Jodie K Sandhu

Name

Jodie Sandhu

Email

jh89@le.ac.uk

Qualifications

MPhil Biochemistry/Toxicology
B.Sc (Hons) Applied Biology

Research Area

Mass Spectrometry (Waters Synapt G2S, Thermo QExactive, Waters Xevo TQ)
HPLC, ELISA Proteomics, Lipidomics and Metabonomics

Research Aim

Investigating Vitamin D as a prognostic marker in acute myocardial infarction

Overview

Investigating Vitamin D as a prognostic marker in acute myocardial infarction

I run the Thermo Q Exactive within the cardiovascular department and the wider college within the University Of Leicester as a tool for identifying novel biomarkers in cardiovascular disease. I carry out post processing analysis of mass spec data and data sets, using Scaffold, Protein Centre, MaxQuant, Mascot, PD 2.0, Progenesis and Protein lynx global server.

Committee

Athena Swan

Memberships

British Mass Spectrometry Society
British Society for Cardiovascular Research

Publications

Ng LL, Bhandari SS, Sandhu JK, Quinn PA, Squire IB, Davies JE, Struck J, Bergmann A, Dones DJ. Growth hormone for risk stratification and effects of therapy in acute myocardial infarction. Biomarkers 2015;20:371-5

Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Bergmann A, Maisel A, Jones DJ. Pro-substance p for evaluation of risk in acute myocardial infarction. J Am Coll Cardiol 2014;64:1698-707

Sandhu JK, Auluck J, Ng LL, Jones DJ. Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular researchBiomed Chromatogr 2014;28:913-7

Ng LL*, Sandhu JK*, Narayan H, Quinn PA, Squire IB, Davies JE, Bergmann A, Maisel A, Jones DJ. Proenkephalin and prognosis after acute myocardial infarction. J Am Coll Cardiol 2014;28:280-9

Ng LL, Sandhu JK, Squire IB, Davies JE, Jones DJ. Vitamin D and prognosis in acute myocardial infarction. Int J Cardiol 2013;168:2341-6

Armstrong CA, Jones GD, Anderson R, Iyer P, Narayanan D, Sandhu JK, Singh R, Talbot CJ and Tufarelli C. DNMTs are required for delayed genome instability caused by radiation. Epigenetics 2012;7:892-902

Mistry V, Teichert F, Sandhu JK, Singh R, Evans MD, Farmer PB, Cooke MS. Non-invasive assessment of oxidatively damaged DNA: liquid chromatography-tandem mass spectrometry analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Methods Mol Biol 2011;682:79-89

Garratt LW, Mistry V, Singh R, Sandhu JK, Sheil B, Cooke MS, Sly PD and on behalf of ARESTCF. Interpretation of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine is adversely affected by methodological inaccuracies when using a commercial ELISA. Free Radic Biol Med 2010;48:1460-4

European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS, Rossner Jr. P, Sram R, Henriksen T, Poulsen HE, Weimann A, Barbieri A, Sabatini L, Violante F, Kino S, Ochi T, Sakai K, Takeuchi M, Kasai H, Meerman JHN, Gackowski D, Rozalski R, Siomek A, Halliwell B, Jenner AM, Wang H, Cerda C, Saez G, Haghdoost S, Svoboda P, Hu C-W, Chao M-R, Peng K-Y, Shih W-C, Wu K-Y, Orhan H, Istanbullu NS, Mistry V, Farmer PB, Sandhu JK, Singh R, Cortez C, Su Y, Santella RM, Lambert P, Smith R. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress. FASEB J 2010;24:1249-60

Singh R, Sandhu JK, Kaur B, Juren T, Steward WP, Segerbäck D, Farmer PB. Evaluation of the DNA damaging potential of cannabis cigarette smoke by the determination of acetaldehyde derived N2-ethyl-2′-deoxyguanosine adducts. Chem Res Toxicol 2009;22:1181-8

Sandhu JK, Kaur B, Armstrong C, Talbot CJ, Steward WP, Farmer PB, Singh R. Determination of 5-methyl-2′-deoxycytidine in genomic DNA using high performance liquid chromatography-ultraviolet detection. J Chromatogr B 2009;877:1957-61

* equal contribution

 

 


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