Dr Kazi Asif Adnan

Clinical Research Fellow & MD Student

Specialty Registrar in Cardiology

University of Leicester: Department of Cardiovascular Science

Contact Details

  • Tel: 01162502502
  • Email: kaa31@le.ac.uk
  • Office: Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP

Education and training

  • 2001: MBBS (Dhaka Medical College, Dhaka University, Bangladesh)
  • 2007: MRCP (UK), Royal College of Physicians
  • 2010- current: Holder of National Training Number (NTN) in Cardiology, East Midlands Deanery (fellow in intervention cardiology)

Memberships and affiliations

  • General Medical Council (GMC)
  • British Cardiovascular Society (BCS), British Junior Cardiologists’ Association (BJCA) & British Cardiovascular Intervention Society (BCIS)
  • Resuscitation Council UK (RCUK) accredited Advanced Life Support (ALS) Instructor

MD Project

Title: The novel application of coronary optical coherence tomography (OCT) and computational fluid dynamic (CFD) modelling as an adjunct to post-mortem computed tomographic angiography (PMCTA) to aid minimally invasive autopsy

Overview:

In this research, we set out to investigate the role of coronary optical coherence tomography (OCT) and potential application of computational fluid dynamic (CFD) modelling as an adjunct to an established post mortem computed tomographic angiography technique. The results will be compared against the findings of a pathologist performing conventional autopsy.

OCT is an intra-coronary catheter based imaging technology with a resolution of 10-20 microns and has very high level and accurate correlation to histology. This provides the most robust anatomical information about coronary luminal stenosis and histological nature of the plaque. On the other hand, CFD modelling is a well-established simulation method in many fields of engineering. In recent years, researchers have started to apply this for modelling blood flow.  We hypothesize that application of CFD modelling using the rich anatomical data from CT/OCT co-registration will provide an objective assessment of anatomical and functional significance of a stenosis and thus prove to be equivalent, if not superior, to conventional autopsy techniques.

Figure: OCT of a repressurized cadaveric coronary artery showing a ‘mixed’ plaque (calcified and fibro fatty component) causing luminal stenosis which can be accurately quantified at sub-millimetre level
 
These techniques, if established, will help in reducing the number of ‘open’ autopsies significantly while also will provide fresh insight into the disease processes leading to cardiovascular deaths with implications for patients’ risk stratification and clinical care.

Publications

Peer reviewed:

Coats, T. J., Morgan, B., Robinson, C., Biggs, M., Adnan, A., & Rutty, G. (2015). End-tidal CO2 detection during cadaveric ventilation. Emergency Medicine Journal, 1–2. http://doi.org/10.1136/emermed-2015-204950

Joseph, S., Adnan, A., Subhash, H. M., Leahy, M., & Adlam, D. (2015). Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systems. Biomedical Optics Express, 6(3), 668. http://doi.org/10.1364/BOE.6.000668

Adlam, D., Morgan, B., Robinson, C., Biggs, M., Adnan, A., Rutty, G. N., … Lambrechtsen, J. (2014). Letter to the Editor- Optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – Technical note. Journal of Forensic Radiology and Imaging, 2(3), 158. http://doi.org/10.1016/j.jofri.2014.03.010

Book Chapter:
Adnan, A., & Adlam, D. (2014). Coronary Artery Disease and Acute Coronary Syndrome. In T. England & A. Nasim (Eds.),  ABC of Arterial and Venous Disease (3rd ed., pp. 17–24). WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.

Oral Presentation:

‘Investigating the role of Coronary Optical Coherence Tomography (OCT) in minimally invasive Autopsy’ – ISFRI/IAFR Congress 2015, Leicester , UK

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Address

East Midlands Forensic Pathology Unit
Level 3, Robert Kilpatrick Clinical Sciences Building
Leicester Royal Infirmary
Leicester, LE2 7LX
United Kingdom

Tel: +44 (0)116 252 3221
Fax: +44 (0)116 252 3274

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