Professor Leong Loke Ng

Professor of Medicine and Therapeutics, University of Leicester

Honorary Consultant Physician, Cardiovascular Unit, University Hospitals of Leicester NHS Trust

Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester LE3 9QP

Tel: +44 (0)116 250 2449

Email: lln1@le.ac.uk

Personal details

Qualifications

  • BA (Medical Sciences Tripos (1st Class), Cambridge, 1976
  • MB B Chir (Distinction), Cambridge, 1979
  • MRCP (UK), London, 1982
  • MD, Cambridge, 1988
  • FRCP, London, 1996
  • FBPhS, 2012

External positions

  • External Examiner for PhD, MD (Universities of Oxford, Manchester, Birmingham, London, Melbourne)
  • Editorial Advisory Board, Clinical Science
  • Secretary and Member of SAC, Clinical Pharmacology and Therapeutics

Website

Publications

1: Kobayashi M, Voors AA, Ouwerkerk W, Duarte K, Girerd N, Rossignol P, Metra M, Lang CC, Ng LL, Filippatos G, Dickstein K, van Veldhuisen DJ, Zannad F, Ferreira JP. Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure. Clin Cardiol. 2021 May 7. doi: 10.1002/clc.23576. Epub ahead of print. PMID: 33960439.

2: Emmens JE, Jia C, Ng LL, van Veldhuisen DJ, Dickstein K, Anker SD, Lang CC, Filippatos G, Cleland JGF, Metra M, Voors AA, de Boer RA, Tietge UJF. Impaired High-Density Lipoprotein Function in Patients With Heart Failure. J Am Heart Assoc. 2021 May 4;10(9):e019123. doi: 10.1161/JAHA.120.019123. Epub 2021 Apr 17.PMID: 33870728.

3: Romaine SPR, Denniff M, Codd V, Nath M, Koekemoer A, Anker SD, Cleland JG, Filippatos G, Levin D, Metra M, Mordi IR, Ouwerkerk W, Ter Maaten JM, van Veldhuisen DJ, Zannad F, Ng LL, van der Harst P, Lang CC, Voors AA, Nelson CP, Samani NJ. Telomere length is independently associated with all-cause mortality in chronic heart failure. Heart. 2021 Mar 31:heartjnl-2020-318654. doi: 10.1136/heartjnl-2020-318654. Epub ahead of print. PMID: 33789973.

4: Gupta P, Voors AA, Patel P, Lane D, Anker SD, Cleland JGF, Dickstein K, Filippatos G, Lang CC, van Veldhuisen DJ, Metra M, Zannad F, Samani NJ, Jones DJL, Squire IB, Ng LL. Non-adherence to heart failure medications predicts clinical outcomes: assessment in a single spot urine sample by liquid chromatography-tandem mass spectrometry (results of a prospective multicentre study). Eur J Heart Fail. 2021 Mar 23. doi: 10.1002/ejhf.2160. Epub ahead of print. PMID: 33759308.

5: Núñez J, Bayés-Genís A, Revuelta-López E, Miñana G, Santas E, Ter Maaten JM, de la Espriella R, Carratalá A, Lorenzo M, Palau P, Llàcer P, Valle A, Bodi V, Núñez E, Lupón J, Lang C, Ng LL, Metra M, Sanchis J, Voors AA. Optimal carbohydrate antigen 125 cutpoint for identifying low-risk patients after admission for acute heart failure. Rev Esp Cardiol (Engl Ed). 2021 Mar 18:S1885-5857(21)00064-5. English, Spanish. doi: 10.1016/j.rec.2021.02.002. Epub ahead of print. PMID: 33745912.

6: Pandhi P, Streng KW, Anker SD, Cleland JG, Damman K, Dickstein K, Pellicori P, Lang CC, Ng L, Samani NJ, Zannad F, Metra M, Rossignol P, Filippatos G, van Veldhuisen DJ, Voors AA, Ter Maaten JM. The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure. J Cachexia Sarcopenia Muscle. 2021 Mar 20. doi: 10.1002/jcsm.12690. Epub ahead of print. PMID: 33742549.

7: Kanagala P, Arnold JR, Khan JN, Singh A, Gulsin GS, Squire IB, McCann GP, Ng LL. Plasma P-selectin is a predictor of mortality in heart failure with preserved ejection fraction. ESC Heart Fail. 2021 Mar 10. doi: 10.1002/ehf2.13280. Epub ahead of print. PMID: 33694306.

8: Woolley RJ, Ceelen D, Ouwerkerk W, Tromp J, Figarska SM, Anker SD, Dickstein K, Filippatos G, Zannad F, Marco M, Ng L, Samani N, van Veldhuisen D, Lang C, Lam CS, Voors AA. Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction. Eur J Heart Fail. 2021 Mar 2. doi: 10.1002/ejhf.2144. Epub ahead of print. PMID: 33651430.

9: Israr MZ, Bernieh D, Salzano A, Cassambai S, Yazaki Y, Heaney LM, Jones DJL, Ng LL, Suzuki T. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 2021 Apr;234:71-80. doi: 10.1016/j.ahj.2021.01.006. Epub 2021 Jan 14. PMID: 33454370.

10: Davison BA, Senger S, Sama IE, Koch GG, Mebazaa A, Dickstein K, Samani NJ, Metra M, Anker SD, Cleland JG, Ng LL, Mordi IR, Zannad F, Filippatos GS, Hillege HL, Ponikowski P, van Veldhuisen DJ, Lang CC, van der Meer P, Núñez J, Bayés- Genís A, Edwards C, Voors AA, Cotter G. Is acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF. Eur J Heart Fail. 2021 Jan;23(1):43-57. doi: 10.1002/ejhf.2077. Epub 2021 Jan 22. PMID: 33340221.

11: Chan DCS, Singh A, Greenwood JP, Dawson DK, Lang CC, Berry C, Pakkal M, Everett RJ, Dweck MR, Ng LL, McCann GP. Effect of the 2017 European Guidelines on Reclassification of Severe Aortic Stenosis and Its Influence on Management Decisions for Initially Asymptomatic Aortic Stenosis. Circ Cardiovasc Imaging. 2020 Dec;13(12):e011763. doi: 10.1161/CIRCIMAGING.120.011763. Epub 2020 Dec 8. PMID: 33287584.

12: Zhao B, Bryant L, Cordell R, Wilde M, Salman D, Ruszkiewicz D, Ibrahim W, Singapuri A, Coats T, Gaillard E, Beardsmore C, Suzuki T, Ng L, Greening N, Thomas P, Monks P, Brightling C, Siddiqui S, Free RC. LabPipe: an extensible bioinformatics toolkit to manage experimental data and metadata. BMC Bioinformatics. 2020 Dec 2;21(1):556. doi: 10.1186/s12859-020-03908-5. PMID: 33267792; PMCID: PMC7709404.

13: Singh A, Chan DCS, Kanagala P, Hogrefe K, Kelly DJ, Khoo JP, Sprigings D, Greenwood JP, Abdelaty AMSEK, Jerosch-Herold M, Ng LL, McCann GP. Short-term adverse remodeling progression in asymptomatic aortic stenosis. Eur Radiol. 2020 Nov 19. doi: 10.1007/s00330-020-07462-9. Epub ahead of print. PMID: 33215248.

14: Ferreira JP, Ouwerkerk W, Santema BT, van Veldhuisen DJ, Lang CC, Ng LL, Anker SD, Dickstein K, Metra M, Cleland JGF, Nilesh SJ, Filippatos G, Aboumsallem JP, de Boer RA, Figarska S, Sama IE, Voors AA, Zannad F. Differences in biomarkers and molecular pathways according to age for patients with HFrEF. Cardiovasc Res. 2020 Oct 1:cvaa279. doi: 10.1093/cvr/cvaa279. Epub ahead of print. PMID: 33002110.

15: Kanagala P, Arnold JR, Khan JN, Singh A, Gulsin GS, Eltayeb M, Gupta P, Squire IB, McCann GP, Ng LL. Fibroblast-growth-factor-23 in heart failure with preserved ejection fraction: relation to exercise capacity and outcomes. ESC Heart Fail. 2020 Sep 16;7(6):4089–99. doi: 10.1002/ehf2.13020. Epub ahead of print. PMID: 32935918; PMCID: PMC7755022.

16: Kanagala P, Arnold JR, Khan JN, Singh A, Gulsin GS, Chan DCS, Cheng ASH, Yang J, Li Z, Gupta P, Squire IB, McCann GP, Ng LL. Plasma Tenascin-C: a prognostic biomarker in heart failure with preserved ejection fraction. Biomarkers. 2020 Nov;25(7):556-565. doi: 10.1080/1354750X.2020.1810319. Epub 2020 Aug 28. PMID: 32803990.

17: Nelson CP, Sama IE, Codd V, Webb TR, Ye S, Lang CC, Voors AA, Ng LL, Samani NJ. Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk. Circulation. 2020 Sep 15;142(11):1117-1119. doi: 10.1161/CIRCULATIONAHA.120.049007. Epub 2020 Jul 7. PMID: 32795093.

18: Kanagala P, Arnold JR, Singh A, Khan JN, Gulsin GS, Gupta P, Squire IB, Ng LL, McCann GP. Prevalence of right ventricular dysfunction and prognostic significance in heart failure with preserved ejection fraction. Int J Cardiovasc Imaging. 2021 Jan;37(1):255-266. doi: 10.1007/s10554-020-01953-y. Epub 2020 Jul 31. PMID: 32737707; PMCID: PMC7878207.

19: Runau F, Arshad A, Isherwood JD, Sandhu JK, Ng LL, Dennison AR, Jones DJL. Proteomic Characterization of Circulating Molecular Perturbations Associated With Pancreatic Adenocarcinoma Following Intravenous ω-3 Fatty Acid and Gemcitabine Administration: A Pilot Study. JPEN J Parenter Enteral Nutr. 2020 Jul 27. doi: 10.1002/jpen.1952. Epub ahead of print. PMID: 32716569.

20: Israr MZ, Salzano A, Yazaki Y, Voors AA, Ouwerkerk W, Anker SD, Cleland JG, Dickstein K, Metra M, Samani NJ, Ng LL, Suzuki T; BIOSTAT-CHF Consortium (see Appendix). Implications of serial measurements of natriuretic peptides in heart failure: insights from BIOSTAT-CHF. Eur J Heart Fail. 2020 Aug;22(8):1486-1490. doi: 10.1002/ejhf.1951. Epub 2020 Jul 30. PMID: 32666670.

21: Yazaki Y, Aizawa K, Israr MZ, Negishi K, Salzano A, Saitoh Y, Kimura N, Kono K, Heaney L, Cassambai S, Bernieh D, Lai F, Imai Y, Kario K, Nagai R, Ng LL, Suzuki T. Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients. ESC Heart Fail. 2020 Oct;7(5):2373-2378. doi: 10.1002/ehf2.12777. Epub 2020 Jun 29. PMID: 32598563; PMCID: PMC7524106.

22: Ouwerkerk W, Teng TK, Tromp J, Tay WT, Cleland JG, van Veldhuisen DJ, Dickstein K, Ng LL, Lang CC, Anker SD, Zannad F, Hung CL, Sawhney JPS, Naik A, Shimizu W, Hagiwara N, Wander GS, Anand I, Richards AM, Voors AA, Lam CSP. Effects of combined renin-angiotensin-aldosterone system inhibitor and beta- blocker treatment on outcomes in heart failure with reduced ejection fraction: insights from BIOSTAT-CHF and ASIAN-HF registries. Eur J Heart Fail. 2020 Aug;22(8):1472-1482. doi: 10.1002/ejhf.1869. Epub 2020 Jun 25. PMID: 32583922.

23: Sama IE, Ravera A, Santema BT, van Goor H, Ter Maaten JM, Cleland JGF, Rienstra M, Friedrich AW, Samani NJ, Ng LL, Dickstein K, Lang CC, Filippatos G, Anker SD, Ponikowski P, Metra M, van Veldhuisen DJ, Voors AA. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020 May 14;41(19):1810-1817. doi: 10.1093/eurheartj/ehaa373. PMID: 32388565; PMCID: PMC7239195.

24: Shi C, van der Wal HH, Silljé HHW, Dokter MM, van den Berg F, Huizinga L, Vriesema M, Post J, Anker SD, Cleland JG, Ng LL, Samani NJ, Dickstein K, Zannad F, Lang CC, van Haelst PL, Gietema JA, Metra M, Ameri P, Canepa M, van Veldhuisen DJ, Voors AA, de Boer RA. Tumour biomarkers: association with heart failure outcomes. J Intern Med. 2020 Aug;288(2):207-218. doi: 10.1111/joim.13053. Epub 2020 May 5. PMID: 32372544; PMCID: PMC7496322.

25: Kanagala P, Arnold JR, Singh A, Chan DCS, Cheng ASH, Khan JN, Gulsin GS, Yang J, Zhao L, Gupta P, Squire IB, Ng LL, McCann GP. Characterizing heart failure with preserved and reduced ejection fraction: An imaging and plasma biomarker approach. PLoS One. 2020 Apr 29;15(4):e0232280. doi: 10.1371/journal.pone.0232280. PMID: 32349122; PMCID: PMC7190371.

26: Sama IE, Woolley RJ, Nauta JF, Romaine SPR, Tromp J, Ter Maaten JM, van der Meer P, Lam CSP, Samani NJ, Ng LL, Metra M, Dickstein K, Anker SD, Zannad F, Lang CC, Cleland JGF, van Veldhuisen DJ, Hillege HL, Voors AA. A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure. Eur J Heart Fail. 2020 May;22(5):821-833. doi: 10.1002/ejhf.1811. Epub 2020 Apr 3. PMID: 32243695; PMCID: PMC7319432.

27: Henson J, Edwardson CL, Davies MJ, Gill JMR, Heaney LM, Khunti K, Ng L, Sattar N, Zaccardi F, Yates T. Physical activity and lipidomics in a population at high risk of type 2 diabetes mellitus. J Sports Sci. 2020 May;38(10):1150-1160. doi: 10.1080/02640414.2020.1744836. Epub 2020 Mar 30. PMID: 32228122.

28: Mordi IR, Ouwerkerk W, Anker SD, Cleland JG, Dickstein K, Metra M, Ng LL, Samani NJ, van Veldhuisen DJ, Zannad F, Voors AA, Lang CC. Heart failure treatment up-titration and outcome and age: an analysis of BIOSTAT-CHF. Eur J Heart Fail. 2021 Mar;23(3):436-444. doi: 10.1002/ejhf.1799. Epub 2020 Mar 25. PMID: 32216000.

29: Núñez J, Bayés-Genís A, Revuelta-López E, Ter Maaten JM, Miñana G, Barallat J, Cserkóová A, Bodi V, Fernández-Cisnal A, Núñez E, Sanchis J, Lang C, Ng LL, Metra M, Voors AA. Clinical Role of CA125 in Worsening Heart Failure: A BIOSTAT- CHF Study Subanalysis. JACC Heart Fail. 2020 May;8(5):386-397. doi: 10.1016/j.jchf.2019.12.005. Epub 2020 Mar 11. PMID: 32171764.

30: Kobayashi M, Stienen S, Ter Maaten JM, Dickstein K, Samani NJ, Lang CC, Ng LL, Anker SD, Metra M, Preud'homme G, Duarte K, Lamiral Z, Girerd N, Rossignol P, van Veldhuisen DJ, Voors AA, Zannad F, Ferreira JP. Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure. ESC Heart Fail. 2020 Jun;7(3):953-963. doi: 10.1002/ehf2.12634. Epub 2020 Mar 13. PMID: 32167681; PMCID: PMC7261568.

31: Tromp J, Voors AA, Sharma A, Ferreira JP, Ouwerkerk W, Hillege HL, Gomez KA, Dickstein K, Anker SD, Metra M, Lang CC, Ng LL, van der Harst P, van Veldhuisen DJ, van der Meer P, Lam CSP, Zannad F, Sama IE. Distinct Pathological Pathways in Patients With Heart Failure and Diabetes. JACC Heart Fail. 2020 Mar;8(3):234-242. doi: 10.1016/j.jchf.2019.11.005. Epub 2020 Feb 5. PMID: 32035890.

32: Kanagala P, Arnold JR, Singh A, Khan JN, Gulsin GS, Gupta P, Squire IB, Ng LL, McCann GP. Intra-study and inter-technique validation of cardiovascular magnetic resonance imaging derived left atrial ejection fraction as a prognostic biomarker in heart failure with preserved ejection fraction. Int J Cardiovasc Imaging. 2020 May;36(5):921-928. doi: 10.1007/s10554-020-01785-w. Epub 2020 Feb 6. PMID: 32030576; PMCID: PMC7174265.

33: Ter Maaten JM, Martens P, Damman K, Dickstein K, Ponikowski P, Lang CC, Ng LL, Anker SD, Samani NJ, Filippatos G, Cleland JG, Zannad F, Hillege HL, van Veldhuisen DJ, Metra M, Voors AA, Mullens W. Higher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction. Clin Res Cardiol. 2020 Aug;109(8):1048-1059. doi: 10.1007/s00392-020-01598-w. Epub 2020 Jan 30. PMID: 32002631; PMCID: PMC7375987.

34: Lombardi CM, Ferreira JP, Carubelli V, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Voors A, Metra M. Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study. Clin Res Cardiol. 2020 Aug;109(8):967-977. doi: 10.1007/s00392-019-01588-7. Epub 2020 Jan 29. PMID: 31996990.

35: Kloosterman M, Santema BT, Roselli C, Nelson CP, Koekemoer A, Romaine SPR, Van Gelder IC, Lam CSP, Artola VA, Lang CC, Ng LL, Metra M, Anker S, Filippatos G, Dickstein K, Ponikowski P, van der Harst P, van der Meer P, van Veldhuisen DJ, Benjamin EJ, Voors AA, Samani NJ, Rienstra M. Genetic risk and atrial fibrillation in patients with heart failure. Eur J Heart Fail. 2020 Mar;22(3):519-527. doi: 10.1002/ejhf.1735. Epub 2020 Jan 9. PMID: 31919934; PMCID: PMC7319410.

36: Bomer N, Grote Beverborg N, Hoes MF, Streng KW, Vermeer M, Dokter MM, IJmker J, Anker SD, Cleland JGF, Hillege HL, Lang CC, Ng LL, Samani NJ, Tromp J, van Veldhuisen DJ, Touw DJ, Voors AA, van der Meer P. Selenium and outcome in heart failure. Eur J Heart Fail. 2020 Aug;22(8):1415-1423. doi: 10.1002/ejhf.1644. Epub 2019 Dec 6. PMID: 31808274; PMCID: PMC7540257.

37: Norman RL, Singh R, Langridge JI, Ng LL, Jones DJL. The measurement of KRAS G12 mutants using multiplexed selected reaction monitoring and ion mobility mass spectrometry. Rapid Commun Mass Spectrom. 2020 Sep;34 Suppl 4(Suppl 4):e8657. doi: 10.1002/rcm.8657. Epub 2020 Feb 14. PMID: 31800120; PMCID: PMC7539944.

38: Hoes MF, Tromp J, Ouwerkerk W, Bomer N, Oberdorf-Maass SU, Samani NJ, Ng LL, Lang CC, van der Harst P, Hillege H, Anker SD, Metra M, van Veldhuisen DJ, Voors AA, van der Meer P. The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach. Eur J Heart Fail. 2020 Nov;22(11):2102-2111. doi: 10.1002/ejhf.1674. Epub 2019 Dec 3. PMID: 31797504; PMCID: PMC7754332.

39: Ferreira JP, Ouwerkerk W, Tromp J, Ng L, Dickstein K, Anker S, Filippatos G, Cleland JG, Metra M, van Veldhuisen DJ, Voors AA, Zannad F. Cardiovascular and non-cardiovascular death distinction: the utility of troponin beyond N-terminal pro-B-type natriuretic peptide. Findings from the BIOSTAT-CHF study. Eur J Heart Fail. 2020 Jan;22(1):81-89. doi: 10.1002/ejhf.1654. Epub 2019 Dec 2. PMID: 31793144.

40: Nauta JF, Hummel YM, Tromp J, Ouwerkerk W, van der Meer P, Jin X, Lam CSP, Bax JJ, Metra M, Samani NJ, Ponikowski P, Dickstein K, Anker SD, Lang CC, Ng LL, Zannad F, Filippatos GS, van Veldhuisen DJ, van Melle JP, Voors AA. Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment. Eur J Heart Fail. 2020 Jul;22(7):1147-1155. doi: 10.1002/ejhf.1632. Epub 2019 Nov 11. PMID: 31713324; PMCID: PMC7540540.

41: Kobayashi M, Voors AA, Girerd N, Billotte M, Anker SD, Cleland JG, Lang CC, Ng LL, van Veldhuisen DJ, Dickstein K, Metra M, Duarte K, Rossignol P, Zannad F, Ferreira JP. Heart failure etiologies and clinical factors precipitating for worsening heart failure: Findings from BIOSTAT-CHF. Eur J Intern Med. 2020 Jan;71:62-69. doi: 10.1016/j.ejim.2019.10.017. Epub 2019 Nov 8. PMID: 31708361.

42: Cao TH, Jones DJL, Voors AA, Quinn PA, Sandhu JK, Chan DCS, Parry HM, Mohan M, Mordi IR, Sama IE, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Metra M, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zannad F, Lang CC, Ng LL. Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets. Eur J Heart Fail. 2020 Jan;22(1):70-80. doi: 10.1002/ejhf.1608. Epub 2019 Nov 6. PMID: 31692186; PMCID: PMC7028019.

43: van der Wal HH, Grote Beverborg N, Dickstein K, Anker SD, Lang CC, Ng LL, van Veldhuisen DJ, Voors AA, van der Meer P. Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. Eur Heart J. 2019 Nov 21;40(44):3616-3625. doi: 10.1093/eurheartj/ehz680. PMID: 31556953; PMCID: PMC6868426.

44: Santema BT, Ouwerkerk W, Tromp J, Sama IE, Ravera A, Regitz-Zagrosek V, Hillege H, Samani NJ, Zannad F, Dickstein K, Lang CC, Cleland JG, Ter Maaten JM, Metra M, Anker SD, van der Harst P, Ng LL, van der Meer P, van Veldhuisen DJ, Meyer S, Lam CSP; ASIAN-HF investigators, Voors AA. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. Lancet. 2019 Oct 5;394(10205):1254-1263. doi: 10.1016/S0140-6736(19)31792-1. Epub 2019 Aug 22. PMID: 31447116.

45: Salzano A, Israr MZ, Yazaki Y, Heaney LM, Kanagala P, Singh A, Arnold JR, Gulsin GS, Squire IB, McCann GP, Ng LL, Suzuki T. Combined use of trimethylamine N-oxide with BNP for risk stratification in heart failure with preserved ejection fraction: findings from the DIAMONDHFpEF study. Eur J Prev Cardiol. 2020 Dec;27(19):2159-2162. doi: 10.1177/2047487319870355. Epub 2019 Aug 14. PMID: 31412713.

46: Kanagala P, Arnold JR, Cheng ASH, Singh A, Khan JN, Gulsin GS, Yang J, Zhao L, Gupta P, Squire IB, Ng LL, McCann GP. Left atrial ejection fraction and outcomes in heart failure with preserved ejection fraction. Int J Cardiovasc Imaging. 2020 Jan;36(1):101-110. doi: 10.1007/s10554-019-01684-9. Epub 2019 Aug 10. PMID: 31401742; PMCID: PMC6942575.

47: Yazaki Y, Salzano A, Nelson CP, Voors AA, Anker SD, Cleland JG, Lang CC, Metra M, Samani NJ, Ng LL, Suzuki T. Geographical location affects the levels and association of trimethylamine N-oxide with heart failure mortality in BIOSTAT-CHF: a post-hoc analysis. Eur J Heart Fail. 2019 Oct;21(10):1291-1294. doi: 10.1002/ejhf.1550. Epub 2019 Jul 28. PMID: 31353762.

48: Gulsin GS, Kanagala P, Chan DCS, Cheng ASH, Athithan L, Graham-Brown MPM, Singh A, Yang J, Li Z, Khunti K, Davies MJ, Arnold JR, Squire IB, Ng LL, McCann GP. Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes. Ther Adv Endocrinol Metab. 2019 Jul 5;10:2042018819861593. doi: 10.1177/2042018819861593. PMID: 31308926; PMCID: PMC6613057.

49: Santema BT, Chan MMY, Tromp J, Dokter M, van der Wal HH, Emmens JE, Takens J, Samani NJ, Ng LL, Lang CC, van der Meer P, Ter Maaten JM, Damman K, Dickstein K, Cleland JG, Zannad F, Anker SD, Metra M, van der Harst P, de Boer RA, van Veldhuisen DJ, Rienstra M, Lam CSP, Voors AA. The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure. Clin Res Cardiol. 2020 Mar;109(3):331-338. doi: 10.1007/s00392-019-01513-y. Epub 2019 Jul 1. Erratum in: Clin Res Cardiol. 2020 Nov 3;: PMID: 31263996; PMCID: PMC7042190.

50: Emmens JE, Ter Maaten JM, Damman K, van Veldhuisen DJ, de Boer RA, Struck J, Bergmann A, Sama IE, Streng KW, Anker SD, Dickstein K, Lang CC, Metra M, Samani NJ, Ng LL, Voors AA. Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure. Circ Heart Fail. 2019 May;12(5):e005544. doi: 10.1161/CIRCHEARTFAILURE.118.005544. PMID: 31091993.

51: Markousis-Mavrogenis G, Tromp J, Ouwerkerk W, Devalaraja M, Anker SD, Cleland JG, Dickstein K, Filippatos GS, van der Harst P, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, Zannad F, Zwinderman AH, Hillege HL, van Veldhuisen DJ, Kakkar R, Voors AA, van der Meer P. The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study. Eur J Heart Fail. 2019 Aug;21(8):965-973. doi: 10.1002/ejhf.1482. Epub 2019 May 14. PMID: 31087601.

52: Ibrahim W, Wilde M, Cordell R, Salman D, Ruszkiewicz D, Bryant L, Richardson M, Free RC, Zhao B, Yousuf A, White C, Russell R, Jones S, Patel B, Awal A, Phillips R, Fowkes G, McNally T, Foxon C, Bhatt H, Peltrini R, Singapuri A, Hargadon B, Suzuki T, Ng LL, Gaillard E, Beardsmore C, Ryanna K, Pandya H, Coates T, Monks PS, Greening N, Brightling CE, Thomas P, Siddiqui S. Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study. BMJ Open. 2019 Mar 8;9(3):e025486. doi: 10.1136/bmjopen-2018-025486. PMID: 30852546; PMCID: PMC6429860.

53: Ter Maaten JM, Kremer D, Demissei BG, Struck J, Bergmann A, Anker SD, Ng LL, Dickstein K, Metra M, Samani NJ, Romaine SPR, Cleland J, Girerd N, Lang CC, van Veldhuisen DJ, Voors AA. Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure. Eur J Heart Fail. 2019 Jun;21(6):732-743. doi: 10.1002/ejhf.1437. Epub 2019 Mar 6. PMID: 30843353.

54: Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL, McCann GP. Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction. JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 2):2291-2301. doi: 10.1016/j.jcmg.2018.11.031. Epub 2019 Feb 13. PMID: 30772227.

55: Kanagala P, Squire IB, Jones DJL, Cao TH, Chan DCS, McCann G, Sandhu JK, Quinn PA, McAdam J, Marsh AM, Davies JE, Struck J, Bergmann A, Sabti Z, Twerenbold R, Herrmann T, Kozhuharov N, Mueller C, Ng LL; GREAT (Global Research on Acute Conditions Team) Network. Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study. Clin Res Cardiol. 2019 Aug;108(8):940-949. doi: 10.1007/s00392-019-01424-y. Epub 2019 Feb 14. PMID: 30767059; PMCID: PMC6652170.

56: Mordi IR, Santema BT, Kloosterman M, Choy AM, Rienstra M, van Gelder I, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Metra M, Ng LL, Ouwerkerk W, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Voors AA, Lang CC. Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub- optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. Clin Res Cardiol. 2019 Jul;108(7):797-805. doi: 10.1007/s00392-018-1409-x. Epub 2019 Jan 4. PMID: 30610382; PMCID: PMC6584244.

57: Ferreira JP, Metra M, Anker SD, Dickstein K, Lang CC, Ng L, Samani NJ, Cleland JG, van Veldhuisen DJ, Voors AA, Zannad F. Clinical correlates and outcome associated with changes in 6-minute walking distance in patients with heart failure: findings from the BIOSTAT-CHF study. Eur J Heart Fail. 2019 Feb;21(2):218-226. doi: 10.1002/ejhf.1380. Epub 2019 Jan 1. PMID: 30600578.

58: Tromp J, Ouwerkerk W, Demissei BG, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Voors AA, van der Meer P. Novel endotypes in heart failure: effects on guideline-directed medical therapy. Eur Heart J. 2018 Dec 21;39(48):4269-4276. doi: 10.1093/eurheartj/ehy712. PMID: 30551207.

59: Streng KW, Nauta JF, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA. Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. Int J Cardiol. 2018 Nov 15;271:132-139. doi: 10.1016/j.ijcard.2018.04.001. Epub 2018 Jul 7. PMID: 30482453.

60: Cao TH, Jones DJL, Quinn PA, Chan DCS, Hafid N, Parry HM, Mohan M, Sandhu JK, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Metra M, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zannad F, Zwinderman AH, Voors AA, Lang CC, Ng LL. Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure. Clin Proteomics. 2018 Nov 2;15:35. doi: 10.1186/s12014-018-9213-1. PMID: 30410428; PMCID: PMC6214161.

61: Suzuki T, Yazaki Y, Voors AA, Jones DJL, Chan DCS, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Lang CC, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Metra M, Ng LL. Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure: results from BIOSTAT-CHF. Eur J Heart Fail. 2019 Jul;21(7):877-886. doi: 10.1002/ejhf.1338. Epub 2018 Oct 29. PMID: 30370976.

62: Ferreira JP, Metra M, Mordi I, Gregson J, Ter Maaten JM, Tromp J, Anker SD, Dickstein K, Hillege HL, Ng LL, van Veldhuisen DJ, Lang CC, Voors AA, Zannad F. Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study. Eur J Heart Fail. 2019 Jan;21(1):112-120. doi: 10.1002/ejhf.1323. Epub 2018 Oct 19. PMID: 30338883.

63: Tromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege HL, van der Meer P, Voors AA. Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction. J Am Coll Cardiol. 2018 Sep 4;72(10):1081-1090. doi: 10.1016/j.jacc.2018.06.050. PMID: 30165978.

64: Santema BT, Kloosterman M, Van Gelder IC, Mordi I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Van der Harst P, Hillege HL, Ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, Van der Meer P, Rienstra M, Voors AA. Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction. Eur Heart J. 2018 Nov 14;39(43):3867-3875. doi: 10.1093/eurheartj/ehy421. PMID: 30137304.

65: Streng KW, Voors AA, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Lang CC. Waist-to-hip ratio and mortality in heart failure. Eur J Heart Fail. 2018 Sep;20(9):1269-1277. doi: 10.1002/ejhf.1244. Epub 2018 Jul 2. PMID: 29963737.

66: Israr MZ, Heaney LM, Ng LL, Suzuki T. B-type natriuretic peptide molecular forms for risk stratification and prediction of outcome after acute myocardial infarction. Am Heart J. 2018 Jun;200:37-43. doi: 10.1016/j.ahj.2018.02.016. Epub 2018 Mar 3. PMID: 29898847.

67: Vanezis AP, Arnold JR, Rodrigo G, Lai FY, Debiec R, Nazir S, Khan JN, Ng LL, Chitkara K, Coghlan JG, Hetherington SL, McCann GP, Samani NJ. Daily remote ischaemic conditioning following acute myocardial infarction: a randomised controlled trial. Heart. 2018 Dec;104(23):1955-1962. doi: 10.1136/heartjnl-2018-313091. Epub 2018 May 10. PMID: 29748420; PMCID: PMC6252375.

68: Yuyun MF, Ng LL, Ng GA. Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy? Microvasc Res. 2018 Sep;119:7-12. doi: 10.1016/j.mvr.2018.03.012. Epub 2018 Mar 27. PMID: 29596860.

69: Ouwerkerk W, Zwinderman AH, Ng LL, Demissei B, Hillege HL, Zannad F, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Ter Maaten JM, Lang CC, van der Harst P, Filippatos G, Dickstein K, Cleland JG, Anker SD, Voors AA. Biomarker- Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF. J Am Coll Cardiol. 2018 Jan 30;71(4):386-398. doi: 10.1016/j.jacc.2017.11.041. PMID: 29389354.

70: Beusekamp JC, Tromp J, van der Wal HH, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Rossignol P, Zannad F, Voors AA, van der Meer P. Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT- CHF. Eur J Heart Fail. 2018 May;20(5):923-930. doi: 10.1002/ejhf.1079. Epub 2018 Jan 12. PMID: 29327797.

71: Kanagala P, Cheng ASH, Singh A, McAdam J, Marsh AM, Arnold JR, Squire IB, Ng LL, McCann GP. Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in heart failure with preserved ejection fraction - implications for clinical trials. J Cardiovasc Magn Reson. 2018 Jan 11;20(1):4. doi: 10.1186/s12968-017-0424-9. PMID: 29321034; PMCID: PMC5763769.

72: Ter Maaten JM, Voors AA, Damman K, van der Meer P, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Navis G, Ng L, Ouwerkerk W, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, de Borst MH. Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure. Int J Cardiol. 2018 Feb 15;253:84-90. doi: 10.1016/j.ijcard.2017.10.010. PMID: 29306478.

73: Emmens JE, Jones DJL, Cao TH, Chan DCS, Romaine SPR, Quinn PA, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Lang CC, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Metra M, de Boer RA, Voors AA, Ng LL. Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure. Eur J Heart Fail. 2018 Feb;20(2):260-267. doi: 10.1002/ejhf.1101. Epub 2017 Dec 18. PMID: 29251807.

74: Singh A, Chan DCS, Greenwood JP, Dawson DK, Sonecki P, Hogrefe K, Kelly DJ, Dhakshinamurthy V, Lang CC, Khoo JP, Sprigings D, Steeds RP, Zhang R, Ford I, Jerosch-Herold M, Yang J, Li Z, Ng LL, McCann GP. Symptom Onset in Aortic Stenosis: Relation to Sex Differences in Left Ventricular Remodeling. JACC Cardiovasc Imaging. 2019 Jan;12(1):96-105. doi: 10.1016/j.jcmg.2017.09.019. Epub 2017 Dec 13. PMID: 29248646.

75: Siong Chan DC, Cao TH, Ng LL. Proenkephalin in Heart Failure. Heart Fail Clin. 2018 Jan;14(1):1-11. doi: 10.1016/j.hfc.2017.08.001. Epub 2017 Sep 28. PMID: 29153195.

76: Bayes-Genis A, Núñez J, Zannad F, Ferreira JP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Metra M, Lupón J, Voors AA. The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis. J Am Coll Cardiol. 2017 Oct 24;70(17):2128-2136. doi: 10.1016/j.jacc.2017.08.057. PMID: 29050560.

77: Ferreira JP, Rossignol P, Demissei B, Sharma A, Girerd N, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Voors A, Zannad F. Coronary angiography in worsening heart failure: determinants, findings and prognostic implications. Heart. 2018 Apr;104(7):606-613. doi: 10.1136/heartjnl-2017-311750. Epub 2017 Aug 10. PMID: 28798192.

78: Ferreira JP, Rossignol P, Machu JL, Sharma A, Girerd N, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Lang CC, Ter Maaten JM, Metra M, Ng L, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Voors A, Zannad F. Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF. Eur J Heart Fail. 2017 Oct;19(10):1284-1293. doi: 10.1002/ejhf.900. Epub 2017 Jun 5. PMID: 28580625.

79: Voors AA, Ouwerkerk W, Zannad F, van Veldhuisen DJ, Samani NJ, Ponikowski P, Ng LL, Metra M, Ter Maaten JM, Lang CC, Hillege HL, van der Harst P, Filippatos G, Dickstein K, Cleland JG, Anker SD, Zwinderman AH. Development and validation of multivariable models to predict mortality and hospitalization in patients with heart failure. Eur J Heart Fail. 2017 May;19(5):627-634. doi: 10.1002/ejhf.785. Epub 2017 Mar 1. PMID: 28247565.

80: Suzuki T, Israr MZ, Heaney LM, Takaoka M, Squire IB, Ng LL. Prognostic Role of Molecular Forms of B-Type Natriuretic Peptide in Acute Heart Failure. Clin Chem. 2017 Apr;63(4):880-886. doi: 10.1373/clinchem.2016.265140. Epub 2017 Feb 9. PMID: 28183728.

81: Suzuki T, Heaney LM, Jones DJ, Ng LL. Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction. Clin Chem. 2017 Jan;63(1):420-428. doi: 10.1373/clinchem.2016.264853. Epub 2016 Nov 8. Erratum in: Clin Chem. 2017 Apr;63(4):926. PMID: 28062632.

82: Ng LL, Squire IB, Jones DJL, Cao TH, Chan DCS, Sandhu JK, Quinn PA, Davies JE, Struck J, Hartmann O, Bergmann A, Mebazaa A, Gayat E, Arrigo M, Akiyama E, Sabti Z, Lohrmann J, Twerenbold R, Herrmann T, Schumacher C, Kozhuharov N, Mueller C; GREAT Network. Proenkephalin, Renal Dysfunction, and Prognosis in Patients With Acute Heart Failure: A GREAT Network Study. J Am Coll Cardiol. 2017 Jan 3;69(1):56-69. doi: 10.1016/j.jacc.2016.10.038. PMID: 28057251.

83: Hudson SR, Chan D, Ng LL. Change in plasma volume and prognosis in acute decompensated heart failure: an observational cohort study. J R Soc Med. 2016 Sep;109(9):337-46. doi: 10.1177/0141076816661316. PMID: 27609799; PMCID: PMC5017520.

84: Mbasu RJ, Heaney LM, Molloy BJ, Hughes CJ, Ng LL, Vissers JP, Langridge JI, Jones DJ. Advances in quadrupole and time-of-flight mass spectrometry for peptide MRM based translational research analysis. Proteomics. 2016 Aug;16(15-16):2206-20. doi: 10.1002/pmic.201500500. Epub 2016 Jul 28. PMID: 27214876.

85: Voors AA, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Ter Maaten JM, Ng L, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Metra M. A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure: rationale, design, and baseline characteristics of BIOSTAT-CHF. Eur J Heart Fail. 2016 Jun;18(6):716-26. doi: 10.1002/ejhf.531. Epub 2016 Apr 29. PMID: 27126231.

86: Suzuki T, Heaney LM, Bhandari SS, Jones DJ, Ng LL. Trimethylamine N-oxide and prognosis in acute heart failure. Heart. 2016 Jun 1;102(11):841-8. doi: 10.1136/heartjnl-2015-308826. Epub 2016 Feb 11. PMID: 26869641.

87: Yuyun MF, Narayan HK, Quinn PA, Struck J, Bergmann A, Hartmann O, Ng LL. Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown). 2017 Jan;18(1):42-50. doi: 10.2459/JCM.0000000000000299. PMID: 26766169.

88: Bhandari SS, Narayan H, Jones DJ, Suzuki T, Struck J, Bergmann A, Squire IB, Ng LL. Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure. Eur J Heart Fail. 2016 Mar;18(3):281-9. doi: 10.1002/ejhf.459. Epub 2015 Dec 15. PMID: 26670643.

89: Seronde MF, Vausort M, Gayat E, Goretti E, Ng LL, Squire IB, Vodovar N, Sadoune M, Samuel JL, Thum T, Solal AC, Laribi S, Plaisance P, Wagner DR, Mebazaa A, Devaux Y; GREAT network. Circulating microRNAs and Outcome in Patients with Acute Heart Failure. PLoS One. 2015 Nov 18;10(11):e0142237. doi: 10.1371/journal.pone.0142237. PMID: 26580972; PMCID: PMC4651494.

90: Heaney LM, Jones DJ, Mbasu RJ, Ng LL, Suzuki T. High mass accuracy assay for trimethylamine N-oxide using stable-isotope dilution with liquid chromatography coupled to orthogonal acceleration time of flight mass spectrometry with multiple reaction monitoring. Anal Bioanal Chem. 2016 Jan;408(3):797-804. doi: 10.1007/s00216-015-9164-6. Epub 2015 Nov 14. PMID: 26573169.

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  • studies on the role of cardiovascular peptides in heart disease

  • the use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments

  • use of proteomic technologies in biomarker discovery

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