Professor Shu Ye

Professor Shu YeProfessor of Cardiovascular Molecular Medicine and Genetics

MD, 1991, Sun Yat-sen University of Medical Sciences
PhD, 1996, University College London
FRCPath (by publications), 2008

Tel: 0116 204 4754


Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP

Personal details

MD, 1991, Sun Yat-sen University of Medical Sciences
PhD, 1996, University College London
FRCPath (by publications), 2008

External Positions

Associate Editor of Heart, 2010-2013)
Associate Editor of BMC Medical Genetics, 2010-2012
Editorial Advisory Panel of Clinical Science, 2008-


Key recent publications


Hu Y, Guo F, Xu Y, Li P, Lu Z, McVey DG, Ye JH, Zheng L, Wang Q, Kang C, Wu S, Zhao J, Ma X, Yang Z, Fang F, Qiu Y, Xu B, Xiao L, Wu Q, Wu L, Ding L, Webb TR, Samani NJ, Ye S. NEXN regulated by NEXN-AS1 plays a protective role against atherosclerosis. J Clin Invest 129:1115-1128; 2019.

Zhao G, Yang W, Wu J, Chen B, Yang X, Chen J, McVey DG, Andreadi C, Gong P, Webb TR, Samani NJ, Ye S. Influence of a coronary artery disease-associated genetic variant on FURIN expression and effect of furin on macrophage behavior. Arterioscler Thromb Vasc Biol 38:1837-1844; 2018.

Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ, Ye S. Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet 2017

Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ, Ye S. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genet 2016 Jul 7;12(7):e1006127.

Zhang R, Witkowska K, Afonso Guerra-Assunção J, Ren M, Ng FL, Mauro C, Tucker AT, Caulfield MJ, Ye S. A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. Hum Mol Genet 25:4117-4126; 2016.

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Tucker AT, Xu Q, Caulfield MJ, Ye S. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary artery disease associated variant. Am J Hum Genet 92:366-74; 2013.

Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol 61:957-70; 2013.

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai TN, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q, Ye S. A functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res 112:35-47; 2013.

Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ, Ye S. Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet 21:4021-9; 2012.

Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung KY, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q, Ye S. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res 105:921-929; 2009.

Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis – a population-based, prospective study. J Am Coll Cardiol 52:378-84; 2008.

Kyriakou T, Pontefract DE, Viturro E, Hodgkinson CP, Laxton RC, Bogari N, Cooper G, Davies M, Giblett J, Day IN, Simpson IA, Albrecht C, Ye S. Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. Hum Mol Genet 16:1412-22; 2007.

Recent papers


  • Cardiovascular genetics
  • Mechanisms underlying influences of genetic variants on cardiovascular diseases
  • Pathogenesis of atherosclerosis
  • Roles of proteinases in cardiovascular diseases

Share this page: