Frank Dudbridge

Frank Dudbridge JPG

Professor of Statistical Genetics

Genetic Epidemiology Research Group

Department of Health Sciences
University of Leicester
Leicester LE1 7RH

Tel: +44 (0)116 252 5474

Personal details

I am interested in the genetic epidemiology of common disease, particularly in statistical methodology and computation.


Dudbridge F, Allen RJ, Sheehan NA, Schmidt AF, Lee JC, Jenkins RG, Wain LV, Hingorani AD, Patel RS (2019) Adjustment for index event bias in genome-wide association studies of subsequent events.  Nat Commun 10:1561
Dudbridge F, Pashayan N, Yang J (2018) Predictive accuracy of combined genetic and environmental risk scores.  Genet Epidemiol 42:4-19
Schmidt AF, Dudbridge F (2018) Mendelian randomization with Egger pleiotropy correction and weakly informative Bayesian priors. Int J Epidemiol 47:1217-1228
Dudbridge F, Brown SJ, Ward L, Wilson SG, Walsh JP (2018) How many cases of disease in a pedigree imply familial disease?  Ann Hum Genet 82:109-113
Saffari A, Silver MJ, Zavattari P, Moi L, Columbano A, Meaburn EL, Dudbridge F (2017) Estimation of a significance threshold for epigenome-wide association studies.  Genet Epidemiol 42:20-33
Charoen P, Nitsch D, Engmann J, Shah T, White J, Zabaneh D, Jefferis B, Wannamethee G, Whincup P, Mulick Cassidy A, Gaunt T, Day I, McLachlan S, Price J, Kumari M, Kivimaki M, Brunner E, Langenberg C, Ben-Shlomo Y, Hingorani A, Whittaker J, Casas JP, Dudbridge F; UCLEB Consortium (2016) Mendelian Randomisation study of the influence of eGFR on coronary heart disease.  Sci Rep 6:28514
Dudbridge F (2016) Polygenic epidemiology.  Genet Epidemiol 40:268-72
Schmidt AF, Hingorani AD, Jefferis BJ, White J, Groenwold R, Dudbridge F; UCLEB Consortium (2016) Comparison of variance estimators for meta-analysis of instrumental variable estimates.  Int J Epidemiol 45:1975-1986
Dudbridge F, Newcombe P (2015) Accuracy of gene scores when pruning markers by linkage disequilibrium.  Hum Hered 80:178-86

Palla L, Dudbridge F (2015) A fast method that uses polygenic scores to estimate the variance explained by genome-wide marker panels and the proportion of variants affecting a trait.  Am J Hum Genet 97:250-259

Dudbridge F (2015) Tobacco consumption and body weight: Mendelian randomization across a range of exposure (commentary).  Int J Epidemiol epub Mar 16

Silverwood RJ, Holmes MV, Dale CE, Lawlor DA, Whittaker JC, Smith GD, Leon DA, Palmer T, Keating BJ, Zuccolo L, Casas JP, Dudbridge F; on behalf of the Alcohol-ADH1B Consortium (2014) Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits.  Int J Epidemiol 43:1781-90

Dudbridge F, Fletcher O (2014) Gene-environment dependence creates spurious gene-environment interaction.  Am J Hum Genet 95:301-307

Dudbridge F (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9:e1003348

Evangelou M, Rendon A, Ouwehand WH, Wernisch L, Dudbridge F (2012) Comparison of methods for competitive tests of pathway analysis. PLoS One 7:e41018

Wason JMS, Dudbridge F (2012) A General Framework for Two-Stage Analysis of Genome-wide Association Studies and Its Application to Case-Control Studies.  Am J Hum Genet 90:760-773

Dudbridge F, Fletcher O, Walker K, Johnson N, Orr N, Dos Santos Silva I, Peto J (2012) Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases. Cancer Epidemiol Biomarkers Prev 21:262-72

Tachmazidou I, De Iorio M, Dudbridge F (2011) Application of the Optimal Discovery Procedure to Genetic Case-Control Studies: Comparison with p Values and Asymptotic Bayes Factors. Hum Hered 71:37-49

Dudbridge F, Holmans PA, Wilson SG (2011) A Flexible Model for Association Analysis in Sibships with Missing Genotype Data. Ann Hum Genet 75:428-38

Wason JM, Dudbridge F (2010) Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia. BMC Genet 11:80

Sawcer S, Ban M, Wason J, Dudbridge F (2010) What role for genetics in the prediction of multiple sclerosis? Ann Neurol 67:3-10

Bowden J, Dudbridge F (2009) Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Genet Epidemiol 33:406-18

Dudbridge F (2008) Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66:89-98

Dudbridge F, Gusnanto A (2008) Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32:227-34

Dudbridge F (2006) A note on permutation tests in multi-stage association scans. Am J Hum Genet 78:1094-5

Dudbridge F, Gusnanto A, Koeleman BPC (2006) Detecting multiple associations in genomewide studies. Hum Genomics 2:310-7

Dudbridge F, Koeleman BPC (2004) Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet 75:424-435

Dudbridge F, Carver T, Williams GW (2004) Pelican: pedigree editor for linkage computer analysis. Bioinformatics 20:2327-8

Dudbridge F (2003) A survey of current software for linkage analysis. Human Genomics 1:63-5

Dudbridge F, Koeleman BPC (2003) Rank truncated product of P values, with application to genomewide association scans. Genet Epidemiol 25:360-66

Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-21

Koeleman BPC, Dudbridge F, Cordell HJ, Todd JA (2000) Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the conditional extended transmission/disequilibrium test. Ann Hum Genet 64:207-13

Dudbridge F, Koeleman BPC, Todd JA, Clayton DG (2000) Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet 66:2009-12


My research interests include

  • Theory and applications of polygenic risk scores
  • Genetic prediction of disease risk
  • Causal inference and Mendelian randomisation
  • Phylogenetics of tumour evolution
  • Multiple testing problems
  • Family-based association studies

I collaborate with groups studying a range of complex diseases including:

  • Cardiovascular disease
  • Respiratory disease
  • Breast cancer
  • Mesothelioma
  • Psychotic experiences
  • Schizophrenia
  • Osteoporosis

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Tel: +44 (0) 116 252 3211

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