Clostridium difficile bacteriophages are effective anti-biofilm agents

Clostridium difficile causes antibiotic-induced diarrhoea and death in 10% of patients. Conventional antibiotics (e.g. vancomycin) cannot penetrate the protective extracellular polymetric substance (EPS) in biofilms and could result in treatment failure and recurrent C. difficile infection (CDI). We showed that pre-treatment of surfaces with bacteriophages (viruses of bacteria) (A) prevented biofilm formation and eliminated aggregated bacteria (B, C). In addition, bacteriophages lysed the EPS (D), matured biofilms (E) and free bacteria (F). Thus, bacteriophages are highly promising in the targeted eradication of CDI and are being developed to either supplement or replace antibiotics.

Janet Nale Infection, Immunity and Inflamation

 

Janet Nale 1065

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