Brain Magnetic Resonance Imaging (MRI)

Brain MRI research conducted by our team focuses on using MRI techniques to image the arteries supplying the brain and improve the detection and quantification of brain injuries. We work closely with Neuroradiologists, Clinicians, and Scientists in developing novel imaging techniques and to support the interpretation and analysis of MRI scans for clinical research studies.

Detection of subtle changes to the brain using MRI

As we get older, there are often subtle changes in the brain, due to small pieces of debris (emboli) becoming lodged in the cerebral arteries, resulting in small lesions. Often, these lesions can be difficult for Radiologists to spot, particularly if there are pre-existing small infarcts where it can be a laborious task to distinguish the old from the new. As part of MRI research investigating brain injury following cardiac surgery, we have been refining methods for digital registration and subtraction of MRI images to provide a 'difference map' making it easier to spot subtle changes in the brains of patients between scans. This research, conducted by Dr Emma Chung in partnership with Mark Horsfield (Xinapse) is soon to be published in the American Journal of Radiology (in press).

MRI studies of cerebral Autoregulation

Our team previously developed a novel method for mapping dynamic cerebral blood flow autoregulation to assess autoregulatory efficiency throughout the brain using MRI (published in PLoS ONE).

Models of cerebrovascular anatomy

Time-of-flight MR angiography techniques can be used to create a 3D reconstruction of the cerebral arteries for inclusion in computational models of cerebral blood flow and the development of realistic vascular phantoms. Our vascular phantoms are Ultrasound and MRI compatible and can be used for fluid dynamics experiments and testing novel methods of measuring of blood flow and brain tissue motion.   

 

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