Professor Yuri E. Dubrova

Professor of Genetics

Tel: +44 (0)116 252 5654
Fax: +44 (0)116 252 3378
Email: yed2@le.ac.uk

Personal details

BSc (Kiev), PhD (Moscow), DrSci (Moscow)

I grew up in Kiev, Ukraine and did my undergraduate degree in Biology at Kiev State University (Ukraine). My PhD and DrSci in Genetics are from the NI Vavilov Institute of General Genetics, Moscow. In 1994, I moved to Leicester.

I am

A member of the Research Team
Chair of the Safety Team

and am on the Radiation Protection Subcommittee.

Websites

PubMed at the US National Library of Medicine for Professor Y. Dubrova
Leicester Research Archive: Professor Y. Dubrova
Google Scholar: Professor Y. Dubrova

Publications

To view my publications please click HERE

Research

My research interests focus on the analysis of germline mutation induction in humans and mice following exposure to ionising radiation, chemical mutagens and some anticancer drugs. My recent research has also involved transgenerational genomic instability manifesting in the offspring of exposed parents.

Projects

Germline mutation induction in mice
The project involves the study on the effects of paternal irradiation on copy number variation in the mouse germline.

Mechanisms of transgenerational instability in mice
The project involves analysis of epigenetic mechanisms underlying transgenerational instability in the offspring of irradiated male mice. The work on this project involves a genome-wide profiling of gene expression and DNA methylation in the offspring of irradiated parents, as well as the study on the effects of low-dose parental irradiation on the manifestation of transgenerational instability.

Transgenerational genomic instability caused by anticancer drugs
The project aims to establish whether paternal exposure to mutagenic anticancer drugs results in long-term transgenerational changes in mutation rates in the mouse germline and somatic tissues.

The genetic and epigenetic effects of folic acid deficiency in mice
The project aims to analyse the long-term impact of a folate-deficient diet on genome stability, DNA methylation and gene expression in treated mice and their offspring.

Supervision

You can search FindaPhD.com for PhDs supervised by Professor Y. Dubrova.

Current PhD projects in Lab

Epigenetic Mechanisms of Transgenerational Instability in Mice
The effects of Folic Acid Deficiency on Genome Stability
The Dose and Dose-rate Effects on Transgenerational Instability in Mice
The Effects Maternal Irradiation on ESTR Mutation Induction and Transgenerational Instability in Mice