Recent Papers - Professor G André Ng

Publications (last 5 years) by Professor G André Ng, Department of Cardiovascular Sciences, University of Leicester

Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G; EAST-AFNET 4 Trial Investigators. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020 Aug 29. doi: 10.1056/NEJMoa2019422.

Li X, Almeida TP, Dastagir N, Guillem MS, Salinet J, Chu GS, Stafford PJ, Schlindwein FS, Ng GA. Standardizing Single-Frame Phase Singularity Identification Algorithms and Parameters in Phase Mapping During Human Atrial Fibrillation. Front Physiol. 2020 Jul 21;11:869. doi: 10.3389/fphys.2020.00869.

Koeckerling D, Barker J, Mudalige NL, Oyefeso O, Pan D, Pareek M, Thompson JP, Ng GA. Awake prone positioning in COVID-19. Thorax. 2020 Jun 16:thoraxjnl-2020-215133. doi: 10.1136/thoraxjnl-2020-215133.

Zakeri R, Morgan JM, Phillips P, Kitt S, Ng GA, McComb JM, Williams S, Wright DJ, Gill JS, Seed A, Witte KK, Cowie MR; REM-HF Investigators. Prevalence and prognostic significance of device-detected subclinical atrial fibrillation in patients with heart failure and reduced ejection fraction. Int J Cardiol. 2020 Mar 3. pii: S0167-5273(19)34926-5. doi: 10.1016/j.ijcard.2020.03.008.

Chin SH, Allen E, Brack KE, Ng GA. Effects of sympatho-vagal interaction on ventricular electrophysiology and their modulation during beta-blockade. J Mol Cell Cardiol. 2020 Jan 29;139:201-212. doi: 10.1016/j.yjmcc.2020.01.011.

Zakeri R, Morgan JM, Phillips P, Kitt S, Ng GA, McComb JM, Williams S, Wright DJ, Gill JS, Seed A, Witte KK, Cowie MR; REM-HF Investigators. Impact of remote monitoring on clinical outcomes for patients with heart failure and atrial fibrillation: results from the REM-HF trial. Eur J Heart Fail. 2020 Jan 7. doi: 10.1002/ejhf.1709.

Mistry A, Vali Z, Sidhu B, Budgeon C, Yuyun MF, Pooranachandran V, Li X, Newton M, Watts J, Khunti K, Samani NJ, Ng GA. Disparity in implantable cardioverter defibrillator therapy among minority South Asians in the United Kingdom. Heart. 2020 Jan 10. pii: heartjnl-2019-315978. doi: 10.1136/heartjnl-2019-315978.

Almeida TP, Li X, Soriano DC, Schlindwein FS, Ng GA. Pitfalls in the definition of complex fractionated atrial electrograms for atrial fibrillation studies. J Cardiovasc Electrophysiol. 2019 Dec 4. doi: 10.1111/jce.14302.

Willems S, Meyer C, de Bono J, Brandes A, Eckardt L, Elvan A, van Gelder I, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Haeusler KG, Kautzner J, Mont L, Ng GA, Szumowski L, Themistoclakis S, Wegscheider K, Kirchhof P. Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation. Eur Heart J. 2019 Dec 7;40(46):3793-3799c.

Mistry A, Vali Z, Taher A, Sidhu B, Li X, Newton M, Ng GA. Consideration for primary prevention implantable cardioverter defibrillators differ between specialities. Postgrad Med J. 2019 Apr;95(1122):205-209.

Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 Aug;597(15):3867-3883.

Hausenloy DJ, Botker HE, Ferdinandy P, Heusch G, Ng GA, Redington A, Garcia-Dorado D, on behalf of the EU-CARDIOPROTECTION COST Action (CA16225). Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection. Cardiovascular Research 2019. pii: cvz053. doi: 10.1093/cvr/cvz053.

Almeida TP, Schlindwein FS, Salinet JL, Li X, Chu GS, Tuan JH, Stafford PJ, Ng GA, Soriano DC. The temporal stability of recurrence quantification analysis attributes from chronic atrial fibrillation electrograms. Research on Biomedical Engineering 2019 (in press)

O’Shea C, Holmes AP, Yu TY, Winter J, Wells SP, Correia J, Boukens BJ, De Groot JR, Chu GS, Li X, Ng GA, Kirchhof P, Fabritz L, Rajpoot K, Pavlovic D. ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology. Nature – Scientific Reports 2019;9(1):1389. doi: 10.1038/s41598-018-38263-2.

Vanheusden FJ, Chu GS, Li X, Salinet J, Almeida TP, Dastagir N, Stafford PJ, Ng GA, Schlindwein FS. Systematic differences of non-invasive dominant frequency estimation compared to invasive dominant frequency estimation in atrial fibrillation. Comput Biol Med. 2018 pii: S0010-4825(18)30379-2. doi: 10.1016/j.compbiomed.2018.11.017.

Ng GA, Mistry A, Schlindwein FS, Nicolson WB. LifeMap: towards the development of a new technology in sudden cardiac death risk stratification for clinical use. Europace 2018;20(FI2):f162-f170. doi: 10.1093/europace/euy080.

Patel V, Karteris E, Chen J, Kyrou I, Mattu HS, Dimitriadis GK, Rodrigo G, Antoniades C, Antonopoulos A, Tan BK, Hillhouse EW, Ng A, Randeva H. Functional Cardiac Orexin Receptors: Role of Orexin-B/Orexin 2 Receptor in Myocardial Protection. Clin Sci (Lond). 2018 Nov 22. pii: CS20180150. doi: 10.1042/CS20180150.

Almeida TP, Schlindwein FS, Salinet J, Li X, Chu GS, Tuan JH, Stafford PJ, André Ng G, Soriano DC. Characterization of human persistent atrial fibrillation electrograms using recurrence quantification analysis. Chaos. 2018 Aug;28(8):085710. doi: 10.1063/1.5024248.

Trethewey SP, Nicolson WB, Ng GA. Investigation of the relationship between two novel electrocardiogram-based sudden cardiac death risk markers and autonomic function. Journal of Electrocardiology. 2018;51:889-894.

Somani R, Ng GA, Hobson NA, Redfearn DP, Caldwell JC. A comparison of the efficacy of voltage-directed cavotricuspid isthmus ablation using mini versus conventional electrodes. Journal of Innovations in Cardiac Rhythm Management. 2018;9:3198-3203. DOI:10.19102/icrm.2018.090603

Allen E, Coote JH, Grubb BD, Batten TF, Pauza DH, Brack KE, Ng GA. The electrophysiological effects of nicotinic and electrical stimulation of intrinsic cardiac ganglia in the absence of extrinsic autonomic nerves in the rabbit heart.Heart Rhythm 2018 pii: S1547-5271(18)30505-8. doi:10.1016/j.hrthm.2018.05.018.

Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM. Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. 2018 Jun 25. doi: 10.1113/JP276396.

Fitzpatrick C, Chatterjee S, Seidu S, Bodicoat DH, Ng GA, Davies MJ, Khunti K. Association of hypoglycaemia and cardiac arrhythmia risk in patients with diabetes mellitus: A systematic review and meta‐analysis. Diabetes, Obersity and Metabolism. 2018 doi:10.1111/dom.13348.

Yuyun MF, Ng LL, Ng GAEndothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy? Microvasc Res. 2018 doi: 10.1016/j.mvr.2018.03.012.

Chauhan RA, Coote JH, Allen E, Pongpaopattanakul P, Brack KE, Ng GA. Functional selectivity of cardiac preganglionic sympathetic neurones in the heart. International Journal of Cardiology 2018 doi: 10.1016/j.ijcard.2018.03.119

Yuyun MF, Squire IB, Ng GA, Samani NJ. Evidence for reduced susceptibility to cardiac bradycardias in South Asians compared with Caucasians. Heart 2018 doi: 10.1136/heartjnl-2017-312374

Chauhan RA, Coote JH, Allen E, Pongpaopattanakul P, Brack KE, Ng GA. Data highlighting the effects of spinal segmental stimulation of preganglionic sympathetic neutrons on the electrophysiology of the heart. International Journal of Cardiology 2018 doi:10.1016/j.dib.2018.04.077

Ng GA. Adrenergic control mechanisms of heart rate - down to a T? J Physiol 2018 doi:10.1113/JP275711

Grimaldi M, Swarup V, DeVille B, Sussman J, Jaïs P, Gaita F, Duytschaever M, Ng GA, Daoud E, Lakkireddy DD, Horton R, Wickliffe A, Ellis C, Geller L. Importance of anticoagulation and postablation silent cerebral lesions: Subanalyses of REVOLUTION and reMARQable studies. Pacing Clin Electrophysiol. 2017 Oct 4. doi: 10.1111/pace.13205.

Lobo MD, Ott C, Sobotka PA, Saxena M, Stanton A, Cockcroft JR, Sulke N, Dolan E, van der Giet M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszewicz A, Schoors D, Tsioufis K, Rensing BJ, Scott B, Ng GA, Schmieder RE. Central Iliac Arteriovenous Anastomosis for Uncontrolled Hypertension: One-Year Results From the ROX CONTROL HTN Trial. Hypertension. 2017 Dec;70(6):1099-1105.

Almeida TP, Chu GS, Li X, Dastagir N, Tuan JH, Stafford PJ, Schlindwein FS, Ng GA. Atrial electrogram fractionation distribution before and after pulmonary vein isolation in human persistent atrial fibrillation - a retrospective multivariate statistical analysis. Front Physiol 8:589:1-12 doi: 10.3389/fphys.2017.00589

Almeida TP, Chu GS, Bell MJ, Li X, Salinet JL, Dastagir N, Tuan JH, Stafford PJ, Ng GA, Schlindwein FS. The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation. Med Biol Eng Comput. 2017 doi:10.1007/s11517-017-1667-1

Morgan JM, Kitt S, Gill J, McComb JM, Ng GA, Raftery J, Roderick P, Seed A, Williams SG, Witte KK, Wrght DJ, Harris S, Cowie MR. Remote management of heart failure using implantable electronic devices. European Heart Journal 2017;38(30):2352-2360.

Salinet J, Schlindwein FS, Stafford P, Almeida TP, Li X, Vanheusden FJ, Guillem MS, Ng GA. Propagation of meandering rotors surrounded by high dominant frequency areas in persistent atrial fibrillation. Heart Rhythm 2017;14(9):1269-1278.

Li X, Salinet JL, Almeida TP, Vanheusden FJ, Chu GS, Ng GA, Schlindwein FS. An interactive platform to guide catheter ablation in human persistent atrial fibrillation using dominant frequency, organiszation and phase mapping. Comput Methods Programs Biomed. 2017;141:83-92. DOI: 10.1016/j.cmpb.2017.01.011

Ott C, Lobo MD, Sobotka PA, Mahfoud F, Stanton A, Cockcroft J, Sulke N, Dolan E, van der Giet M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszewicz A, Schoors D, Tsioufis K, Rensing BJ, Saxena M, Scott B, Ng GA, Achenbach S, Schmieder RE. Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension. Journal of the American Heart Association 2016 Dec 21;5(12). pii: e004234. doi: 10.1161/JAHA.116.004234.

Ng GA. Feasibility of selection of antiarrhythmic drug treatment on the basis of arrhythmogenic mechanism - relevance of electrical restitution, wavebreak and rotors. Pharmacology and Therapeutics 2016; 5(12). pii: e004234. doi:10.1016/j.pharmthera.2016.10.002

Melgari D, Ng GA, Hancox JC."Ivabradine: Role in the Chronic Heart Failure Armamentarium". Circulation. 2016 Sep 27;134(13):e296-7. doi: 10.1161/CIRCULATIONAHA.116.023752. (Letter)

Ng GA. Neuro-cardiac interaction in malignant ventricular arrhythmia and sudden cardiac death. Autonomic Neuroscience 2016 doi:10.1016/j.autneu.2016.07.001

Salinet JL, Masca N, Stafford PJ, Ng GA, Schlindwein FS. Three-dimensional dominant frequency mapping using autoregressive spectral analysis of atrial electrograms of patients in persistent atrial fibrillation. Biomed Eng Online. 2016 Mar 8 15 1 28

A Goette, JL Merino, MD Ezekowitz, D Zamoryakhin, M Melino, J Jin,Ezekowitz MD, Zamoryakhin D, Melino M, Jin J, Mercuri MF, Grosso MA, Fernandez V, Al-Saady N, Pelekh N, Merkely B, Zenin S, Kushnir M, Spinar J, Batushkin V, de Groot JR, Lip GY; ENSURE-AF investigators. Edoxaban versus enoxaparin–warfarin in patients undergoing cardioversion of atrial fibrillation (ENSURE-AF): a randomised, open-label, phase 3b trial. The Lancet 2016; 388(10055), 1995-2003.

Almeida TP, Chu GS, Salinet JL, Vanheusden FJ, Li X, Tuan JH, Stafford PJ, Ng GA, Schlindwein FS. Minimizing discordances in automated classification of fractionated electrograms in human persistent atrial fibrillation Med Biol Eng Comput. 2016;54(11):1695-1706.

Hancox JC, Melgari D, Dempsey CE, Brack KE, Mitcheson J, Ng GA. hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes Ther Adv Drug Saf. 2015; 6(4):177-9.

Melgari D, Brack KE, Zhang Y, El Harchi A, Mitcheson JS, Dempsey CE, Ng GA, Hancox JC. hERG potassium channel inhibition by ivabradine requires channel gating. J Mol Cell Cardiol. 2015;87:126-8.

Chu GS, Coviello I, Mollo R, Ng GA. Successful Ablation of Atrial Fibrillation by Targeting Fractionation in a Left-Sided Superior Vena Cava. J Cardiovasc Electrophysiol. 2015 May 21 Epub

Mahida S, Hooks DA, Nentwich K, Ng GA, Grimaldi M, Shin DI, Derval N, Sacher F, Berte B, Yamashita S, Denis A, Hocini M, Deneke T, Haissaguerre M, Jais P. nMARQ Ablation for Atrial Fibrillation: Results from a Multicentre Study. J Cardiovasc Electrophysiol. 2015 Jul 26;(7):724-9. doi: 10.1111/jce.12698.

Melgari D, Brack KE, Zhang C, Zhang Y, El Harchi A, Mitcheson JS, Dempsey CE, Ng GA, Hancox JC. hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine. J Am Heart Assoc. 2015;

Shebani SO, Ng GA, Stafford P, Duke C. Radiofrequency ablation on veno-arterial extracorporeal life support in treatment of very sick infants with incessant tachymyopathy. Europace 2015 Apr;17(4):622-7. doi: 10.1093/europace/euu365.

Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J 2015;1;36(5):255-6. doi: 10.1093/eurheartj/ehu476.

Lobo MD, Sobotka PA, Stanton A, Cockroft JR, Silke N, Dolan E, van der Geit M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszwicz A, Schoors D, Tsoufis K, Rensing BJ, Scott B, Ng GA, Ott C, Schmeider RE for the ROX CONTROL HTN Investigators, et al. Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial. Lancet 2015 doi: 10.1016/S0140-6736(14)62053-5

Morgan JM, Dimitrov BD, Gill J, Kitt S, Ng GA, McComb JM, Raftery J, Roderick P, Seed A, Williams SG, Witte KK, Wright DJ, Yao GL, Cowie MR. Rationale and study design of the REM-HF study: remote management of heart failure using implanted devices and formalized follow-up procedures. Eur J Heart Fail. 2014 doi: 10.1002/ejhf.149.

Nicolson WB, McCann GP, Smith MI, Sandilands AJ, Stafford PJ, Schlindwein FS, Samani NJ, Ng GA. Prospective evaluation of two novel ECG-based restitution biomarkers for prediction of sudden cardiac death risk in ischaemic cardiomyopathy. Heart 2014 doi: 10.1136/heartjnl-2014-305672.

Coote JH, Brack KE, Ng GA. Does the cervical vagus contain sympathetic fibres that act on the heart? Re: Seki A et al (2014). Sympathetic nerve fibres in human cervical and thoracic vagus nerves. Heart Rhythm doi:10.1016/ j.hrthm.2014.04.032, Heart Rhythm,

Sims MW, Winter J, Brennan S, Norman RI, Ng GA, Squire IB, Rainbow RD. PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function. Am J Physiol Heart Circ Physiol. 2014 Jun 20. pii: ajpheart.00894.2013.

Winter J, Brack KE, Coote JH, Ng GA. Cardiac contractility modulation increases action potential duration dispersion and decreases ventricular fibrillation threshold via <beta>1-adrenoceptor activation in the crystalloid perfused normal heart. International Journal of Cardiology 2014 doi:10.1016/j.ijcard.2013.12.184

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