Dr Alkiviadis Tsamis, PhD, AFHEA

Lecturer in Engineering
Contact Details

Mechanics of Materials Research Group

Michael Atiyah Building | Room 214
University Road | Leicester | LE1 7RH | UK

t: +44 (0)116 252 3716
e:
at441@leicester.ac.uk

ORCiD Profile: https://orcid.org/0000-0001-8101-3302

Google Scholar Profile: https://scholar.google.co.uk/citations?user=5xDoui8AAAAJ&hl=en

Alkis
Brief Biography

Dr. Tsamis is a Lecturer at University of Leicester’s Department of Engineering. Prior to that, he was senior Postdoctoral Researcher at Carnegie Mellon University’s Department of Biomedical Engineering. Also, he was a Postdoctoral Researcher at Stanford University’s Department of Mechanical Engineering and University of Pittsburgh’s Department of Bioengineering under a fellowship by the Swiss National Science Foundation. He completed his Ph.D. in Biotechnology and Bioengineering at École Polytechnique Fédérale de Lausanne in 2010. His positions have afforded him the valuable experience of interfacing directly with senior laboratory professionals and clinical collaborators, and navigating the barriers that come with inter-disciplinary research in multi-cultural Engineering environments.

Dr. Tsamis’ research focuses on the integration of multi-scale experimental and computational techniques in both tissue mechanics and tissue engineering, with the aim to investigate structural mechanisms which are indicative of the development of disease or damage/fracture in fibre-reinforced multilayer composite biological materials such as cardiovascular tissues. His recent work has focused on developing extracellular matrix (ECM)-based nanomechanical biosensors (NMBS) to dynamically measure cell-cell and cell-ECM 3D multi-scale mechanical strains and stresses in cardiovascular tissues during embryonic development. NMBS can integrate into the living tissues without perturbation of morphogenetic processes. This is of primary interest in basic science and disease pathogenesis, and can be of particular clinical significance when designing novel therapies, which would allow us to control the progression of a type of disease in both cardiovascular and other types of soft fibrous tissues.

Education
09/2005-01/2010 PhD, Biotechnology and Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [Funded by Swiss National Science Foundation (SNSF) #118274, #103823]
09/1998-10/2003 Diploma, Mechanical Engineering (5-year Bachelor’s & Master’s combined degree), National Technical University of Athens (NTUA), Athens, Greece. [1st-Class Honours]
Work Experience
09/2016- Lecturer, Department of Engineering, College of Science and Engineering, University of Leicester, Leicester, Leicestershire, UK.
04/2014-08/2016 Senior Postdoctoral Researcher, Department of Biomedical Engineering, College of Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
10/2011-03/2014 Postdoctoral Research Scholar, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
04/2010-06/2011 Postdoctoral Research Scholar, Department of Mechanical Engineering, School of Engineering, Stanford University, Stanford, CA, USA.
09/2005-01/2010 Graduate Research Fellow, Interfaculty Institute of Bioengineering, School of Life Sciences, EPFL, Lausanne, Switzerland.
03/2004-03/2005 Seaman, Hellenic Navy (Obligatory Military Service): Salamis Naval Base and Navy Supply Centre, Greece.
03/2002-10/2003 Undergraduate Research Assistant, School of Mechanical Engineering, National Technical University of Athens, Athens, Greece.
Grants

09/2019-03/2023

09/2017-09/2020

EPSRC DTP Studentship (Primary Supervisor), University of Leicester. "Effect of microstructure in the mechanical response of cost-effective biomimetic constructs for rapid wound healing," Budget 57K GBP.

College-funded Stand-Alone PhD Studentship (Primary Supervisor), College of Science and Engineering, Department of Engineering, University of Leicester. “Investigating small airway closure in the human lung using multi scale approaches,” Budget 48K GBP.

02/2013-01/2014 Advanced Researcher Postdoctoral Fellowship from SNSF (PI). “Characterization and modeling of fiber architecture of human aorta in health and disease,” PA00P2_145399, Budget 82K USD. (follow-up project)
02/2012-01/2013 Advanced Researcher Postdoctoral Fellowship from SNSF (PI). “Characterization and modeling of fiber architecture of human aorta in health and disease,” PA00P2_139684, Budget 73K USD.
04/2010-03/2011 Prospective Researcher Postdoctoral Fellowship from SNSF (PI). “Can passive cardiac support prevent heart failure? A hybrid experimental / computational approach,” PBELP2-130913, Budget 64K USD.
PhD Students
09/2017-09/2021 Mr. James Campbell. Thesis title: “Investigating small airway closure in the human lung using multi scale approaches,” Department of Engineering, University of Leicester.
Research Interests
  • Soft fibrous tissue mechanics (e.g., cardiovascular, gastrointestinal)
  • Soft fibrous tissue engineering
  • Role of micro-structure on the mechanical response of soft fibrous tissue
  • Experimental bioengineering
  • Computational bioengineering (analytical/finite element approach)
  • Mechanics and modelling at multiple time/length scales
  • Fluorescence imaging
  • Characterisation of ECM micro-/nano-environment
  • Micro-/nano-fabrication technologies
  • ECM-based biosensors
Membership in Professional Bodies
08/2014-present American Association for the Advancement of Science
09/2012-present American Society of Mechanical Engineers
02/2010-present A3 EPFL Alumni
06/2007-present Biomedical Engineering Society
06/2007-present European Society of Biomechanics
06/2005-present Technical Chamber of Greece (Professional Chartered Mechanical Engineer)
Teaching
  • 1st Year Computer Programming for Engineers (10 Credits, Spring Semester, Self-taught Teaching)
  • 1st Year Circuits & Systems I (10 Credits, Spring Semester 2017 only, Self-taught Teaching)
  • 2nd Year Circuits & Systems II (10 Credits, Fall Semester 2017 only, Self-taught Teaching)
  • 2nd Year Programming & Numerical Methods (10 Credits, Fall Semester 2017 only, Self-taught Teaching)
  • 2nd Year Engineering Mechanics I: Solid Mechanics (10 Credits, Spring Semester, Self-taught Teaching)
  • 3rd Year Engineering Mechanics II: Fluid Mechanics (10 Credits, Fall Semester, Self-taught Teaching)
  • 3rd Year Properties of Materials (10 Credits, Fall Semester, Self-taught Teaching)
  • 3rd Year Thermodynamics & Heat Transfer (10 Credits, Starting Spring Semester 2019, Self-taught Teaching)
Journal Publications
  1. Stearns-Reider KM, D’Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan R, Ambrosio F. “Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.” Aging Cell 16(3): 518-528, 06/2017. (Aging Cell's Best Paper 2017)
  2. Tsamis A, Phillippi JA, Koch RG, Krawiec JT, D’Amore A, Watkins SC, Wagner WR, Vorp DA, Gleason TG. “Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathy.” The Journal of Thoracic and Cardiovascular Surgery 151: 1718-1728.e5, 06/2016.
  3. Pasta S, Phillippi JA, Tsamis A, D’Amore A, Raffa GM, Pilato M, Scardulla C, Watkins SC, Wagner WR, Gleason TG, Vorp DA. “Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters.” Medical Engineering & Physics 38(2): 121-130, 02/2016.
  4. Hemmasizadeh A, Tsamis A, Cheheltani R, Assari S, D’Amore A, Autieri M, Kiani MF, Pleshko N, Wagner WR, Watkins SC, Vorp DA, Darvish K. “Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta.” Journal of the Mechanical Behavior of Biomedical Materials 47: 12-20, 07/2015.
  5. Tsamis A, Pal S, Phillippi JA, Gleason TG, Maiti S, Vorp DA. “Effect of aneurysm on biomechanical properties of "radially-oriented" collagen fibers in human ascending thoracic aortic media.” Journal of Biomechanics 47(16): 3820-3824, 12/2014.
  6. Tsamis A, Pocivavsek L, Vorp DA. “Elasticity and geometry: a computational model of the Heineke-Mikulicz strictureplasty.” Biomechanics and Modeling in Mechanobiology 13(6): 1185-1198, 11/2014.
  7. Koch RG, Tsamis A [co-first author], D’Amore A, Wagner WR, Watkins SC, Gleason TG, Vorp DA. “A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy.” Journal of Biomechanics 47(5): 935-943, 03/2014.
  8. Pal S, Tsamis A, Pasta S, D’Amore A, Gleason TG, Vorp DA, Maiti S. “A mechanistic model on the role of "radially-running" collagen fibers on dissection properties of human ascending thoracic aorta.” Journal of Biomechanics 47(5): 981-988, 03/2014.
  9. Tsamis A, Phillippi JA, Koch RG, Pasta S, D'Amore A, Watkins SC, Wagner WR, Gleason TG, Vorp DA. “Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm media.” Journal of Biomechanics 46(16): 2787-2794, 11/2013.
  10. Tsamis A, Krawiec JT, Vorp DA. “Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review.” Journal of the Royal Society Interface 10(83): 20121004, 03/2013.
  11. Tsamis A, Cheng A, Nguyen TC, Langer F, Miller DC, Kuhl E. “Kinematics of cardiac growth: In vivo characterization of growth tensors and strains.” Journal of the Mechanical Behavior of Biomedical Materials 8(1): 165-177, 04/2012.
  12. Tsamis A, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. “Active contraction of cardiac muscle: In vivo characterization of mechanical activation sequences in the beating heart.” Journal of the Mechanical Behavior of Biomedical Materials 4(7): 1167-1176, 10/2011.
  13. Tsamis A, Rachev A, Stergiopulos N. “A Constituent-based model of age-related changes in conduit arteries.” American Journal of Physiology - Heart and Circulatory Physiology 301(4): H1286-H1301, 10/2011.
  14. Tsamis A, Stergiopulos N, Rachev A. “A structure-based model of arterial remodeling in response to sustained hypertension.” Journal of Biomechanical Engineering 131(10): 101004, 10/2009.
  15. Tsamis A, Stergiopulos N. “Arterial remodeling in response to increased blood flow using a constituent-based model.” Journal of Biomechanics 42(4): 531-536, 03/2009.
  16. Roy S, Tsamis A [co-first author], Prod’hom G, Stergiopulos N. “On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall.” Journal of Biomechanics 41(4): 737-743, 07/2008.
  17. Papadopoulos E, Tsamis A, Vlachos K. “Development of a real-time visual and force environment for a haptic medical training simulator.” Artificial Life and Robotics 12(1): 307-316, 03/2008.
  18. Tsamis A, Stergiopulos N. “Arterial remodeling in response to hypertension using a constituent-based model.” American Journal of Physiology - Heart and Circulatory Physiology 293(5): H3130-H3139, 11/2007.
  19. Papadopoulos E, Tsamis A, Vlachos K. “A real-time graphic environment for a urological operation training simulator.” IEEE Transactions on Robotics and Automation 2(WE‐12): 1295-1300, 04/2004. (Award for Publication of Novel Scientific Project)

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