Current projects

  • Biomarkers of Diastolic Heart Failure

Heart failure can be caused by failure of the heart as a pump (systolic heart failure) and many advances have been made in the detection and treatment of this condition. However, at least half of heart failure patients have diastolic heart failure (which is caused by decreased distensibility of the heart), for which there are drugs that reduce hospitalisation but not mortality. The conditions which could lead to diastolic heart failure include high blood pressure, diabetes and valve disease (including aortic stenosis), all very prevalent within an ageing population. A major problem is in the diagnosis of diastolic heart failure and useful plasma biomarkers will facilitate the diagnosis. Improving the diagnosis will enable pharmaceutical companies to develop new therapies which may affect patient outcomes. In addition, novel biomarkers will also indicate the disease processes that could be targeted by research for new therapies.

  • EU FP7 Biostat - Initiative to detect patients who respond poorly to heart failure therapies

The EU FP7 funded BioStat - a systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure - programme is combining genomic and proteomic strategies to discover novel markers of response to therapy in over 4000 heart failure patients samples.

  • MRC DTG - The role of plasma proteomics toimprove the accuracy of predictions of R2I2 in ICD patients.

We aim to use High resolution proteomics to examine the plasma proteome of patients who have received implantable cardioverter defibrillators (ICDs) and undergone a determination of a novel risk stratification index (R2I2), to investigate whether plasma proteomics could improve the accuracy of predictions of R2I2, and hence improve the specificity of the method.  This will translate to improved targeting of ICD implantations in patients.

  • Novel methods for sample preparation for plasma proteomics.

 

Links

Research Facility

Publications

John and Lucille van Geest Biomarker Facility

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