Frank Dudbridge

Frank Dudbridge JPG

Professor of Statistical Genetics

Genetic Epidemiology Research Group

Department of Health Sciences
Centre for Medicine
University of Leicester
Leicester LE1 7RH

Tel: +44 (0)116 252 5474
Email: frank.dudbridge@leicester.ac.uk

Personal details

I am interested in the genetic epidemiology of common disease, particularly in statistical methodology and computation.

Publications

Palla L, Dudbridge F (2015) A fast method that uses polygenic scores to estimate the variance explained by genome-wide marker panels and the proportion of variants affecting a trait.  Am J Hum Genet 97:250-259

Dudbridge F (2015) Tobacco consumption and body weight: Mendelian randomization across a range of exposure (commentary).  Int J Epidemiol epub Mar 16

Silverwood RJ, Holmes MV, Dale CE, Lawlor DA, Whittaker JC, Smith GD, Leon DA, Palmer T, Keating BJ, Zuccolo L, Casas JP, Dudbridge F; on behalf of the Alcohol-ADH1B Consortium (2014) Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits.  Int J Epidemiol 43:1781-90

Dudbridge F, Fletcher O (2014) Gene-environment dependence creates spurious gene-environment interaction.  Am J Hum Genet 95:301-307

Dudbridge F (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9:e1003348

Evangelou M, Rendon A, Ouwehand WH, Wernisch L, Dudbridge F (2012) Comparison of methods for competitive tests of pathway analysis. PLoS One 7:e41018

Wason JMS, Dudbridge F (2012) A General Framework for Two-Stage Analysis of Genome-wide Association Studies and Its Application to Case-Control Studies.  Am J Hum Genet 90:760-773

Dudbridge F, Fletcher O, Walker K, Johnson N, Orr N, Dos Santos Silva I, Peto J (2012) Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases. Cancer Epidemiol Biomarkers Prev 21:262-72

Tachmazidou I, De Iorio M, Dudbridge F (2011) Application of the Optimal Discovery Procedure to Genetic Case-Control Studies: Comparison with p Values and Asymptotic Bayes Factors. Hum Hered 71:37-49

Dudbridge F, Holmans PA, Wilson SG (2011) A Flexible Model for Association Analysis in Sibships with Missing Genotype Data. Ann Hum Genet 75:428-38

Wason JM, Dudbridge F (2010) Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia. BMC Genet 11:80

Sawcer S, Ban M, Wason J, Dudbridge F (2010) What role for genetics in the prediction of multiple sclerosis? Ann Neurol 67:3-10

Bowden J, Dudbridge F (2009) Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Genet Epidemiol 33:406-18

Dudbridge F (2008) Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66:89-98

Dudbridge F, Gusnanto A (2008) Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32:227-34

Dudbridge F (2006) A note on permutation tests in multi-stage association scans. Am J Hum Genet 78:1094-5

Dudbridge F, Gusnanto A, Koeleman BPC (2006) Detecting multiple associations in genomewide studies. Hum Genomics 2:310-7

Dudbridge F, Koeleman BPC (2004) Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet 75:424-435

Dudbridge F, Carver T, Williams GW (2004) Pelican: pedigree editor for linkage computer analysis. Bioinformatics 20:2327-8

Dudbridge F (2003) A survey of current software for linkage analysis. Human Genomics 1:63-5

Dudbridge F, Koeleman BPC (2003) Rank truncated product of P values, with application to genomewide association scans. Genet Epidemiol 25:360-66

Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-21

Koeleman BPC, Dudbridge F, Cordell HJ, Todd JA (2000) Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the conditional extended transmission/disequilibrium test. Ann Hum Genet 64:207-13

Dudbridge F, Koeleman BPC, Todd JA, Clayton DG (2000) Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet 66:2009-12

Research

My research interests include

  • Analysis of genome-wide association scans, especially multiple testing problems
  • Theory and applications of polygenic risk scores
  • Genetic prediction of disease risk
  • Causal inference by Mendelian randomisation
  • Phylogenetics of tumour evolution

I collaborate with groups studying a range of complex diseases including:

  • Cardiovascular disease
  • Schizophrenia
  • Breast cancer
  • Osteoporosis
  • Autistic spectrum disorders
  • Mesothelioma

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Contact Us

Department of Health Sciences
University of Leicester
Centre for Medicine
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44 (0) 116 252 5402

Head of Department:
Prof. Graham Martin

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