Research selected as ChemBioChem VIP paper

Recently published research by Dr. Richard Hopkinson and co-workers has been selected as a VIP article in ChemBioChem. The article describes biochemical studies on an oxygen-dependent formaldehyde-producing demethylase, KDM4A, which contains a key lysine residue in its active site. Combined MS and NMR analyses suggest this lysine residue (lysine-241) is essential for ensuring efficient demethylation activity, but does not affect KDM4A’s reaction with oxygen. The work implies that small molecule binders to lysine-241 in KDM4A may induce catalytic inactivation.

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