Shining a light into the kidney

IgA nephropathy is a common form of kidney disease worldwide, and is characterised by the abnormal deposition of the antibody, Immunoglobulin A (IgA), on the filters of the kidney. Despite current therapy, around 30% of patients progress to kidney failure, necessitating dialysis or kidney transplantation.

This image shows the deposition of IgA (in red) on a kidney filter, using a new technique called multiphoton microscopy that allows us to study how IgA is handled by different parts of the kidney. Increasing our understanding of this interaction will ultimately help us develop new treatments for this condition.

 

Dr Chee Kay Cheung Infection, Immunity and Inflamation

Chee Kay Cheung 1065

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