Professor Yuri Dubrova’s research interests focus on the analysis of germline mutation induction in humans and mice following exposure to ionising radiation, chemical mutagens and some anticancer drugs. His recent research has also involved transgenerational genomic instability manifesting in the offspring of exposed parents.

Research Projects:

Germline mutation induction in mice

Professor Yuri Dubrova Lecture
Professor Yuri Dubrova Lecture

The project involves the study on the effects of paternal irradiation on copy number variation in the mouse germline.

Mechanisms of transgenerational instability in mice
The project involves analysis of epigenetic mechanisms underlying transgenerational instability in the offspring of irradiated male mice. The work on this project involves a genome-wide profiling of gene expression and DNA methylation in the offspring of irradiated parents, as well as the study on the effects of low-dose parental irradiation on the manifestation of transgenerational instability.

Transgenerational genomic instability caused by anticancer drugs
The project aims to establish whether paternal exposure to mutagenic anticancer drugs results in long-term transgenerational changes in mutation rates in the mouse germline and somatic tissues.

The genetic and epigenetic effects of folic acid deficiency in mice
The project aims to analyse the long-term impact of a folate-deficient diet on genome stability, DNA methylation and gene expression in treated mice and their offspring.


Research Links

Search PubMed at the US National Library of Medicine for this author: Prof Y. Dubrova
Search Leicester Research Archive: Prof Y.Dubrova
Search Google Scholar: Prof Y. Dubrova




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University of Leicester

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