Richard Allen

Richard Allen

Action for Pulmonary Fibrosis Mike Bray Research Fellow

CONTACT DETAILS

Department of Health Sciences
University of Leicester
George Davies Centre
University Road
Leicester LE1 7RH

Tel: 00 44 116 229 7281

Email: rja34@leicester.ac.uk

Personal Details

I did a Mathematics and Statistics BSc at the University of York. Whilst there I became interested in medical research during an internship reviewing the quality of wound trials and decided to do a masters in Medical Statistics at the University of Leicester. I undertook my PhD in genetic epidemiology, also at Leicester, where I studied the genetics of IPF, and have continued my research into the genetics of IPF after my PhD. Since 2019, my research has been funded as part of a fellowship awarded by the patient led charity Action for Pulmonary Fibrosis.

Research

My research focusses on understanding the genetics of a devastating lung disease called idiopathic pulmonary fibrosis (IPF). IPF occurs when there is scarring to the air sacs in the lung due to an unknown cause. This scarring builds up over time, restricting the lungs ability to expand and impairing gas transfer. There is no cure and half of individuals die within 3-5 years of diagnosis. I am performing large-scale genetic analyses to identify changes in DNA that can either increase risk of IPF or affect how quickly the disease progresses. Understanding the underlying biological mechanisms driving IPF aids drug development and will help us target treatments to individuals where they are more likely to be effective.

Publications

For a full list of publications see https://scholar.google.com/citations?user=azeTVe0AAAAJ&hl=en

Leavy OC, Ma SF, Molyneaux PL, …, Allen RJ. Proportion of idiopathic pulmonary fibrosis risk explained by known genetic loci. medRxiv (2020)

Dhindsa RS, Mattson J, Nag A, …, Allen R, …. Identification of a novel missense variant in SPDL1 associated with idiopathic pulmonary fibrosis. bioRxiv (2020)

Duckworth A, Gibbons MA, Allen RJ, …. Evidence that telomere length is causal for idiopathic pulmonary fibrosis but not chronic obstructive pulmonary disease: A Mendelian randomisation study. Lancet Respir Med (In press)

Allen RJ, Guillen-Guio B, Oldham JM, …. Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2020) 201(5):564-574

Allen RJ. Using genetics to identify drug targets for fibrotic lung diseases. Drug Target Review (2020)

Allen RJ and Ortega VE. Resequencing to fine map known idiopathic pulmonary fibrosis risk genes: Homing in on causal variant. Am J Respir Crit Care Med (2019) 200(2):125-127

Hobbs BD, Putman RK, Araki T, …, Allen RJ, …. Overlap of genetic risk between interstitial lung abnormalities and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2019) 200(11):1402-1413

Lorenzo-Salazar JM, Ma SF, Jou J, …, Allen RJ, …. Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing. ERJ Open Res (2019) 5:00071-2019

Dudbridge F, Allen RJ, Sheehan NA, …. Adjustment for index event bias in genome-wide association studies of subsequent events. Nat Commun (2019) 10:1591

Shrine N, Guyatt AL, Erzurumluoglu AM, …, Allen RJ, …. New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet (2019) 51:481-493

Allen RJ, Porte J, Braybrooke R, …. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: A genome-wide association study. Lancet Respir Med (2017) 5(11):869-880

Wain L, Shrine N, Soler Artigas M, …, Allen R, ….Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet (2017) 49:416-425

Wain L, Shrine N, Miller S, …, Allen R, …. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med (2015) 3:769-81

Hodgson R, Allen R, Broderick E, …. Funding source and the quality of reports of chronic wounds trials: 2004 to 2011. Trials (2014) 15:19

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