Platelet Biology and Haemostatic Mechanisms

Normal haemostasis depends on the interaction of platelets, coagulation factors and other blood cells. This area, led by Professor Alison Goodall, is principally directed towards an understanding of the factors that affect inter-individual variation in haemostatic mechanisms, and overlaps with the programme  in Cardiovascular Genetics and Genomics specific areas of interest include the understanding of the regulation of the platelet haemostatic response, in which platelets, and platelet-derived microparticles support the generation of thrombin. Platelet-derived microparticles also convey a range of molecules to other cells and this forms part of a research programme into the interaction of platelets, and platelet-derived factors, such as oxylinins and microRNA, “talk” to other blood cells (especially monocytes) and regulate gene expression.

Platelets bound to leucocytes within a thrombusThe platelet programme also includes clinical studies, for example investigating the relationship between platelet responsiveness and the functional and clinical efficacy of anti-platelet drugs. We have recently taken part in a European Union FP7 Integrated Project; PRESTIGE (2010-2014) to investigate the causes and potential prevention of stent thrombosis in coronary artery disease patients and we currently have a collaboration with Astra Zeneca to investigate the effect of the P2Y12 antagonist ticagrelor in preventing cancer metastases
Professor Goodall is also a Founding Director of a University of Leicester Spin-out company, Haemostatix Ltd. that has developed first-in-class clotting agents for the treatment of bleeding and has recently been acquired by Ergomed plc

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