Prof Mark A Jobling

Mark is an evolutionary geneticist interested in the pattern and process of human genome variation. He came to the University of Leicester in 1992 having identified the only known hypervariable human Y-chromosome-specific minisatellite, and attracted by the presence of Alec Jeffreys, discoverer of DNA fingerprinting. He contributed to the development of Y-chromosomal short-tandem repeats (Y-STRs), as well as to international projects typing these markers in global samples. He was lead author of the seminal review on the Y chromosome in forensics, and co-author of the Thomas Jefferson paternity case paper, a major stimulus for the field of genetic genealogy. Other contributions have included membership of forensic nomenclature committees, studies of Y-chromosome rearrangements that affect the interpretation of STR profiles, work on surname prediction from Y haplotypes, and population databases. He is a member of the Forensic Science Regulator's Y-STR Working Group, and (from 2018) The Biometric and Forensics Ethics Group, a non-departmental advisory body of the Home Office. As well as this forensic-related work, Mark has a track record in human population genetics and molecular evolution including studies on European population history, sex-biased admixture, and mutation processes (e.g. gene conversion and non-allelic homologous recombination). His laboratory has recently undertaken large-scale NGS studies in humans and great apes.

Selected publications

  • Khubrani Y, Hallast P, JOBLING MA and Wetton JH (2019) Massively parallel sequencing of autosomal STRs and identity-informative SNPs highlights consanguinity in Saudi ArabiaForensic Sci. Int. Genet., 43, 102164.
  • Huszar TI, Wetton JH & Jobling MA (2019) Mitigating the effects of reference sequence bias in single-multiplex massively parallel sequencing of the mitochondrial DNA control region. Forensic Sci. Internat. Genet., 40: 9-17.
  • Khubrani Y, Wetton JH & Jobling MA (2019) Analysis of 21 autosomal STRs in Saudi Arabia reveals population structure and the influence of consanguinity. Forensic Sci. Internat. Genet., 39: 97-102.
  • Huszar TI, Jobling MA & Wetton JH (2018) A phylogenetic framework facilitates Y-STR variant discovery and classification via massively parallel sequencing. Forensic Sci. Internat. Genet., 35: 97-106.
  • Khubrani Y, Wetton JH & Jobling MA (2017) Extensive geographical and social structure in the paternal lineages of Saudi Arabia revealed by analysis of 27 Y-STRsForensic Sci. Internat. Genet., 3: 98–105.
  • Jobling MA & Tyler-Smith C (2017) Human Y chromosome variation in the genome sequencing eraNature Rev. Genet., 18, 485–497.
  • Hallast P, Maisano Delser P, Batini C, Zadik D, Rocchi M, Schempp W, Tyler-Smith C & Jobling MA (2016) Great-ape Y-chromosome and mitochondrial DNA phylogenies reflect sub-species structure and patterns of mating and dispersal. Genome Res. 26: 427-439.
  • Sun M, Jobling MA, Taliun D, Pramstaller PP, Egeland T & Sheehan NA (2015) On the use of dense SNP marker data for the identification of distant relative pairs. Theor. Popul. Biol. 107: 14-25.
  • Ballantyne KN, et al. (2014) Towards complete male individualization with rapidly mutating Y-chromosomal STRs. Hum. Mut. 5: 1021-1032.
  • King TE & Jobling MA (2009) Founders, drift and infidelity: the relationship between Y chromosome diversity and patrilineal surnames. Mol. Biol. Evol. 26: 1093-1102.
  • Jobling MA, Lo ICC, Turner DJ, Bowden GR, Lee AC, Xue Y, Carvalho-Silva D, Hurles ME, Adams SM, Chang YM, Kraaijenbrink T, Henke J, Guanti G, McKeown B, van Oorschot RAH, Mitchell RJ, de Knijff P, Tyler-Smith C & Parkin EJ (2007) Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y. Hum. Mol. Genet. 16: 307-316.
  • Adams SM, King TE, Bosch E & Jobling MA (2006) The case of the unreliable SNP: recurrent back-mutation of Y-chromosomal marker P25 through gene conversion. Forensic Sci. Int. 159: 14-20.
  • King, T.E., Ballereau, S. J., Schürer, K. & Jobling, M.A. (2006) Genetic signatures of coancestry within surnames. Curr. Biol. 16, 384-388.
  • Jobling MA & Gill P (2004) Encoded evidence: DNA in forensic analysis. Nature Rev. Genet. 5: 739-751.
  • Kayser M, Kittler R, Erler A, Hedman M, Lee AC, Mohyuddin A, Mehdi SQ, Rosser Z, Stoneking M, Jobling MA, Sajantila A & Tyler-Smith C (2004) A comprehensive survey of human Y-chromosomal microsatellites. Am. J. Hum. Genet. 74: 1183-1197.
  • Foster EA, Jobling MA, Taylor PG, Donnelly P, de Knijff P, Mieremet R, Zerjal T & Tyler-Smith C (1998) Jefferson fathered slave's last child. Nature 396: 27-28.
  • Jobling MA, Pandya A & Tyler-Smith C (1997) The Y chromosome in forensic analysis and paternity testing. Int. J. Legal Med. 110: 118-124


JOBLING, M., Hollox, E., Hurles, M., Kivisild, T. and Tyler-Smith, C. (2014) Human Evolutionary Genetics (2nd edition). 670pp., Garland Science, New York/London.


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