Professor G. André Ng

Research focus in - Sudden Cardiac Death prediction and prevention - Atrial Fibrillation mechanisms

Dr G Andre NgProfessor of Cardiac Electrophysiology
Consultant Cardiologist and Electrophysiologist

Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester, LE3 9QP

Tel: +44 (0)116 250 2438

Email: gan1@le.ac.uk

 

Personal details

  • MB ChB (commendation), Glasgow, 1989
  • MRCP (UK), 1992
  • PhD, Glasgow, 1998
  • FRCP, Glasgow, 2003 (Fellow of the Royal College of Physicians and Surgeons of Glasgow)
  • FRCP, London, 2005 (Fellow of the Royal College of Physicians)
  • FESC, 2010 (Fellow of the European Society of Cardiology)
  • FHEA, 2017 (Fellow of the Higher Education Academy)
  • FEHRA, 2017 (Fellow of the European Heart Rhythm Association)
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    External positions

    • Chair (2009 - 2018), Specialist Training Committee, East Midlands South Deanery
    • Director (2009 - 2018), Higher Specialist Training, Cardiology Programme, HEE-East Midlands (South)
    • Specialist Adviser (2010-13), NICE Interventional Procedures Programme
    • Member (2012 - 2016), Specialist Advisory Committee, Cardiology, JRCPTB, Royal College of Physicians
    • Member (2011 - 2017), REM-HF Steering Committee
    • Member (2017 - ), British Heart Foundation Project Grants Committee
    • Elected Member (2016 - ), British Cardiovascular Society Programme Committee
    • Member (2018 - ), University of Leicester Centre for Black, Minority Ethnic Health, Steering Committee
    • Member (04/2018 - ), Clinical Senate, University Hospitals of Leicester NHS Trust
    • Deputy Lead (04/2018 - ), NIHR Leicester Biomedical Research Centre, Cardiovascular Theme
    • Regional Specialty Adviser (7/2018 - ), British Cardiovascular Society / Royal College of Physicians
    • Member (2018 - ), LD3, Leicester Precision Medicine Institute, Steering Committee
    • Academic Lead (2018 - ), NIHR-BHF Cardiovascular Partnership

     

    Websites

  • Research Group
  • Internet Links
  • Department of Cardiovascular Sciences
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    Key Publications

    Ng GA, Mistry A, Schlindwein FS, Nicolson WB. LifeMap: towards the development of a new technology in sudden cardiac death risk stratification for clinical use. EP Europace 2018 doi:10.1093/europace/euy080

    Allen E, Coote JH, Grubb BD, Batten TF, Pauza DH, Brack KE, Ng GA. The electrophysiological effects of nicotinic and electrical stimulation of intrinsic cardiac ganglia in the absence of extrinsic autonomic nerves in the rabbit heart. Heart Rhythm 2018 pii: S1547-5271(18)30505-8. doi:10.1016/j.hrthm.2018.05.018.

    Chauhan RA, Coote JH, Allen E, Pongpaopattanakul P, Brack KE, Ng GA. Functional selectivity of cardiac preganglionic sympathetic neurones in the heart. International Journal of Cardiology 2018 doi: 10.1016/j.ijcard.2018.03.119

    Salinet J, Schlindwein FS, Stafford P, Almeida TP, Li X, Vanheusden FJ, Guillem MS, Ng GA. Propagation of meandering rotors surrounded by high dominant frequency areas in persistent atrial fibrillation. Heart Rhythm 2017 doi: 10.1016/j.hrthm.2017.04.031

    Ng GA. Feasibility of selection of antiarrhythmic drug treatment on the basis of arrhythmogenic mechanism - relevance of electrical restitution, wavebreak and rotors. Pharmacology and Therapeutics 2016 doi:10.1016/j.pharmthera.2016.10.002

    Ng GA. Neuro-cardiac interaction in malignant ventricular arrhythmia and sudden cardiac death. Autonomic Neuroscience 2016 doi:10.1016/j.autneu.2016.07.001

    Nicolson WB, McCann GP, Smith MI, Sandilands AJ, Stafford PJ, Schlindwein FS, Samani NJ, Ng GA. Prospective evaluation of two novel ECG-based restitution biomarkers for prediction of sudden cardiac death risk in ischaemic cardiomyopathy. Heart 2014 doi: 10.1136/heartjnl-2014-305672.

    Winter J, Brack KE, Coote JH, Ng GA. Cardiac contractility modulation increases action potential duration dispersion and decreases ventricular fibrillation threshold via <beta>1-adrenoceptor activation in the crystalloid perfused normal heart. International Journal of Cardiology 2014 doi:10.1016/j.ijcard.2013.12.184

    Ng GA. Vagal modulation of cardiac ventricular arrhythmia. Experimental Pysiology 2013 doi: 10.1113/expphysiol.2013.072652

    Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, Pugsley MK, Ng GA, Roden DM, Camm AJ, Walker MJA. The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology & Therapeutics 2013 doi: 10.1016/j.pharmthera.2013.04.008

    Banning AS, Ng GA. Driving and arrhythmia: a review of scientific basis for international guidelines. European Heart Journal 2012 34(3):236-244.

    Nicolson WB, McCann GP, Brown PD, Sandilands AJ, Stafford PJ, Schlindwein FS, Samani NJ, Ng GA. A Novel Surface Electrocardiogram Based Marker of Ventricular Arrhythmia Risk in Patients with Ischemic Cardiomyopathy. Journal of the American Heart Association 2012 1:e001552 doi: 10.1161/JAHA.112.001552.

    Brack KE, Winter J, Ng GAMechanisms underlying the autonomic modulation of ventricular fibrillation initiation - tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure. Heart Failure Reviews 2012 DOI: 10.1007/s10741-012-9314-2.

    Brack KE, Coote JH, Ng GA. Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation. Cardiovasc Res. 2011;91:437-46.

    Winter J, Brack KE, Ng GAThe acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by ß1-adrenoceptor signalling. J Mol Cell Cardiol 2011;51(2):252-62.

    Winter J, Brack KE, Ng GACardiac contractility modulation in the treatment of heart failure: initial results and unanswered questions. Eur J Heart Failure 2011;13:700-10.

     Brack KE, Patel VH, Mantravadi R, Coote JH, Ng GADirect evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation. J Physiol. 2009 Jun 15;587(Pt 12):3045-54.

    Ng GA, Mantravadi R, Walker WH, Ortin WG, Choi BR, de Groat W, Salama G. Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution. Heart Rhythm. 2009 May;6(5):696-706.

    Patel VH, Brack KE, Coote JH, Ng GAA novel method of measuring nitric-oxide-dependent fluorescence using 4,5-diaminofluorescein (DAF-2) in the isolated Langendorff-perfused heart. Pflugers Arch. 2008 Jun;456(3):635-45.

    Brack KE, Patel VH, Coote JH, Ng GANitric oxide mediates the vagal protective effect on ventricular fibrillation via effects on action potential duration restitution in the heart. J Physiol. 2007 Sep 1;583(Pt 2):695-704.

    Mantravadi R, Gabris B, Liu T, Choi BR, de Groat WC, Ng GA, Salama G. Autonomic nerve stimulation reverses ventricular repolarization sequence in hearts. Circ Res. 2007 Apr 13;100(7):e72-80.

    Ng GA, Brack KE, Patel VH, Coote JH. Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart. Cardiovasc Res. 2007 Mar 1;73(4):750-60.

    Ng GATreating patients with ventricular ectopic beats. Heart. 2006  Nov;92(11):1707-12.

    Ng GA, Hicks MN, Cobbe SM, Smith GL. Depressed inotropic response to increased preload in hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflugers Arch. 2002 Jul;444(4):513-22.

    Ng GA, Brack KE, Coote JH. Effects of direct sympathetic and vagus nerve stimulation on the physiology of the whole heart--a novel model of isolated Langendorff perfused heart with intact dual autonomic innervation. Exp Physiol. 2001 May;86(3):319-29.

    Ng GA, Cobbe SM, Smith GL. Non-uniform prolongation of intracellular Ca2+ transients recorded from the epicardial surface of isolated hearts with heart failure. Cardiovasc Res. 1998 Feb;37(2):489-502.

     

    Recent Papers

     

    Research

  • Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation

  • Nitric oxide in mediating vagal protection of the heart against VF

  • Non-invasive markers of ventricular arrhythmia risk stratification

  • Atrial fibrillation - spectral characteristics and catheter ablation

  • Electromechanical refinement of multi-site cardiac pacing

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