John Thompson

Professor of Genetic Epidemiology

John Thompson

Contact details

Department of Health Sciences
University of Leicester
Adrian Building, University Road
Leicester, LE1 7RH

Tel: +44(0) 116 229 7269
Email: trj@le.ac.uk

Personal details

Website

Research

My research involves developing and applying new statistical methods to problems in genetics and epidemiology. Current research topics include:

  • Methods for the meta-analysis of genetic association studies
  • Methods for estimating phenotype-disease associations using Mendelian randomisation
  • Methods for analysing whole genome scans
  • Applications of graphical models in epidemiology

Supervision

Recent PhD supervision:

  • Chris Newby: Identifiying Asthma PhenotypesThrough Latent Variable Analysis
    Astra Zeneca funded.
  • Mark Rutherford: Relative Survival Applied to Cancer Registries
    Medical Research Council (MRC) funded.
  • Claire WestonCure Models for Childhood Cancer
  • Thomas Palmer: Extensions to Mendelian Randomization
    MRC funded.
  • Jack Bowden: On the Use of Data Augmentation to Model Biomedical Data in the Presence of Selection Bias
    MRC funded.
  • Cosetta Minelli: Meta-Analysis of Genetic Association studies
    DoH funded.

Publications

Go To: 2009, 2008
2009

Attia, J.; Ioannidis, J.; Thakkinstian, A.; McEvoy, M.; Scott, R.; Minelli, C.; Thompson, J.; Infante-Rivard, C. & Guyatt, G. How to use an article about genetic association A: background concepts JAMA, 2009, 301, 74-8

Attia, J.; Ioannidis, J.; Thakkinstian, A.; McEvoy, M.; Scott, R.; Minelli, C.; Thompson, J.; Infante-Rivard, C. & Guyatt, G. How to use an article about genetic association B: are the results of the study valid? JAMA, 2009, 301, 191-197

Attia, J.; Ioannidis, J.; Thakkinstian, A.; McEvoy, M.; Scott, R.; Minelli, C.; Thompson, J.; Infante-Rivard, C. & Guyatt, G. How to use an article about genetic association C: What are the results and will they help me in caring for my patients? JAMA, 2009, 301, 304-308

Coronary Artery Disease Consortium Large scale association analysis of novel genetic loci for coronary artery disease Arteriosclerosis, thrombosis and vascular biology, 2009, 29, available electronically

Erdmann, J.; Grosshennig, A.; Braund, P.; Konig, I.; Hengstenberg, C.; Hall, A.; Linsel-Nitschke, P.; Kathiresan, S.; Wright, B.; Tregouet, D.; Cambien, F.; Bruse, P.; Aherrahrou, Z.; Wagner, A.; Stark, K.; Scwartz, S.; Salomaa, V.; Elosua, R.; Melander, O.; Voight, B.; O'Donnell, C.; Peltonen, L.; Siscovick, D.; Althuler, D.; Merlini, P.; Peyvandi, F.; Bernardinelli, L.; Ardissino, D.; Schillert, A.; Blankenberg, S.; Zeller, T.; Wild, P.; Schwarz, D.; Tiret, L.; Perret, C.; Schreiber, S.; El Mokhtari, N.; Schafer, A.; Marz, W.; Renner, W.; Bugert, P.; Kluter, H.; Schrezenmeir, J.; Rubin, D.; Ball, S.; Balmforth, A.; Wichmann, H.; Meitinger, T.; Fischer, M.; Meisinger, C.; Baumert, J.; Peters, A.; Ouwehand, W.; Thrombosis, I. A.; vascular Biology Working Group; Wellcome Trust Case Control Consortium; Cardiogenics Consortium; Deloukas, P.; Thompson, J.; Ziegler, A.; Samani, N. & Schunkert, H. New susceptibility locus for coronary artery disease on chromosome 3q22.3 Nature Genetics, 2009, advance online publication

Lambert, P.; Dickman, P.; Weston, C. & Thompson, J. Estimating the cure fraction in population-based cancer studies using finite mixture models Journal of the Royal Statistical Society, Series A, 2009, in press

Myocardial Infarction Genetics Consortium Genome-wide association of early onset myocardial infarction with single nucleotide polymorphisms and copy number variant Nature Genetics, 2009, 301, Advance online publication

Thakkinstian, A.; Thompson, J.; Minelli, C. & Attia, J. Choosing between per-genotype, per-allele and trend approaches for initial detection of gene-disease association Journal of Applied Statistics, 2009, Electronic early view

Tregouet, D.; Konig, I.; Erdmann, J.; Munteanu, A.; Braund, P.; Hall, A.; Grosshennig, A.; Linsel-Nitschke, P.; Perret, C.; DeSuremain, M.; Meitinger, T.; Wright, B.; Preuss, A.; Balmforth, A.; Ball, S.; Meisinger, C.; Germain, C.; Evans, A.; Arveiller, D.; Luc, G.; Ruidavets, J.; Morrison, C.; van der Harst, P.; Schreiber, S.; Neureuther, K.; Schafer, A.; Bugert, P.; El Mokhtari, N.; Schrezenmeir, J.; Stark, K.; Rubin, D.; Wichmann, H.; Hengstenberg, C.; Ouwehand, W.; Wellcome Trust Case Control Consortium; Cardiogenics Consortium; Ziegler, A.; Tiret, L.; Thompson, J.; Cambien, F.; Schunkert, H. & Samani, N. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease Nature Genetics, 2009, Advance online publication

Weston, C. & Thompson, J. The definition of start times in cancer treatment studies analysed by non-mixture cure models Journal of Applied Statistics, 2009, 36, 39-52

2008

Berth-Jones, J.; Thompson, J. & Papp, K. A study examining inter and intra-rater reliability of a novel instrument for assessment of psoriasis: the Copenhagen Psoriasis Severity Index British Journal of Dermatology, 2008, 159, 407-12

Bown, M.; Braund, P.; Thompson, J.; London, N.; Samani, N. & Sayers, R. Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm Circulation: Cardiovascular Genetics, 2008, 1, 39-42

Dias, J.; Rajan, R. & Thompson, J. Which questionnaire is best? The reliability, validity and ease of use of the Patient Evaluation Measure, the Disabilities of the ARM, Shoulder and Hand and the Michigan Hand Outcoem Measure Journal of Hand Surgery - European Volume, 2008, 33, 9-17

Ewies, A.; Elshafie, M.; Li, J.; Stanley, A.; Thompson, J.; Styles, J. & White, I.N. abd Al-Azzawi, F. Changes in transcription profile and cuycloskeleton morphology in pelvic logament fibroblasts in response to stretch: the effects of estradiol and leveormeloxifene Molecular Human Reproduction, 2008, 14, 127-135

Li, J.; Wang, H.; Johnson, S.; Horner-Glister, E.; Thompson, J.; White, I. & Al-Azzawi, F. Differing transcription responses to pulsed or continuous estradiol exposure in umbilical vein endomthelial cell Journal of Steroid Biochemistry and Molecular Biology, 2008, 111, 41-49

Mangino, M.; Brouilette, S.; Braund, P.; Tirmizi, N.; Vasa-Nicotera, M.; Thompson, J. & Samani, N. A regulartory SNP of BICD1 gene contributed to telomere length variation in humans Human Molecular Genetics, 2008, 17, 2518-2523

McGrother, C.; Donaldson, M. & Thompson, J. Re: "Prevalence of the risk factors for urine leakage in a racially and ethnically diverse population of adults: the Boston Area Community (BACH) Survey" American Journal of Epidemiology, 2008, 168, 234

Minelli, C.; Thompson, J.; Abrams, K.; Thakkinstian, A. & Attia, J. How should we use information about HWE in the meta-analysis of genetic association studies? International Journal of Epidemiology, 2008, 37, 136-146

Palmer, T.; Thompson, J.; Tobin, M.; Sheehan, N. & Burton, P. Adjusting for bias and unmeasured confounding in Mendelian randomisation studies with binary responses International Journal of Epidemiology, 2008, 37, 1161-8

Riley, R.; Dodd, S.; Craig, J.; Thompson, J. & Williamson, P. Meta-analysis of diagnostic test studies using individual patient data and aggregate data Statistics in Medicine, 2008, 27, 6111-6136

Riley, R.; Thompson, J. & Abrams, K. An alternative model for bivariate random-effects meta-analysis when the within-study correlations are unknown Biostatistics, 2008, 9, 172-86

Schunkert, H.; Gotz, A.; Braund, P.; McGinnis, R.; Tregouet, D.; Mangino, M.; Linsel-Nitschke, P.; Cambien, F.; Hengstenberg, C.; Stark, K.; Blankenberg, S.; Tiret, L.; Ducimetiere, P.; Keniry, A.; Ghori, M.; Schreiber, S.; El Mokhtari, N.; Hall, A.; Dixon, R.; Goodall, A.; Liptau, H.; Pollard, H.; Schwarz, D.; Hothorn, L.; Wichmann, H.; Konig, I.; Fischer, M.; Meisinger, C.; Ouwehand, W.; Deloukas, P.; Thompson, J.; Erdmann, J.; Ziegler, A.; Samani, N. & Consortium., C. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation, 2008, 117, 1675-84

Thompson, J.; Minelli, C.; Abrams, K.; Thakkinstian, A. & Attia, J. Combining information from related meta-analyses of genetic association studies Journal of the Royal Statistical Society Series C, (Applied Statistics), 2008, 57, 103-116

Ziegler, A.; Konig, I. & Thompson, J. Biostatistical aspects of genome-wide association studies Biometrical Journal, 2008, 50, 8-28

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