Professor Jonathan P Thompson

Dr Jonathan Thompson

Honorary Professor and Consultant in Anaesthesia and Critical Care, University Hospitals of Leicester NHS Trust

Department of Cardiovascular Sciences
Clinical Division of Anaesthesia Critical Care & Pain Management
University Hospitals of Leicester NHS Trust
Robert Kilpatrick Clinical Sciences Building
Leicester Royal Infirmary, Leicester LE2 7LX

Tel: +44 (0)116 252 3132
Email: jt23@le.ac.uk

Personal details

  • B.Sc., (First class Honours) in Medical Sciences, University of Leicester, 1986
  • M.B., Ch.B. University of Leicester, 1988
  • F.R.C.A 1994
  • M.D. University of Leicester, 2002
  • F.F.I.C.M. 2011

General enquiries

Kizzy Laird-Connolly klc35@le.ac.uk +44 (0)116 252 3108

External positions

  • Editor, British Journal of Anaesthesia since April 2008, Assistant Editor 2004-2006
  • Diagnostic Development Unit Management team since 2013
  • East Midlands CRN Lead for Critical Care research since 2014; South Trent CLRN Lead 2007-14
  • Clinical Lead for Organ Donation, UHL NHS Trust since 2014
  • East Midlands Regional Clinical Lead for Organ Donation since 2015
  • Member of UHL R&D Executive Board since 2014
  • Macintosh Professor of Anaesthesia of the Royal College of Anaesthetists 2010-11
  • Examiner, Primary FRCA Examination, Royal College of Anaesthetists since 2005; Lead for Pharmacology, MCQ Core Group
  • Founding editorial Board Member Continuing Education in Anaesthesia Critical Care & Pain 2001-2010
  • Member of Editorial Board, British Journal of Anaesthesia since 2005, and of Perioperative Medicine since 2012
  • Member of Pharmacology Subcommittee, European Society of Anaesthesiologists 2006-12
  • Chairman, Vascular Anaesthesia Society of Great Britain and Ireland 2007-2010 (Hon. Secretary 2003-7, Member of Research Committee 2003- date; Grants Officer 2002-5)
  • Expert Advisor, British National Formulary since 2007
  • Member of Council, Anaesthetic Research Society 2003-8. Anaesthetic Research Society Training Officer 2006-8

Website

Publications

Papers from 2016 - 2006

Batchelder AJ, Scott SWM, Kirkbride D, Naylor AR, Thompson JP. Late survival in non-operated patients with infra-renal abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery 2016 (in press)

Al-Hashimi M, Thompson JP, Lambert DG. Evidence for Nociceptin/Orphanin FQ (NOP) but not µ (MOP), δ (DOP) or κ (KOP) opioid receptor mRNA in whole human blood. British Journal of Anaesthesia 2016; 116 (3): 423–9

Stover CM, Lambert DG, Thompson JP. Properdin levels in human sepsis. Frontiers in Immunology 2015; 6,24: doi:10.3389/fimmu.2015.00024

Thomas RC, Bath MF, Stover CM, Lambert DG, Thompson JP. Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system. Peptides 2014; 61: 56-60.

Beishon L, McDonald J, Thompson JP, Lambert DG. Long-term activation of polymorph cannabinoid receptors does not affect receptor gene transcription. British Journal of Anaesthesia 2014; 113 (1):197-8.

Scott SWM, Bowrey S, Choke E, Bown MJ, Thompson JP. Factors influencing short and long-term mortality after lower limb amputation. Anaesthesia 2014; 69(3): 249–58

Al-Hashimi M, Scott SWM, Griffin Teal N, Thompson JP. Influence of ethnicity on the perception and treatment of early post-operative pain. Br J Pain 2015; 9(3):167-72. DOI: 10.1177/2049463714559254

Wood MJ, Lin ES, Thompson JP. Flow dynamics during high frequency jet ventilation in a model of bronchopleural fistula. British Journal of Anaesthesia 2014; 112 (2): 355-366.

Kranke P, Thompson J, Dalby P, Novikova E, Johnson B, Russ S, Noble R, Brigandi R. Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. Br J Anaesth 2014 doi:10.1093/bja/aeu376

Thompson JP, Serrano-Gomez A, Ladak N, Bowrey S, McDonald J, Lambert DG. The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass. PLOS One 2013 Oct 4;8(10):e76682.

Al-Hashimi, M. A., Scott, S. W. M., Thompson, J. P., & Lambert, D. G. (2013). Opioids and immune modulation:more questions than answers. British Journal of Anaesthesia, 111(1), 80-88.

Grange, R. D., Thompson, J. P., & Lambert, D. G. (n.d.). Radioimmunoassay, Enzyme and non-Enzyme Based Immunoassays. British Journal of Anaesthesia. 2014 Feb;112(2):213-6.

Murphy, P. G., Bodenham, A. R., & Thompson, J. P. (2012). Diagnosis of death and organ donation in 2012. BRITISH JOURNAL OF ANAESTHESIA, 108, I1-I2.

Al-Hashimi, M., & Thompson, J. P. (2012). Drugs acting on the heart: Anti-arrhythmics. Anaesthesia and Intensive Care Medicine, 13(8), 374-377.

Al-Hashimi, M., & Thompson, J. P. (2012). Drugs acting on the heart: Antihypertensive drugs. Anaesthesia and Intensive Care Medicine, 13(8), 369-373.

Scott, S., & Thompson, J. P. (2012). Drugs acting on the heart: Heart failure and coronary insufficiency. Anaesthesia and Intensive Care Medicine, 13(8), 378-383.

Scott, S., & Thompson, J. (2011). Adverse drug reactions. Anaesthesia and Intensive Care Medicine, 12(7), 319-323.

Ladak, N., Beishon, L., Thompson, J. P., & Lambert, D. G. (2011). Cannabinoids and sepsis. Trends in Anaesthesia and Critical Care, 1(4), 191-198.

Wood, M. J., & Thompson, J. P. (2011). Drugs affecting the autonomic nervous system. Anaesthesia and Intensive Care Medicine, 12(2), 73-77.

Serrano-Gomez A, Thompson JP, Lambert DG. Nociceptin/orphanin FQ in inflammation and sepsis. Br J Anaesth. 2011 Jan 106 1 6-12

McDonald J, Leonard AD, Serrano-Gomez A, Young SP, Swanevelder J, Thompson JP, Lambert DG. Assessment of nociceptin/orphanin FQ and micro-opioid receptor mRNA in the human right atrium. Br J Anaesth. 2010 Jun 104 6 698-704

Flint NJ, Russell WC, Thompson JP. Comparison of different methods of ventilation via cannula cricothyroidotomy in a trachea-lung model. Br J Anaesth. 2009 Dec 103 6 891-5

Leonard AD, Thompson JP, Hutchinson EL, Young SP, McDonald J, Swanevelder J, Lambert DG. Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease. Br J Anaesth. 2009 Apr 102 4 477-84

Stoneham MD, Thompson JP. Arterial pressure management and carotid endarterectomy. Br J Anaesth. 2009 Apr 102 4 442-52

Leonard AD, Allsager CM, Parker JL, Swami A, Thompson JP. Comparison of central venous and external jugular venous pressures during repair of proximal femoral fracture. Br J Anaesth. 2008 Aug 101 2 166-70

Williams JP, Thompson JP, Young SP, Gold SJ, McDonald J, Rowbotham DJ, Lambert DG. Nociceptin and urotensin-II concentrations in critically ill patients with sepsis. Br J Anaesth. 2008 Jun 100 6 810-4

Bouch DC, Thompson JP, Damian MS. Post-cardiac arrest management: more than global cooling? Br J Anaesth. 2008 May 100 5 591-4

Williams JP, Thompson JP, Rowbotham DJ, Lambert DG. Human peripheral blood mononuclear cells produce pre-pro-nociceptin/orphanin FQ mRNA. Anesth Analg. 2008 Mar 106 3 865-6

Buczkowski PW, Fombon FN, Lin ES, Russell WC, Thompson JP. Air entrainment during high-frequency jet ventilation in a model of upper tracheal stenosis. Br J Anaesth. 2007 Dec 99 6 891-7

Gold SJ, Thompson JP, Williams JP, Helm EE, Sadler J, Song W, Ng LL, Lambert DG. Does cigarette smoking increase plasma urotensin II concentrations? Eur J Clin Pharmacol. 2007 Mar 63 3 253-7

Thompson JP, Mahajan RP. Monitoring the monitors--beyond risk management. Br J Anaesth. 2006 Jul 97 1 1-3

Song W, McDonald J, Camarda V, Calo G, Guerrini R, Marzola E, Thompson JP, Rowbotham DJ, Lambert DG. Cell and tissue responses of a range of Urotensin II analogs at cloned and native urotensin II receptors. Evidence for coupling promiscuity. Naunyn Schmiedebergs Arch Pharmacol. 2006 May 373 2 148-57

Howell SJ, Thompson JP, Nimmo AF, Snowden C, Edwards ND, Carlisle J, Suleiman MS, Baumbach A. Relationship between perioperative troponin elevation and other indicators of myocardial injury in vascular surgery patients. Br J Anaesth. 2006 Mar 96 3 303-9

Camarda V, Spagnol M, Song W, Vergura R, Roth AL, Thompson JP, Rowbotham DJ, Guerrini R, Marzola E, Salvadori S, Cavanni P, Regoli D, Douglas SA, Lambert DG, Calò G. In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803). Br J Pharmacol. 2006 Jan 147 1 92-100

Papers before 2006

Dale MT, Naik R, Williams JP, Lloyd AJ, Thompson JP. Impairment of sustained attention after major gynaecological surgery. Eur J Anaesthesiol. 2005 Nov 22 11 843-7

Buczkowski PW, Fombon FN, Russell WC, Thompson JP. Effects of helium on high frequency jet ventilation in model of airway stenosis. Br J Anaesth. 2005 Nov 95 5 701-5

Cowley E, Thompson JP, Sharpe P, Waugh J, Ali N, Lambert DG. Effects of pre-eclampsia on maternal plasma, cerebrospinal fluid, and umbilical cord urotensin II concentrations: a pilot study. Br J Anaesth. 2005 Oct 95 4 495-9

Prudon B, Birring SS, Vara DD, Hall AP, Thompson JP, Pavord ID. Cough and glottic-stop reflex sensitivity in health and disease. Chest. 2005 Feb 127 2 550-7

Camarda V, Song W, Marzola E, Spagnol M, Guerrini R, Salvadori S, Regoli D, Thompson JP, Rowbotham DJ, Behm DJ, Douglas SA, Calo' G, Lambert DG. Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors. Eur J Pharmacol. 2004 Sep 13 498 1-3 83-6

Book chapters

Williams JP, Thompson JP. Pain management in Critical Care. In Brooks AM, Girling K, Riley B (eds). Surgical Critical Care. Arnold, London, 2004.

Research

  • Development of novel non-invasive monitoring modalities in acute illness

  • Integration of non-invasive monitoring for early diagnosis in acute illness
  • The role of properdin and complement activation in human and experimental sepsis
  • The nociceptin system in laboratory models of sepsis, in human sepsis and inflammatory states
  • Investigations into the involvement of endogenous cannabinoids in sepsis
  • The effect of stump catheterisation on pain after lower limb amputation

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