Dr Tom Webb

Dr Tom WebbAssociate Professor in Cardiovascular Genomics

Email: tw126@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP.

Personal details

BSc (Genetics) 2001, University of Sheffield
PhD 2005, MRC Human Genetics Unit, Edinburgh

Research

My research group aims to identify and understand the genetic causes of common cardiovascular diseases, such as coronary artery disease. We combine bioinformatics, state-of-the art molecular techniques and cellular and in vivo models to investigate the underlying mechanisms and pathways to provide new knowledge of disease pathogenesis.


Recent publications

  1. Winkler MJ, Müller P, Sharifi AM, Wobst J, et al. Functional investigation of the coronary artery disease gene SVEP1. Basic Res Cardiol. 2020;115(6):67.
  2. Karss KJ, Baranowska AA, Armisen JA, Webb TR, et al. Spontaneous Coronary Artery Dissection: Insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020;13(6):e003030.
  3. Verstraeten A, Perik M, Baranowska A, Meester J, et al. Enrichment of rare variants in Loeys-Dietz syndrome genes in spontaneous coronary artery dissection but not in sever fibromuscular dysplasia. Circulation. 2020;142:1021–1024.
  4. Debiec R, Hamby SE, Jones PD, Coolman S, Asiani M, Kharodia S, Skinner GJ, Samani NJ, Webb TR, Bolger A. Novel loss of function mutation in NOTCH1 in a family with bicuspid aortic valve, ventricular septal defect, thoracic aortic aneurysm, and aortic valve stenosis. Molecular Genetics & Genomic Medicine. doi.org/10.1002/mgg3.1437. 2020.
  5. Nelson CP, Sama IE, Codd V, Webb TR, Ye S, Lang CC, Voors AA, Ng LL, Samani NJ. Genetic Associations with Plasma ACE2 Concentration: Potential Relevance to COVID-19 Risk. Circulation. 2020;142(11):1117-1119.
  6. Georges A, Albuisson J, Berrandou T, Dupré D, et al. Rare Loss-of-function Mutations of PTGIR are enriched in Fibromuscular Dysplasia. Cardiovascular Research. 2021;117(4):1154-1165.
  7. Yang X, Yang W, McVey DG, Zhao G, Hu J, Poston RN, Ren M, Willeit K, Coassin S, Willeit J, Webb TR, Samani NJ, Mayr M, Kiechl S, Ye S. FURIN expression in vascular endothelial cells is modulated by a coronary artery disease-associated genetic variant and influences monocyte trans-endothelial migration. J Am Heart Assoc. 2020; 9(4), e0143332020.
  8. Jones PD, Webb TR. From GWAS to new biology and treatments. Aging (Albany NY). 2019; 11(6): 1611. 2019
  9. Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J, Ye S. Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis. Atherosclerosis. 2020; 296:11-17.
  10. Prestel M, Prell-Schicker C, Webb TR, Malik R, Lindner B, Ziesch N, Rex-Haffner M, Röh S, Viturawong T, Lehm M, Mokry M, den Ruijter H, Haitjema S, Asare Y, Söllner F, Najafabadi MG, Aherrahrou R, Civelek M, Samani NJ, Mann M, Haffner C, Dichgans M. The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1. Stroke. 2019; 50(10):2651-2660.
  11. Aravani D, Morris GE, Jones PD, Tattersall HK, Karamanavi E, Kaiser MA, Kostogrys RB, Ghaderi Najafabadi M, Andrews SL, Nath M, Ye S, Stringer EJ, Samani NJ, Webb TR. HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. Circulation. 2019; 140(6):500-513.
  12. Nelson CP, Lai FY, Nath M, Ye S, Webb TR, Schunkert H, Samani NJ. Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors. Circ Genom Precis Med. 2019; 12(1):e002196.
  13. Hu YW, Guo FX, Xu YJ, Li P, Lu ZF, McVey DG, Zheng L, Wang Q, Ye JH, Kang CM, Wu SG, Zhao JJ, Ma X, Yang Z, Fang FC, Qiu YR, Xu BM, Xiao L, Wu Q, Wu LM, Ding L, Webb TR, Samani NJ, Ye S. Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. J Clin Invest. 2019; 129(3):1115-1128.
  14. Inouye M, Abraham G, Nelson CP, Wood AM, et al. Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention. J Am Coll Cardiol. 2018; 72(16):1883-1893.
  15. Zhao G, Yang W, Wu J, Chen B, Yang X, Chen J, McVey DG, Andreadi C, Gong P, Webb TR, Samani NJ, Ye S. Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior. Arterioscler Thromb Vasc Biol. 2018; 38(8):1837-1844.
  16. Jones PD, Kaiser MA, Ghaderi Najafabadi MG, Koplex S, Zhao Y, Douglas G, Kyriakou T, Andrews S, Rajmohan R, Watkins H, Channon KM, Ye S, Yang X, Björkegren JLM, Samani NJ, Webb TR. JCAD, a gene at the 10p11 coronary artery disease locus, regulates Hippo signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2018; 38:1711-1722.
  17. Lempiäinen H, Brænne I, Michoel T, Tragante V, et al. Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets Sci Rep. 8(1):3434. 2018.
  18. Zhao G, Yang W, Wu J, Chen B, Yang X, McVey DG, Webb TR, Samani NJ, Ye S. Influence of a coronary-artery-disease-associated genetic variant on FURIN expression and effect of Furin on macrophage behaviour. Arterioscler Thromb Vasc Biol. 2017; 38:1821-1836.
  19. Nelson CP, Goel A, Butterworth AS, Kanini S, Webb TR, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 2017; 49(9):1385-1391.
  20. Morris GE, Braund PS, Moore JS, Samani NJ, Codd V, Webb TR. Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes. Arterioscler Thromb Vasc Biol. 2017; 37:1050-1057.
  21. Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol. 2017; 69(7):823-836.
  22. Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, et al. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circ Res. 2017; 120(2):341-353.
  23. Jones PD, Kaiser MA, Ghaderi Najafabadi M, McVey DG, Beveridge AJ, Schofield CL, Samani NJ, Webb TR. The Coronary Artery Disease Associated Coding Variant in Zinc finger C3HC-type containing 1 (ZC3HC1) Affects Cell Cycle Regulation. J Biol Chem. 2016; 291(31):16318-27.
  24. Stitziel NO, Stirrups KE, Masca NG, Erdmann J, et al. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med. 2016; 374(12):1134-44.
  25. Nikpay M, Goel A, Won H-H, Hall LM, Willenborg C, et al. A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015; 372:1608-18.
  26. Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët D-A, Hao K, Topol EJ, Schadt EE, Yang X, Samani NJ, Björkegren JLM, Erdmann JE, Schunkert H, Lusis AJ. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler Thromb Vasc Biol. 2015; 35(10):2207-17

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