Douglas Tincello

Professor of Female Pelvic Medicine and Reconstructive Surgery, University Hospitals of Leicester NHS Trust

For NHS patient queries please contact Teresa Shalloe on 0116 258 8391

Doug Tincello

Contact details

Department of Health Sciences
University of Leicester
George Davies Centre
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44(0) 116 252 5451 (for academic matters only)
Email: dgt4@le.ac.uk

Personal details

I graduated in medicine from the University of Edinburgh in 1990. My early training was completed in Edinburgh, including two years working at the Medical Research Council Centre for Reproductive Biology. I completed my training in Merseyside where I developed an interest in urogynaecology. I took up a position of Senior Lecturer in Urogynaecology at the University of Leicester in April 2002 (Professor of Urogynaecology from 2012) and have established a portfolio of clinical and laboratory based research in female pelvic floor dysfunction. I have active research projects in northern Ethiopia in collaboration with colleagues at the University of Gondar.

Professional activities

  • Member of the NIHR Clinical Trials and Evaluation Board 2016-19
  • Chairman of Wellbeing of Women (WoW) Research Advisory Committee (RAC) June 2012-date (Wellbeing of Women is the charity most closely associated with the Royal College of Obstetricians & Gynaecologists, and gives research grants in all areas of women’s health, plus providing Research Training Fellowships for young clinical scientists in Obstetrics & Gynaecology)
  • Previously vice chairman of WoW RAC 2010-2012 and member of the RAC since 2006
  • Member of NIHR Programme Grants for Applied Research College of Experts 2011- 2016
  • Editorial board member of BJOG 2012-date
  • Scientific editor of BJOG, an International Journal of Obstetrics & Gynaecology 2004-2012

Websites

Publications

Gurol-Urganci I, Geary RS, Mamza JB, Duckett J, El-Hamamsy D, Dolan L, Tincello DG, van der Meulen J. Long-term Rate of Mesh Sling Removal Following Midurethral Mesh Sling Insertion Among Women With Stress Urinary Incontinence. JAMA. 2018;320:1659-1669. doi: 10.1001/jama.2018.14997.

Obloza A, Teo R, Marriott E, Parker G, Tincello D. Association of baseline severity of lower urinary tract symptoms with the success conservative therapy for urinary incontinence in women. Int Urogynecol J. 2018 Oct 10. doi: 10.1007/s00192-018-3778-0.

Medina Lucena H, Tincello DG. Validation of a water-load protocol to define the pattern of bladder sensation. Int Urogynecol J. 2018 Sep 5. doi: 10.1007/s00192-018-3760-x.

Medina Lucena H, Williams K, Tincello DG, Lipp A, Shaw C. Evaluation of the IncoStress device for urinary incontinence: a feasibility study and pilot randomised controlled trial. Int Urogynecol J 2018;

Homer T, Shen J, Vale L, McColl E, Tincello DG, Hilton P. Invasive urodynamic testing prior to surgical treatment for stress urinary incontinence in women: cost-effectiveness and value of information analyses in the context of a mixed methods feasibility study. Pilot Feasibility Studies 2018;4:67  doi: 10.1007/s00192-018-3749-5.

Maxwell M, Semple K, Wane S, Elders A, Duncan E, Abhyankar P, Wilkinson J, Tincello D, Calveley E, MacFarlane M, McClurg D, Guerrero K, Mason H, Hagen S. PROPEL: implementation of an evidence based pelvic floor muscle training intervention for women with pelvic organ prolapse: a realist evaluation and outcomes study protocol. BMC Health Serv Res. 2017 Dec 22;17:843. doi: 10.1186/s12913-017-2795-x.

Tincello DG, Armstrong N, Hilton P, Buckley B, Mayne C. Surgery for recurrent stress incontinence: views of surgeons and women. Neurourol Urodyn 2018;29:45-54 DOI: 10.1007/s00192-017-3376-6.

Bakali E, Hong J, Gillespie J, Tincello DG. Saccharin increases perception of bladder filling in a forced diuresis experiment. Neurourol Urodyn 2017;36:1363-8. doi: 10.1002/nau.23112.

Owen RK, Abrams KR, Mayne C, Slack M, Tincello DG. Comparison of the effectiveness of repeated injections of onabotulinum toxin A for refractory idiopathic detrusor overactivity: analysis of an open label extension of a randomized trial (the RELAX study). Neurourol Urodyn 2017;36:1201-7. doi: 10.1002/nau.23095

Owen RK, Abrams KR, Mayne CJ, Slack MC, Tincello DG. Patient factors associated with onabotulinum toxin A treatment outcome in women in women with detrusor overactivity Neurourol Urodyn 2017 36:426-43 doi: 10.1002/nau.22948.

Hilton P, Buckley BS, McColl E, Howel D, Tincello DG, Brennand C; INVESTIGATE studies group. Understanding variations in patient screening and recruitment in a multicentre pilot randomised controlled trial: a vignette-based study. Trials. 2016 Oct 26;17:522.

Medina Lucena H, Giarenis I, Tincello DG. Early post-operative voiding dysfunction after insertion of retropubic midurethral tape. Int Urogynecol J 2016;27:1529-33 doi: 10.1007/s00192-016-2992-x.
Bakali E, Mbaki Y, Lambert DG, Mason R, Elliott RA, Tincello DG. Effects of cannabinoid receptor activation by CP55,940 on normal and irritation induced bladder overactivity in rats. Int Urogynecol J 2016;27:1393-400 doi: 10.1007/s00192-016-2984-x

Armstrong N, Shaw E, McColl E, Tincello DG, Hilton P. Trial participation as avoidance strategy: a qualitative study. Health Exp 2016;19:1346-1354. doi: 10.1111/hex.12437

Hilton P, Armstrong N, Brennand C, Howel D, Shen J, Bryant A, Tincello DG, Lucas MG, Buckley BS, Chapple CR, Homer T, Vale L, McColl E; INVESTIGATE Studies Group. A mixed methods study to assess the feasibility of a randomised controlled trial of invasive urodynamic testing versus clinical assessment and non-invasive tests prior to surgery for stress urinary incontinence in women: the INVESTIGATE-I study. Trials. 2015 Sep 8;16:400. doi: 10.1186/s13063-015-0928-2.

Bakali E, McDonald J, Elliott RA, Lambert DG, Tincello DG. Cannabinoid receptor expression in the bladder is altered in detrusor overactivity. Int Urogynecol J 2016:27;129-39

Hilton P, Armstrong N, Brennand C, Howel D, Shen J, Bryant A, Tincello DG, Lucas MG, Buckley BS, Chapple CR, Homer T, Vale L, McColl E. INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?): a mixed-methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing prior to surgery for stress urinary incontinence in women. Health Technol Assess 2015;19(15):1-274 DOI: 10.3310/hta19150

Owen RK, Tincello DG, Abrams KR. Network meta-analysis: development of a three-level hierarchical modelling approach incorporating dose-related constraints. Value Health 2015;18:116-20.
Bhandari HM, Li K, Mayne CJ, Tincello DG. Maximum bladder volume as surrogate screening test for detrusor overactivty. J Obstet Gynecol 2014;34:420-3.

Bakali E, Elliott RA, Taylor AH, Lambert DG, Willets JM, Tincello DG. Human urothelial cell lines as potential models for studying cannabinoid and excitatory receptor interactions in the urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 2014;387:581-9.

Baskayne K, Willars J, Pitchforth EL, Tincello DG. Expectations of women having prolapse surgery: a qualitative study. Neurourol Urodyn 2014;33:85-89

Elliot, RA, Tonnu A, Ghaffar N, Taylor AH, Tincello DG, Norman RI. Enhanced Purinergic Contractile Responses and P2X1 Receptor Expression in Detrusor Muscle during Cycles of Hypoxia-Glucopenia and Reoxygenation. Exp Physiol 2013;98:1683-95

Bakali E, Buckley BS, Hilton P, Tincello DG. Treatment of recurrent stress urinary incontinence after failed minimally invasive synthetic suburethral tape surgery in women. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009407. DOI: 10.1002/14651858.CD009407.

Tincello DG, Owen RK, Slack MC, Abrams KR, Validation of the Patient Global Impression of Severity and Improvement Scales for overactive bladder and detrusor overactivity. BJOG 2013;120:212-6.

Hilton P, Bryant A, Howel D, McColl E, Buckley B, Lucas M, Tincello DG, Armstrong N. Assessing professional equipoise and views about a future clinical trial of invasive urodynamics prior to surgery for stress urinary incontinence in women: a survey within a mixed methods feasibility study. Neurourol Urodyn 2012;31:1223-30.

Bakali E, Elliott RA, Willets J, Marczylo TM, Taylor AH, Konje JC, Tincello DG. Distribution and function of the endocannabinoid system in the rat and human bladder. IUGA J 2013;24:855-63.

Tincello DG, Kenyon S, Abrams KR, Mayne CJ, Toozs-Hobson P, Taylor DJ, Slack MC. Botulinum toxin A versus placebo for refractory detrusor overactivity in women: a randomised, blinded, placebo controlled trial of 240 women (the RELAX study) . Eur Urol 2012;62:507-514.

Elliott RA, Kapoor S, Tincello DG. Expression and Distribution of the Sweet Taste Receptor isoforms TAS1R2, TAS1R3 in Human and Rat Urinary Bladder. J Urol 2011;186:2455-62.

Tincello DG, Botha T, Grier D, Jones P, Subramanian D, Urquhart C, Kirkemo A, Khandwala S. The TVT World Registry: A prospective evaluation of the safety and efficacy of three suburethral sling insertion approaches. J Urol 2011;186:2310-5.

Teo REC, Mayne CJ, Moran P, Tincello DG. Randomised controlled trial of TVT versus TVT-O for urodynamic stress incontinence in women. J Urol 2011;185:1350-5.

Bakali E, Pitchforth E, Kenyon S, Jones DR, Tincello DG, the CARPET 1 Trial Group. Clinicians’ views on feasibility of surgical randomised trials: questionnaire survey for the CARPET 1 trial. Neurourol Urodyn 2011;30:69-74.

Jackson CJ, Dixon-Woods M, Eborall H, Kenyon S, Toozs Hobson P, Tincello DG. Women’s views and experiences of a patient preference trial in surgery: a qualitative study of the CARPET 1 trial. Clinical Trials 2010;7: 696–704.

Tincello DG, Kenyon S, Slack MC, Toozs-Hobson PM, Mayne CJ, Jones DR, Taylor DJ. Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: results of and lessons from a pilot randomised patient preference study (CARPET 1) BJOG 2009; 116:1809-14.

Research publication supplementary material

Tincello DG, Botha T, Grier D, Jones P, Subramanian D, Urquhart C, Kirkemo A, Khandwala S. The TVT World Registry: A prospective evaluation of the safety and efficacy of three suburethral sling insertion approaches. J Urol 2011;186:2310-5.

Supplementary Tables (pdf)

Research

The Prolapse and Incontinence Research Group has established a strong international reputation for clinical and laboratory research. Currently, the research focus is on clinical, qualitative and health service delivery research in both the developed world and low and middle income countries, including a priority setting partnership in Gondar, Ethiopia.

Previous research grants

  • Wellcome Seed Award £99, 864.
    Pelvic floor disorders in women in rural Ethiopia. Tincello D.
  • CCF Programme Grants £1,894,963.
    Antenatal Prophylactic Pelvic floor Exercises And Localisation (APPEAL) Programme. Ismail K, Bick D, Coleman T, Daniels J, Davenport C, Dean S, Hemming K, Kidd-Chadwick J, Pearson M, Tincello DG, Bridges N, Hay-Smith J, MacArthur C, Roberts T, Johnston T.
  • NIHR HSDR £559,837.
    Surgical care for female urinary incontinence in England. Van der Meulen J, Gurol-Urganci I, Kiran A, Cohn S, Cromwell D, Tincello D, Duckett J, Gammerman S, Smith R, Henley P, Wilson A.
  • NIHR HSDR £583,216
    Implementation of an evidence based pelvic floor muscle training intervention for women with pelvic organ prolapse (PROlapse and PFMT: implementing Evidence Locally - PROPEL). Maxwell M, Duncan E, Glazener C, Guerrero K, Hagen S, Mason H, Calveley E, Gordon D, Tincello DG, Lough K, Elders A, Wilkinson J.
  • NIHR Methods PhD Fellowship £234,983
    Evaluation of interventions for Overactive Bladder and Detrusor Overactivity: Development and application of evidence synthesis methods for extensive treatment networks. Owen RK, Abrams KR, Bujkiewicz S, Tincello DG.
  • Wellbeing of Women: £70,754
    Surgery for recurrent stress urinary incontinence: surgeons’ and women’s views. Wellbeing of Women. Tincello DG, Armstrong N, Hilton P, Buckley B, Mayne CJ. 2014-15.
  • Moulton Charitable Trust: £10,000
    A pilot comparison of bladder awareness during filling and changes in sensation in Caucasian and Asian Indian women.  Bakali E, Gillespie J, Tincello DG.
  • Wellbeing of Women Research Training Fellowship: £199,973
    Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilisation in human and rat bladder. Bakali E, Tincello DG. 2011-2014.
  • HTA £429,624.
    INVESTIGATE - I (INVasive Evaluation before Surgical Treatment for Incontinence Gives Added Therapeutic Effect?): a pragmatic multicentre pilot study to assess the feasibility of a randomised controlled trial. Hilton P, McColl E, Howell D, Deverill M, Buckley B, Lucas M, Wagg A, Tincello DG.
  • Wellbeing of Women: £103,993
    Randomised trial of botulinum toxin A versus placebo for refractory detrusor overactivity. Tincello DG, Slack M, Mayne CJ, Toozs-Hobson PM, Abrams KR. 2008-2010.
  • Moulton Charitable Trust. £158,288.
    Randomised trial of botulinum toxin A versus placebo for refractory detrusor overactivity. Tincello DG, Slack MC, Mayne CJ, Kenyon S, Taylor DJ, Abrams KR. 2005-2015.
  • Wellbeing of Women £15,894
    Sweet taste receptor expression in the uterus. Smith J, Tincello DG.
  • Medical Research Council: £129,803
    Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: a pilot study. 2005-2007. Tincello DG, Kenyon S, Mayne CJ, Slack M, Toozs-Hobson PM, Jones DR, Taylor DJ. 2005- 2008.

Supervision

  • Dina El-Hamamsy
    Robotic Skills, Gynaecological Practice and Staff Experiences
  • Hayser Medina Lucena
    Bladder Sensation in Health and Disease
  • Hersha Patel
    Attitudes, understanding and compliance with cervical cancer screening in Eastern European migrants
  • Rekha Pillai
    Prediction of miscarriage using a combination of biochemical and ultrasound scan markers - A prospective cohort study
  • Rhiannon Owen, NIHR Methods PhD Fellowship
    Evaluation of interventions for Overactive Bladder and Detrusor Overactivity: Development and application of evidence synthesis methods for extensive treatment networks (£234,983).
  • Evangelia Bakali, Wellbeing of Women Research Training Fellowship
    Wellbeing of Women Research Training Fellowship . Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in human and rat bladder (£199,973).

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