David Rowbotham, MD, MRCP, FRCA, FFARCSI

Professor of Anaesthesia and Pain Management


CONTACT DETAILS

Department of Health Sciences
Anaesthesia & Pain Management
University of Leicester
Level 3, Victoria Building
Leicester Royal Infirmary
Leicester
LE1 5WW

 

Tel: 00 44 116 2585735/2585376

Email: djr8@le.ac.uk    

 

RESEARCH INTERESTS:

Laboratory investigations of the opioid receptor system, including the development of novel analgesic molecules and the clinical management of chronic nociceptive and neuropathic pain.

Governance and efficient delivery system for clinical research within the NHS.

 

RESEARCH PROJECTS

Co-investigator

  • Bridging technological and clinical research - cementing the alliance of Loughborough University and the University Hospitals of Leicester NHS Trust
  • Establishment of the LNR Collaboration in Leadership in Applied Health Research and Care
  • Strategies to reduce morphine tolerance in cancer: evaluation of novel bifunctional opioids
  • Trust applicant for the cardiovascular Leicester Biomedical Research Unit

 

PROFESSIONAL AWARDS
  • Association of Anaesthetists Henry Featherstone Award for contributions to anaesthesia 2008 
  • Vice-President medal and the Anniversary medal, Association of Anaesthetists of Great Britain & Ireland for services to the specialty

 

PROFESSIONAL ACTIVITIES
  • Vice Dean, Faculty of Pain Medicine, Royal College of Anaesthetists (2009-present)
  • Advisor to NICE guidelines on the treatment of neuropathic pain (2008-present)
  • Vice President, Association of Anaesthetists of Great Britain & Ireland, (2008-2009)
  • Founding Chairman, National Institute for Academic Anaesthesia Research Council (2008-present)
  • Chairman Academic & Research Committee, Royal College of Anaesthetists (2007-2008)
  • Clinical Director LNR Comprehensive Local Research network (2007-present)
  • Ministry of Defence Civilian Advisor for Anaesthesia (2007-present)
  • East Midlands NIHR Research for Patient Benefit Committee (2006-present)
  • Council Member, Royal College of Anaesthetists (2006-present)
  • Chairman, Research Committee, Association of Anaesthetists (2005-present)
  • Board Member, Faculty of Pain Medicine, Royal College of Anaesthetists (2005-present)
  • Council Member, Anaesthetic Research Society (2005-present)
  • Board Member, NHS Confederation Health Services Research Network (2005-6)
  • Council Member, Association of Anaesthetists of Great Britain & Ireland, (2004-present)
  • Research Committee, European Federation of IASP Chapters (2003-5)
  • Research Grant Awards Committee, International Association for the Study of Pain (2002-present)
  • Editor-in-Chief, Continuing Education in Anaesthesia, Critical Care & Pain (2000-present)
  • Advisor to the British National Formulary (2000-present)
  • Rsearch Grants Programme Committee, European Society of Anaesthesiologists (1999-2004)
  • Editor, British Journal of Anaesthesia (1996-2005)
  • Board of British Journal of Anaesthesia (1993-present)

 

INVITED LECTURES
  • Cecil Grey Memorial Lecture, Tri-service Anaesthetic Society 2006

 

POSTGRADUATE SUPERVISION

Co-supervised:

  • Nikolas Dietis, Full-time PhD Student
    Title of Thesis: Novel bifunctional opioids
    Funder: HOPE against Cancer
  • Hesham Nasnoush, Full-time PhD Student
    Title of Thesis: Physical activity in chronic low back pain
    Funder: Libyan Embassy Department of Education
  • Julia Morris, MSc, Part-time PhD Student
    Title of Thesis: A community intervention in low back pain
    Funder: States of Jersey

 

TEACHING ACTIVITIES
  • Director, MSc Pain management course
  • Module Lead, MSc Pain Intro/research methods

  • Module Lead, MSc pain Dissertation clinics

  • Various lectures on pain management and research organisation 

  • Regular lectures at national and international conferences on pain management

 

SELECTED PUBLICATIONS

Rowbotham DJ. Neurokinin-1 antagonists: a step change in prevention of postoperative nausea and vomiting? British Journal of Anaesthesia 2009; 103: 5-6

Dietis N, Guerrini R, Calo G, Salvadori S, Rowbotham DJ, Lambert DG. Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile. British Journal of Anaesthesia 2009; 103: 38-49

Williams JP, Thompson JP, Rowbotham DJ, Lambert DG. Human peripheral blood mononuclear cells produce pre-pro-nociceptin/orphanin FQ mRNA. Anesthesia & Analgesia 2008; 106: 865-6

Williams JP, Thompson JP, Young SP, Gold SJ, McDonald J, Rowbotham DJ, Lambert DG. Nociceptin and urotensin-II concentrations in critically ill patients with sepsis. British Journal of Anaesthesia 2008; 100: 810-4

Barnes TA, McDonald J, Rowbotham DJ, Duarte TL, Lambert DG. Effects of receptor density on Nociceptin/OrphaninFQ peptide receptor desensitisation: studies using the ecdysone inducible expression system. Naunyn-Schmiedebergs Archives of Pharmacology 2007; 376: 217-25

Fernandez MI, Watson PJ, Rowbotham DJ. Effect of pulsed magnetic field therapy on pain reported by human volunteers in a laboratory model of acute pain. British Journal of Anaesthesia 2007; 99: 266-9

Gore M, Dukes E, Rowbotham DJ, Tai KS, Leslie D. Clinical characteristics and pain management among patients with painful peripheral neuropathic disorders in general practice. European Journal of Pain 2007; 11: 652-64

Kitayama M, McDonald J, Barnes TA, Calo G, Guerrini R, Rowbotham DJ, Lambert DG. In vitro pharmacological characterisation of a novel cyclic nociceptin/orphanin FQ analogue c[Cys(7,10)]N/OFQ(1-13)NH2. Naunyn-Schmiedebergs Archives of Pharmacology 2007; 375: 369-76

Sneyd JR, Langton JA, Allan LG, Peacock JE, Rowbotham DJ. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. British Journal of Anaesthesia 2007; 98: 672-6

Williams JP, Thompson JP, McDonald J, Barnes TA, Cote T, Rowbotham DJ, Lambert DG. Human peripheral blood mononuclear cells express nociceptin/orphanin FQ, but not mu, delta, or kappa opioid receptors. Anesthesia & Analgesia 2007; 105: 998-1005

Camarda V, Spagnol M, Song W, Vergura R, Roth A, Cavanni P, Guerrini R, Marzola E, Savadori S, Regoli D, Douglas SA, Thompson JP, Rowbotham DJ, Lambert DG, Calo G.  In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803). British Journal of Pharmacology 2006; 147:92-100

Song W, McDonald J, Camarda V, Calo G, Guerrini R, Marzola E, Thompson JP, Rowbotham DJ, Lambert DG. Cell and tissue responses of a range of urotensin II analogs at cloned and native urotensin II receptors.  Naunyn-Schmiedederg’s Archives of Pharmacology 2006; 373: 148-7

McDermott AM, Toelle TR, Rowbotham DJ, Schafer CP, Dukes EM. The burden of neuropathic pain: results from a cross-sectional survey. European Journal of Pain 2006; 10: 127-135

Gore M, Dukes E, Rowbotham D, Tai K-S, Leslie DL. Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline.  Pain Practice 2006; 6: 265-272

 

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