Dr Jenny Shepherd

Lecturer

Mechanics of Materials Research Group

Michael Atiyah Building

Room M138

University Road, Leicester, LE1 7RH UK

t: +44(0) 116 252 5670

e: js1005@leicester.ac.uk

ORCiD profile https://orcid.org/0000-0002-3790-0323

Google Scholar Profile: https://scholar.google.com/citations?hl=en&user=w1obUv4AAAAJ

 

Biography

After a MEng in Materials Science at the University of Oxford, Jenny moved to Cambrige for a PhD focussed on the production of carbonate substituted hydroxyapatite scaffolds for bone repair. Her early post-doctoral career concentrated on the application of synthetic collagen structures in the repair of load-bearing soft tissues such as tendons and the meniscus. This work included a 12 month EPSRC funded knowledge transfer secondment to Tigenix UK Ltd. Attempting to replicate the structure of these tissues led to a desire to investigate the natural tissues further and Jenny joined QMUL as part of a Wellcome Trust Project considering the mechanics and biology of developing tendinopathy. In 2013 she returned to Cambridge and the biomaterials field working on an ERC project on 3D Engineered Environments for Tissue Engineering with a particular emphasis on structurally and chemically graduated scaffolds for ex vivo blood platelet generation. In 2019 Jenny became a Lecturer in the Mechanics of Materials Group within the University of Leicester’s Department of Engineering.

 

Research Interests

  • Biomaterials and tissue engineering
  • Tissue structure / mechanics relationship
  • Mechanical, structural and chemical materials characterisation
  • Imaging – with a particular emphasis on micro-computed tomography and confocal / fluorescent imaging.

 

Journal Publications

J.H. Shepherd and D. Howard, A.K. Waller, H.R. Foster, A. Muller, T. Moreau, A.L. Evans, M. Arumugam, G. Bouët Chalon , E. Vriend, N. Davidenko, C. Ghevaert, S.M. Best, R.E. Cameron; Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: enhancing production and purity; Biomaterials 182 (2018), 135-144

D.V. Shepherd, J.H. Shepherd, S.M. Best, R.E. Cameron; 3D Imaging of Cells in Scaffolds: Direct Labelling in Micro CT; Journal of Materials Science: Materials in Medicine 29 (2018), 86

R.N. Widmer, G.I. Lampronti, B. Kunz, C. Battaglia, J.H. Shepherd, S.A.T. Redfern, T.D. Bennett; Manufacturing Macroporous Monoliths of Microporous Metal–Organic Frameworks; ACS Applied Nano Materials 1 (2018), pp 497–500

R. Middleton, X. Li, J. Shepherd, Z. Li, W. Wang, S.M. Best, R.E. Cameron, and Y.Y.S. Huang; Near-Field Electrospinning Patterning Polycaprolactone and Polycaprolactone/Collagen Interconnected Fiber Membrane 303 (2018), 1700463.

J. Shepherd, D. Bax, S. Best, R. Cameron, Collagen-Fibrinogen Lyophilised Scaffolds for Soft Tissue Regeneration. Materials 2017, 10, 568.

A. Naik, D.V. Shepherd, J.H. Shepherd, S.M. Best, R.E. Cameron, The effect of the type of HA on the degradation of PLGA/HA composites. Materials Science and Engineering: C. 70 (2017); 824-831,

K.M. Pawelec, J. Shepherd, R. Jugdaohsingh, S.M. Best, R.E.  Cameron, R.A. and Brooks; Collagen Scaffolds as a tool for understanding the biological effect of Silicates. Materials Letters. 157 (2015); 176-179

Z. Ahmad, J.H. Shepherd, D.V. Shepherd, S. Ghose, S.J. Kew, R.E. Cameron, S.M. Best, R.A. Brooks, J.  Wardale, N. Rushton. Effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair. Regenerative Biomaterials, (2015) p.rbv005.

D.V. Shepherd, J.H. Shepherd, S. Ghose, S.J. Kew, R.E. Cameron, S.M. Best;  The process of EDC-NHS cross-linking of reconstituted collagen fibres increases collagen fibrillar order and alignment. APL Materials 3 (2015), 014902

J.H. Shepherd, G.P. Riley, H.R.C. Screen; Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level. Journal of the Mechanical Behaviour of Biomedical Materials 38 (2014); 163-172

J.H. Shepherd, K. Legerlotz, T. Demirci, C. Klemt, G.P. Riley, H.R.C. Screen; Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 228 (2014); 49-59

J.H. Shepherd, H.R.C. Screen; Fatigue Loading of Tendon. International Journal of Experimental Pathology. 94, 260-270 (2013)

D. Howard, J.H. Shepherd, S.J. Kew, S. Ghose, J.A. Wardale, N. Rushton; The Release of Growth Factors from a Fibre Reinforced Collagen GAG Matrix Supplemented with Platelet Rich Plasma: Influence on In Vitro Cultured Human Meniscal Cartilage Cells. Journal of Orthopaedic Research. 32 273-278 (2013)

J. H. Shepherd, S. Ghose, S.J. Kew, A. Moavenian, S.M. Best, R.E. Cameron; Effect of fibre cross-linking on collagen-fibre reinforced collagen-chondroitin-6-sulphate materials for regenerating load-bearing soft tissues .  Journal of Biomedical Materials Research Part A. 101A, 176-184 (2013)

D. Enea, J. Gwynne, S. Kew,  M. Arumugam,  J. Shepherd, R. Brooks, S. Ghose,  S. Best, R. Cameron, N. Rushton; Collagen fibre implant for tendon and ligament biological augmentation - In vivo study in an ovine model. Knee Surgery, Sports Traumatology, Arthroscopy. 21, 1783-1793 (2013)

J.H. Shepherd, D.V. Shepherd, S.M. Best; Substituted hydroxyapatites for Bone Repair. Journal of Materials Science: Materials in Medicine: 23, 2335-2347 (2012)

J.H. Shepherd, S.M. Best; Calcium Phosphate Scaffolds for Bone Repair. JOM 63, 83-92 (2011)

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