Selected Publications


Bishop NC, Walker GJ, Gleeson M, Fiona A. Wallace FA, Hewitt CRA. 2009
Human T lymphocyte migration towards the supernatants of Human Rhinovirus infected airway epithelial cells: Influence of exercise and carbohydrate intake.
Exercise Immunology Review, 15, 42-59

El Rachkidy RG, Hales JM, Freestone PPE, Hewitt CRA, Osborne JE, Camp RDR 2005
IgGs reactive with proteins secreted by Streptococcus pyogenes are more abundant in serum from patients with chronic plaque psoriasis than healthy controls.
British Journal of Dermatology 152(4):838

El-Rachkidy R, Freestone PPE, Hales JM, Hewitt CRA, Osborne JE, Camp RDR. 2004
Analysis of autoantigens in the proteomes of human epidermis and Streptococcus pyogenes: A route to understanding the pathogenesis of the autoimmune skin disease, psoriasis
Molecular and Cellular Proteomics 3(10):149

Kadioglu A, Coward W, Colston MJ, Hewitt CRA, Andrew PW. 2004
CD4-T-Lymphocyte Interactions with Pneumolysin and Pneumococci Suggest a Crucial Protective Role in the Host Response to Pneumococcal Infection
Infection and Immunity, 72, 2689–2697

McKean MC, Hewitt CRA, Lambert PC, Myint SH, Silverman, M. 2003
An adult model of viral wheeze: Soluble markers of inflammation in the upper and lower respiratory tracts.
Clinical and Experimental Allergy, 33, 912-920.

Bolton, SJ, McNulty, CA, Thomas, RJ, Hewitt CRA and Wardlaw, AJ 2003
Expression of and functional responses to protease-activated receptors on human eosinophils.
Journal of Leukocyte Biology 74, 60-68

Foster S, Bedford KJ, Gould MEL, Coward WR, and Hewitt CRA. 2003
Respiratory Syncytial Virus Infection and Virus-Induced Inflammation are modified by Contaminants of Indoor Air
Immunology. 108, 109-115

Phillips, C, Coward, WR, Pritchard, DI, and Hewitt, CRA. 2003.
Basophils express a type 2 cytokine profile on exposure to proteinases from helminths and house dust mites.
Journal of Leukocyte Biology, 73, 165-171.

Bunn, HJ, Hewitt, CRA, Grigg, J. 2002
Attenuation of Alveolar Macrophage Mediated Suppression of T cells in Very Young Infants.
Clinical and Experimental Immunology.128 313-317.

Grigg, J, Hewitt, CRA, McGarr, C, MacNee, W, Donaldson, K, 2002
Homotypic aggregation of rat alveolar macrophages stimulated by ultrafine carbon black is associated with up-regulation of intercellular adhesion molecule-1.
Annals of Occupational Hygiene, 46, 227-230.

McKean, MC, Leech, MD, Lambert PC, Hewitt, CRA, Myint, SH, Silverman, M. 2001
An adult model of coronavirus-induced wheeze: Changes in symptoms compared to lung physiology.
European Respiratory Journal. 18, 23-32.

McKean MC, Silverman M, Myint S, Hewitt CRA, O'Sullivan S 2001
An adult model of viral wheeze: Nasal and sputum leukotriene response
Thorax 56: 124

Openshaw, PJM and Hewitt, CRA, 2000
Protective and harmful effects of viral infections in childhood on wheezing disorders and asthma.
American Journal of Respiratory and Critical Care Medicine. 162, 40-43.

Lawley, WJ, Fletcher, S, Squire, IB, Woods, KL, and Hewitt, CRA. 2000
T cell recognition of discrete regions of the immunogenic drug, Streptokinase.
Clinical Science. 99, 239-246.

Pritchard, DI, Brown, AP, Kasper, G, McElroy P, Loukas P, Hewitt, CRA, Berry, C, Füllkrug, R, and Beck, E.. 1999
A Hookworm Allergen Which Strongly Resembles Calreticulin.
Parasite Immunology. 21, 439-450.

Squire, IB, Lawley, WJ, Fletcher, S, Holme, E, Hillis, WS, Hewitt, CRA, and Woods, KL. 1999.
Humoral and cellular immune responses up to 7.5 years after administration of streptokinase for acute myocardial infarction.
European Heart Journal. 20, 1245-1252.

Hewitt, CRA, Foster, S, Phillips, C, Horton, H, Jones, RM, Brown, AP, Hart, BJ, and Pritchard, DI. 1998.
Mite Allergens: Significance of Enzymatic Activity.
Allergy. 53:60-63.

Hewitt, CRA. 1998. Attraction and the single cell.
Molecular Medicine Today. 4:14.

Horton, H, Weston, SD, and Hewitt, CRA. 1998.
Allergy to antibiotics: T cell recognition of amoxycillin is HLA-DR restricted and does not require antigen processing.
Allergy. 53:83-88.

Hewitt, CRA. 1997. Microbes signal the route to destruction.
Molecular Medicine Today. 3:377-378.

Hewitt, CRA. 1997. IgE from the centre of the lung.
Molecular Medicine Today. 3:189.

Pritchard, DI, Hewitt, CRA, and Moqbel, R. 1997.
The relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminths.
Parasitology. 115:33-44.

Hewitt, CRA, Horton, H, Jones, RM, and Pritchard, DI. 1997.
Heterogeneous proteolytic specificity and activity of the house dust mite proteinase allergen Der p1.
Clinical and Experimental Allergy. 27:201-207.

Hewitt, CRA. 1996. Antibody Applications. Essential Techniques Series.
Biomedical Chromatography. 10:45. (Book Review).

Hewitt, CRA. 1996. Breaking down immunity at the fungal wall.
Molecular Medicine Today. 2:495.

Hewitt, CRA. 1996. C3d Complements immunity.
Molecular Medicine Today. 2:96.

Hewitt, CRA. 1996. Alveolar macrophages just say NO.
Molecular Medicine Today. 2:51.

Hewitt, CRA, Brown, AP, Hart, BJ, and Pritchard, DI. 1995.

A major house dust mite allergen disrupts the IgE network by selectively cleaving CD23: Innate protection by antiproteinases.
Journal of Experimental Medicine. 182:1537-1544.

Hewitt, CRA. 1995. Autoreactive T cell receptors not excluded.
Molecular Medicine Today. 1:403

Niedergang, F, Hemar, A, Hewitt, CRA, Owen, MJ, Dautry-Varsat, A and Alcover, A. 1995.
The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down regulation by increasing its internalisation.
The Journal of Biological Chemistry. 270:12839-12845.

O'Hehir, RE, Hewitt, CRA, Higgins, JA, Jarman, ER, Verhoef, A, Lake, RA, and Lamb, JR. 1995.
The Activation of Allergen Reactive T Lymphocytes and Mechanisms of Hyposensitisation. In: Asthma and Rhinitis. Ed. Holgate ST, and Busse W. Blackwell Scientific. Cambridge, MA. USA.

Morris, A, Hewitt, CRA, and Young, S. 1994.
The major histocompatibility complex: Its genes and their roles in antigen presentation.
Molecular Aspects of Medicine. 15:377-504.

Wedderburn, L, O'Hehir, RE,  Hewitt, CRA, Lamb, JR, and Owen, MJ. 1993.
Analysis of TcRV gene usage by T cells reactive with house dust mite allergens.
Proceedings of the National Academy of Sciences USA. 90:8214-8218.

Hewitt CRA, Lamb JR, Hayball, JD, Hill M, Owen, MJ, and O'Hehir, RE. 1992.
MHC independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor.
Journal of Experimental Medicine. 175:1493-1499.

Viney, JL, Prosser, HM, Hewitt, CRA, Lamb, JR and Owen, MJ. 1992.
Generation of monoclonal antibodies against a human T cell receptor  chain expressed in transgenic mice.
Hybridoma. 11:701-713.

Hewitt, CRA, O'Hehir, RE., Hayball, JD and Lamb, JR. 1992.
The Superantigenic activities of bacterial enterotoxins In: Molecular Biology of Bacterial Infection, Current Status and Future Perspectives. Society for General Microbiology Symposium. Eds. Hormaeche, CE, Penn, CW, & Smyth, CJ. 49:149-172. Cambridge University Press. UK.

Hewitt, CRA and Lamb, JR. 1992.
Peptide-mediated anergy in human CD4+T cells.
Research in Immunology. 143: 294-296.

Hewitt, CRA and Owen, MJ. 1990.
Development of a soluble T cell antigen receptor.
Journal of Cellular Biochemistry. 15: 295.

Hewitt, CRA. and Feldmann, M. 1989.
Human T cell clones present antigen.
Journal of Immunology. 143: 762-769.

Smith PR, Venables PJW, Williams D, Hewitt CRA, Lam K, Maini RN 1984
Monoclonal Antibodies to SS-B (LA)
British Journal of Rheumatology 23 122


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