Brad Manktelow

Professor of Medical Statistics

 

CONTACT DETAILSBrad Manktelow

Department of Health Sciences
University of Leicester
George Davies Centre
University Road
Leicester LE1 7RH

+44 (0)116 2525496

brad.manktelow@le.ac.uk

ResearchGate

 

Research interests

Grants

Teaching

Publications

 

Research Interests

I am Professor of Medical Statistics within The Infant Mortality and Morbidity Studies (TIMMS) research group at the University of Leicester.

I am Programme Director of the MSc Quality and Safety in Healthcare at the University of Leicester, which covers both the theoretical and the practical aspects of healthcare quality and patient safety.

My current research and teaching interests centre on the use of data for quality improvement and quality assurance in healthcare. I am also interested in the statistical issues arising from research in perinatal, neonatal and paediatric medicine.

I am also a co-investigator for MBRRACE-UK, the national collaborative programme of work involving the surveillance and investigation of stillbirths, neonatal deaths, and maternal deaths. As the lead statistician for MBRRACE-UK, I supervise the analysis of data for the UK's national perinatal mortality surveillance report.

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Grants

Current

  • HQIP: £714,453. Maternal, Newborn and Infant Clinical Outcome Review Programme (MBRRACE-UK) 2017-2021. Kurinczuk JJ, Knight M, Gray R, Redshaw M, Draper ES, Field DJ, Manktelow BN, Smith LK, Bevan C, Scott J, Brocklehurst P, Neilson J, Kenyon S, Shakespeare J. (https://www.npeu.ox.ac.uk/mbrrace-uk)
  • EU Horizon 2020: £540,241 (UoL). RECAP PRETERM. Draper ES, Johnson S, Manktelow BN.
  • NIHR: £298,828 Optimising Neonatal Service Provision for Preterm Babies (OPTIPREM).

Previous

  • Action Medical Research: £64,088. Standardisation of the PARCA-R.
  • MRC: £1,159,287.16. Optical coherence tomography in infants and children. Gottlob I, Proudlock F, Draper E, Manktelow B.
  • HQIP: £2,145,000. Maternal, Newborn and Infant Clinical Outcome Review Programme (MBRRACE-UK) 2012-2017. Kurinczuk JJ, Knight M, Gray R, Redshaw M, Draper ES, Field DJ, Manktelow BN, Smith LK, Bevan C, Scott J, Brocklehurst P, Neilson J, Kenyon S, Shakespeare J, Modi N. (2012-2017)
  • The Health Foundation / NHS England, Independent evaluation of the feasibility of using the patient activation measure in the NHS in England. Armstrong N, Tarrant C, Martin G, Manktelow B. (2014-2017)
  • NIHR HS&DR Follow-on Studies: £336,577. NeoNet: The right cot, at the right time, at the right place 2. Providing a national demand/capacity model for neonatal care in England. Platt MA, Allen M, Spencer A, Gibson A, Prosser S, Manktelow B, Thornton S, Modi N. (2014-2017)
  • NIHR Research Method Fellowship and Internship (Round 3): £91,000. Manktelow B, Baker R. (2012-2014)
  • NIHR Research for Patient Benefit: £245,125. The hidden risks of preterm birth: How should we follow-up vulnerable babies? Boyle E, Johnson S, Armstrong N, Petrou S, Manktelow B, Field D, Wolke D. (2012-2014)
  • Neonatal and Paediatric Pharmacists Group: £26,251. Intermittent intravenous vancomycin dosage in children aged over 1 month: What dose should we start with and how should we adjust dosage to get optimum trough levels? Nash C, Gooding N, Mulla H, Manktelow B. (2013-2014)
  • NIHR SDO: £133,468. The right cot, at the right time, at the right place. Use of Neonatal Survey data and computer simulation technology to improve design and organisation of neonatal care networks. Pitt MA, Gibson A, Allen M, Manktelow BN, Allwood ACL, Spencer A, Prosser S. (2011-2014)
  • London Strategic Health Authority: £37,550. PICANet scoping exercise on behalf of the NSCT for PIC. Draper ES, Manktelow BN. (2013-2014)
  • NIHR Research Method Fellowship and Internship (Round 2): £91,000. Manktelow B, Baker R. (2011-2013)
  • NIHR Programme Grant: £906,340. Towards reducing variations in infant mortality and morbidity: a population approach. Field D, Draper E, Manktelow B, Smith L, Boyle E, Taylor D, Marlow N, Petrou S, Maubach P. (2008-2013)
  • NIHR Research Method Fellowship and Internship (Round 1): £135,422. Manktelow B, Field D. (2009-2012)
  • NIHR Research for Patient Benefit: £51,774. Assessing the bioequivalence of unlicensed liquid Captopril formulations used in the treatment of children with heart failure: a randomised, open-label, single-centre, crossover study in healthy adults. Mulla H, Pandya H, Tofeig M, Samani N, Tanna S, Tuleau C, Manktelow B. (2007-2009)
  • Yorkshire & The Humber SCG: £23,959. Confidential Enquiry for North Neonatal Network. Draper ES, Field DJ, Manktelow BN. (2008-2010)
  • NHS Executive West Midlands (via North Staffs HA): £265,058. Follow‑up of children treated with neonatal CNEP in Stoke on Trent. Marlow N, Vyas H, Draper ES, Manktelow B. (2002-2004)
  • University Hospitals of Leicester NHS Trust and Leicester Primary Care Research Alliance: £17,801. Neonatal intensive care outcomes and resource utilisation in Trent: 2001-2003 compared with 1991-1993. Dorling J, Lamming C, Draper E, Manktelow B, Bohin S, Field D.

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Teaching

MSc Quality & Safety in Healthcare

PhD Supervision

  • Ruth Matthews

Title of Thesis: Extended perinatal mortality in the UK.

Funder: College of Life Sciences, University of Leicester.

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Recent Publications

Selected Publications

 

Draper, E. S., Manktelow, B. N., Cuttini, M., Maier, R. F., Fenton, A. C., Van Reempts, P., . . . Zeitlin, J. J. (2017). Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe. PEDIATRICS, 139(4), 11 pages. doi:10.1542/peds.2016-1990

 

Smith, L. K., Blondel, B., Van Reempts, P., Draper, E. S., Manktelow, B. N., Barros, H., . . . Zeitlin, J. (2017). Variability in the management and outcomes of extremely preterm births across five European countries: a population-based cohort study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 102(5), F400-F408. doi:10.1136/archdischild-2016-312100

 

Zeitlin, J., Manktelow, B. N., Piedvache, A., Cuttini, M., Boyle, E., van Heijst, A., . . . Maier, R. F. (2016). Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort. BMJ-BRITISH MEDICAL JOURNAL, 354, 10 pages. doi:10.1136/bmj.i2976

 

Johnson, S., Evans, T. A., Draper, E. S., Field, D. J., Manktelow, B. N., Marlow, N., . . . Boyle, E. M. (2015). Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 100(4), F301-F308. doi:10.1136/archdischild-2014-307684

 

Guy, A., Seaton, S. E., Boyle, E. M., Draper, E. S., Field, D. J., Manktelow, B. N., . . . Johnson, S. (2015). Infants Born Late/Moderately Preterm Are at Increased Risk for a Positive Autism Screen at 2 Years of Age. JOURNAL OF PEDIATRICS, 166(2), 269-+. doi:10.1016/j.jpeds.2014.10.053

 

Seaton, S. E., Draper, E. S., Abrams, K. R., Modi, N., Manktelow, B. N., Babirecki, M., . . . Samy, M. (2019). Can we estimate the length of stay of very preterm multiples?. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 104(5), F568-+. doi:10.1136/archdischild-2018-316321

 

Draper, E. S., Zeitlin, J., Manktelow, B. N., Piedvache, A., Cuttini, M., Edstedt Bonamy, A. K., . . . Johnson, S. J. (2020). EPICE cohort: Two-year neurodevelopmental outcomes after very preterm birth. Archives of Disease in Childhood: Fetal and Neonatal Edition, 105(4), 350-356. doi:10.1136/archdischild-2019-317418

 

Best, K. E., Seaton, S. E., Draper, E. S., Field, D. J., Kurinczuk, J. J., Manktelow, B. N., & Smith, L. K. (2019). Assessing the deprivation gap in stillbirths and neonatal deaths by cause of death: a national population-based study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 104(6), F624-+. doi:10.1136/archdischild-2018-316124

 

Pillay, T., Modi, N., Rivero-Arias, O., Manktelow, B., Seaton, S. E., Armstrong, N., . . . Boyle, E. M. (2019). Optimising neonatal service provision for preterm babies born between 27 and 31 weeks gestation in England (OPTI-PREM), using national data, qualitative research and economic analysis: a study protocol. BMJ OPEN, 9(8), 9 pages. doi:10.1136/bmjopen-2019-029421

 

Seaton, S. E., Barker, L., Draper, E. S., Abrams, K. R., Modi, N., Manktelow, B. N., . . . Millman, G. (2019). Estimating neonatal length of stay for babies born very preterm. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 104(2), F182-F186. doi:10.1136/archdischild-2017-314405

 

Villeneuve, E., Landa, P., Allen, M., Spencer, A., Prosser, S., Gibson, A., . . . Pitt, M. (n.d.). A framework to address key issues of neonatal service configuration in England: the NeoNet multimethods study. National Institute for Health Research. doi:10.3310/hsdr06350

 

Patel, A., Manktelow, B., Fawke, J., Proudlock, F. A., & Gottlob, I. (2018). OPTIC NERVE HEAD MORPHOLOGY IN PREMATURE INFANTS 30-42 WEEKS POST MENSTRUAL AGE BY RETINOPATHY OF PREMATURITY STATUS USING HAND-HELD ULTRA-HIGH RESOLUTION SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 59 (pp. 2 pages). Honolulu, HI: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. Retrieved from http://gateway.webofknowledge.com/

 

Norris, T., Seaton, S. E., Manktelow, B. N., Baker, P. N., Kurinczuk, J. J., Field, D., . . . Smith, L. K. (2018). Updated birth weight centiles for England and Wales. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 103(6), F577-F582. doi:10.1136/archdischild-2017-313452

 

Johnson, S., Waheed, G., Manktelow, B. N., Field, D. J., Marlow, N., Draper, E. S., & Boyle, E. M. (2018). Differentiating the Preterm Phenotype: Distinct Profiles of Cognitive and Behavioral Development Following Late and Moderately Preterm Birth. JOURNAL OF PEDIATRICS, 193, 85-+. doi:10.1016/j.jpeds.2017.10.002

 

Smith, L., Matthews, R., Draper, E., Kurinczuk, J., Marlow, N., Manktelow, B., & Field, D. (2017). Trends in the incidence and survival of births at 22 to 26 weeks in England: A population based study. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 124 (pp. 15-16). WILEY. Retrieved from http://gateway.webofknowledge.com/

 

Norris, T., Manktelow, B. N., Smith, L. K., & Draper, E. S. (2017). Causes and temporal changes in nationally collected stillbirth audit data in high-resource settings. SEMINARS IN FETAL & NEONATAL MEDICINE, 22(3), 118-128. doi:10.1016/j.siny.2017.02.003

 

Manktelow, B. N., Seaton, S. E., & Evans, T. A. (2016). Funnel plot control limits to identify poorly performing healthcare providers when there is uncertainty in the value of the benchmark. STATISTICAL METHODS IN MEDICAL RESEARCH, 25(6), 2670-2684. doi:10.1177/0962280214530281

 

Seaton, S. E., Barker, L., Draper, E. S., Abrams, K. R., Modi, N., & Manktelow, B. N. (2016). Modelling Neonatal Care Pathways for Babies Born Preterm: An Application of Multistate Modelling. PLOS ONE, 11(10), 15 pages. doi:10.1371/journal.pone.0165202

 

Seaton, S. E., Barker, L., Jenkins, D., Draper, E. S., Abrams, K. R., & Manktelow, B. N. (2016). What factors predict length of stay in a neonatal unit: a systematic review. BMJ OPEN, 6(10), 10 pages. doi:10.1136/bmjopen-2015-010466

 

Zeitlin, J., Manktelow, B. N., Piedvache, A., Cuttini, M., Boyle, E., van Heijst, A., . . . Maier, R. F. (2016). IMPROVING OUTCOME IN VERY PRETERM INFANTS Tocolysis may optimise outcomes in very preterm infants - IMPROVING OUTCOME IN VERY PRETERM INFANTS Introducing a preterm care bundle: magnesium sulphate can be the fifth component Reply. BMJ-BRITISH MEDICAL JOURNAL, 354, 2 pages. doi:10.1136/bmj.i4671

 

Mohammed, M. A., Manktelow, B. N., & Hofer, T. P. (2016). Comparison of four methods for deriving hospital standardised mortality ratios from a single hierarchical logistic regression model. STATISTICAL METHODS IN MEDICAL RESEARCH, 25(2), 706-715. doi:10.1177/0962280212465165

 

Field, D., Boyle, E., Draper, E., Evans, A., Johnson, S., Khan, K., . . . Smith, L. (2016). Towards reducing variations in infant mortality and morbidity: a population-based approach.

 

Johnson, S., Matthews, R., Draper, E. S., Field, D. J., Manktelow, B. N., Marlow, N., . . . Boyle, E. M. (2016). Eating difficulties in children born late and moderately preterm at 2 y of age: a prospective population-based cohort study. AMERICAN JOURNAL OF CLINICAL NUTRITION, 103(2), 406-414. doi:10.3945/ajcn.115.121061

 

Johnson, S., Matthews, R., Draper, E. S., Field, D. J., Manktelow, B. N., Marlow, N., . . . Boyle, E. M. (2015). Early Emergence of Delayed Social Competence in Infants Born Late and Moderately Preterm. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 36(9), 690-699. doi:10.1097/DBP.0000000000000222

 

Robinson, S. E., Seaton, S. E., Johnson, S., Draper, E. S., Manktelow, B. N., Smith, L. K., . . . Boyle, E. (2015). Respiratory outcomes in late and moderately preterm infants: results from a population-based study. In Journal of Pediatric and Neonatal Individualized Medicine Vol. 4 (pp. 19-20). Budapest.

 

Khan, K. A., Petrou, S., Dritsaki, M., Johnson, S. J., Manktelow, B., Draper, E. S., . . . Boyle, E. M. (2015). Economic costs associated with moderate and late preterm birth: a prospective population-based study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 122(11), 1495-1505. doi:10.1111/1471-0528.13515

 

Field, D., Spata, E., Davies, T., Manktelow, B., Johnson, S., Boyle, E., & Draper, E. S. (2016). Evaluation of the use of a parent questionnaire to provide later health status data: the PANDA study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 101(4), F304-F308. doi:10.1136/archdischild-2015-309247

 

Smith, L. K., Draper, E. S., Evans, T. A., Field, D. J., Johnson, S. J., Manktelow, B. N., . . . Boyle, E. M. (2015). Associations between late and moderately preterm birth and smoking, alcohol, drug use and diet: a population-based case-cohort study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 100(6), F486-F491. doi:10.1136/archdischild-2014-307265

 

Boyle, E. M., Johnson, S., Manktelow, B., Seaton, S. E., Draper, E. S., Smith, L. K., . . . Field, D. J. (2015). Neonatal outcomes and delivery of care for infants born late preterm or moderately preterm: a prospective population-based study. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 100(6), F479-F485. doi:10.1136/archdischild-2014-307347

 

Field, D., Smith, L., Manktelow, B., McParland, P., & Draper, E. S. (2015). Interpretation of early life mortality rates. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 100(2), F99-F100. doi:10.1136/archdischild-2014-306731

 

Kurinczuk, J. J., Draper, E. S., Field, D. J., Bevan, C., Brocklehurst, P., Gray, R., . . . Knight, M. (2014). Experiences with maternal and perinatal death reviews in the UK-the MBRRACE-UK programme. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 121, 41-46. doi:10.1111/1471-0528.12820

 

Manktelow, B. N., Draper, E. S., Field, C., & Field, D. J. (n.d.). Estimates of length of neonatal stay for very premature babies in the UK. Archives of Disease in Childhood. Fetal and Neonatal Edition, 95(4), F288-F292. doi:10.1136/adc.2009.168633

 

Johnson, S., Bountziouka, V., Brocklehurst, P., Linsell, L., Marlow, N., Wolke, D., & Manktelow, B. N. (2019). Standardisation of the Parent Report of Children's Abilities-Revised (PARCA-R): a norm-referenced assessment of cognitive and language development at age 2 years. LANCET CHILD & ADOLESCENT HEALTH, 3(10), 705-712. doi:10.1016/S2352-4642(19)30189-0

 

Armstrong, N., Tarrant, C., Martin, G., Manktelow, B., Brewster, L., & Chew, S. (n.d.). Independent evaluation of the feasibility of using the Patient Activation Measure in the NHS in England - Final report.

 

Parekh, S. A., Boyle, E. M., Guy, A., Blaggan, S., Manktelow, B. N., Wolke, D., & Johnson, S. (2016). Correcting for prematurity affects developmental test scores in infants born late and moderately preterm. EARLY HUMAN DEVELOPMENT, 94, 1-6. doi:10.1016/j.earlhumdev.2016.01.002

 

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