Recent Papers

Recent Papers by Professor Leong Loke Ng, Department of Cardiovascular Science, University of Leicester

Suzuki T, Heaney LM, Bhandari SS, Jones DJ, Ng LL. 2016. Trimethylamine N-oxide and prognosis in acute heart failure. Heart. 102(11): 841-8. Epub 2016 Feb 11.

Yuyun MF, Narayan HK, Quinn PA, Struck J, Bergmann A, Hartmann O, Ng LL. 2016. Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown). 13 Jan 2016 Epub.

Bhandari SS, Narayan H, Jones DJ, Suzuki T, Struck J, Bergmann A, Squire IB, Ng LL. 2016. Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure. Eur J Heart Fail. 18(3): 281-9.

Heaney LM, Jones DJ, Mbasu RJ, Ng LL, Suzuki T. 2016. High mass accuracy assay for trimethylamine N-oxide using stable-isotope dilution with liquid chromatography coupled to orthogonal acceleration time of flight mass spectrometry with multiple reaction monitoring. Anal Bioanal Chem. 408(3): 797-804.

Seronde MF, Vausort M, Gayat E, Goretti E, Ng LL, Squire IB, Vodovar N, Sadoune M, Samuel JL, Thum T, Solal AC, Laribi S, Plaisance P, Wagner DR, Mebazaa A, Devaux Y; GREAT network. 2015. Circulating microRNAs and Outcome in Patients with Acute Heart Failure. PLoS One. 10(11): e0142237.

Ng LL, Bhandari SS, Sandhu JK, Quinn PA, Squire IB, Davies JE, Struck J, Bergmann A, Jones DJ. 2015. Growth hormone for risk stratification and effects of therapy in acute myocardial infarction. Biomarkers. 20: 371-5.

Cao TH, Quinn PA, Sandhu JK, Voors AA, Lang CC, Parry HM, Mohan M, Jones DJ, Ng LL. 2015. Identification of novel biomarkers in plasma for prediction of treatment response in patients with heart failure. Lancet. 385: Suppl 1:S26.

Norris L, Malkar A, Horner-Glister E, Hakimi A, Ng LL, Gescher AJ, Creaser C, Sale S, Jones DJ. 2015. Search for novel circulating cancer chemopreventive biomarkers of dietary rice bran intervention in Apc(Min) mice model of colorectal carcinogenesis, using proteomic and metabolic profiling strategies. Mol Nutr Food Res. 59(9): 1827-36.

Zheng B, Bernier M, Zhang XH, Suzuki T, Nie CQ, Li YH, Zhang Y, Song LL, Shi HJ, Liu Y, Zheng CY, Wen JK. 2015. miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation. J Mol Cell Cardiol. 82: 201-12.

Yuyun MF, Narayan HK, Ng LL. 2015. Prognostic significance of adrenomedullin in patients with heart failure and with myocardial infarction. Am J Cardiol. 115(7): 986-91.

Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Struck J, Bergmann A, Maisel A, Jones DJ. 2014. Pro-substance p for evaluation of risk in acute myocardial infarction. J Am Coll Cardiol. 64(16): 1698-707.

Sandhu JK, Auluck J, Ng LL, Jones DJ. 2014. Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. Biomed Chromatogr. 28(6): 913-917.

Jutla SK, Yuyun MF, Quinn PA, Ng LL. 2014. Plasma cortisol and prognosis of patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown). 15(1): 33-41.

Daly CE, Ng LL, Hakimi A, Willingale R, Jones DJ. 2014. Qualitative and quantitative characterization of plasma proteins when incorporating traveling wave ion mobility into a liquid chromatography-mass spectrometry workflow for biomarker discovery: use of product ion quantitation as an alternative data analysis tool for label free quantitation. Anal Chem. 86(4): 1972-1979.

Bhandari SS, Davies JE, Struck J, Ng LL. 2014. sma C-terminal proEndothelin-1 (CTproET-1) is affected by age, renal function, left atrial size and diastolic blood pressure in healthy subjects. Peptides. 52: 53-57.

Hakimi A, Auluck J, Jones GD, Ng LL, Jones DJ. 2014. Assessment of reproducibility in depletion and enrichment workflows for plasma proteomics using label-free quantitative data-independent LC-MS. Proteomics. 14(1): 4-13.

Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Bergmann A, Maisel A, Jones DJ. 2014. Proenkephalin and prognosis after acute myocardial infarction. J Am Coll Cardiol. 63(3): 280-289.

Dhillon OS, Narayan HK, Khan SQ, Kelly D, Quinn PA, Squire IB, Davies JE, Ng LL. 2013. Pre-discharge risk stratification in unselected STEMI: Is there a role for ST2 or its natural ligand IL-33 when compared with contemporary risk markers? Int J Cardiol. 167(5):2182-8.

Weir RA, Petrie CJ, Murphy CA, Clements S, Steedman T, Miller AM, McInnes IB, Squire IB, Ng LL, Dargie HJ, McMurray JJ. 2013. Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction. Circ Heart Fail. 6(3): 492-8.

Ng LL, Sandhu JK, Squire IB, Davies JE, Jones DJ. 2013. Vitamin D and prognosis in acute myocardial infarction. Int J Cardiol. 168(3): 2341-6.

Jani PP, Narayan H, Ng LL. 2013. The differential extraction and immunoluminometric assay of Urotensin II and Urotensin-related peptide in heart failure. Peptides. 40: 72-76.

Devaux Y, Vausort M, McCann GP, Zangrando J, Kelly D, Razvi N, Zhang L, Ng LL, Wagner DR, Squire IB. 2013. MicroRNA-150: A Novel Marker of Left Ventricular Remodeling After Acute Myocardial Infarction. Circ Cardiovasc Genet. 6(3): 290-8.

Richards M, Di Somma S, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Clopton P, Filippatos GS, Anand I, Ng L, Daniels LB, Neath SX, Shah K, Christenson R, Hartmann O, Anker SD, Maisel A. 2013. Atrial Fibrillation Impairs the Diagnostic Performance of Cardiac Natriuretic Peptides in Dyspneic Patients: Results From the BACH Study (Biomarkers in ACute Heart Failure). JACC Heart Fail. 1(3): 192-9.

Bhandari SS, Davies JE, Struck J, Ng LL. 2012. The diagnostic performance of mid-regional portion of pro-atrial natriuretic peptide for the detection of left ventricular hypertrophy in Caucasian hypertensive patients. J Hum Hypertens. 26(12): 711-5.

Maisel A, Neath SX, Landsberg J, Mueller C, Nowak RM, Peacock WF, Ponikowski P, Möckel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand I, Ng LL, Daniels LB, Christenson RH, Potocki M, McCord J, Terracciano G, Hartmann O, Bergmann A, Morgenthaler NG, Anker SD. 2012. Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial. Eur J Heart Fail. 14: 278-86.

Daniels LB, Clopton P, Potocki M, Mueller C, McCord J, Richards M, Hartmann O, Anand IS, Wu AH, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Filippatos GS, Di Somma S, Ng L, Neath SX, Christenson R, Morgenthaler NG, Anker SD, Maisel AS. 2012. Influence of age, race, sex, and body mass index on interpretation of midregional pro atrial natriuretic peptide for the diagnosis of acute heart failure: results from the BACH multinational study. Eur J Heart Fail. 14: 22-31.

Steadman CD, Jerosch-Herold M, Grundy B, Rafelt S, Ng LL, Squire IB, Samani NJ,. McCann GP. 2012. Determinants and Functional Significance of Reduced Myocardial Perfusion Reserve in Severe Aortic Stenosis. JACC Cardiovascular Imaging. 5: 182-9.

Weir RA, Miller AM, Petrie CJ, Clements S, Steedman T, Dargie HJ, Squire IB, Ng LL, McInnes IB, McMurray JJ. 2012. Interleukin-21 - A biomarker of importance in predicting myocardial function following acute infarction? Cytokine. 60(1): 220-5.

Devaux Y, Vausort M, Azuaje F, Vaillant M, Lair ML, Gayat E, Lassus J, Ng LL,  Kelly D, Wagner DR, Squire IB. 2012. Low levels of vascular endothelial growth factor B predict left ventricular remodeling after acute myocardial infarction. J Card Fail. 18(4): 330-7.

Wu AH, Tabas J, Stein J, Potocki M, Mueller C, McCord J, Richards M, Hartmann O, Nowak R, Peacock WF, Ponikowski P, Moeckel M, Hogan C, Filippatos GS, Di Somma S, Anand I, Ng L, Neath SX, Christenson R, Morgenthaler NG, Anker SD, Maisel AS. 2012. The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea. Biomarkers. 17(6): 490-7.

Gholap NN, Mehta RL, Ng L, Davies MJ, Khunti K, Squire IB. 2012. Is admission blood glucose concentration a more powerful predictor of mortality after myocardial infarction than diabetes diagnosis? A retrospective cohort study. BMJ Open.  2(5). pii: e001596.

Scott PA, Zeidan B, Ng LL, Zeb M, Rosengarten JA, Garbis S, Curzen NP, Morgan JM, Townsend PA. 2012. Proteomic profiling to identify prognostic biomarkers in heart failure. In Vivo. 26(6): 875-82.

Weir RA, Miller AM, Petrie CJ, Clements S, Steedman T, Dargie HJ, Squire IB, Ng LL, McInnes IB, McMurray JJ. 2012. Interleukin-21--a biomarker of importance in predicting myocardial function following acute infarction? Cytokine. 60(1): 220-5.

Bhandari SS, Davies JE, Struck J, Ng LL. 2011. Influence of confounding factors on plasma Mid-Regional pro-Adrenomedullin and Mid-Regional pro-A-type Natriuretic Peptide concentrations in healthy individuals. Biomarkers. 16(3): 281-7.

Narayan H, Dhillon OS, Quinn P, Struck J, Squire IB, Davies JE, Ng LL. 2011. C-Terminal Provasopressin (Copeptin) as Prognostic Marker after Acute Non ST Elevation Myocardial Infarction - Leicester Acute Myocardial Infarction Peptide II (LAMP II) study. Clin Sci (Lond). 121(2): 79-89.

Ng LL, Khan SQ, Narayan H, Quinn P, Squire IB, Davies JE. 2010. Proteinase 3 and prognosis of patients with acute myocardial infarction. Clin Sci (Lond). 120(6): 231-8.

Kelly D, Squire IB, Khan SQ, Dhillon O, Narayan H, Ng KH, Quinn P, Davies JE, Ng LL. 2010. Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarction. Am J Cardiol. 106(4): 477-82.

Dhillon OS, Khan SQ, Narayan HK, Ng KH, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL. 2010. Prognostic value of mid-regional pro-adrenomedullin levels taken on admission and discharge in non-ST-elevation myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) II study. J Am Coll Cardiol. 56(2): 125-33.

Chan D, Ng LL. 2010. Biomarkers in acute myocardial infarction. BMC Med. 7(8): 34.

Gupta S, Waywell C, Gandhi N, Clayton N, Keevil B, Clark AL, Ng LL, Brooks N, Neyses L. 2010. The effects of adding torasemide to standard therapy on peak oxygen consumption, natriuretic peptides, and quality of life in patients with compensated left ventricular systolic dysfunction. Eur J Heart Fail. 12(7): 746-52.

Maisel A, Mueller C, Nowak R, Peacock WF, Ponikowski P, Möckel M, Hogan C, Wu A, Richards M, Clopton P, Filippatos G, Di Somma S, Anand I, Ng LL, Daniels L, Neath S-X, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler N, Anker S. 2010. Mid-Region ProHormone Markers for Diagnosis and Prognosis in Acute Dyspnea: Results from the BACH (Biomarkers in ACute Heart failure) Trial. J Am Coll Cardiol. 55(19): 2062-76.

Steadman CD, Ray S, Ng LL, McCann GP. 2010. Natriuretic peptides in common valvular heart disease. J Am Coll Cardiol. 55(19): 2034-48.

Hunt BD, Ng LL, Lambert DG. 2010. A rat brain atlas of urotensin-II receptor expression and a review of central urotensin-II effects. Naunyn Schmiedebergs Arch Pharmacol. 382(1): 1-31.

Kelly D, Khan SQ, Dhillon O, Quinn P, Struck J, Squire IB, Davies JE, Ng LL. 2010. Procalcitonin as a prognostic marker in patients with acute myocardial infarction. Biomarkers. 15(4): 325-31.

Narayan H, Mohammed N, Quinn PA, Squire IB, Davies JE, Ng LL. 2010. Activation of a novel natriuretic endocrine system in humans with heart failure. Clin Sci (Lond). 118(5): 367-74.

Bhandari SS, Davies JE, Struck J, Ng LL. 2010. The midregional portion of proadrenomedullin is an independent predictor of left ventricular mass index in hypertension. Metabolism. 59(1): 7-13.

Weir RA, Balmain S, Steedman T, Ng LL, Squire IB, Rumley A, Dargie HJ, Lowe GD. 2010. Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarction. J Thromb Thrombolysis. 29(4): 421-8.

Squire IB, Nelson CP, Ng LL, Jones DR, Woods KL, Lambert PC. 2010. Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction; Results from 4702 index cases in routine practice. Clin Sci (Lond).  118(8): 527-35.

Batuwangala MS, Calo G, Guerrini R, Ng LL, McDonald J, Lambert DG. 2009. Desensitisation of native and recombinant human urotensin-II receptors. Naunyn Schmiedebergs Arch Pharmacol. 380(5): 451-7.

Foley PW, Stegemann B, Ng K, Ramachandran S, Proudler A, Frenneaux MP, Ng LL, Leyva F. 2009. Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy. Eur Heart J. 30(22): 2749-57.

Leyva F, Foley PW, Stegemann B, Ward JA, Ng LL, Frenneaux MP, Regoli F, Smith RE, Auricchio A. 2009. Development and validation of a clinical index to predict survival after cardiac resynchronisation therapy. Heart. 95(19): 1619-25.

Dhillon OS, Khan SQ, Narayan HK, Ng KH, Mohammed N, Quinn PA, Squire IB, Davies JE, Ng LL. 2009. Matrix Metalloproteinase-2 predicts mortality in patients with acute coronary syndrome. Clin Sci (Lond). 118(4): 249-57.

Weir RA, Mark PB, Petrie CJ, Clements S, Steedman T, Ford I, Ng LL, Squire IB, Wagner GS, McMurray JJ, Dargie HJ. 2009. Left ventricular remodeling after acute myocardial infarction: does eplerenone have an effect? Am Heart J. 157(6): 1088-96.

Batuwangala M, Camarda V, McDonald J, Marzola E, Lambert DG, Ng LL, Calo' G, Regoli D, Trapella C, Guerrini R, Salvadori S. 2009. Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor. Peptides. 30(6): 1130-6.

Khan SQ, Narayan H, Ng KH, Dhillon OS, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL. 2009. N-terminal pro B type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndrome. Clin Sci (Lond). 117(1): 31-9.

Khan SQ, Ng K, Dhillon O, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL. 2009. Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction. Eur Heart J. 30(9): 1057-65

Bhandari SS, Loke I, Davies JE, Squire IB, Struck J, Ng LL. 2009. Gender and renal function influence plasma levels of copeptin in healthy individuals. Clin Sci (Lond). 116(3): 257-63.

Kelly D, Squire IB, Khan SQ, Quinn P, Struck J, Morgenthaler NG, Davies JE, Ng LL. 2009. C-Terminal Provasopressin (Copeptin) is Associated With Left Ventricular Dysfunction, Remodeling, and Clinical Heart Failure in Survivors of Myocardial Infarction. J Card Fail. 14(9): 739-45.

Cleland JG, Squire I, Ng LL. 2008. Interpretation of amino-terminal pro-brain natriuretic peptide levels in the HPS and the CORONA study. J Am Coll Cardiol. 52(13): 1104-5.

Kelly D, Khan SQ, Thompson M, Cockerill G, Ng LL, Samani N, Squire IB. 2008. Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction. Eur Heart J. 29(17): 2116-24.

Khan SQ, Dhillon O, Kelly D, Squire IB, Struck J, Quinn P, Morgenthaler NG, Bergmann A, Davies JE, Ng LL. 2008. Plasma N-terminal B-Type natriuretic peptide as an indicator of long-term survival after acute myocardial infarction: comparison with plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) study. J Am Coll Cardiol. 51(19): 1857-64.

Kelly D, Khan S, Cockerill G, Ng LL, Thompson M, Samani NJ, Squire IB. 2008. Circulating Stromelysin-1 (MMP-3): A novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction. Eur J Heart Fail. 10(2): 133-9.

Khan SQ, Quinn P, Davies JE, Ng LL. 2008. N-terminal pro-B-type natriuretic peptide is better than TIMI risk score at predicting death after acute myocardial infarction. Heart. 94(1): 40-3.

Orn S, Manhenke C, Squire IB, Ng LL, Anand I, Dickstein K. 2007. Plasma MMP-2, MMP-9 and N-BNP in long-term survivors following complicated myocardial infarction: relation to cardiac magnetic resonance imaging measures of left ventricular structure and function. J Card Fail. 13(10): 843-9.

Khan SQ, Dhillon O, Struck J, Quinn P, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL. 2007. C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study. Am Heart J. 154(4): 736-42.

Jones DJ, Willingale R, Quinn PA, Lamb JH, Farmer PB, Davies JE, Ng LL. 2007. Improving the diagnostic accuracy of N-terminal B-type natriuretic peptide in human systolic heart failure by plasma profiling using mass spectrometry. J Proteome Res. 6(8): 3329-34.

Potter DD, Araoz PA, Ng LL, Kruger DG, Thompson JL 3rd, Hamner CE, Rysavy JA, Mandrekar JN, Sundt TM 3rd. 2007. Cardiotropin-1 and myocardial strain change heterogeneously in cardiomyopathy. J Surg Res. 141(2): 277-83.

Khan SQ, Dhillon OS, O'Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL. 2007. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation. 115(16): 2103-10.

Khan SQ, O'Brien RJ, Struck J, Quinn P, Morgenthaler N, Squire I, Davies JE, Bergmann A, Ng LL. 2007. Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study. J Am Coll Cardiol. 49(14): 1525-32.

Kelly D, Cockerill G, Ng LL, Thompson M, Khan S, Samani NJ, Squire IB. 2007. Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study. Eur Heart J. 28(6): 711-8.

Kelly D, Hickey PM, Davies JE, Ng LL, Chin D. 2007. Acute management of pregnancy associated cardiomyopathy with cardiac resynchronisation therapy. Eur J Heart Fail. 9(5): 542-4.

Gold SJ, Thompson JP, Williams JP, Helm EE, Sadler J, Song W, Ng LL, Lambert DG. 2007. Does cigarette smoking increase plasma urotensin II concentrations? Eur J Clin Pharmacol. 63(3): 253-7.

Heart Protection Study Collaborative Group, Emberson JR, Ng LL, Armitage J, Bowman L, Parish S, Collins R. 2007. N-terminal Pro-B-type natriuretic peptide, vascular disease risk, and cholesterol reduction among 20,536 patients in the MRC/BHF heart protection study. J Am Coll Cardiol.  49(3): 311-9.

Khan SQ, Kelly D, Quinn P, Davies JE, Ng LL. 2007. Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction. Heart. 93(7): 826-31.

Ng LL, O'Brien RJ, Quinn PA, Squire IB, Davies JE. 2007. Oxygen-regulated protein 150 and prognosis following myocardial infarction. Clin Sci (Lond). 112(9): 477-84.

Khan SQ, Kelly D, Quinn P, Davies JE, Ng LL. 2007. Myotrophin is a more powerful predictor of major adverse cardiac events following acute coronary syndrome than N-terminal pro-B-type natriuretic peptide. Clin Sci (Lond). 112(4): 251-6.

Khan SQ, Bhandari SS, Quinn P, Davies JE, Ng LL. 2007. Urotensin II is raised in acute myocardial infarction and low levels predict risk of adverse clinical outcome in humans. Int J Cardiol. 117(3): 323-8.

Khan SQ, Kelly D, Quinn P, Davies JE, Ng LL. 2006. Cardiotrophin-1 predicts death or heart failure following acute myocardial infarction. J Card Fail. 12(8): 635-40.

Ng LL, Pathik B, Loke IW, Squire IB, Davies JE. 2006. Myeloperoxidase and C-reactive protein augment the specificity of B-type natriuretic peptide in community screening for systolic heart failure. Am Heart J. 152(1): 94-101.

Doukas G, Samani NJ, Alexiou C, Oc M, Chin DT, Stafford PG, Ng LL, Spyt TJ. 2005. Left atrial radiofrequency ablation during mitral valve surgery for continuous atrial fibrillation: a randomized controlled trial. JAMA. 294(18): 2323-9.

Squire IB, Ørn S, Ng LL, Manhenke C, Shipley L, Aarsland T, Dickstein K. 2005. Plasma natriuretic peptides up to 2 years after acute myocardial infarction and relation to prognosis: an OPTIMAAL substudy. J Card Fail. 11(7): 492-7.

Ng LL, Loke IW, Davies JE, Geeranavar S, Khunti K, Stone MA, Chin DT, Squire IB. Community screening for left ventricular systolic dysfunction using plasma and urinary natriuretic peptides. J Am Coll Cardiol. 2005 Apr 5 45 7 1043-50

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