PhD Projects in Genetics

For a complete list of PhD Projects available in the Department of Genetics go to: Find a PhD.com


The Department of Genetics offers a range of Research Projects with the following academics: 

Prof Mark Jobling

We are interested in patterns of human genetic diversity, and how these are influenced by population-level processes including migration, social organisation, language and culture, as well as fundamental genome-level processes of mutation, copy number variation, gene conversion and recombination. Our work has a translational aspect in forensic genetics and genomics. 

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Prof Charalambos Kyriacou

There are a number of possible project areas available in the Drosphila Laboratories, such as, Aggression in Drosophila, Sleep and circadian rhythms in the fly and the molecular control of tidal rhythms in the sea louse Eurydice pulchra Proteomic approaches to studying the fly clock.

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Prof Flaviano Giorgini

We use a variety of genetic, molecular, biochemical and microscopic approaches to understand  the mechanisms which underlie neurodegenerative disorders such as Parkinson’s, Alzheimer’s and Huntington’s diseases. We have particular interests in the roles of the kynurenine pathway, altered vesicle trafficking and mitochondrial dysfunction in the pathogenesis of these disorders, with the goal of developing novel therapeutic strategies.

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Dr Richard Badge

We are interested in, the impact of L1 retrotransposons on human genetic variation and gene expression, the development of retrotransposon based marker systems for use in Chimpanzee conservation genetics and the IAP retrotransposon activity in mouse cell lines deficient in DNA methylation.

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Dr Chris Bayliss

Dr Bayliss has projects in the following areas, Meningococcal haemoglobin receptors, Phase variation during meningococcal carriage, Determinants of phase variation rate in Campylobacter jejuni, Selection of phase variants in Campylobacter jejuni, Genomic analyses of repetitive DNA in C. jejuni and N. meningitidis and Computer modelling of phase variation in bacterial populations.

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Dr Raymond Dalgleish

Human genome sequence variants should be reported in the literature and in clinical reports using the HGVS sequence variant nomenclature (den Dunnen et al., 2016). This requirement is endorsed by several international organisations which regulate standards-compliance in clinical genetics testing. However, published and anecdotal evidence shows that the quality of reporting is variable with examples of incorrect syntax and/or data being presented in the literature. Such errors certainly lead to confusion, but might also result in inappropriate medical treatment in certain instances. VariantValidator (https://variantvalidator.org/) (Freeman et al., 2017) has been developed as a software tool to provide rigorous checking of sequence variant descriptions with respect to syntax and data inconsistencies. We are building software tools to help researchers and clinicians ensure that sequence variation data are accurate, exchangeable and fit for purpose in the era of genome sequencing.

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Dr Celia May

Current projects in the laboratory offered by Dr Celia May are concerned with genome variability, meiotic recombination and genome instability particularly within the pseudoautosomal regions of the human sex chromosomes. 

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Dr Ezio Rosato

We welcome enquiries from motivated and self funded individuals. We offer PhD projects in the following areas. Entrainment of the circadian clock of Drosophila, Sleep homeostasis and circadian clock in Drosophila, Memory, learning and clock in Drosophila and Marine clocks.

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Dr Eamonn Mallon

We are interested in the role of epigenetics in social insect biology. Epigenetics in the stable and heritable change in a gene's expression, with no change in the underlying genomic sequence. Social insects (ants. bees, wasps and termites) have come to the fore recently in epigenetic research due to the discovery of a fully functional methylation (the main epigenetic tag) system in these insects.

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Dr Julie Morrissey

Antimicrobial resistance and high levels of air pollution causing increased respiratory disease are major public health concerns according to the World Health Organisation. Our ground-breaking research has shown that bacterial infection is effected by air pollution, and that environmental stress impacts antibiotic resistance.  Our  aim is to use a range of molecular microbiology techniques to further investigate antibiotic resistance, elucidate the impact of air pollution on bacteria and respiratory disease, and identify new therapeutic targets to prevent infection by two major global respiratory pathogens Staphylococcus aureus and Streptococcus pneumonia.

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Prof David Twell

We are interested in the control and evolution of plant reproduction and crop fertility. We use molecular, genetic and genomic approaches to study processes that are important for plant development and crop fertility. The knowledge and tools arising from our research informs basic understanding of plant development and new plant breeding strategies to help maintain food security. PhD projects are available in the broad areas of research detailed in the link below and prospective applicants are encouraged to contact me to discuss research objectives and areas of interest.

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Prof Yuri Dubrova

We are interested in the long-term genetic effects of exposure to environmental mutagens, including ionising radiation. The work in our group focuses on the genome-wide analysis of mutation induction in the germline of irradiated human in mouse families (next generation sequencing), the long-term radiation-induced changes in gene expression and the transgenerational effects of parental exposure to mutagens.

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Postgraduate Contact Details

Dr Celia May
Postgraduate Admissions Tutor
Tel: +44 (0)116 252 3413
E Mail: cam5@le.ac.uk

 

General enquiriesgeneticspgr@le.ac.uk