smith RJ, Wilkinson KA, Nicol MP, Garton NJ, Staples KJ, Stewart GR, Wain JR, Martineau AR, Fandrich S, Smallie T, Foxwell B, Al-Obaidi A, Shafi J, Rajakumar K, Andrew PW, Ziegler-Heitbrock L, Barer MR, Wilkinson RJ. A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. Proc Natl Acad Sci USA 2006;103(42):15594-8.

Yesilkaya H, Meacci F, Niemann S, Hillemann D, Rusch-Gerdes S, Barer MR, LONG DRUG Study Group, Andrew PW, Oggioni MR. Evaluation of molecular-beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed Mycobacterium tuberculosis DNA extracts. J Clin Microbiol 2006;44(10):3826-9.

Tilley SJ, Orlova EV, Gilbert RJC, Andrew PW, Saibil HR. Structural basis of pore formation by the bacterial toxin pneumolysin. Cell 2005;121(2):247-56.

Kadioglu A, Andrew PW. Susceptibility and resistance to pneumococcal disease in mice. Brief Funct Genomic Proteomic 2005;4(3):241-7

Perni S, Andrew PW, Shama G. Estimating the maximum growth rate from microbial growth curves: definition is everything. Food Microbiol 2005;22:491-5

Kerr AR, Kirkham LAS, Kadioglu A, Andrew PW, Garside P, Thompson H, Mitchell TJ. Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes Infect 2005;7(5-6):845-52.

Jounblat R, Clark H, Eggleton P, Hawgood S, Andrew PW, Kadioglu A. The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Respir Res 2005;6:126-38.

Kadioglu A, Andrew PW. The innate immune response to pneumococcal lung infection: the untold story. Trends Immunol 2004;25(3):143-9

Echenique J, Kadioglu A, Romao S, Andrew PW, Trombe MC. Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae. Infect Immun 2004;72(4):2434-7.

Kadioglu A, Coward W, Colston MJ, Hewitt CRA, Andrew PW. CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun 2004;72(5):2689-97

Kerr AR, Wei XQ, Andrew PW, Mitchell TJ. Micro. Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae. Microb Pathog 2004;36(6):303-10

Rajakumar K, Shafi J, Smith RJ, Stabler RA, Andrew PW, Modha D, Bryant G, Monk P, Hinds J, Butcher PD, Barer MR. Use of genome level-informed PCR as a new Investigational approach for analysis of outbreak-associated Mycobacterium tuberculosis isolates. J Clin Microbiol 2004;42(5):1890-6

Hirst RA, Kadioglu A, O'Callaghan C, Andrew PW. The role of pneumolysin in pneumococcal pneumonia and meningitis. Clin Exp Immunol 2004;138:195-201

Hirst RA, Mohammed BJ, Mitchell TJ, Andrew PW, O'Callaghan C. Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. Infect Immun 2004;72(1):6694-8

Yesilkaya H, Barer MR, Andrew PW. Antibiotic resistance may affect alkali decontamination of specimens containing mycobacteria. Diagn Microbiol Infect Dis 2004;50(2):153-5

Jounblat R, Kadioglu A, Iannelli F, Pozzi G, Eggleton P, Andrew PW. Binding and afflutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils. Infect Immun 2004;72(2):709-16

Hughes R, Andrew PW, Kilvington S. Enhanced killing of Acanthamoeba cysts with a plant peroxidase-hydrogen peroxide-halide antimicrobial system. Appl Environ Microbiol 2003;69(5):2563-7

Faleiro ML, Andrew PW, Power D.  Stress response of Listeria monocytogenes isolated from cheese and other foods. Internl J Food Microbiol 2003;84:207-16

Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW. Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. J Infect Immun 2003;71(4):1813-19

Denny P, Hopes E, Gingles N, Broman KW, McPheat W, Morten J, Alexander J, Andrew PW, Brown SD. A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice. Mamm Genome 2003;14(7):448-53.

Kadioglu A, Echenique J, Manco S, Trombe MC, Andrew PW. The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae. Infect Immun 2003;71(11):6676-9.

Hirst RA, Gosai B, Rutman A, Andrew PW, O'Callaghan C.  Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis. Infect Immun 2003;71(10):6095-6100

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951