Professor Leong Loke Ng

Professor of Medicine and Therapeutics, University of Leicester

Honorary Consultant Physician, Cardiovascular Unit, University Hospitals of Leicester NHS Trust

Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester LE3 9QP

Tel: +44 (0)116 250 2449

Email: lln1@le.ac.uk

Personal details

Qualifications

  • BA (Medical Sciences Tripos (1st Class), Cambridge, 1976
  • MB B Chir (Distinction), Cambridge, 1979
  • MRCP (UK), London, 1982
  • MD, Cambridge, 1988
  • FRCP, London, 1996
  • FBPhS, 2012

External positions

  • External Examiner for PhD, MD (Universities of Oxford, Manchester, Birmingham, London, Melbourne)
  • Editorial Advisory Board, Clinical Science
  • Secretary and Member of SAC, Clinical Pharmacology and Therapeutics

Website

Publications

Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Struck J, Bergmann A, Maisel A, Jones DJL. Pro-substance P for evaluation of risk in acute myocardial infarctionJ Am Coll Cardiol., 2014; 64, pp. 1698-707.

Daly CE, Ng LL, Hakimi A, Willingale R, Jones DJ. Qualitative and quantitative characterization of plasma proteins when incorporating traveling wave ion mobility into a liquid chromatography-mass spectrometry workflow for biomarker discovery: use of product ion quantitation as an alternative data analysis tool for label free quantitation. Anal Chem., 2014; 86, pp. 1972-9.

Hakimi A, Auluck J, Jones GD, Ng LL, Jones DJ. Assessment of reproducibility in depletion and enrichment workflows for plasma proteomics using label-free quantitative data-independent LC-MS. Proteomics, 2014; 14(1), pp. 4-13.

Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Bergmann A, Maisel A, Jones DJ. Proenkephalin and prognosis after acute myocardial infarction. J Am Coll Cardiol., 2014; 63(3), pp. 280-9.

Maisel A, Mueller C, Nowak RM, Peacock AF, Ponikowski P, Mockel M, Hogan C, Wu AHB, Richards M, Clopton O, Filippatos GS, Di Somma S, Anand I, Ng LL, Daniels LB, Neath S-X, Christenson R, Potocki M, McCord J, Hartmann O, Morgenthaler NG, and Anker SD. Midregion Prohormone Adrenomedullin and Prognosis in Patients Presenting With Acute Dyspnea. Results From the BACH (Biomarkers in Acute Heart Failure) TrialJ Am Coll Cardiol., 2011; 58, pp. 1057-67.

Maisel A, Mueller C, Nowak R, Peacock WF, Ponikowski P, Möckel M, Hogan C, Wu A, Richards M, Clopton P, Filippatos G, Di Somma S, Anand I, Ng L, Daniels L, Neath S-X, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler N, Anker S. Mid-Region ProHormone Markers for Diagnosis and Prognosis in Acute Dyspnea: Results from the BACH (Biomarkers in ACute Heart failure) TrialJ Am Coll Cardiol., 2010; 55, pp. 2062–76.

Dhillon OS, Khan SQ, Narayan HK, Ng KH, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL. Prognostic value of mid-regional pro-adrenomedullin levels taken on admission and discharge in non-ST-elevation myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) II study. J Am Coll Cardiol., 2010; 56(2), pp. 125-33.

Khan SQ, Ng K, Dhillon O, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL.  Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarctionEur Heart J., 2009; 30(9), pp. 1057-65.

Khan SQ, Dhillon O, Kelly D, Squire IB, Struck J, Quinn P, Morgenthaler NG, Bergmann A, Davies JE, Ng LL. Plasma N-terminal B-Type natriuretic peptide as an indicator of long-term survival after acute myocardial infarction: comparison with plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) study J Am Coll Cardiol., 2008; 51, pp. 1857-64.

Khan SQ, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL.  Prognostic value of Mid-regional pro-Adrenomedullin in Patients With Acute Myocardial Infarction. Leicester Acute Myocardial Infarction Peptide (LAMP) Study. J Am Coll Cardiology, 2007; 49, pp. 1525-32.

Willingale R, Jones DJL, Lamb JH, Quinn PA, Farmer PB, Ng LL.   Searching for biomarkers of heart failure in the mass spectra of blood plasma. Proteomics, 2006; 6, pp. 5903-14.

Jones DJL, Willingale R, Quinn PA, Lamb JH, Farmer PB, Davies JE, Ng LL.   Improving the diagnostic accuracy of N-terminal B-type natriuretic peptide in human systolic heart failure by plasma profiling using mass spectrometry. J Proteome Research, 2007; 6, pp. 3329-3334.

Emberson JR, Ng LL, Armitage J, Bowman L, Parish S, Collins R.  N-terminal pro-B-type natriuretic peptide, vascular disease risk and cholesterol reduction among 20 536 patients in the MRC/BHF Heart Protection StudyJ Am College Cardiology, 2007; 49, pp. 311-319.

Khan SQ, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL.  C-terminal proVasopressin (Copeptin) as a Novel and Prognostic Marker In Acute Myocardial Infarction- Leicester Acute Myocardial Infarction Peptide  (LAMP) Study. Circulation, 2007; 115, pp. 2103-2110.

Ng LL, Loke I, Davies JE, Geeranavar S, Khunti K, Stone M, Chin DT, Squire IB.  Community screening for heart failure using plasma and urinary natriuretic peptides. Journal of American College of Cardiology, 2005; 45, pp. 1043-50.

Ng LL, Loke I, O’Brien RJ, Squire IB, Davies JE.  Plasma Urotensin in Human Systolic Heart Failure. Circulation, 2002; 106, pp. 2877-2880.

Omland T, Persson A, Ng LL, O’Brien R, Karlsson T, Herlitz J, Hartford M, Caidahl K.  N-terminal Pro-B-type Natriuretic Peptide and Long-Term Mortality in Acute Coronary Syndromes. Circulation, 2002; 106, pp. 2913-2918.

Recent papers

Book chapters

Research

  • studies on the role of cardiovascular peptides in heart disease

  • the use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments

  • use of proteomic technologies in biomarker discovery

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