Douglas Tincello

Professor of Urogynaecology and Honorary Consultant Gynaecologist, University Hospitals of Leicester NHS Trust

For NHS patient queries please contact Teresa Shalloe on 0116 258 8391

Contact details

Department of Health Sciences
University of Leicester
Centre for Medicine
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44(0) 116 252 5451 (for academic matters only)
Email: dgt4@le.ac.uk

Personal details

I graduated in medicine from the University of Edinburgh in 1990. My early training was completed in Edinburgh, including two years working at the Medical Research Council Centre for Reproductive Biology. I completed my training in Merseyside where I developed an interest in urogynaecology. I took up a position of Senior Lecturer in Urogynaecology at the University of Leicester in April 2002 (Professor of Urogynaecology from 2012) and have now established a portfolio of clinical and laboratory based research in urogynaecology.

Professional activities

  • Chairman of Wellbeing of Women (WoW) Research Advisory Committee (RAC) June 2012-date (Wellbeing of Women is the charity most closely associated with the Royal College of Obstetricians & Gynaecologists, and gives research grants in all areas of women’s health, plus providing Research Training Fellowships for young clinical scientists in Obstetrics & Gynaecology)
  • Previously vice chairman of WoW RAC 2010-2012 and member of the RAC since 2006
  • Member of NIHR Programme Grants for Applied Research College of Experts 2011- 2016
  • Editorial board member of BJOG 2012-date
  • Scientific editor of BJOG, an International Journal of Obstetrics & Gynaecology 2004-2012

Websites

Publications

Bakali E, Elliott RA, Taylor AH, Lambert DG, Willets JM, Tincello DG. Human urothelial cell lines as potential models for studying cannabinoid and excitatory receptor interactions in the urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 2014;387:581-9.

Baskayne K, Willars J, Pitchforth EL, Tincello DG. Expectations of women having prolapse surgery: a qualitative study. Neurourol Urodyn 2014;33:85-89

Elliot, RA, Tonnu A, Ghaffar N, Taylor AH, Tincello DG, Norman RI. Enhanced Purinergic Contractile Responses and P2X1 Receptor Expression in Detrusor Muscle during Cycles of Hypoxia-Glucopenia and Reoxygenation. Exp Physiol 2013;98:1683-95

Bakali E, Buckley BS, Hilton P, Tincello DG. Treatment of recurrent stress urinary incontinence after failed minimally invasive synthetic suburethral tape surgery in women. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009407. DOI: 10.1002/14651858.CD009407.

Tincello DG, Owen RK, Slack MC, Abrams KR, Validation of the Patient Global Impression of Severity and Improvement Scales for overactive bladder and detrusor overactivity. BJOG 2013;120:212-6.

Hilton P, Bryant A, Howel D, McColl E, Buckley B, Lucas M, Tincello DG, Armstrong N. Assessing professional equipoise and views about a future clinical trial of invasive urodynamics prior to surgery for stress urinary incontinence in women: a survey within a mixed methods feasibility study. Neurourol Urodyn 2012;31:1223-30.

Bakali E, Elliott RA, Willets J, Marczylo TM, Taylor AH, Konje JC, Tincello DG. Distribution and function of the endocannabinoid system in the rat and human bladder. IUGA J 2013;24:855-63.

Tincello DG, Kenyon S, Abrams KR, Mayne CJ, Toozs-Hobson P, Taylor DJ, Slack MC. Botulinum toxin A versus placebo for refractory detrusor overactivity in women: a randomised, blinded, placebo controlled trial of 240 women (the RELAX study) . Eur Urol 2012;62:507-514.

Elliott RA, Kapoor S, Tincello DG. Expression and Distribution of the Sweet Taste Receptor isoforms TAS1R2, TAS1R3 in Human and Rat Urinary Bladder. J Urol 2011;186:2455-62.

Tincello DG, Botha T, Grier D, Jones P, Subramanian D, Urquhart C, Kirkemo A, Khandwala S. The TVT World Registry: A prospective evaluation of the safety and efficacy of three suburethral sling insertion approaches. J Urol 2011;186:2310-5.

Teo REC, Mayne CJ, Moran P, Tincello DG. Randomised controlled trial of TVT versus TVT-O for urodynamic stress incontinence in women. J Urol 2011;185:1350-5.

Bakali E, Pitchforth E, Kenyon S, Jones DR, Tincello DG, the CARPET 1 Trial Group. Clinicians’ views on feasibility of surgical randomised trials: questionnaire survey for the CARPET 1 trial. Neurourol Urodyn 2011;30:69-74.

Jackson CJ, Dixon-Woods M, Eborall H, Kenyon S, Toozs Hobson P, Tincello DG. Women’s views and experiences of a patient preference trial in surgery: a qualitative study of the CARPET 1 trial. Clinical Trials 2010;7: 696–704.

Tincello DG, Kenyon S, Slack MC, Toozs-Hobson PM, Mayne CJ, Jones DR, Taylor DJ. Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: results of and lessons from a pilot randomised patient preference study (CARPET 1) BJOG 2009; 116:1809-14.

Research publication supplementary material

Tincello DG, Botha T, Grier D, Jones P, Subramanian D, Urquhart C, Kirkemo A, Khandwala S. The TVT World Registry: A prospective evaluation of the safety and efficacy of three suburethral sling insertion approaches. J Urol 2011;186:2310-5.

Supplementary Tables (pdf)

Research

The Prolapse and Incontinence Research Group has established a strong international reputation for clinical and laboratory research. Specific areas of clinical research currently under investigation include:

  • Evaluation of the efficacy and safety of botulinum toxin for treatment of detrusor overactivity in women
  • An assessment of the clinical utility of urodynamic testing before the decision to perform surgery on women with symptoms of stress urinary incontinence, in collaboration with Mr Paul Hilton and the University of Newcastle, as co-investigators in the INVESTIGATE-I study
  • Evaluation of the safety and efficacy of standard prolapse surgery compared with synthetic and biological mesh, as an investigator site for the PROSPECT study and the VUE study

Specific areas of laboratory research include:

  • Study of the biology of endogenous cannabinoids within the human and rodent bladder, in collaboration with members of the Endocannabinoid Research Group, and with Professor Justin Konje, Professor Dave Lambert and Dr Jonathon Willets Study of the function of the T1R taste receptor G-protein coupled receptor family in the rodent and human bladder, continuing recent work describing the presence of these receptors in the bladder for the first time.

Previous research grants

  • Wellbeing of Women: £70,754
    Surgery for recurrent stress urinary incontinence: surgeons’ and women’s views. Wellbeing of Women. Tincello DG, Armstrong N, Hilton P, Buckley B, Mayne CJ. 2014-15.
  • Wellbeing of Women Research Training Fellowship: £199,973
    Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilisation in human and rat bladder. Bakali E, Tincello DG. 2011-2014.
  • Wellbeing of Women: £103,993
    Randomised trial of botulinum toxin A versus placebo for refractory detrusor overactivity. Tincello DG, Slack M, Mayne CJ, Toozs-Hobson PM, Abrams KR. 2008-2010.
  • Moulton Charitable Trust: £158,288
    Randomised trial of botulinum toxin A versus placebo for refractory detrusor overactivity. Tincello DG, Slack MC, Mayne CJ, Kenyon S, Taylor DJ, Abrams KR. 2005-2015.
  • Human Tissue Authority: £429,624
    INVESTIGATE - I (INVasive Evaluation before Surgical Treatment for Incontinence Gives Added Therapeutic Effect?): a pragmatic multicentre pilot study to assess the feasibility of a randomised controlled trial. Hilton P, McColl E, Howell D, Deverill M, Buckley B, Lucas M, Wagg A, Tincello DG. 2010-2013.
  • Wellbeing of Women Entry Level Scholarship: £19,507
    Distribution and expression of cannabinoid receptors in human and rodent bladders and action upon pre- and post-synaptic neurotransmitter pathways. Bakali E, Tincello DG. 2009-2010.
  • International Urogynaecology Association: $20,000
    The role and significance of the sweet taste receptor isoform T1R3 in the rodent and human bladder. Tincello DG, Elliott RA, Taylor AH, Willets J, Mayne CJ. 2008-2010.
  • Medical Research Council: £129,803
    Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: a pilot study. 2005-2007. Tincello DG, Kenyon S, Mayne CJ, Slack M, Toozs-Hobson PM, Jones DR, Taylor DJ. 2005- 2008.
  • ucb Pharma Ltd. £14,946
    A study to compare bladder function of healthy Asian and Caucasian women. Tincello DG, Doshani A, Piper JA, Mayne CJ. 2006-2008.
  • Ethicon Inc. $41,388
    A study to examine the expectations of women due for prolapse surgery. Tincello DG, Pitchforth E. 2006-2008
  • Astellas Pharma Ltd: £10,000
    Continence Awareness in South Asian Women. Tincello DG, Doshani A, Pitchforth E. 2006-2008.
  • BUPA Foundation: £104,120
    Evaluation of diet and lifestyle, comorbidity and socio-economic factors in the aetiology of urinary storage disorder in women. McGrother C, Tincello DG, Thompson J, Wagg A. 2005-2007.

Supervision

  • Rhiannon Owen, NIHR Methods PhD Fellowship
    Evaluation of interventions for Overactive Bladder and Detrusor Overactivity: Development and application of evidence synthesis methods for extensive treatment networks (£234,983)
  • Evangelia Bakali, Wellbeing of Women Research Training Fellowship
    Wellbeing of Women Research Training Fellowship £199,973. Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in human and rat bladder

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