Cerebral Haemodynamics in Ageing and Stroke Medicine

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CHiASM MembersGroup Members

Karen Appiah, Hardeep S. Aujla, Caroline Banahan, Juliana Caldas Ribeiro Bittencourt, Emma Chung, Max Chacon, Alice C. Durham, Kaza Evangelia, Claire L. Gibson, Victoria Haunton, Man Lam, Osian Llwyd, Jatinder Minhas, Amit Mistri, Ronney Panerai, Kumar Ramnarine, Thompson G. Robinson.

Summary

Researchers in the CHiASM group combine clinical research with experiments in healthy volunteers, in vitro studies, and mathematical models to develop our understanding of cerebral haemodynamics in health, ageing and disease. In addition to studies of dementia and Parkinson’s disease, a major research focus of our group is Stroke. Stroke is the second leading cause of death in the world resulting in 6.7 million deaths each year. The burden of disease (disability, illness and premature deaths) caused by stroke is set to double worldwide by 2030. The CHIASM group’s research interests include the development of novel ultrasound methods for the detection of brain injury, development of novel biometrics for assessing carotid plaque vulnerability (a major cause of stroke), ultrasound embolus detection, and detection of impaired cerebral autoregulation. The aim of our research is to develop novel diagnostic imaging, physiological measurements, and interventions for patient benefit.

CHiASM Research

Cerebral Haemodynamics and Autoregulation

The group use an array of laboratory techniques and mathematical models to research and develop the field of cerebral haemodynamics. Using acute neuroimaging techniques (mainly Ultrasound and MRI) the groups’ main research interest is the cerebral autoregulatory (CA) system.  A mechanism that continuously adjusts the diameters of arteries in response to the metabolic demands of brain tissue or fluctuations in blood pressure.  This ensures an adequate supply of oxygenated blood is maintained to the brain and it protects brain tissue from receiving too much or too little blood flow.  In the absence of CA there would be a tendency for individuals to lose consciousness when changing posture, or for capillaries to rupture during exercise.

Stroke Medicine

Stroke is the second single most common cause of death in the world causing 6.7 million deaths each year. The burden of disease (disability, illness and premature deaths) caused by stroke is set to double worldwide by 2030. The CHIASM group’s research interests include the study of cerebral haemodynamics, and in particular the impact of changes in cerebral haemodynamic control mechanisms on the management of blood pressure, blood pressure variability and other physiological perturbations following acute stroke. We also collaborate with basic researchers using experimental models of stroke.

Further information on our latest work and projects can be found in the links below.

Current research includes:

 

Cardiovascular Research Centre imageBRU and Translational Medicine Facility imageDavid Wilson Biobank imagevan Geest Biomarker Facility image

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