Frank Dudbridge
Professor of Statistical Genetics
Genetic Epidemiology Research Group
Department of Health Sciences
University of Leicester
Leicester LE1 7RH
Tel: +44 (0)116 252 5474
Email: frank.dudbridge@leicester.ac.uk
Personal details
I am interested in the genetic epidemiology of common disease, particularly in statistical methodology and computation.
Publications
Palla L, Dudbridge F (2015) A fast method that uses polygenic scores to estimate the variance explained by genome-wide marker panels and the proportion of variants affecting a trait. Am J Hum Genet 97:250-259
Dudbridge F (2015) Tobacco consumption and body weight: Mendelian randomization across a range of exposure (commentary). Int J Epidemiol epub Mar 16
Silverwood RJ, Holmes MV, Dale CE, Lawlor DA, Whittaker JC, Smith GD, Leon DA, Palmer T, Keating BJ, Zuccolo L, Casas JP, Dudbridge F; on behalf of the Alcohol-ADH1B Consortium (2014) Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits. Int J Epidemiol 43:1781-90
Dudbridge F, Fletcher O (2014) Gene-environment dependence creates spurious gene-environment interaction. Am J Hum Genet 95:301-307
Dudbridge F (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9:e1003348
Evangelou M, Rendon A, Ouwehand WH, Wernisch L, Dudbridge F (2012) Comparison of methods for competitive tests of pathway analysis. PLoS One 7:e41018
Wason JMS, Dudbridge F (2012) A General Framework for Two-Stage Analysis of Genome-wide Association Studies and Its Application to Case-Control Studies. Am J Hum Genet 90:760-773
Dudbridge F, Fletcher O, Walker K, Johnson N, Orr N, Dos Santos Silva I, Peto J (2012) Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases. Cancer Epidemiol Biomarkers Prev 21:262-72
Tachmazidou I, De Iorio M, Dudbridge F (2011) Application of the Optimal Discovery Procedure to Genetic Case-Control Studies: Comparison with p Values and Asymptotic Bayes Factors. Hum Hered 71:37-49
Dudbridge F, Holmans PA, Wilson SG (2011) A Flexible Model for Association Analysis in Sibships with Missing Genotype Data. Ann Hum Genet 75:428-38
Wason JM, Dudbridge F (2010) Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia. BMC Genet 11:80
Sawcer S, Ban M, Wason J, Dudbridge F (2010) What role for genetics in the prediction of multiple sclerosis? Ann Neurol 67:3-10
Bowden J, Dudbridge F (2009) Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Genet Epidemiol 33:406-18
Dudbridge F (2008) Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66:89-98
Dudbridge F, Gusnanto A (2008) Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32:227-34
Dudbridge F (2006) A note on permutation tests in multi-stage association scans. Am J Hum Genet 78:1094-5
Dudbridge F, Gusnanto A, Koeleman BPC (2006) Detecting multiple associations in genomewide studies. Hum Genomics 2:310-7
Dudbridge F, Koeleman BPC (2004) Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet 75:424-435
Dudbridge F, Carver T, Williams GW (2004) Pelican: pedigree editor for linkage computer analysis. Bioinformatics 20:2327-8
Dudbridge F (2003) A survey of current software for linkage analysis. Human Genomics 1:63-5
Dudbridge F, Koeleman BPC (2003) Rank truncated product of P values, with application to genomewide association scans. Genet Epidemiol 25:360-66
Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-21
Koeleman BPC, Dudbridge F, Cordell HJ, Todd JA (2000) Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the conditional extended transmission/disequilibrium test. Ann Hum Genet 64:207-13
Dudbridge F, Koeleman BPC, Todd JA, Clayton DG (2000) Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet 66:2009-12
Research
My research interests include
- Theory and applications of polygenic risk scores
- Genetic prediction of disease risk
- Causal inference and Mendelian randomisation
- Phylogenetics of tumour evolution
- Multiple testing problems
- Family-based association studies
I collaborate with groups studying a range of complex diseases including:
- Cardiovascular disease
- Respiratory disease
- Breast cancer
- Mesothelioma
- Psychotic experiences
- Schizophrenia
- Osteoporosis