Dr Tom Webb

Dr Tom WebbAssociate Professor in Cardiovascular Genomics

Email: tw126@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP.

Personal details

BSc (Genetics) 2001, University of Sheffield
PhD 2005, MRC Human Genetics Unit, Edinburgh

Recent publications

M Inouye, G Abraham, CP Nelson, AM Wood, MJ Sweeting, F Dudbridge, et al. Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention. J Am Coll Cardiol. 2018;72(16), 1883-1893

Jones PD, Kaiser MA, Ghaderi Najafabadi MG, Koplex S, Zhao Y, Douglas G, Kyriakou T, Andrews S, Rajmohan R, Watkins H, Channon KM, Ye S, Yang X, Björkegren JLM, Samani NJ, Webb TR. JCAD, a gene at the 10p11 coronary artery disease locus, regulates Hippo signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2018;38:1711-1722.

Zhao G, Yang W, Wu J, Chen B, Yang X, McVey DG, Webb TR, Samani NJ, Ye S. Influence of a coronary-artery-disease-associated genetic variant on FURIN expression and effect of Furin on macrophage behaviour. Arterioscler Thromb Vasc Biol. 2017; 38:1821-1836.

Lempiäinen H, Brænne I, Michoel T, Tragante V, Vilne B, Webb TR, et al. Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets. Sci Rep. 2018;8(1):3434. *Contributed equally.

Nelson CP, Goel A, Butterworth AS, Kanini S, Webb TR, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 2017;49(9):1385-1391.

Morris GE, Braund PS, Moore JS, Samani NJ, Codd V, Webb TR. Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes. Arterioscler Thromb Vasc Biol. 2017;37:1050-1057.

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG,…(127 authors)…Kathiresan S. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol. 2017;69(7):823-836.

Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, et al. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circ Res. 2017;120(2):341-353.

Jones PD, Kaiser MA, Ghaderi Najafabadi M, McVey DG, Beveridge AJ, Schofield CL, Samani NJ, Webb TR. The Coronary Artery Disease Associated Coding Variant in Zinc finger C3HC-type containing 1 (ZC3HC1) Affects Cell Cycle Regulation. J Biol Chem. 2016;291(31):16318-27.

Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, et al. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med. 2016;374(12):1134-44.

The CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015;372:1608-18.

 

Research

My research group aims to identify and understand the genetic causes of common cardiovascular diseases, such as coronary artery disease. We combine bioinformatics, state-of-the art molecular techniques and cellular and in vivo models to investigate the underlying mechanisms and pathways to provide new knowledge of disease pathogenesis.

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