Dr Kogularamanan (Rama) Suntharalingam

Associate Professor in Inorganic Chemistry

Email: k.suntharalingam@le.ac.uk

Twitter: @_Suntharalingam

Personal details:

Recent recognitions:

RSC Dalton Young Researchers Award, Rising Star in Coordination Chemistry Award, RSC 175 Faces of Chemistry, and Fellow of the Higher Education Academy.

Research Interests:

For current postgraduate opportunities, please click here.

For current postdoctoral opportunities, please click here.

Cancer stem cells (CSCs) are a distinct population of tumour cells that have the ability to self-renew, differentiate, and form metastatic tumours. CSCs effectively evade conventional chemotherapy and radiotherapy as these treatments specifically target fast growing cancer cells, and CSCs, due to their stem cell-like properties, divide more slowly. After surviving treatment, CSCs are able to regenerate the original tumour and/or produce invasive cancer cells that are able to colonise distant organs. For these reasons, CSCs are widely thought to be responsible for cancer relapse. Therefore, to provide a durable response and prevent tumour recurrence, chemotherapeutics must have the ability to remove the entire population of cancer cells, including CSCs. Therapeutic strategies capable of selectively killing CSCs and disrupting the microenvironments (niches) supporting these cells are the focus of several research programmes. Potential CSC therapeutic targets such as cell surface markers and various deregulated signalling pathways have been identified, but there is still no clinically approved drug that specifically kills CSCs. Many academia- and pharmaceutical-led studies aimed at developing chemical or biological anti-CSC agents are ongoing. Our group aims to harness the diversity and versatility offered by metals to develop inorganic compounds capable of potently and selectively killing CSCs (over bulk cancer cells and normal non-proliferating cells).

More generally, our group aims to use the structural, optical, redox, magnetic, and catalytic diversity offered by metal-containing small molecules to design and develop new generations of metallopharmaceuticals for the treatment of cancer as well as other diseases. The group also focuses on engineering new nano-material systems to deliver therapeutics to their site(s) of action.

Selected Publications:

“A Triangular Platinum(II) Multinuclear Complex with Cytotoxicity Towards Breast Cancer Stem Cells” Eskandari A,  Kundu A,  Ghosh S, Suntharalingam K*, Angewandte Chemie International Edition, 2019 DOI: 10.1002/anie.201905389.

“A reactive oxygen species-generating, cancer stem cell-potent manganese(II) complex and its encapsulation into polymeric nanoparticles” Eskandari A, Suntharalingam K*, Chemical Science, 2019, DOI: 10.1039/C9SC01275C.

“Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes” Zheng P, Eskandari A, Lu C, Laws K, Aldous L, Suntharalingam K*, Dalton Transactions, 2019, 48, 5892-5896.

“A Copper(II)-Phenanthroline Metallopeptide that Targets and Disrupts Mitochondrial Function in Breast Cancer Stem Cells” Laws K, Bineva-Todd G, Eskandari A, Lu C, O'Reilly N, Suntharalingam K*, Angewandte Chemie International Edition, 2018 57, 287-291.

“Highly charged, cytotoxic, cyclometalated iridium(III) complexes as cancer stem cell mitochondriotropics” Laws K, Eskandari A, Lu C, Suntharalingam K*, Chemistry - A European Journal, 2018, 24(57), 15205-15210.

“Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(II)-polypyridyl complexes” Eskandari A, Kundu A, Lu C, Ghosh S, Suntharalingam K*, Dalton Transactions, 2018, 47, 5755-5763.

“Diflunisal-adjoined cobalt(III)-polypyridyl complexes as anti-cancer stem cell agents” Abe DO, Eskandari A, Suntharalingam K*, Dalton Transactions, 2018, 47(39), 13761-13765.

“The next generation of anticancer metallopharmaceuticals: cancer stem cell‐active inorganics” Laws K, Suntharalingam K*, ChemBioChem, 2018, 19(21), 2246-2253.

“A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster” Lu C, Laws K, Eskandari A, Suntharalingam K*, Dalton Transactions, 2017, 46, 12785-12789.

“Cancer Stem Cell and Bulk Cancer Cell Active Copper(II) Complexes with Vanillin Schiff Base Derivatives and Naproxen” Lu C, Eskandari A, Suntharalingam K*, Chemistry - A European Journal, 2017, 23(47), 11366-11374.

“Breast Cancer Stem Cell Potent Copper(II)–Non-Steroidal Anti-Inflammatory Drug Complexes” Boodram NJ, Mcgregor IJ, Bruno PM, Hemann MT, Suntharalingam K*, Angewandte Chemie International Edition, 2016, 55, 2845-2850.

“Advances in cobalt complexes as anticancer agents” Munteanu CR, Suntharalingam K*, Daltons Transactions 2015, 44 (31), 13796-13808.

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Contact Details

Department of Chemistry
University of Leicester
Leicester, LE1 7RH, UK

Email: chemistry@le.ac.uk

Tel: [+44] (0)116 252 2100

Fax: [+44] (0)116 252 3789

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