Research

Professor Alec Jeffreys’ research is focussed on understanding human DNA diversity and exploring processes that generate variation in the human genome.

DNA Fingerprint
DNA Fingerprint

His early work on minisatellites not only resulted in DNA
fingerprinting, for which his laboratory is best known,
but also opened up major areas of enquiry into human
genome dynamics which remain the focus of much of
his and his colleagues’ activity. Current areas of research
include:


Patterns and processes of human meiotic recombination,
including understanding how recombination hotspots are
specified and how they evolve as highly dynamic entities
in the human genome.

 

Ectopic recombination and genome instability.
Unequal crossover is a major process creating copy number variation in the human genome, often with pathological consequences, and is being directly explored by detecting
de novo rearrangements using single DNA molecule analysis.


Base mutation. Prof. Jeffreys’ group is also developing methods to allow the direct detection of rare de novo base substitutions in the human germline and to explore the relationship between mutation and recombination.

 

Alec Jeffreys and Genetic Fingerprinting
Laboratory Research group: Mutation and recombination web pages

 

Research Links

Search PubMed at the US National Library of Medicine for this author: Prof AJ Jeffreys
Search Leicester Research Archive: Prof AJ Jeffreys
Search Google Scholar: Prof AJ Jeffreys

 

 

 

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Contact Details

Department of Genetics
University of Leicester

Adrian Building
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44 (0)116 252 3374
E Mail: genetics@le.ac.uk

Head of Department
Professor Jacqui Shaw

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