Clustered centrosomes in cancer

Normal cells have two centrosomes whereas cancer cells frequently have more. This image shows cells taken from a neuroblastoma undergoing division with more than two centrosomes (green).

To survive, these cells cluster the extra centrosomes into two poles thereby creating a bipolar spindle (red) that can equally segregate the duplicated DNA (blue) between two daughter cells. Our aim is to identify mechanisms that cancer cells use to cluster centrosomes and which can then be inhibited to selectively kill the tumour without affecting normal tissues.

Josephina Sampson Molecular and Cell Biology

Josephina Sampson 1065

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