Professor Yuri E. Dubrova

Professor Yuri DubrovaProfessor of Genetics

Tel: +44 (0)116 252 5654
Fax: +44 (0)116 252 3378

Personal details

BSc (Kiev), PhD (Moscow), DrSci (Moscow)

I grew up in Kiev, Ukraine and did my undergraduate degree in Biology at Kiev State University (Ukraine). My PhD and DrSci in Genetics are from the NI Vavilov Institute of General Genetics, Moscow. In 1994, I moved to Leicester.

I am

  • A member of the Research Team
  • Chair of the Safety Team

and am on the Radiation Protection Subcommittee.



To view my publications please click HERE


My research interests focus on the analysis of germline mutation induction in humans and mice following exposure to ionising radiation, chemical mutagens and some anticancer drugs. My recent research has also involved transgenerational genomic instability manifesting in the offspring of exposed parents.


Professor Yuri Dubrova Lecture

Germline mutation induction in mice
The project involves the study on the effects of paternal irradiation on copy number variation in the mouse germline.

Mechanisms of transgenerational instability in mice
The project involves analysis of epigenetic mechanisms underlying transgenerational instability in the offspring of irradiated male mice. The work on this project involves a genome-wide profiling of gene expression and DNA methylation in the offspring of irradiated parents, as well as the study on the effects of low-dose parental irradiation on the manifestation of transgenerational instability.

Transgenerational genomic instability caused by anticancer drugs
The project aims to establish whether paternal exposure to mutagenic anticancer drugs results in long-term transgenerational changes in mutation rates in the mouse germline and somatic tissues.

The genetic and epigenetic effects of folic acid deficiency in mice
The project aims to analyse the long-term impact of a folate-deficient diet on genome stability, DNA methylation and gene expression in treated mice and their offspring.


You can search for PhDs supervised by Professor Y. Dubrova.

Current PhD projects in Lab

  • Epigenetic Mechanisms of Transgenerational Instability in Mice
  • The effects of Folic Acid Deficiency on Genome Stability
  • The Dose and Dose-rate Effects on Transgenerational Instability in Mice
  • The Effects Maternal Irradiation on ESTR Mutation Induction and Transgenerational Instability in Mice

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Contact Details

Department of Genetics
University of Leicester

Adrian Building
University Road
United Kingdom

Tel: +44 (0)116 252 3374
E Mail:

Head of Department
Professor Jacqui Shaw

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