Recent Papers

Recent papers by Professor Toru Suzuki, Department of Cardiovascular Sciences, University of Leicester

Nienaber C, Clough R, Sakalihasan N, Suzuki T, Gibbs R, Mussa F, Jenkins M, Thompson M, Evangelista A, Cheshire N, Rosendahl U, Pepper J. Aortic dissection. Nature Reviews Disease Primers. (in press)

Suzuki T, Lyon A, Saggar R, Heaney LM, Aizawa K, Cittadini A, Mauro C, Citro R, Limongelli G, Ferrara F, Vriz O, Morley-Smith A, Calabro P, Bossone E. Biomarkers of acute cardiovascular and pulmonary diseases. European Heart Journal: Acute Cardiovascular Care. (in press)

Suzuki T, Heaney LM, Bhandari SL, Jones DJL, Ng LL. Trimethylamine N-oxide and prognosis in acute heart failure. Heart. 2016;102:841-8

Gallardo-Vara E, Blanco FJ, Roqué M, Friedman SL, Suzuki T, Botella L, Bernabeu C. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis. 2016;19:155-71.

Zhan H, Aizawa K, Sun J, Tomida S, Otsu K, Conway SJ, McKinnon PJ, Manabe I, Komuro I, Miyagawa K, Nagai R, Suzuki T. Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2016;110:85-95.

Bhandari SS, Narayan H, Jones DJ, Suzuki T, Struck J, Bergmann A, Squire IB, Ng LL. Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure. Eur J Heart Fail. 2016;18:281-9. 

Heaney LM, Suzuki T. Clinical mass spectrometry in heart disease. Cardiogenetics. 2015; 5:5459

Heaney LM, Jones DJ, Mbasu RJ, Ng LL, Suzuki T. High mass accuracy assay for trimethylamine N-oxide using stable-isotope dilution with liquid chromatography coupled to orthogonal acceleration time of flight mass spectrometry with multiple reaction monitoring. Anal Bioanal Chem. 2016;408:797-804.

Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. Atherosclerosis. 2015;242:433-442.

Sawaki D, Hou L, Tomida S, Sun J, Zhan H, Aizawa K, Son BK, Kariya T, Takimoto E, Otsu K, Conway SJ, Manabe I, Komuro I, Friedman SL, Nagai R, Suzuki T. Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes. Cardiovasc Res. 2015;107:420-430.

Pape LA, Awais M, Woznicki EM, Suzuki T, Trimarchi S, Evangelista A, Myrmel T, Larsen M, Harris KM, Greason K, Di Eusanio M, Bossone E, Montgomery DG, Eagle KA, Nienaber CA, Isselbacher EM, O'Gara P. Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection. J Am Coll Cardiol. 2015 Jul 28;66:350-358.

Zheng B, Bernier M, Zhang XH, Suzuki T, Nie CQ, Li YH, Zhang Y, Song LL, Shi HJ, Liu Y, Zheng CY, Wen JK. miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation. J Mol Cell Cardiol. 2015;82:201-212. 

Son BK, Sawaki D, Tomida S, Fujita D, Aizawa K, Aoki H, Akishita M, Manabe I, Komuro I, Friedman SL, Nagai R, Suzuki T. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nat Commun. 2015;6:6994. 
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Suzuki T, Eagle KA, Bossone E, Ballotta A, Froehlich JB, Isselbacher EM. Medical management in type B aortic dissection. Ann Cardiothorac Surg. 3:413-417, 2014. 

Dean JH, Woznicki EM, O'Gara P, Montgomery DG, Trimarchi S, Myrmel T, Pyeritz RE, Harris KM, Suzuki T, Braverman AC, Hughes GC, Kline-Rogers E, Nienaber CA, Isselbacher EM, Eagle KA, Bossone E. Cocaine-related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection. Am J Med. 127:878-885, 2014.

Hoff E, Eagle T, Pyeritz RE, Ehrlich M, Voehringer M, Bossone E, Hutchison S, Peterson MD, Suzuki T, Greason K, Forteza A, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA. Pulse Pressure and Type A Acute Aortic Dissection In-Hospital Outcomes (from the International Registry of Acute Aortic Dissection). Am J Cardiol. 113:1255-1259, 2014.

Miyairi T, Miyata H, Taketani T, Sawaki D, Suzuki T, Hirata Y, Shimizu H, Motomura N, Takamoto S; Japan Adult Cardiovascular Database Organization. Risk model of cardiovascular surgery in 845 Marfan patients using the Japan adult cardiovascular surgery database. Int Heart J. 54:401-404, 2013.

Bossone E, Corteville DC, Harris KM, Suzuki T, Fattori R, Hutchison S, Ehrlich MP, Pyeritz RE, Steg PG, Greason K, Evangelista A, Kline-Rogers E, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA. Stroke and outcomes in patients with acute type a aortic dissection. Circulation. 128:S175-179, 2013.

Fujimoto H, Suzuki T, Aizawa K, Sawaki D, Ishida J, Ando J, Fujita H, Komuro I, Nagai R. Processed B-Type Natriuretic Peptide Is a Biomarker of Postinterventional Restenosis in Ischemic Heart Disease. Clin. Chem. 59:1330-1337, 2013.

Bossone E, Suzuki T, Eagle KA, Weinsaft JW. Diagnosis of Acute Aortic Syndromes - Imaging and Beyond. Herz. 38:269-276, 2013.

Sawaki D, Suzuki T. Targeting Transforming Growth Factor-beta signaling in aortopathies in Marfan Syndrome. Circ. J. 77:898-899, 2013.

Suzuki T, Bossone E, Sawaki D, Jánosi RA, Erbel R, Eagle K, Nagai R. Biomarkers of aortic diseases. Am. Heart J. 165:15-25, 2013.

Larsen M, Bartnes K, Tsai TT, Eagle KA, Evangelista A, Nienaber CA, Suzuki T, Fattori R, Froehlich JB, Hutchison S, Sundt TM, Januzzi JL, Isselbacher EM, Montgomery DG, Myrmel T. Extent of preoperative false lumen thrombosis does not influence long-term survival in patients with acute type a aortic dissection. J. Am. Heart. Assoc. 2:e000112, 2013.

Enokoku K, Ikeda H, Kato R, Kume Y, Yoshida H, Ono T, Aizawa K, Suzuki T, Yamazaki T, Yatomi Y. Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: a cross-sectional study. Clin. Chim. Acta. 421:147-151, 2013.

Bechmann L, Vetter D, Ishida J, Hannivoort R, Lang U, Kocabayoglu P, Fiel M, Muñoz U, Patman G, Ge F, Yakar S, Li X, Agius L, Lee Y, Zhang W, Hui K, Televantou D, Schwartz G, Leroith D, Berk P, Nagai R, Suzuki T, Reeves HL, Friedman SL. Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. J Hepatol. 58:1000-1006, 2013.

Garrido-Martín E, Blanco F, Roque M, Novensà L, Tarocchi M, Lee U, Suzuki T, Friedman S, Botella L, Bernabeu C. Vascular injury triggers Krüppel-like factor 6 (KLF6) mobilization and cooperation with Sp1 to promote endothelial activation through upregulation of the Activin Receptor-Like Kinase 1 (ALK1) gene. Circ. Res. 112:113-127, 2013.

Di Eusanio M, Trimarchi S, Patel H, Hutchison S, Suzuki T, Peterson M, Di Bartolomeo R, Folesani G, Pyeritz R, Braverman A, Montgomery D, Isselbacher E, Nienaber C, Eagle K, Fattori R. Clinical presentation, management, and short-term outcome of patients with type A acute dissection complicated by mesenteric malperfusion: Observations from the International Registry of Acute Aortic Dissection. J. Thorac. Cardiovasc. Surg. 145:385-390, 2013.

Suzuki T, Tomiyama H, Higashi Y. Vascular dysfunction even after 20 years in children exposed to passive smoking – alarming results and need for awareness. Arterioscler. Thromb. Vasc. Biol. 32:841-842, 2012.

Ishida J, Suzuki T, Aizawa K, Sawaki D, Nagai R. Comparison of Analytical Performance of Two Single-step Measurement Devices of B-type Natriuretic Peptide. Int. Heart J. 53:320-323, 2012.

Suzuki T, Isselbacher E, Nienaber C, Pyeritz R, Eagle K, Tsai T, Cooper J, Januzzi J, Braverman A, Montgomery D, Fattori R, Pape L, Harris K, Booher A, Oh J, Peterson M, Ramanath V, Froehlich J. Type-selective benefits of medications in treatment of acute aortic dissection; (from the International Registry of Acute Aortic Dissection [IRAD]). Am. J. Cardiol. 109:122-127, 2012.

Maisel AS, Nakao K, Ponikowski P, Peacock WF, Yoshimura M, Suzuki T, Tsutamoto T, Filippatos GS, Saito Y, Seino Y, Minamino N, Hirata Y, Mukoyama M, Nishikimi T ,Nagai R. Japanese-Western Consensus Meeting on Biomarkers Executive Summary. Int. Heart J. 52:253-265, 2011.

Suzuki T, Trimarchi S, Sawaki D, Grassi V, Costa E, Rampoldi V, Nagai R, Eagle KA. Circulating transforming growth factor-beta levels in acute aortic dissection. J. Am. Coll. Cardiol. 58:775, 2011.

Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, de Luca Tupputi Schinosa L, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander J, Counselman F, Vijayendran R, Bossone E, Eagle K. Response to Letter Regarding Article, "Diagnosis of Acute Aortic Dissection by D-Dimer: The International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) Experience" Circulation. 121:e24, 2010.

Trimarchi S, Sangiorgi G, Sang X, Rampoldi V, Suzuki T, Eagle KA, Elefteriades JA. In search of blood tests for thoracic aortic diseases. Ann. Thorac. Surg. 90:1735-1742, 2010.

Suzuki T, Distante A, Eagle KA. Biomarker-assisted diagnosis of acute aortic dissection; how far we have come and what to expect. Curr. Opin. Cardiol. 25:541-545, 2010.

Trimarchi S, Eagle K, Nienaber C, Pyeritz R, Jonker F, Suzuki T, O'Gara P, Hutchinson S, Rampoldi V, Grassi V, Bossone E, Muhs B, Evangelista A, Tsai T, Froehlich J, Cooper J, Montgomery D, Meinhardt G, Myrmel T, Upchurch G, Sundt T, Isselbacher E; on behalf of the International Registry of Acute Aortic Dissection (IRAD) Investigators. Importance of refractory pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation. 122:1283-1289, 2010.

Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R. Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. J. Biol. Chem. 285:29662-29670, 2010.

Tochio N, Umehara T, Munemasa Y, Suzuki T, Sato S, Tsuda K, Koshiba S, Kigawa T, Nagai R, Yokoyama S. Solution structure of histone chaperone ANP32B: Interaction with core histones H3-H4 through its acidic concave domain. J. Mol. Biol. 401:97-114, 2010.

Suzuki T. Cardiovascular diagnostic biomarkers: the past, present and future. Circ. J. 73:806-809, 2009.

Matsumura T, Suzuki T, Aizawa K, Sawaki D, Munemasa Y, Ishida J, Nagai R. Regulation of transforming growth factor-b-dependent cyclooxygenase-2 expression in fibroblasts. J. Biol. Chem. 284:35861-35871, 2009.

Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, de Luca Tupputi Schinosa L, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander JE, Counselman F, Vijayendran R, Bossone E, Eagle K; for the IRAD-Bio Investigators. Diagnosis of acute aortic dissection by D-Dimer: the International Registry of Acute Aortic Dissection substudy on Biomarkers (IRAD-Bio) experience. Circulation. 119:2702-2707, 2009.

Suzuki T, Sawaki D, Aizawa K, Munemasa Y, Matsumura T, Ishida J, Nagai R. Krüppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis. J. Biol. Chem. 284:9549-9557, 2009.

Suzuki T, Nagai R. Molecular markers for cardiovascular disease: cardiovascular biomarkers to proteomic discovery. Nat. Clin. Pract. Cardiovasc. Med. 5:295, 2008.

Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, de Luca Tupputi Schinosa L, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander JE, Counselman F, Bossone E, Eagle K; International Registry of Acute Aortic Dissection substudy on Biomarkers (IRAD-Bio) Investigators. Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection. Eur. Heart J. 29:1439-1445, 2008.

Kada N, Suzuki T, Aizawa K, Munemasa Y, Matsumura T, Sawaki D, Nagai R. Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha. FEBS Lett. 582:1755-1760, 2008.

Munemasa Y, Suzuki T, Aizawa K, Miyamoto S, Imai Y, Matsumura T, Horikoshi M, Nagai R. Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5. Mol. Cell. Biol. 28:1171-1181, 2008.

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