Recent Papers

Professor Shu Ye, Department of Cardiovascular Sciences, University of Leicester

Department of Cardiovascular Sciences


Chen Y, Ke Z, Xiao J, Lin M, Huang X, Yan C, Ye S*, Tan X*. Subcutaneous injection of nitroglycerin at the radial artery puncture site reduces the risk of early radial artery occlusion after transradial coronary catheterization: a randomized, placebo-controlled clinical trial. Circ Cardiovasc Interv 11:e006571; 2018 (*corresponding authors).

Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S, Brozynska M, Wang T, Ye S, Webb TR, Rutter MK, Tzoulaki I, Patel RS, Loos RJF, Keavney B, Hemingway H, Thompson J, Watkins H, Deloukas P, Di Angelantonio E, Butterworth AS, Danesh J, Samani NJ. Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention. J Am Coll Cardiol 72:1883-1893; 2018.

Ren M, Ng FL, Warren H, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs A, Ye S*, Caulfield M.* The biological impact of blood pressure associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Hum Mol Genet 27:199-210; 2018 (*corresponding authors).

Chan K, Pu X, Sandesara P, Poston RN, Simpson IA, Quyyumi AA, Ye S*, Patel RS. Genetic variation at the ADAMTS7 locus is associated with reduced severity of coronary artery disease. J Am Heart Assoc 6:e006928; 2017 (*corresponding author).

Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ, Ye S. Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet 2017

Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ, Ye S. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial InfarctionPLoS Genet 2016 Jul 7;12(7):e1006127.

Zhang R, Witkowska K, Afonso Guerra-Assunção J, Ren M, Ng FL, Mauro C, Tucker AT, Caulfield MJ, Ye S. A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicityHum Mol Genet 25:4117-4126; 2016.

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton A, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley S, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey R, Mayr M. 2016. Association of MicroRNAs and YRNAs with Platelet Function. Circ Res. 118(3): 420-32.

Wen G, Zhang C, Chen Q, Luong LA, Mustafa A, Ye S,* Xiao Q.* 2015. A novel role of matrix metalloproteinase-8 in macrophage differentiation and polarization. J Biol Chem. 290:19158-72 (*share senior authorship).

Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q, Ye S. 2014. Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol. 34:90-8.

Chen Y, Chen C, Ke X, Xiong L, Shi Y, Li J, Tan X, Ye S. 2014. Analysis of circulating cholesterol levels as a mediator of an association between ABO blood group and coronary heart disease. Circ Cardiovasc Genet. 7:43-8.

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Tucker AT, Xu Q, Caulfield MJ, Ye S. 2013. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary artery disease associated variant. Am J Hum Genet. 92:366-74.

Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. 2013. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol. 61:957-70.

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai TN, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q, Ye S. 2013. A functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res. 112:35-47.

Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ, Ye S. 2012. Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet. 21:4021-9.

Kiechl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC, Xiao Q, Bonora E, Willeit J, Xu Q, Witteman JCM, Chasman D, Tracy RP, Ballantyne CM, Ridker PM, Benjamin EJ, Ye S. 2011. Association of variation at the ABO locus with circulating levels of sICAM-1, sP-selectin and sE-selectin: a meta-analysis. Circ Cardiovasc Genet. 4:681-686.

Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtimäki TJ, Keavney B, Xu Q, Ye S. 2010. Coronary artery disease related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler Thromb Vasc Biol 30:2678-2683.

Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung KY, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q, Ye S. 2009. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res 105:921-929.

Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. 2008. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis – a population-based, prospective study. J Am Coll Cardiol 52:378-84.

Kyriakou T, Pontefract DE, Viturro E, Hodgkinson CP, Laxton RC, Bogari N, Cooper G, Davies M, Giblett J, Day IN, Simpson IA, Albrecht C, Ye S. 2007. Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. Hum Mol Genet. 16:1412-22.


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