Professor Louise V. Wain

Professor Louise Wain

GSK / British Lung Foundation Chair in Respiratory Research

CONTACT DETAILS

Department of Health Sciences
University of Leicester
Centre for Medicine, University Road
Leicester, LE1 7RH

Tel: 00 44 116 229 7252
Email: louisewain@le.ac.uk

********* PhD studentship (studying IPF genetics) currently available - contact me for more information*******

 

My research aims are to understand the genetic factors that contriute to risk of developing respiratory disease. My main areas of focus are idiopathic pulmonary fibrosis (IPF) are chronic obstructive pulmonary disease (COPD). IPF is a highly debilitating but rare disease that leads to scarring of the lungs and has a median survival time of 3 years. COPD is a common disease for which smoking is the biggest risk factor yet not all smokers develop the disease (and some non-smokers develop it too). These two diseases are also known to exhibit hetergeneity of symptoms and progression with some individuals experiencing stable disease over many months or years and others experiencing rapid progression and frequent hospitalisations. Identification of the genetic determinants of disease risk and disease progression will improve our understanding of these diseases and lead to new treatments.

SELECTED PUBLICATIONS

2018

Adewoye A.B.,....  Hollox E.J.#, Wain L.V.# (2018) Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function. Wellcome Open Res. 2018 Feb 21;3:13. doi: 10.12688/wellcomeopenres.13902.2. eCollection 2018 (# joint senior author)

2017

Allen R.J.,... Wain L.V.#, Jenkins R.G.# (2017) Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. The Lancet Respiratory Medicine. 5(11):869-880. doi: 10.1016/S2213-2600(17)30387-9 (# joint senior author)

Wain L.V., et al (2017) Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet. ePub 6 Feb doi:10.1038/ng.3787.

Hobbs B.D., de Jong K., Lamontagne M., Bossé Y., Shrine N.,L Soler Artigas M., Jackson V.E., Wain L.V., et al (2017) Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. ePub 6 Feb doi: 10.1038/ng.3752

Ware J.S.*, Wain L.V*. Channavajjhala S.K.* et al (2017) The phenotype and pharmacogenetics of Thiazide Induced Hyponatremia. Journal of Clinical Investigation. doi: 10.1172/JCI89812 (*joint first author)

Wain L.V. et al (2017) Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney. Hypertension. doi: 10.1161/HYPERTENSIONAHA.117.09438

McKay J.D. et al (2017) Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet. doi: 10.1038/ng.3892

Gill D, Sheehan NA, .... Wain L.V., Henderson J, Jarvis D, Minelli C. (2017) Age at menarche and lung function: a Mendelian randomization study. Eur J Epidemiol. doi: 10.1007/s10654-017-0272-9.

Willems S.M. et al (2017)  Large-Scale GWAS Identifies Multiple Loci Associated with Hand Grip Strength and Provides New Insights into the Biology of Muscular Fitness. Nature Communications. In press.

Warren H.R., ......, Wain L.V., [Consortium authorships], Barnes M.R., Tzoulaki I., Caulfield M.J., Elliott P. (2017) Discovery and validation of 107 blood pressure loci from UK Biobank offers novel biological insights into cardiovascular risk. Nat Genet. doi: 10.1038/ng.3768.

John, C., Soler Artigas M. ……Wain L.V.#, Tobin M.D.# (2017) Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline. Thorax. doi: 10.1136/thoraxjnl-2016-208448. (# joint senior authors)

Soler Artigas M., Wain L.V. et al (2017) Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls. PLoS ONE. doi.org/10.1371/journal.pone.0170222

Aschard H., [28 authors], Wain L.V., et al (2017) Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol, doi: 10.1093/ije/dyw318

2016

O'Connell J, Sharp K, Shrine N, Wain L, Hall I, Tobin M, Zagury JF, Delaneau O, Marchini J. Haplotype estimation for biobank-scale data sets. Nature Genetics  doi:10.1038/ng.3583 (2016)

Jackson VE, Ntalla I, Sayers I, .... Strachan DP, Hall IP, Tobin MD, Wain LV. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax 71(6):501-9. doi: 10.1136/thoraxjnl-2015-207876 (2016)

2015

Soler Artigas M, Wain LV, Miller S, Kheirallah AK, Huffman JE, Ntalla I, Shrine N, et al.  Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications 6:8658. doi: 10.1038/ncomms9658 (2015)

Wain, L. V., Shrine, N., Miller, S., Jackson, V. E., Ntalla, I., Artigas, M. S., Billington, C. K., Kheirallah, A. K., Allen, R., Cook, J. P. et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. The Lancet Respiratory Medicine 3, 769-781, doi:10.1016/s2213-2600(15)00283-0 (2015).

UK10K Consortium, Walter, K., Min, J. L., Huang, J., Crooks, L., Memari, Y., McCarthy, S., Perry, J. R., Xu, C., Futema, M. et al. The UK10K project identifies rare variants in health and disease. Nature 526, 82-90, doi:10.1038/nature14962 (2015).

Obeidat, M., Hao, K., Bosse, Y., Nickle, D. C., Nie, Y., Postma, D. S., Laviolette, M., Sandford, A. J., Daley, D. D., Hogg, J. C. et al. Molecular mechanisms underlying variations in lung function: a systems genetics analysis. The Lancet Respiratory Medicine 3, 782-795, doi:10.1016/s2213-2600(15)00380-x (2015).

Gharib, S. A., Loth, D. W., Soler Artigas, M., Birkland, T. P., Wilk, J. B., Wain, L. V., Brody, J. A., Obeidat, M., Hancock, D. B., Tang, W. et al. Integrative pathway genomics of lung function and airflow obstruction. Human Molecular Genetics, doi:10.1093/hmg/ddv378 (2015).

2014

Wain, L. V., Sayers, I., Soler Artigas, M., Portelli, M. A., Zeggini, E., Obeidat, M., Sin, D. D., Bosse, Y., Nickle, D., Brandsma, C. A. et al. Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genetics 10, e1004314, doi:10.1371/journal.pgen.1004314 (2014).

Wain, L. V., Odenthal-Hesse, L., Abujaber, R., Sayers, I., Beardsmore, C., Gaillard, E. A., Chappell, S., Dogaru, C. M., McKeever, T., Guetta-Baranes, T. et al. Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PloS one 9, e84192, doi:10.1371/journal.pone.0084192 (2014).

Wain, L. V. Blood Pressure Genetics and Hypertension: Genome-Wide Analysis and Role of Ancestry. Current Genetic Medicine Reports 2, 13-22 (2014).

Wain, L. V. Rare variants and cardiovascular disease. Briefings in functional genomics, doi:10.1093/bfgp/elu010 (2014).

Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C. et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature Genetics, doi:10.1038/ng.3011 (2014).

Glover, M., Ware, J. S., Henry, A., Wolley, M., Walsh, R., Wain, L. V., Xu, S., Van't Hoff, W. G., Tobin, M. D., Hall, I. P. et al. Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome). Clinical science (London, England : 1979) 126, 721-726, doi:10.1042/cs20130326 (2014).

2011-2013

Obeidat, M., Miller, S., Probert, K., Billington, C. K., Henry, A. P., Hodge, E., Nelson, C. P., Stewart, C. E., Swan, C., Wain, L. V. et al. GSTCD and INTS12 regulation and expression in the human lung. PloS one 8, e74630, doi:10.1371/journal.pone.0074630 (2013).

Wan, Y. I., Shrine, N. R., Soler Artigas, M., Wain, L. V., Blakey, J. D., Moffatt, M. F., Bush, A., Chung, K. F., Cookson, W. O., Strachan, D. P. et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax 67, 762-768, doi:10.1136/thoraxjnl-2011-201262 (2012).

Wain, L. V., Soler Artigas, M. & Tobin, M. D. What can genetics tell us about the cause of fixed airflow obstruction? Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 42, 1176-1182, doi:10.1111/j.1365-2222.2012.03967.x (2012).

Soler Artigas, M., Wain, L. V. & Tobin, M. D. Genome-wide association studies in lung disease. Thorax 67, 271-273, 280, doi:10.1136/thoraxjnl-2011-200724 (2012).

Wain, L. V., Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V. et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics 43, 1005-1011, doi:10.1038/ng.922 (2011).

Wain, L. V. & Tobin, M. D. Copy number variation. Methods in molecular biology (Clifton, N.J.) 713, 167-183, doi:10.1007/978-1-60327-416-6_13 (2011).

Soler Artigas, M., Wain, L. V., Repapi, E., Obeidat, M., Sayers, I., Burton, P. R., Johnson, T., Zhao, J. H., Albrecht, E., Dominiczak, A. F. et al. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. American journal of respiratory and critical care medicine 184, 786-795, doi:10.1164/rccm.201102-0192OC (2011).

Soler Artigas, M., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E. et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics 43, 1082-1090, doi:10.1038/ng.941 (2011).

Obeidat, M., Wain, L. V., Shrine, N., Kalsheker, N., Soler Artigas, M., Repapi, E., Burton, P. R., Johnson, T., Ramasamy, A., Zhao, J. H. et al. A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PloS one 6, e19382, doi:10.1371/journal.pone.0019382 (2011).

International Consortium for Blood Pressure Genome-Wide Association, S., Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C. et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103-109, doi:10.1038/nature10405 (2011).

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