Sylwia Bujkiewicz

Associate Professor of Biostatistics

Contact details

Department of Health Sciences
University of Leicester
Centre for Medicine,
University Road
Leicester, LE1 7RH

Tel: +44 (0)116 229 7258


Personal details

MSc in Medical Statistics, University of Leicester

PhD, Wroclaw University of Science and Technology

MSc in Applied Mathematics, Wroclaw University of Science and Technology

Fellow of the Royal Statistical Society

Fellow of the Higher Education Academy


Professional activities

I am the joint course director for the MSc in Medical Statistics


MSc in Medical Statistics:

  • Module lead for the Generalized Linear Models module
  • Co-lead for the Modelling in Epidemiology project
  • Multivariate meta-analysis and surrogate endpoint evaluation, as part of the Advanced Evidence Synthesis module
  • MSc dissertation projects


Short CPD courses:

  • Bayesian multivariate meta-analysis with application to surrogate endpoint evaluation and extensions to multivariate network meta-analysis, Roche, Basel, Switzerland.
  • Introduction to Bayesian Statistics, NIHR CLAHRC, University of Nottingham


I have acted as both an internal and external PhD examiner and as a member of clinical trial data monitoring committee.

I am a member of the committee of the local East Midlands group of the Royal Statistical Society.



  • Methods in meta-analysis
  • Multi-parameter evidence synthesis
  • Bayesian methods in healthcare evaluation
  • Bayesian evidence synthesis for surrogate endpoints evaluation
  • Statistical methods in Health Technology Assessment (HTA)
  • Methods for inclusion of Real World Evidence (RWE) in HTA
  • Graphical methods in Health Technology Assessment



  • HOD1: Inferring relative treatment effects from combined randomised and observational data, Medical Research Council, Methodology Research Grant (co-Investigator, January 2019 - December 2021).
  • Bayesian multivariate evidence synthesis methods to incorporate surrogate endpoints in health care evaluation, Medical Research Council, New Investigator Methodology Research Grant (Principal Investigator, March 2014 - August 2017).
  • Real life data in drug development (GetReal), EU’s 7th Framework Programme, Innovative Medicines Initiative (co-investigator, as part of an international consortium of academia, HTA and regulatory agencies, patient representatives and EFPIA companies, October 2013 - March 2017).


PhD supervision:

  • Tasos Papanikos, (2017 -- ) Bayesian evidence synthesis for surrogate endpoints in precision medicine
  • Sze Huey Tan, (2011-2015) Graphical and statistical methods in health technology assessment (partly funded by Johnson & Johnson)
  • Rhiannon Owen, (2013-2017) Evaluation of interventions for Overactive Bladder and Detrusor Overactivity: Development and application of evidence synthesis methods for extensive treatment networks (NIHR funded).


Working papers:

  • Jenkins D, Bujkiewicz S, Marina R, Dequen P, Abrams KR, Methods for the inclusion of real world evidence in network meta-analysis (available at arXiv:1805.06839)
  • Elia EG, Städler N, Ciani O, Taylor RS, Bujkiewicz S, Combining tumour response and progression free survival as surrogate endpoints for overall survival in advanced colorectal cancer  (available at arXiv:1809.02935)
  • Papanikos T, Thompson JT, Abrams KR, Städler N,  Ciani O, Taylor RS, Bujkiewicz S, A Bayesian hierarchical meta-analytic method for modelling surrogate relationships that vary across treatment classes (available at arXiv:1905.07194)
  • Bujkiewicz S, Achana FA, Papanikos T, Riley RD, Abrams KR, NICE DSU Technical Support Document (TSD): Multivariate meta-analysis of summary data for combining treatment effects on correlated outcomes and evaluating surrogate endpoints (forthcoming, 2019).



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