Prof Guiqing Lily Yao, PhD, MSc, and BSc

Research interests: My expertise lines in economic evaluations alongside large clinical trials and decision analytic models particularly in health technology assessment (HTA). I have successfully led on economic components for more than 30 large scale studies including projects funded by the Nation Institute of Health Research (NIHR) and those commissioned by NICE (National Institute of Clinical Excellence). Most of those have led to high impact publications. My research interests have recently expanded to economic evaluation in public health. I am currently conducting several research projects in public health including projects to address antibiotic resistance in China (funded by MRC joint with China NSFC), mental health as well as multi-morbidity. In my previous job, I was head of Health Economics Analytic Team in Academic Unit of Primary Care and Population Science in University of Southampton. In the past, I was awarded several scholarships including the high prestigious one by Sino-British Friendship Scheme.

CONTACT DETAILS

Department of Health Sciences

University of Leicester

University Road

Leicester LE1 7RH

Tel: 00 44 116 252 5110

Email:   gy38@le.ac.uk

 

Personal Details:

Professor in Health Economics

PhD in Health Economics (University of Birmingham)

MSc in Economics of Public Policy (University of Hull)

BSc in Mathematics (Sun Yat-sen University)

Other roles:

Core member of NICE Public Health Advisory Committee;

Health economics lead,  Research Design Services (RDS), East Midland, National Institute of Health Research (NIHR);

Member of MD Board of studies, Medical School;

Postgraduate tutor, Department of Health Science;

Member of MSc Medical Statistics Board of Studies;

Teaching

MRes Health economics

Current PhD/DM students:

James  Morris:  DM project: Treatment Burden for patients with multi-morbidity. University of Southampton

Dr Samuel Tromans:  PhD project: The Prevalence of Social Communication PRoblems in Adult Psychiatric INpaTients (The SPRINT study). University of Leicester.

Research

On-going/recent completed projects:

  1. Research Title: Peripheral arterial disease, High blood pressure and Aneurysm Screening Trial (PHAST) – An evaluation of the acceptability, effectiveness and cost effectiveness of screening for peripheral arterial disease and high blood pressure at the same time as abdominal aortic aneurysm. Start Date 01/04/2020  End Date 30/06/2028. total grant over £2m
  2. PGfAR Competition 29 Stage 2; Reference: NIHR200868 Date submitted:  Programme Programme Grants for Applied Research Call PGfAR Competition 29 Stage 2 Lead Applicant Professor Peter McCulloch Host organisation Oxford University Hospitals NHS Foundation Trust Research. Title: RESPOND study (Rescue for Emergency Surgery Patients Observed to uNdergo acute Deterioration) Start Date 01/03/2020  End Date. Prof Yao is co-applicant and leads health economics of the project. Total grant over £2m
  3. The UK-China AMR Hub on Strategies to reduce the burden of antibiotic resistance in China.  This project is led by Professors Helen Lambert in Bristol and Bo Zheng at Peking University in Beijing funded by a joint UKRI (UK)-NSFC (China) Newton Fund initiative. Prof Yao is CO-PI leads WP3 and methodological group. UK Hub partners (Bristol, Leicester, Bath, Southampton, Public Health England and North Bristol NHS Trust). Total funding in the UK side: Total grant about  £2m; Funded Period: Feb 19 - Jan 22. Prof Yao is co-applicant and leads health economics of the project.
  4. Assessment of patients aged 65+ years with an upper limb fracture for frailty and sarcopenia for the prevention of future falls and fractures: a feasibility study. Funded by RfPB. PI Professor Helen Roberts at University Hospital Southampton NHS Foundation Trust. Prof Yao is co-applicant and leads health economics of the project. Funded Period: Jan 2019 - July 2020. Total grant: about £250 K.
  5. Patient-reported outcome measures for monitoring primary care patients with depression: PROMDEP randomised controlled trial. Prof Yao is co-applicant and leads health economics of the project. Funded Period: 01/01/2019 to: 31/12/2021 (36 months). Total grant about £2m..
  6. Screen and TREAt for Malnutrition (STREAM) Programme”, NIHR PGfAR. Led by Paul Little, University of Southampton, Prof Yao is co-PI and leading health economic component. Total grant over £2m; Funded Period:  01/02/2016-30/05/2021
  7. REducing and preventing COgnitive impairment iN older age groups (the RECON Programme)” NIHR PGfAR. Led by Paul Little, University of Southampton, Prof Yao is co-PI and leading health economic components. Total grant about £3m.  Funded Period:  01/04/2017 -30/03/2015
  8. REviewing long term anti-Depressant Use by Careful monitoring in Everyday practice (REDUCE) programme” NIHR PGfAR. Led by Tony Kendrick, University of Southampton, Prof Yao is co-PI and leading health economic components. Total grant over £2m; Funded Period:  01/10/2016 -30/09/2022
  9. Cancer: Life Affirming Survivorship support in Primary care (CLASP) Programme” NIHR PGfAR. Led by Paul Little, University of Southampton, Prof Yao is co-PI and leading health economic components. Total grant over £2m; Funded Period: 01/01/2016 -31/12/2020
  10. Antibiotics for lower Respiratory Tract Infection in Children presenting in Primary Care (ARTIC PC)” NIHR HTA. Led by Paul Little, University of Southampton, Prof Yao is co-PI and leading health economic components. Total grant over £1m; Funded Period:  01/09/2014 – 30/08/2020
  11. Delayed antibiotic prescribing for respiratory tract infections - an evidence synthesis of individual patient data” NIHR RfPB. Led by Beth Stuart, University of Southampton, Prof Yao is co-PI and leading health economic components. Total grant about £300k; Funded Period:  01/09/2017 -30/08/2020.
  12. A randomised controlled trial comparing three brief interventions to manage overweight in primary care (POWER). The project is led by Paul Little and funded by NIHR HTA. Lily led the health economics components. Duration Jan 2012 – 2015.  HTA monograph published in 2017 and paper published in Lancet.
  13. Creating Learning Environments for Compassionate Care (CLECC): a feasibility study. Funded by HS&DR. PI Dr Jackie Bridges, Faculty of Health Sciences. Lily co-applicant and leads on health economics. Total funding £485,000. started from 1 Dec 2014 for two years.  Completed and reported submitted to HS&DR. March 2017
  14. Feasibility study for a randomised controlled trial of patient reported outcome measures (PROMs) in the assessment and follow-up monitoring of patients with depression in primary care. NIHR Research for Patient Benefit (RfPB). PI Prof Tony Kendrick, University of Southampton. Lily Co-applicant. Total funding £ 300,000 started from 1 Sep 2014 for 2 years. Completed and reported submitted to RfPB and main paper was published to BMJ open.
  15. A Primary Care Trial of a Website Based Infection Control Intervention to Modify Influenza- like Illness and Respiratory Infection Transmission (PRIMIT). Led by Prof Paul Little, Lily co - leads on health economics. Funded by NIHR program grant. Completed in 2016. Main paper published in Lancet.
  16. Probiotics for Preventing Antibiotic Associated Diarrhoea Including Clostridium Difficult Infection. Led Professor Chakravarthi Rajkumar. Lily co-leads on health economics. Funded by DANONE.  Completed and a report submitted to Danone.
  17. Randomised Controlled Trial to Assess the Clinical and Cost-Effectiveness of Physiotherapy and Occupational Therapy in Parkinson's Disease (PD REHAB).  Lily Yao led and supervised a Research Fellow on the Health Economic section. The project is funded by NIHR HTA. Duration Jan 2009 – 2013.  HTA monograph published in 2016
  18. Randomised Study of Autoinflation in 4-11 Years Old School Children with Otitis Media with Effusion (OME) In Primary Care :AIRS;  led by Ian Williams, Lily led the health economics components. Funded by HTA. Completed at 01/10/2014.  Monograph published in 2016.
  19. A Systematic Review and Observational Study of the Epidemiology and Natural History of Progressive Neurological Disease, Targeting User Priorities and Modelling the Impact on Care Services. Led by Professor Cath Sackley. Lily Yao is a co-applicant and leads and co-supervises the Research Fellow on health economic study. NIHR Policy Programme with a total grant of £390,190.  Duration 2008 to 2010. Lily Yao co-applicant. This project completed successfully in Feb. 2009.

Publications in 2020

  1. Zhang J, Dong L, Zhang Y, Chen Y, Yao Y and Han Z. Investigating time, strength, and duration of measures in controlling the spread of COVID-19 using a networked meta-population model. Nonlinear Dynamics (2020). https://doi.org/10.1007/s11071-020-05769-2https://link.springer.com/article/10.1007/s11071-020-05769-2
  2. Tromans, S., Chester, V., Gemegah, E., Roberts, K., Morgan, Z., Yao, G.L. and Brugha, T. (2020), "Autism identification across ethnic groups: a narrative review", Advances in Autism, Vol. ahead-of-print. https://doi.org/10.1108/AIA-03-2020-0017
  3. Kendrick T, Moore M, Leydon G, Stuart B, Geraghty AWA, Yao G, Lewis G, Griffiths G, May C, Dewar-Haggart R et al  Patient-reported outcome measures for monitoring primary care patients with depression (PROMDEP): Study protocol for a randomised controlled trial;   Trials 21, 441 (2020). https://doi.org/10.1186/s13063-020-04344-9.
  4. Kendrick T, Geraghty A, Bowers H, Stuart B, Leydon G, May C, Yao Y, O’Brien W, Glowacka M, Holley S, Williams S, Zhu S, Dewar-Haggart R, Palmer B, Bell B, Collinson S, Fry G,  Lewis G, Griffiths G, Gilbody G, Moncrieff J,  Moore M, Macleod U, Little P, Dowrick C.   REDUCE (Reviewing long-term antidepressant use by careful monitoring in everyday practice) internet and telephone support to people coming off long-term antidepressants: protocol for a randomised controlled trial. Trials 21, 419 (2020). https://doi.org/10.1186/s13063-020-04338-7.
  5. Marius Roman, Riccardo Abbasciano, Suraj Pathak, Shwe Oo, Syabira Yussoff, Marcin Wozniak, Saqib Qureshi, Florence Lai, Tracy Kumar, Guiqing Yao, and Gavin J Murphy. systematic review and meta-analysis of RCTs that have evaluated the Efficacy, Effectiveness, or Cost Effectiveness of Patient Blood Management Interventions in Surgery Patients. British Journal of Anaesthesia, in press and available on line in June 2020. doi: 10.1016/j.bja.2020.04.087.
  6. Tim Colbourn,  William Waites,  Jasmina Panovska-Griffiths.,  David Manheim.,  Simone Sturniolo,  Greg Colbourn,  Prof Cam Bowie, Prof Keith M Godfrey9,  Prof Julian Peto,  Rochelle A Burgess.,  Derek Foster, Prof David McCoy, Nisreen A Alwan., Prof Guiqing Yao., Prof Kang Ouyang, Prof Paul J Roderick , Elena Pizzo., Tony Hill, Prof Nuala McGrath,  Miriam Orcutt, Owain Evans, Nathan J Cheetham, Prof Mark Sculpher, Prof Chris Bonell, Manuel Gomes, Prof Rosalind Raine ; Modelling the health and economic impacts of Population-wide Testing, contact Tracing and Isolation (PTTI) strategies for COVID-19 in the UK. Submitted for the Lancet and now addressing review comments. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3627273

Open Letters

1. Julian Peto,a Nisreen A Alwan,b Keith M Godfrey,c,d Rochelle A Burgess,e David J Hunter,f Elio Riboli,g,h Paul Romer,i and 27 signatories. Universal weekly testing as the UK COVID-19 lockdown exit strategy, Lancet. 2020 2-8 May; 395(10234): 1420–1421. Published online 2020 Apr 21.  doi: 10.1016/S0140-6736(20)30936-3, PMCID: PMC7172826, PMID: 32325027. The full letter at https://ephg-covid-19.org/

2. Dominic Cummings’ actions damage public trust.  a letter sent to No 10 on Friday, 26 May. senior UK academics and health administrators. Published in Guardian.com

https://www.theguardian.com/commentisfree/2020/may/30/dominic-cummings-actions-damage-public-health

3. Open letter recommendation of face mask wearing in public places. Sky News. https://news.sky.com/story/coronavirus-britons-should-wear-cloth-face-coverings-in-public-health-experts-tell-government-11977113.

Full letter https://docs.google.com/forms/d/e/1FAIpQLSeS_4rQIsqNYonGF2VjazPvCzrlIB6NtJ_N-8ybqqOspaqAAg/viewform?from=groupmessage&isappinstalled=0

Leading authors: Paul Roderick and Lily Yao April 2020 et al;

4. Open letter to:  Rt Hon Matt Hancock MP, Secretary of State for Health. Request for immediate introduction of telemedical abortion services to reduce coronavirus transmission. published in the Daily Mail March 2020.

https://www.dailymail.co.uk/femail/article-8367467/Abortions-post-got-rushed-approval-lockdown-troubling-stories-emerging.html

Key Publications

  1. Sam Tromans, Guiqing Yao, Reza Kiani, Regi Alexander, Mohammed Al-Uzri, Traolach Brugha. An investigation of the prevalence of autism among adults admitted to acute mental health wards: A cross-sectional study.  accepted for publication in BMJ open.
  2. Letouze D, Yao G, Clarke SC. The costs associated with the public health management of a cluster of meningococcal infection in England. Vaccine. 2014 Sep 29;32(43):5549-51. doi: 10.1016/j.vaccine.2014.08.044. Epub 2014 Aug 27. PMID: 25173479
  3. Wu J., Zhu S., Yao G., Mohammed M.A., Marshall T. Patient Factors Influencing the Prescribing of Lipid Lowering Drugs for Primary Prevention in UK General Practice: A National Retrospective Cohort Study. PLOT PLoS One. 2013 Jul 26;8(7):e67611.
  4. Yao G., Novielli N., Manaseki-Holland S., Chen Y., van der Klink M., Lilford R.J.. Pre-development evaluation of service delivery interventions: an application to an intervention to improve clinical handover.  BMJ Qual Saf. 2012 Dec;21 Suppl 1:i29-38
  5. Zhu, Shihua, Song, Fujian, Lilford, Richard, Bayliss, Sue, Chilton, Peter, Cummins, Carole, Duffy, John and Yao, GuiqingLily (2012) Ambu aScope2 in unexpected difficult airways management. External Assessment Report  Birmingham, GB NICE 140pp.  https://www.nice.org.uk/guidance/mtg14/resources/ambu-ascope2-for-use-in-unexpected-difficult-airways-eac-assessment-report2
  6. Yao G., Freemantle N., Marcus F.,Tharmanathan P., Coats A. and Poole-Wilson P.A.. Long-Term Cost-effectiveness Analysis of Nebivolol Compared With Placebo In Elderly Patients With Heart Failure – An Individual Patient based Simulation Model – Pharmacoeconomics. 2008;26(10):879-889.
  7. Yao G., Freemantle N.,  Calvert M. J., Bryan S., Claude, Daubert. Cleland J.G.F. The Long-term Cost-Effectiveness of Cardiac Resynchronization Therapy with or Without an Implantable Cardioverter-Defibrillator. European Heart Journal 2007 28: 42-51.
  8. Miners A., Yao G., Raftery J, Taylor R.. Calcineurin Inhibitors in Renal Transplantation: A Review of Their Cost Effectiveness. Pharmacoeconomics. 2007;25(11):935-47
  9. Wilson J, Yao GL, Raftery J, Bohlius J, Brunskill S, Sandercock J, Bayliss S, Moss P, Stanworth S, Hyde C. A systematic review and economic evaluation of epoetin alpha, epoetin beta and darbepoetin alpha in anaemia associated with cancer, especially that attributable to cancer treatment. Health Technol Assess. 2007 Apr;11(13):1-202, iii-iv. Review.
  10. Yao G., Albon E., Adi, Y, Milford D., Bayliss S., Ready A., Raftery J., and Taylor R.. A systematic review and economic model of the clinical and cost-effectiveness of immunosuppressive therapy for renal transplantation in children.. Health Technology Assessment. 2006 Dec;10 (49):1-178.
  11. Woodroffe, Yao GL, Meads C., Bayliss S., Ready A., Raftery J. and Taylor RS.. Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study. Health Technology Assessment 2005; Vol. 9, No. 21
  12. Calvert M., Freemantle N., Yao G.,  Cleland J., Billingham C.,  Daubert J.,  Bryan S. . Cost-Effectiveness of Cardiac Resynchronization Therapy: Results from the CARE-HF Trial. On Behalf of the CARE-HF Investigators. European Heart Jornal Nov 11, 2005
  13. Raftery J.P., Yao G.L., Murchie P., Campbell N.C., Ritchie L.D.. The cost effectiveness of nurse-led secondary prevention clinics for coronary heart disease in primary care: four- year follow up of a randomised trial. British Medical Journal, Mar 2005; 330: 707
  14. Copas A.J., Farewell V., Mercer C.M. and Yao. G.. The sensitivity of estimates of the change in population behaviour to realistic changes in bias in repeated surveys Journal of Royal Statistical Society. A (2004) 167, Part 4, pp. 579–595

Publications:

  1. Sam Tromans, Guiqing Yao, Reza Kiani, Regi Alexander, Mohammed Al-Uzri, Traolach Brugha. An investigation of the prevalence of autism among adults admitted to acute mental health wards: A cross-sectional study.  accepted to BMJ open, in press.
  2. John Hughes, Geraldine M Leydon, Sam Watts, Stephanie Hughes, Lucy Brindle, Emily Arden-Close, Roger Bacon, Brian Birch, Lallita Carballo, Hilary Plant, Caroline Moore, Neophytos Petrides, Beth Stuart, Lily Yao, George Lewith, Alison Richardson. A feasibility study of a psycho-educational support intervention for men with prostate cancer on active surveillance. Cancer Reports. Accepted for publication. In press
  3. Ibrahim K, Mullee M, Yao GL, Zhu S, Baxter M, Tilly S, Russell C, Roberts HC. Southampton Arm Fracture Frailty and Sarcopenia Study (SAFFSS): a study protocol for the feasibility of assessing frailty and sarcopenia among older patients with an upper limb fracture. BMJ Open. 2019 Aug 15;9(8):e031275. doi: 10.1136/bmjopen-2019-031275. PMID: 31420400 Free PMC Article
  4. Krusche A, Bradbury K, Corbett T, Barnett J, Stuart B, Yao GL, Bacon R, Böhning D, Cheetham-Blake T, Eccles D, Foster C, Geraghty AWA, Leydon G, Müller A, Neal RD, Osborne R, Rathod S, Richardson A, Sharman G, Summers K, Watson E, Wilde L, Wilkinson C, Yardley L, Little P. Renewed: Protocol for a randomised controlled trial of a digital intervention to support quality of life in cancer survivors. BMJ Open. 2019 Mar 1;9(3):e024862. doi: 10.1136/bmjopen-2018-024862.  PMID: 30826763
  5. Stuart B, Hounkpatin H, Becque T, Yao G, Zhu S, Alonso-Coello P, Altiner A, Arroll B, Böhning D, Bostock J, Bucher HCC, de la Poza M, Francis NA, Gillespie D, Hay AD, Kenealy T, Löffler C, Mas-Dalmau G, Muñoz L, Samuel K, Moore M, Little P.  Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis.   BMJ Open. 2019 Jan 21;9(1):e026925. doi: 10.1136/bmjopen-2018-026925.
  6. Amy Whitehead, Catherine Simpson, Frances Webley, Merlin Willcox, Alastair D Hay, Chris Butler, Lily Yao, Emma Wrixon, Margaret Bell, Jennifer Bostock, Paul Little, Gareth Griffiths and Michael Moore. HATRIC: A study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults: study protocol for a double blind, placebo-controlled randomised feasibility trial.  Pilot Feasibility Stud. 2019 Jul 31;5:98. doi: 10.1186/s40814-019-0478-6. eCollection 2019.
  7. Beth Stuart, Paul Little, Michael Moore,  Mark Lown, Tammy Thomas  , Jo Kelly,  Mark Mullee  Gerry Leydon, Ian Williamson, Samantha Richards-Hall,  Lucy Yardley, Lisa McDermott, James Raftery, Shihua Zhu, Guiqing Yao, David Mant, Sue Smith, Kyle Knox, Ann van den Bruel, Matthew J Thompson. Project Title:  PRimary care Infection Management for Everyday practice (PRIME). Report submitted to NIHR programme library Oct 2019
  8. Neelam Kalita,  Karen Pickett, Joanne Lord,  Geoff Frampton,  G. Lily Yao,  Joanna Picot. Daratumumab in combination with bortezomib and dexamethasone for treating relapsed or refractory multiple myeloma. Produced by Southampton Health Technology Assessments Centre:     https://www.nice.org.uk/guidance/ta573/documents/committee-papers. published in 2018
  9. Hodgson LE., Roderick PJ, Venn RM, Yao G, Dimitrov B. Forni LG. Impact analysis of a Clinical prediction rule and Electronic AKI alert in general medical patients.    2018 Aug 8;13(8):e0200584. doi: 10.1371/journal.pone.0200584. eCollection 2018.
  10. Bridges J., Pickering R. M.,  Barker H., Rosemary  Chable R. Fuller A.,  Gould L., Libberton P.,  Mesa-Eguiagaray I., Raftery J.,  Sayer A. A.,  Westwood G.,  Wigley W., Yao G., Zhu S,  Griffiths P. Creating Learning Environments for Compassionate Care (CLECC): a feasibility study. In press with HS&DR Journal: planned publication in 2018.
  11. Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, George S, Little P, Djukanovic R, Price D, Pavord ID, Holgate ST, Thomas M. Physiotherapy breathing retraining for asthma: a randomised controlled trial.  Lancet Respir Med. 2018 Jan;6(1):19-28. doi: 10.1016/S2213-2600(17)30474-5. Epub 2017 Dec 14. PMID: 29248433
  12. Sonuga-Barke EJS, Barton J, Daley D, Hutchings J, Maishman T, Raftery J, Stanton L, Laver-Bradbury C, Chorozoglou M, Coghill D, Little L, Ruddock M, Radford M, Yao GL, Lee L, Gould L, Shipway L, Markomichali P, McGuirk J, Lowe M, Perez E, Lockwood J, Thompson MJJ. A comparison of the clinical effectiveness and cost of specialised individually delivered parent training for preschool attention-deficit/hyperactivity disorder and a generic, group-based programme: a multi-centre, randomised controlled trial of the New Forest Parenting Programme versus Incredible Years. Eur Child Adolesc Psychiatry. 2018 Jun;27(6):797-809. doi: 10.1007/s00787-017-1054-3. Epub 2017 Oct 30.  PMID: 29086103
  13. Thomas M, Bruton A, Little P, Holgate S, Lee A, Yardley L, George S, Raftery J, Versnel J, Price D, Pavord I, Djukanovic R, Moore M, Kirby S, Yao G, Zhu S, Arden-Close E, Thiruvothiyur M, Webley F, Stafford-Watson M, Dixon E, Taylor L. A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults. Health Technol Assess. 2017 Sep;21(53):1-162. doi: 10.3310/hta21530. PMID: 28944752
  14. Little P, Stuart B, Wingrove Z, Mullee M, Thomas T, Johnson S, Leydon G, Richards-Hall S, Williamson I, Yao L, Zhu S, Moore M. Probiotic capsules and xylitol chewing gum to manage symptoms of pharyngitis: a randomized controlled factorial trial.  CMAJ. 2017 Dec 18;189(50):E1543-E1550. doi: 10.1503/cmaj.170599. PMID: 29255098
  15. Paul Little, Beth Stuart, Mark Mullee, Tammy Thomas, Sophie Johnson, Gerry Leydon, David Rabago, Samantha Richards-Hall, Ian Williamson, Guiqing Yao, James Raftery, Shihua Zhu and Michael Moore; for the SNIFS Study Team. Effectiveness of steam inhalation and nasal irrigation for chronic or recurrent sinus symptoms in primary care: a pragmatic randomized controlled trial. CMAJ September 20, 2016 188 (13) 940-949; DOI: https://doi.org/10.1503/cmaj.160362
  16. Kendrick T, Stuart B, Leydon GM, Geraghty AW, Yao L, Ryves R, Williams S, Zhu S, Dowrick C, Lewis G, Moore M. Patient-reported outcome measures for monitoring primary care patients with depression: PROMDEP feasibility randomised trial. BMJ Open. 2017 Mar 30;7(3):e015266. doi: 10.1136/bmjopen-2016-015266.
  17. Little P, Stuart B, Hobbs FR, Kelly J, Smith ER, Bradbury KJ, Hughes S, Smith PW, Moore MV, Lean ME, Margetts BM, Byrne CD, Griffin S, Davoudianfar M, Hooper J, Yao G, Zhu S, Raftery J, Yardley L. Randomised controlled trial and economic analysis of an internet-based weight management programme: POWeR+ (Positive Online Weight Reduction). Health Technol Assess. 2017 Jan;21(4):1-62. doi: 10.3310/hta21040. PMID: 28122658
  18. Band R, Morton K, Stuart B, Raftery J, Bradbury K, Yao GL, Zhu S, Little P, Yardley L, McManus RJ. Home and Online Management and Evaluation of Blood Pressure (HOME BP) digital intervention for self-management of uncontrolled, essential hypertension: a protocol for the randomised controlled HOME BP trial. BMJ Open. 2016 Nov 7;6(11):e012684. doi: 10.1136/bmjopen-2016-012684. PMID: 27821598
  19. Paul Little, Beth Stuart, Mark Mullee, Tammy Thomas, Sophie Johnson, Gerry Leydon, David Rabago, Samantha Richards-Hall, Ian Williamson, Guiqing Yao, James Raftery, Shihua Zhu and Michael Moore; for the SNIFS Study Team Reducing the use of antibiotics for upper respiratory tract infections is needed to limit Effectiveness of steam inhalation and nasal irrigation for chronic or recurrent sinus symptoms in primary care: a pragmatic randomized controlled trial CMAJ September 20, 2016 188 (13) 940-949; DOI: https://doi.org/10.1503/cmaj.160362
  20. Clarke CE, Patel S, Ives N, Rick CE, Woolley R, Wheatley K, Walker MF, Zhu S, Kandiyali R, Yao G, Sackley CM. Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB). Health Technol Assess. 2016 Aug;20(63):1-96. doi: 10.3310/hta20630.
  21. Paul Little,  Beth Stuart, Richard FD Hobbs,  Jo Kelly, Emily R Smith,  Katherine J Bradbury,  Stephanie Hughes, Peter WF Smith, Michael V Moore,  Mike EJ Lean, Barrie M Margetts,  Chris D Byrne, Simon Griffin,  Mina Davoudianfar, Julie Hooper, Guiqing Yao,   Shihua Zhu,   James Raftery and  Lucy Yardley.  A randomised controlled trial of a web-based intervention (POWeR+) with brief nurse support to manage obesity in primary care. Lancet Diabetes Endocrinol. 2016 Oct;4(10):821-8. doi: 10.1016/S2213-8587(16)30099-7. Epub 2016 Jul 26.
  22. Little P, Stuart B, Hobbs FD, Moore M, Barnett J, Popoola D, Middleton K, Kelly J, Mullee M, Raftery J, Yao G, Carman W, Fleming D, Stokes-Lampard H, Williamson I, Joseph J, Miller S, Yardley L. An internet-delivered handwashing intervention to modify influenza-like illness and respiratory infection transmission (PRIMIT): a primary care randomised trial. Lancet. 2015 Aug 6. pii: S0140-6736(15)60127-1.   PMID: 26256072
  23. Williamson I, Vennik J, Harnden A, Voysey M, Perera R, Kelly S, Yao G, Raftery J, Mant D, Little P. Effect of nasal balloon autoinflation in children with otitis media with effusion in primary care: an open randomized controlled trial. CMAJ. 2015 Jul 27. pii: cmaj.141608. PMID: 26216608
  24. Halligan S, Dadswell E, Wooldrage K, Wardle J, von Wagner C, Lilford R, Yao GL, Zhu S, Atkin W. Computed tomographic colonography compared with colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (the SIGGAR trials). Health Technol Assess. 2015 Jul;19(54):1-134. doi: 10.3310/hta19540. PMID: 26198205
  25. Roderick P, Rayner H, Tonkin-Crine S, Okamoto I, Eyles C, Leydon G, Santer M, Klein J, Yao GL, Murtagh F, Farrington K, Caskey F, Tomson C, Loud F, Murphy E, Elias R, Greenwood R, O’Donoghue D. A national study of practice patterns in UK renal units in the use of dialysis and conservative kidney management to treat people aged 75 years and over with chronic kidney failure. NIHR Journals Library; 2015 Apr. PMID: 25855842
  26. Halligan S, Wooldrage K, Dadswell E, Shah U, Kralj-Hans I, von Wagner C, Faiz O, Teare J, Edwards R, Kay C, Yao G, Lilford RJ, Morton D, Wardle J, Atkin W; SIGGAR Investigators. Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients. Gastroenterology. 2015 Jul;149(1):89-101.e5. doi: 10.1053/j.gastro.2015.03.011. Epub 2015 Mar 18. PMID: 25796362
  27. Williamson I, Vennik J, Harnden A, Voysey M, Perera R, Breen M, Bradley, B Yao G, Raftery J, Mant D2, Little P. An open randomised study of autoinflation in 4 to 11 year-old school children with otitis media with effusion in primary care.  Health Technol Assess. 2015 Sep;19(72):1-150. doi: 10.3310/hta19720. PMID: 26377389
  28. Williamson I, Vennik J, Harnden A, Voysey M, Perera R, Kelly S, Yao G, Raftery J, Mant D, Little P. Effect of nasal balloon autoinflation in children with otitis media with effusion in primary care: an open randomized controlled trial. CMAJ. 2015 Sep 22;187(13):961-9. doi: 10.1503/cmaj.141608. Epub 2015 Jul 27. PMID: 26216608
  29. Williams JE, Peacock J, Gubbay AN, Kuo PY, Ellard R, Gupta R, Riley J, Sauzet O, Raftery J, Yao G, Ross Routine screening for pain combined with a pain treatment protocol in head and neck cancer: a randomised controlled trial. Br J Anaesth. 2015 Oct;115(4):621-8. doi: 10.1093/bja/aev263.
  30. Steve Halligan, Douglas G Altman, Wendy Atkin, Darren Boone, Thomas R Fanshawe, Alastair Gale,  Alex Ghanouni, Tom Hampshire, David Hawkes, Emma Helbren, Richard J Lilford, Susan Mallett, David Manning, Peter Phillips, Andrew A Plumb, Holger Roth, Stuart A Taylor, Christian von Wagner,  Jane Wardle,  Guiqing L Yao, Shihua Zhu.  Imaging diagnosis of colorectal cancer: Interventions for efficient and acceptable diagnosis in symptomatic and screening populations. Monograph/ Report submitted to Programme Grant for Applied Research:  RP-PG-0407-10338.
  31. Letouze D, Yao G, Clarke SC. The costs associated with the public health management of a cluster of meningococcal infection in England. Vaccine. 2014 Sep 29;32(43):5549-51. doi: 10.1016/j.vaccine.2014.08.044. Epub 2014 Aug 27. PMID: 25173479
  32. Morgan JM, Dimitrov BD, Gill J, Kitt S, Ng GA, McComb JM, Raftery J, Roderick P, Seed A, Williams SG, Witte KK, Wright DJ, Yao GL, Cowie MR. Rationale and study design of the REM-HF study: remote management of heart failure using implanted devices and formalized follow-up procedures. Eur J Heart Fail. 2014 Sep;16(9):1039-45. doi: 10.1002/ejhf.149. Epub 2014 Aug 18. PMID: 25136791
  33. Plumb AA, Boone D, Fitzke H, Helbren E, Mallett S, Zhu S, Yao GL, Bell N, Ghanouni A, von Wagner C, Taylor SA, Altman DG, Lilford R, Halligan S. Detection of Extracolonic Pathologic Findings with CT Colonography: A Discrete Choice Experiment of Perceived Benefits versus Harms. Radiology. 2014 Oct;273(1):144-52.  PMID: 24865308
  34. Ghanouni A, Halligan S, Taylor SA, Boone D, Plumb A, Stoffel S, Morris S, Yao GL, Zhu S, Lilford R, Wardle J, von Wagner C.  Quantifying public preferences for different bowel preparation options prior to screening CT colonography: a discrete choice experiment. BMJ Open. 2014 Apr 3;4(4):e004327. doi: 10.1136/bmjopen-2013-004327. PMID: 24699460
  35. Choudhury S, Hussain S, Yao GL, Hill, J, Malik W, Taheri S. The Impact of a Diabetes Local Enhanced Service (LES) on Quality Outcome Framework diabetes outcomes, PLoS One. 2013 Dec 17;8(12):e83738
  36. Boone D, Mallett S, Zhu S, Yao GL, Bell N, Ghanouni A, von Wagner C, Taylor SA, Altman DG, Lilford R, Halligan S. Patients' & healthcare professionals' values regarding true- & false-positive diagnosis when colorectal cancer screening by CT colonography: discrete choice experiment. PLoS One. 2013 Dec 9;8(12):e80767. doi: 10.1371/journal.pone.0080767. eCollection 2013.
  37. Boone D, Mallett S, Zhu S, Yao GL, Bell N, Ghanouni A, von Wagner C, Taylor SA, Altman DG, Lilford R, Halligan S. Patients' & healthcare professionals' values regarding true- & false-positive diagnosis when colorectal cancer screening by CT colonography: discrete choice experiment. PLoS One. 2013 Dec 9;8(12):e80767. doi: 10.1371/journal.pone.0080767. eCollection 2013. PMID: 24349014
  38. Wu J., Zhu S., Yao G., Mohammed M.A., Marshall T. Patient Factors Influencing the Prescribing of Lipid Lowering Drugs for Primary Prevention in UK General Practice: A National Retrospective Cohort Study. PLOT PLoS One. 2013 Jul 26;8(7):e67611.
  39. Ghanouni A, Smith SG, Halligan S, Plumb A, Boone D, Yao GL, Zhu S, Lilford R, Wardle J, von Wagner C. Public Preferences for Colorectal Cancer Screening Tests: A Review of Conjoint Analysis Studies. Expert Rev Med Devices. 2013 Jul;10(4):489-99.
  40. Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, Yao G, Kay C, Burling D, Faiz O, Lilford R J, Morton D, Wardle J, Halligan S, For the SIGGAR Investigators. Computed Tomographic Colonography Versus Colonoscopy for investigation of Patients with Symptoms of Colorectal Cancer: A Multicentre Randomised Trial in Clinical Practice. Lancet. 2013 Apr 6;381(9873):1194-202.
  41. Halligan S, Wooldrage K, Dadswell E, Kralj-Hans I,  von Wagner C, Edwards R, Yao G, Kay C, Burling B, Faiz O, Lilford R J, Morton D, Wardle J, W  Atkin, for the SIGGAR investigators. Computed tomographic colonography versus double contrast barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients: a multicentre randomised trial in clinical practice.  Lancet. 2013 Apr 6;381(9873):1185-93.
  42. Arora T; Hussain S, Lam K; Yao G, Thomas G N, Taheri S. Exploring the complex pathways among specific types of technology, self-reported sleep duration and body mass index in UK adolescents.  International Journal of Obesity International Journal of Obesity (2013), 1–7
  43. Arora T, Araghi M, Bishop J, Yao G, Thomas G N, Taheri S. The complexity of obesity in UK adolescents: relationships with quantity and type of technology, sleep, academic performance and aspiration.  Journal of Pediatric Obesity. Pediatr Obes. 2013 Oct;8(5):358-66.
  44. Halligan S., Dadswell E., Wooldrage K., Wardle J., von Wagner C., Lilford R., Yao G.,  Zhu S. and Atkin W.. Computed tomographic colonography versus colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (SIGGAR1). HTA monograph, in press, 2013
  45. Yao G., Novielli N., Manaseki-Holland S., Chen Y., van der Klink M., Lilford R.J.. Pre-development evaluation of service delivery interventions: an application to an intervention to improve clinical handover.  BMJ Qual Saf. 2012 Dec;21 Suppl 1:i29-38
  46. Sackley C.M., Burton C.R., Herron-Marx  S., Lett  K., Mant J., Roalfe A.K., Sharp L.J, Sheehan  B., Stant K.E., Walker M.F., Watkins C.L., Wheatley  K., Williams  J., Yao G.L., Feltham M.G. (2012). A cluster randomised controlled trial of an occupational therapy intervention for residents with stroke living in UK care homes (OTCH): study protocol. BMC Neurology, 12:52, 2012.
  47. Sackley C. M., Hoppitt T., Shah S., Padget S., Meek C., Calvert M., Gill P., Yao L. and Pall H.  What matters to patients and carers in the care and management of rare long-term neurological conditions? A study using the Delphi technique.  Journal of the institute of ageing and health, 9-16, No. 18 2012.
  48. Shihua Zhu, Fujian Song, Richard Lilford, Sue Bayliss, Peter Chilton, Carole Cummins, John Duffy, Guiqing Lily Yao.  Ambu aScope2 in unexpected difficult airways management. External Assessment Report. NICE. http://www.nice.org.uk/guidance/mtg14/resources/ambu-ascope2-for-use-in-unexpected-difficult-airways-eac-assessment-report2
  49. Sackley C., Hoppitt T J., Calvert M., Gill P., Eaton B., Yao G., Pall H. Huntington’s Disease: Current Epidemiology and Pharmacological Management in UK Primary Care. Neuroepidemiology 2011;37:216-221.
  50. Hoppitt T., Pall H., Calvert M., Gill P., Yao G, Ramsay J., James G., Jacky Conduit, Cath Sackley, A Systematic Review of the Incidence and Prevalence of Long-Term Neurological Conditions in the UK. Neuroepidemiology 2011;36:19-28.
  51. Yao G., Freemantle N., Marcus F.,Tharmanathan P., Coats A. and Poole-Wilson P.A.. Long-Term Cost-effectiveness Analysis of Nebivolol Compared With Placebo In Elderly Patients With Heart Failure – An Individual Patient based Simulation Model – Pharmacoeconomics. 2008;26(10):879-889.
  52. Miners A., Yao G., Raftery J, Taylor R.. Calcineurin Inhibitors in Renal Transplantation: A Review of Their Cost Effectiveness. Pharmacoeconomics. 2007;25(11):935-47
  53. Yao G., Freemantle N.,  Calvert M. J., Bryan S., Claude, Daubert. Cleland J.G.F. The Long-term Cost-Effectiveness of Cardiac Resynchronization Therapy with or Without an Implantable Cardioverter-Defibrillator. European Heart Journal 2007 28: 42-51.
  54. Wilson J, Yao GL, Raftery J, Bohlius J, Brunskill S, Sandercock J, Bayliss S, Moss P, Stanworth S, Hyde C. A systematic review and economic evaluation of epoetin alpha, epoetin beta and darbepoetin alpha in anaemia associated with cancer, especially that attributable to cancer treatment. Health Technol Assess. 2007 Apr;11(13):1-202, iii-iv. Review.
  55. Whitehurst DGT., Lewis M., Yao GL., Bryan S., Raftery JP., Mullis R., Hay EM.. A brief pain management programme and physical treatments for low back pain: results from an economic analysis alongside a randomised. Arthritis Care & Research 2007, Volume 57, Issue 3 , Pages 466 – 473.
  56. Yao G., Albon E., Adi, Y, Milford D., Bayliss S., Ready A., Raftery J., and Taylor R.. A systematic review and economic model of the clinical and cost-effectiveness of immunosuppressive therapy for renal transplantation in children.. Health Technology Assessment. 2006 Dec;10 (49):1-178.
  57. Raftery J.P., Yao G.L., Murchie P., Campbell N.C., Ritchie L.D.. The cost effectiveness of nurse-led secondary prevention clinics for coronary heart disease in primary care: four- year follow up of a randomised trial. British Medical Journal, Mar 2005; 330: 707
  58. Woodroffe, Yao GL, Meads C., Bayliss S., Ready A., Raftery J. and Taylor RS.. Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study. Health Technology Assessment 2005; Vol. 9, No. 21
  59. Calvert M., Freemantle N., Yao G.,  Cleland J., Billingham C.,  Daubert J.,  Bryan S. . Cost-Effectiveness of Cardiac Resynchronization Therapy: Results from the CARE-HF Trial. On Behalf of the CARE-HF Investigators. European Heart Jornal Nov 11, 2005
  60. Wilson J., Connock M., Song F., Yao G et al. Cost Effectiveness Analysis of imatinib mesylate for the treatment of patients with unresectable and/or metastatic gastro-intestinal stromal tumours. Health Technology Assessment 2005;vol 9, No 25.
  61. Copas A.J., Farewell V., Mercer C.M. and Yao. G.. The sensitivity of estimates of the change in population behaviour to realistic changes in bias in repeated surveys Journal of Royal Statistical Society. A (2004) 167, Part 4, pp. 579–595
  62. Song FJ, Barton P, Sleightholme V, Yao GL, Fry-Smith A. Screening for fragile x syndrome: a literature review and modelling study. Health Technology Assessment 2003; Vol 7: No 16.
  63. Lewsey JD, Holt R, Yao G, Richardson PS, Anderson JQ. The initial dental health status of British Army Gurkha recruits. International Dental Journal 2000:50,279-282.
  64. Zhu, Shihua, Song, Fujian, Lilford, Richard, Bayliss, Sue, Chilton, Peter, Cummins, Carole, Duffy, John and Yao, Guiqing Lily (2012) Ambu aScope2 in unexpected difficult airways management. External Assessment Report  Birmingham, GB NICE 140pp. https://www.nice.org.uk/guidance/mtg14/resources/ambu-ascope2-for-use-in-unexpected-difficult-airways-eac-assessment-report2

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