Michael Sweeting

Associate Professor in Biostatistics


Department of Health Sciences
University of Leicester
George Davies Centre
University Road
Leicester LE1 7RH

Tel: 00 44 116 252 5469

Email:   michael.sweeting@le.ac.uk



I lead the analytical team of the VICORI research programme, investigating the interplay between cardiovascular disease and cancer using English registry and audit datasets.


My research interests include:

  • Linkage of large-scale electronic health records and disease registries for epidemiological research
  • Utilising repeat longitudinal measurements in the modelling of time-to-event data, especially in a joint modelling or landmark analysis framework
  • Health economic discrete event simulation modelling with application to screening programmes
  • Analysis of randomised controlled trials, particularly surgical trials
  • Evidence synthesis (including individual patient data meta-analysis)
  • Design of early phase clinical trials


Personal details


PhD, University of Cambridge 2008

MSc Medical Statistics, University of Leicester 2001

BSc Mathematics and Statistics, University of Warwick 2000





Willeit P, Tschiderer L, Allara E, …, Sweeting MJ, Thompson SG, Lorenz MW. Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients. Circulation. 2020;142(7):621-642. doi: 10.1161/CIRCULATIONAHA.120.046361

Rutherford, MJ., Lambert,PC., Sweeting, MJ., Pennington, R., Crowther, MJ., Abrams, KR., Latimer, NR. NICE DSU Technical Support Document 21. Flexible Methods for Survival Analysis. 2020 [Available from http://www.nicedsu.org.uk]

Xu Y, Wood AM, Sweeting MJ, Roberts DJ, Tom BD. Optimal individualized decision rules from a multi-arm trial: A comparison of methods and an application to tailoring inter-donation intervals among blood donors in the UK. Stat Methods Med Res. 2020;29(11):3113-3134. doi:10.1177/0962280220920669

Wood A, Kaptoge S, Sweeting M, Oliver-Williams C. Meta-Analysis of Epidemiological Data, with a Focus on Individual Participant Data.  In Handbook of Meta-Analysis. Ed. Schmid CH, Stijnen T, White I. Chapman and Hall/CRC; 2020. doi:10.1201/9781315119403

Welch CA, Sweeting MJ, Lambert PC, Rutherford MJ, Jack RH, West D, Adlam D, Peake M. Impact on survival of modelling increased surgical resection rates in patients with non-small cell lung cancer and cardiovascular comorbidities: a VICORI study. British Journal of Cancer 2020; 123: 471–479. doi: 10.1038/s41416-020-0869-8

Gasparini A, Abrams KR, Barrett JK, Major RW, Sweeting MJ, Brunskill NJ, Crowther MJ. Mixed effects models for healthcare longitudinal data with an informative visiting process: a Monte Carlo simulation study. Statistical Neerlandica 2020; 74(1): 5-23. doi: 10.1111/stan.12188

Tschiderer L, Seekircher L, Klingenschmid G, …., Sweeting MJ, Lorenz MW, Willeit P, Proof-ATHERO Study Group. The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale. GER. 2020;66(5):447-459. doi:10.1159/000508498

Freisling H, Viallon V, Lennon H, Bagnardi V, Ricci C, Butterworth AS, Sweeting M, …, Wareham N, Gunter MJ, Ferrari P. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. BMC Medicine 2020; 18, 5. doi: 10.1186/s12916-019-1474-7

Browne A, Fisher SA, Masconi K, Smith G, Doree C, Chung R, Rahimzadeh M, Shah A, Alonso Rodrigues S, Bolton T, Kaptoge S, Wood A, Sweeting M, Roberts DJ. Donor deferral due to low haemoglobin – an updated systematic review. Transfusion Medicine Reviews 2020; 34(1): 10-22. doi: 10.1016/j.tmrv.2019.10.002

Gleadall NS, Veldhuisen B, Gollub J, …, Sweeting M, …, Astle WJ, Watkins NA, Lane WJ on behalf of Blood Transfusion Genomics Consortium. Development and validation of a universal blood donor genotyping platform: a multinational, prospective study. Blood Advances 2020; 4(15): 3495-3506.  doi: 10.1182/bloodadvances.2020001894

Sieri S, Agnoli C, Grioni S, … Sweeting M, … et al. Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study. Am J Clin Nutr. 2020;112(3):631-643. doi:10.1093/ajcn/nqaa157

Kim LG, Sweeting MJ, Epstein D, Venermo M, Rohlffs FEV, Greenhalgh RM. Optimizing surveillance and re-intervention strategy following elective endovascular repair of abdominal aortic aneurysms. Annals of Surgery 2020. doi: 10.1097/SLA.0000000000003625


Wheeler GM, Sweeting MJ, Mander AP. A Bayesian model-free approach to combination therapy phase I trials using censored time-to-toxicity data. Journal of the Royal Statistical Society (Series C) 2019; 68(2): 309-329. doi: 10.1111/rssc.12323

Oliver-Williams C, Sweeting MJ, Jacomelli J, Summers L, Stevenson A, Lees T, Earnshaw JJ. Safety of men with small and medium abdominal aortic aneurysms under surveillance in the National Health Service screening programme. Circulation 2019; 139: 1371-1380. doi: 10.1161/CIRCULATIONAHA.118.036966

Chung RK, Wood AM, Sweeting MJ. Biases incurred from nonrandom repeat testing of haemoglobin levels in blood donors: Selective testing and its implications. Biometrical Journal 2019; 61(2): 454-466. doi: 10.1002/bimj.201700268

Paige E, Clément M, Lareyre F, Sweeting M, …, Freitag DF, Paul DS, Mallat Z. Interleukin-6 receptor signalling and abdominal aortic aneurysm growth rates. Circulation: Genomic and Precision Medicine 2019; 12: e002413. doi: 10.1161/CIRCGEN.118.002413

Pennells L, Kaptoge S, Wood A, Sweeting M, …, D’Agostino RB, Thompson SG, Danesh J, Di Angelantonio E, Emerging Risk Factors Collaboration. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal 2019; 40(7): 621-631. doi: 10.1093/eurheartj/ehy653

Gregson J, Kaptoge S, Bolton T, Pennells L, Willeit P, Burgess S, Bell S, Sweeting M, …, Danesh J, Di Angelantonio E, Meade T, Emerging Risk Factors Collaboration. Cardiovascular risk factors associated with venous thromboembolism. JAMA Cardiology 2019; 4(2): 163-173. doi:10.1001/jamacardio.2018.4537

Adlam D, Olsen TM, Combaret N, …, Sweeting M, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection. Journal of the American College of Cardiology 2019; 73(1): 58-66. doi: 10.1016/j.jacc.2018.09.085


Sweeting MJ, Masconi KL, Jones E, Ulug P, Glover MJ, Michaels JA, Bown MJ, Powell JT, Thompson SG. Analysis of clinical benefit, harms and cost-effectiveness of screening women for abdominal aortic aneurysm. The Lancet 2018; 392(10146): 487-495. doi: 10.1016/S0140-6736(18)31222-4

Thompson SG, Bown MJ, Glover MJ, Jones E, Masconi KL, Michaels JA, Powell JT, Ulug P, Sweeting MJ. Screening women aged 65 years or over for abdominal aortic aneurysm: a modelling study and health economic evaluation. Health Technology Assessment 2018; 22(43). doi: 10.3310/hta22430

Sweeting MJ, Ulug P, Roy J, Hultgren R, Indrakusuma R, Balm R, Thompson MM, Hinchliffe RJ, Thompson SG, Powell JT, Ruptured Aneurysm Collaborators. Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm. British Journal of Surgery 2018; 105(9): 1135-1144. doi: 10.1002/bjs.10820

Paige E, Barrett J, Stevens D, Keogh RH, Sweeting MJ, Nazareth I, Petersen I, Wood AM. Landmark models for optimizing the use of repeated measurements of risk factors in electronic health records to predict future disease risk. American Journal of Epidemiology 2018; 187(7): 1530-1538. doi: 10.1093/aje/kwy018

Murray E, Ross J, Pal K, Li J, Dack C, Stevenson F, Sweeting M, …, Farmer A, O’Donnell O. A web-based self-management programme for people with type 2 diabetes: the HeLP-Diabetes research programme including RCT. Programme Grants Applied Research 2018; 06(05). doi: 10.3310/pgfar06050

Glover MJ, Jones E, Sweeting MJ, Thompson SG and the SWAN collaborators. Discrete event simulation for decision modelling in health care: lessons from abdominal aortic aneurysm screening. Medical Decision Making 2018; 38(4): 491-451. doi: 10.1177/0272989X17753380

Inouye M, Abraham G, Nelson CP, Wood A, Sweeting MJ, Dudbridge F,…, Butterworth AS, Danesh J, Samani NJ, The UK Biobank CardioMetabolic Consortium CHD Working Group. Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention. Journal of the American College of Cardiology 2018; 72(16): 1883-1893. doi: 10.1016/j.jacc.2018.07.079

Wood AM, Kaptoge S, Butterworth A, …, Sweeting M,…, Di Angelantonio E, Danesh J. Risk thresholds for alcohol consumption: combined analysis of individual-participant data on 599,912 current drinkers in 83 prospective studies. The Lancet 2018; 391(10129): 1513-1523. doi: 10.1016/S0140-6736(18)30134-X

Ulug P, Hinchliffe RJ, Sweeting MJ, Gomes M, Thompson MT, Thompson SG, Grieve RJ, Ashleigh R, Greenhalgh RM, Powell JT. Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT. Health Technol Assess 2018;22(31). doi: 10.3310/hta22310

Patel R, Powell JT, Sweeting MJ, Epstein DM, Barrett JK, Greenhalgh RM. The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up. Health Technology Assessment, volume 22, number 5. doi: 10.3310/hta22050

Powell JT, Sweeting MJ, Ulug P, Thompson MM, Hinchliffe RJ. Re-intervention after repair of ruptured abdominal aortic aneurysm: a report from the IMPROVE randomised trial. European Journal of Vascular and Endovascular Surgery 2018; 55(5): 625-632. doi: 10.1016/j.ejvs.2018.01.028

Grootes I, Barrett JK, Ulug P, Rohlffs F, Laukontaus S, Tulamo R, Venermo M, Greenhalgh R, Sweeting MJ. Predicting risk of rupture and rupture-preventing re-intervention utilising repeated measures on aneurysm sac diameter following endovascular abdominal aortic aneurysm repair. British Journal of Surgery 2018; 105(10): 1294-1304. doi: 10.1002/bjs.10964

Oliver-Williams, C, Sweeting M, Turton G, Parkin D, Cooper D, Rodd C, Thompson S, Earnshaw JJ. Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme. British Journal of Surgery 2018; 105(1): 68-74. doi: 10.1002/bjs.10715

Li J, Parrott S, Sweeting M, Farmer A, Ross J, Dack C, Pal K, Yardley L, Barnard M, Hudda M, Alkhaldi G, Murray E. Cost-effectiveness of facilitated access to a self-management website,  compared to usual care, for patients with Type 2 diabetes (HeLP-Diabetes): randomized controlled trial. Journal of Medical Internet Research 2018; 20(6): e201. doi: 10.2196/jmir.9256

Lassale C, Tzoulaki I, Moons KGM, Sweeting M, …, Wareham NJ, Danesh J, Butterworth AS. Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis. European Heart Journal 2018; 39(5): 397-406. doi: 10.1093/eurheartj/ehx448

Ricci C, Wood A, …, Sweeting M, Brennan P, Butterworth AS, Riboli E, Wareham NJ, Danesh J, Ferrari P. Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study. BMJ 2018; 361:k934. doi: 10.1136/bmj.k934

Liu Z, Dumville JC, Hinchliffe RJ, Cullum N, Game F, Stubbs N, Sweeting M, Peinemann F. Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. Cochrane Database of Systematic Reviews 2018. doi: 10.1002/14651858.CD010318.pub3



Sweeting MJ, Barrett JK, Thompson SG, Wood AM. The use of repeated blood pressure measures for cardiovascular risk prediction. A comparison of statistical models in the ARIC study. Statistics in Medicine 2017; 36: 4514-4528. doi: 10.1002/sim.7144

Sweeting MJ. Using predictions from a joint model for longitudinal and survival data to inform the optimal time of intervention in an abdominal aortic aneurysm screening programme. Biometrical Journal 2017. 59(6): 1247-1260. doi: 10.1002/bimj.201600222

IMPROVE Trial Investigators. Comparative clinical effectiveness and cost-effectiveness of endovascular strategy v open repair for ruptured abdominal aortic aneurysm:  three year results of the IMPROVE randomised trial. BMJ 2017; 359:j4589. doi: 10.1136/bmj.j4859

Paige E, Barrett J, Pennells L, Sweeting M, …., Danesh J, Thompson SG, Wood A. Repeated measurements of blood pressure and cholesterol improves cardiovascular disease risk prediction: an individual-participant-data meta-analysis. American Journal of Epidemiology 2017; 186(8): 899-907. doi: 10.1093/aje/kwx149

Sidloff D, Saratzis A, Sweeting M, Michaels J, Powell J, Thompson S, Bown M. Sex differences in mortality after Abdominal Aortic Aneurysm repair in the United Kingdom. British Journal of Surgery 2017; 104(12): 1656-1664. doi: 10.1002/bjs.10600

Barrett JK, Sweeting MJ, Wood AM. Dynamic Risk Prediction for Cardiovascular Disease: An Illustration Using the ARIC Study. Handbook of Statistics, Elsevier, ISSN 0169-7161. 2017. doi: 10.1016/bs.host.2017.05.004

Sweeting MJ, Patel R, Powell JT, Greenhalgh RM, EVAR Trial Investigators. Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair: Very Long-term Follow-up in the EVAR-2 Randomized Controlled Trial. Annals of Surgery 2017; 266(5): 713-719. doi: 10.1097/SLA.0000000000002392

Murray E, Sweeting M, Dack C, Pal K, Modrow K, Hudda M, Li J, Ross J, Alkhaldi G, Barnard M, Farmer A, Michie S, Yardley L, May C, Parrott S, Stevenson F, Knox M, Patterson D.  Web-based self-management support for people with type 2 diabetes (HeLP-Diabetes): randomised controlled trial in English primary care. BMJ Open 2017; 7:e016009. doi: 10.1136/bmjopen-2017-016009

Nelson CP, Goel A, Butterworth A, Kanoni S, …, Sweeting MJ, …, Danesh J, Samani NJ, Watkins H, Deloukas P. Association analyses based on false discovery rate implicate 243 susceptibility loci for coronary artery disease. Nature Genetics 2017; 49: 1385-1391. doi: 10.1038/ng.3913

Rossi SH, Hsu R, Blick C, Goh V, Nathan P, Nicol D, Fleming S, Sweeting M, Wilson ECF, Stewart GD. Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography. British Journal of Surgery 2017; 104(6): 648-659. doi: 10.1002/bjs.10523

Wheeler GM, Sweeting MJ, Mander AP, Lee SM, Cheung YKK. Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration. Statistics in Medicine 2017; 36: 225-241. doi: 10.1002/sim.6912

EVAR-1, DREAM, OVER and ACE trialists. Endovascular or open repair for abdominal aortic aneurysm:  Individual patient data meta-analysis of EVAR-1, DREAM, OVER and ACE trials. British Journal of Surgery 2017; 104: 166–178. doi: 10.1002/bjs.10430

Ulug P, Sweeting MJ, von Allmen RS, Thompson SG, Powell JT, SWAN collaborators. Morphological suitability for endovascular repair, non-intervention rates, and operative mortality in women and men assessed for intact abdominal aortic aneurysm repair: systematic reviews with meta-analysis. The Lancet 2017; 389(10088): 2482-2491. doi: 10.1016/S0140-6736(17)30639-6

Staley J, Jones E, Kaptoge S, Butterworth A, Sweeting M, Wood A, Howson J. A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design. European Journal of Human Genetics 2017; 25: 854-862. doi: 10.1038/ejhg.2017.78

Wheeler GM, Sweeting MJ, Mander AP. Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials. Statistics in Medicine. 2017; 36: 2499-2513. doi: 10.1002/sim.7280

Law M, Sweeting MJ, Donaldson GC, Wedzicha JA. Misspecification of at-risk periods and distributional assumptions in estimating COPD exacerbation rates: the resultant bias in treatment effect estimation. Pharmaceutical Statistics 2017; 16: 201-209. doi: 10.1002/pst.1798



Natriuretic Peptides Studies Collaboration. (2016). Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. The Lancet Diabetes & Endocrinology, 8587(16), 1–10. doi: 10.1016/S2213-8587(16)30196-6

Wheeler GM, Sweeting M, Mander AP. AplusB: a web application for investigating A + B designs for phase I cancer clinical trials. 2016; PLoS ONE 11(7): e0159026. doi: 10.1371/journal.pone.0159026

Patel R, Sweeting MJ, Epstein D, Powell JT, Greenhalgh RM. Endovascular versus open repair of abdominal aortic aneurysm in 15-years follow-up of the UK Endovascular Aneurysm Repair Trial 1 (EVAR trial 1): a randomised controlled trial. Lancet 2016; 388(10058): 2366-2374. doi: 10.1016/S0140-6736(16)31135-7

Peters SAE, van der Schouw YT, Wood AM, Sweeting MJ, …, Wareham NJ, Danesh J, Butterworth AS.  Parity, breastfeeding and risk of coronary heart disease: a pan-European case-cohort study. European Journal for Preventive Cardiology 2016; 23(16): 1755-1765. doi: 10.1177/2047487316658571

Ulug P, Powell JP, Sweeting MJ, Bown MJ, Thompson SG, SWAN collaborative group. Meta-analysis of the current prevalence of screen-detected abdominal aortic aneurysm in women. British Journal of Surgery 2016; 103(9): 1097-1104. doi: 10.1002/bjs.10225



Murray E, Dack C, Barnard M, Farmer A, Li J, Michie S, Pal K, Parrott S, Ross J, Sweeting M, Wood B, Yardley L. HeLP-Diabetes: randomised controlled trial protocol. BMC Health Services Research 2015; 15: 578. doi: 10.1186/s12913-015-1246-9

Sweeting MJ, Ulug P, Powell JT, Desgranges P, Balm R, Ruptured Aneurysm Trialists. Ruptured Aneurysm Trials: The importance of longer-term outcomes and meta-analysis for 1-year mortality. European Journal of Vascular and Endovascular Surgery 2015; 50: 297-302. doi: 10.1016/j.ejvs.2015.04.015

Sweeting MJ, Balm R, Desgranges P, Ulug P, Powell JT, Ruptured Aneurysm Trialists. Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm. British Journal of Surgery 2015; 102(10): 1229-1239. doi: 10.1002/bjs.9852

IMPROVE trial investigators. Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial. European Heart Journal 2015; 36(31): 2061-2069. doi: 10.1093/eurheartj/ehv125

Brill SE, Law M, El-Emir E, Allinson JP, James P, Maddox V, Donaldson G, McHugh T, Nazareth I, Hurst JR, Calverley PMA, Cookson WO, Moffatt MF, Sweeting MJ, Wedzicha JA. Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial. Thorax 2015; 70: 930-38. doi: 10.1136/thoraxjnl-2015-207194

Jones E, Sweeting MJ, Sharp SJ, Thompson SG, EPIC-InterAct Consortium. A method making fewer assumptions gave the most reliable estimates of exposure–outcome associations in stratified case–cohort studies. Journal of Clinical Epidemiology 2015; 68(12): 1397-1405. doi: 10.1016/j.jclinepi.2015.04.007

Nolan T, Dack C, Pal K, Ross J, Stevenson F, Peacock R, Pearson M, Spiegelhalter D, Sweeting M, Murray E. Patient reactions to a web-based cardiovascular risk calculator in type 2 diabetes: qualitative study. British Journal of General Practice 2015; 65(632): e152-e160. doi: 10.3399/bjgp15X683953

Mander AP, Sweeting MJ. A Product of Independent beta Probabilities dose Escalation (PIPE) design for dual-agent Phase I trials. Statistics in Medicine 2015; 34(8):1261-1276. doi: 10.1002/sim.6434

IMPROVE trial investigators. The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm. European Heart Journal 2015; 36: 1328-1334. doi: 10.1093/eurheartj/ehu521

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Interleukin 1 Genetics Consortium. Lancet Diabetes & Endocrinology 2015; 3(4):243-253. doi: 10.1016/S2213-8587(15)00034-0

Crawford MJ, Sanatinia R, Barrett B, Byford S, Dean M, Green J, Jones R, Leurent B, Sweeting MJ, Touquet R, Greene L, Tyrer P,  Ward H, Lingford-Hughes A . The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial. Sexually Transmitted Infections 2015; 91: 37-43. doi: 10.1136/sextrans-2014-051561



IMPROVE trial investigators. Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ 2014; 348:f7661. doi: 10.1136/bmj.f7661

IMPROVE trial investigators. Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm. British Journal of Surgery 2014; 101(3):216-224. doi: 10.1002/bjs.9410

Glover MJ, Kim LG, Sweeting MJ, Thompson SG, Buxton MJ. Cost-effectiveness of the National Health Service abdominal aortic aneurysm screening programme in England. British Journal of Surgery 2014; 101: 976-982. doi: 10.1002/bjs.9528

Turner EL, Sweeting MJ, Lindfield RJ, De Angelis D. Incidence estimation using a single cross-sectional age-specific prevalence survey with differential mortality. Statistics in Medicine 2014; 33(3):422-435. doi: 10.1002/sim.5942

IMPROVE Trial Investigators. An endovascular strategy for suspected ruptured abdominal aortic aneurysm brings earlier home discharge but not early survival or cost benefits. European Journal of Vascular and Endovascular Surgery 2014; 47(4):333-334. doi: 10.1016/j.ejvs.2013.12.017



Thompson S, Brown L, Sweeting M, Bown M, Kim L, Glover M, et al.Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technology Assessment 2013; 17(41). doi: 10.3310/hta17410

Lunn D, Barrett J, Sweeting M, Thompson S. Fully Bayesian hierarchical modelling in two stages, with application to meta-analysis. Journal of the Royal Statistical Society Series C: Applied Statistics 2013; 62(4):551-572. doi: 10.1111/rssc.12007

Sweeting M, Mander A, Sabin T. bcrm: Bayesian Continuous Reassessment Method designs for phase I dose-finding trials. Journal of Statistical Software 2013; 54(13):1-26. doi: 10.18637/jss.v054.i13

Harrington JA, Wheeler GM, Sweeting MJ, Mander AP, Jodrell DI. Adaptive designs for dual-agent Phase I dose-escalation studies. Nature Reviews Clinical Oncology 2013; 10:277-288. doi: 10.1038/nrclinonc.2013.35

RESCAN Collaborators. Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis. Journal of the American Medical Association 2013; 309(8):806-813. doi: 10.1001/jama.2013.950

Dumville JC, Hinchliffe RJ, Cullum N, Game F, Stubbs N, Sweeting M. Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. Cochrane Database of Systematic Reviews 2013; 10:CD010318. doi: 10.1002/14651858.CD010318.pub2



Sanatinia R, Barrett B, Byford S, Dean M, Green J, Jones R, Leurent B, Lingford-Hughes AR, Sweeting M, Touquet R, Tyrer P, Ward H, Crawford MJ. Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial. Trials 2012; 13:149. doi: 10.1186/1745-6215-13-149

Sweeting MJ, Mander AP. Escalation strategies for combination therapy Phase I trials. Pharmaceutical Statistics 2012; 11(3):258-266. doi: 10.1002/pst.1497

Mander AP, Wason JMS, Sweeting MJ, Thompson SG. Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis. Pharmaceutical Statistics 2012; 11(2):91-96. doi: 10.1002/pst.501

Sweeting MJ, Thompson SG, Brown LC, Powell JT, on behalf of the RESCAN collaborators. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. British Journal of Surgery 2012; 99(5):655-665. doi: 10.1002/bjs.8707

Turner RM, Lloyd-Jones M, Anumba DOC, Smith GCS, Spiegelhalter DJ, Squires H, Stevens JW, Sweeting MJ, Urbaniak SJ, Webster R, Thompson SG. Routine antenatal anti-D prophylaxis is effective: meta-analysis adjusted for differences in study design and quality. PLoS ONE 2012; 7(2): e30711. doi: 10.1371/journal.pone.0030711

Sweeting M, Thompson S. Making predictions from complex longitudinal data, with application to planning monitoring intervals in a national screening programme. Journal of the Royal Statistical Society Series A: Statistics in Society 2012; 175(2):596-586. doi: 10.1111/j.1467-985X.2011.01005.x



Sweeting M, Thompson S. Joint modelling of longitudinal and time-to-event data with application to abdominal aortic aneurysm growth and rupture. Biometrical Journal 2011; 53(5):750-763. doi: 10.1002/bimj.201100052

Working Group on Estimation of HIV Prevalence in Europe. HIV in hiding: Methods and data requirements for the estimation of the number of people living with undiagnosed HIV. AIDS 2011; 25:1017-1023. doi: 10.1097/QAD.0b013e3283467087

Powell JT, Sweeting MJ, Brown LC, Gotensparre SM, Fowkes FGR, Thompson SG. Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms. British Journal of Surgery 2011; 98:609-618. doi: 10.1002/bjs.7465

Powell JT, Gotensparre SM, Sweeting MJ, Brown LC, Fowkes FGR, Thompson SG. Rupture rates of small abdominal aortic aneurysms: a systematic review of the literature. European Journal of Vascular and Endovascular Surgery 2011; 41:2-10. doi: 10.1016/j.ejvs.2010.09.005



Sweeting MJ, De Angelis D, Parry J, Suligoi, B. Estimating the distribution of the window period for recent HIV infections: a comparison of statistical methods. Statistics in Medicine 2010; 29:3194-3202. doi: 10.1002/sim.3941

Sweeting MJ, Thompson SG, Brown LC, Greenhalgh RM, Powell JT. Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms. Journal of Vascular Surgery 2010; 52:1-4. doi: 10.1016/j.jvs.2010.02.264

Sweeting MJ, Farewell VT, De Angelis D. Multi-state Markov models for disease progression in the presence of informative examination times: An application to hepatitis C. Statistics in Medicine 2010; 29:1161-1174. doi: 10.1002/sim.3812



IMPROVE Trialists. Time to IMPROVE the Management of Ruptured Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery 2009; 38(2):237–238. doi: 10.1016/j.ejvs.2009.04.002

Sweeting MJ, Hope VD, Hickman M, Parry JV, Ncube F, Ramsay ME, De Angelis D. Hepatitis C infection among injecting drug users in England and Wales (1992-2006): there and back again? American Journal of Epidemiology 2009; 170:352-360. doi: 10.1093/aje/kwp141

Sweeting MJ, De Angelis D, Ades AE, Hickman M. Estimating the prevalence of ex-injecting drug use in the population. Statistical Methods in Medical Research 2009; 18:381-395. doi: 10.1177/0962280208094704

De Angelis D, Sweeting MJ, Ades AE, Hickman M, Hope V, Ramsay M. An evidence synthesis approach to estimating hepatitis C prevalence in England and Wales. Statistical Methods in Medical Research 2009; 18:361-379. doi: 10.1177/0962280208094691

Grishchenko M, Grieve R, Sweeting M, De Angelis D, Thomson BJ, Ryder SD, Irving W and the Trent HCV Study Group. Cost-effectiveness of pegylated interferon and ribavirin for different subgroups of patients with chronic hepatitis C treated in routine clinical practice. International Journal of Technology Assessment in Health Care 2009; 25(2):171-180. doi: 10.1017/S0266462309090229



Sweeting MJ, De Angelis D, Hickman M, Ades AE. Estimating hepatitis C prevalence in England and Wales by synthesizing evidence from multiple data sources. Assessing data conflict and model fit. Biostatistics 2008; 9(4):715-734. doi: 10.1093/biostatistics/kxn004

Sutton AJ, Edmunds WJ, Sweeting MJ, Gill ON. The cost-effectiveness of screening and treatment for hepatitis C in prisons in England and Wales: a cost-utility analysis. Journal of Viral Hepatitis 2008; 15:797-808. doi: 10.1111/j.1365-2893.2008.01008.x

Thomson BJ, Kwong G,  Ratib S,  Sweeting M,  Ryder SD, De Angelis D, Grieve R, Irving WL, Trent HCV Study Group. Response rates to combination therapy for chronic HCV infection in a clinical setting and derivation of probability tables for individual patient management. Journal of Viral Hepatitis 2008; 15(4):271-278. doi: 10.1111/j.1365-2893.2007.00941.x



Sweeting MJ, De Angelis D, Brant LJ, Harris HE, Mann AG, Ramsay ME. The burden of hepatitis C in England. Journal of Viral Hepatitis 2007; 14(8):570-576. doi: 10.1111/j.1365-2893.2007.00851.x



Grieve R, Roberts J, Wright M, Sweeting M, De Angelis D, Rosenberg W, Bassendine M, Main J, Thomas H. Cost-effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C. Gut 2006; 55:1332-1338. doi: 10.1136/gut.2005.064774

Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials. Journal of the American Medical Association 2006; 295(19): 2275-2285. doi: 10.1001/jama.295.19.2275

Sweeting MJ, De Angelis D, Neal KR, Ramsay ME, Wright M, Brant L, Harris HE. Estimating progression to cirrhosis in three UK hepatitis C cohorts: the effect of recruitment bias. Journal of Clinical Epidemiology 2006; 59(2): 144-52. doi: 10.1016/j.jclinepi.2005.06.008



Sweeting MJ, De Angelis D, Aalen OO. Bayesian back-calculation using a multi-state model with application to HIV. Statistics in Medicine 2005; 24(24):3991-4007. doi: 10.1002/sim.2432

Anderson HR, Atkinson RW, Peacock JL, Sweeting MJ, Marston L. Publication bias in studies of the short-term associations between ambient particulate matter and health effects. Epidemiology 2005; 16(2):155-63. doi: 10.1097/01.ede.0000152528.22746.0f



Sweeting MJ, Sutton AJ, Lambert PC. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Statistics in Medicine 2004; 23:1351-1375. doi: 10.1002/sim.1761



Sutton AJ, Cooper NJ, Lambert PC, Jones DR, Abrams KR, Sweeting MJ. Meta-analysis of rare and adverse event data. Expert Review of Pharmacoeconomics & Outcomes Research 2002; 2(4): 367-379. doi: 10.1586/14737167.2.4.367

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