Recent Papers

Recent papers by Professor Gavin J Murphy, Department of Cardiovascular Sciences, University of Leicester

Murphy GJ, Verheyden V, Wozniak M, Sullo N, Dott W,Bhudia S, Bittar N, Morris T, Ring A, Tebbatt A, and Kumar T. Trial Protocol for a randomised controlled trial of red cell washing for the attenuation of transfusion associated organ injury in cardiac surgery: The REDWASH Trial. Open Heart. 2016 Mar 7;3(1):e000344.

Reeves BC, Pike K, Rogers CA, Brierley RCM, Stokes EA, Wordsworth S, Nash RL, Miles A, Mumford AD, Cohen A, Angelini GD, Murphy GJ for the TITRe2 investigators. A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery (TITRe2). HTA Journal June 2016.

Clevenger B, Gurusamy K, Klein AA, Murphy GJ, Anker SD, Richards T. Systematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: Updated and abridged Cochrane review. Eur J Heart Fail. 2016 Apr 28.

Qureshi SM, Rizvi SIA, Patel NN, Murphy GJ. Meta-analysis of colloids versus crystalloids in critically ill, trauma and surgical patients. Br J Surg. 2016 Jan;103(1):14-26.

Norman JE, Lee K, Walker ME, Murden SL, Harris J, Mundell S, Murphy GJ, Mumford AD. Low multiple electrode aggregometry platelet responses are not associated with loss-of-function variants in G-protein coupled receptor genes. Thomb Haemostas 2015 Oct;136(4):818-24.

Ellis L, Murphy GJ, Culliford L, Dreyer L, Clayton G, Downes R, Nicholson E, Stoica S, Reeves BC, Rogers G. The effects of patient-specific cerebral oxygenation monitoring as part of an algorithm on post-operative cognitive function and infectious complications in patients having heart valve surgery using cardiopulmonary bypass: PASPORT, A multi-centre, randomised controlled trial. JMIR Res Protoc. 2015 Dec 18;4(4):e137.

Patel NN, Avlonitis V, Jones H, Sterne JAC, Reeves BC, Murphy GJ. Indications for red cell transfusion in cardiac surgery: A systematic review and meta-analysis of randomised controlled trials and observational studies. Lancet Haematol. 2015 Dec;2(12):e543-53.

Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC on behalf of TITRe2 Investigators. Liberal or restrictive transfusion after cardiac surgery: TITRe2 randomized trial. New England Journal of Medicine 2015;372:997-1008.

Goudie R, Sterne JAC, Verheyden V, Bhabra M, Ranucci M, Murphy GJ. Risk scores to facilitate pre-operative prediction of transfusion and large volume blood transfusion associated with adult cardiac surgery. Br J Anaesthesia 2015;114:757-66

Pike K, Nash RL, Murphy GJ, Reeves BC, Rogers CA. Transfusion Indication Threshold Reduction (TITRe2) randomised controlled trial in cardiac surgery: statistical analysis plan. Trials 2015;16:54

Birnie K, Verheyden V, Pagano D, Bhabra B, Tilling K, Sterne JAS, Murphy GJ. Predictive models for Kidney Disease: Improving Global Outcomes (KDIGO) Defined Acute Kidney Injury in UK Cardiac Surgery. Critical Care 2014;18:606.

Mariscalco G, Biancari F, Juvonen T, Zanobini M, Cottini M, Banach M, Murphy GJ, Beghi C, Angelini GD. Red blood cell transfusion is a determinant of neurological complications after cardiac surgery. Interact Cardiovasc Thorac Surg. 2014 Nov 2. pii: ivu360.

Ghorbel MT, Patel NN, Sheikh M, Angelini GD, Caputo M, Murphy GJ. Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury. BMC Genomics. 2014 Oct 21;15:916.

Brierley RC, Pike K, Miles A, Wordsworth S, Stokes EA, Mumford AD, Cohen A, Angelini GD, Murphy GJ, Rogers CA, Reeves BC. A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol. Transfus Apher Sci. 2014;50:451-61.

Dyke C, Aronson S, Dietrich W, Hofmann A, Karkouti K, Levi M, Murphy GJ, Sellke FW, Shore-Lesserson L, von Heymann C, Ranucci M. Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg. 2014 May;147(5):1458-1463.

Feehally J, Gilmore I, Barasi S, Bosomworth M, Christie B, Davies A, Dhesi J, Dowdle R, Gibbins C, Gonzalez I, Harding S, Lamont D, Murphy GJ, Ostermann M, Parr J, Stevens PE.  RCPE UK consensus conference statement: Management of acute kidney injury: the role of fluids, e-alerts and biomarkers. J R Coll Physicians Edinb. 2013;43(1):37-8.

Sleeman P, Patel NN, Lin H, Walkden GJ, Ray P, Welsh GI, Satchell SC, Murphy GJ. High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine. Crit Care. 2013 Oct 31;17(5):R262.

Walkden GR, Goudie R, Verheyden V, Murphy GJ. Increased perioperative mortality following aprotinin withdrawal: A real world analysis of blood management strategies in adult cardiac surgery. Intensive Care Med. 2013 Oct;39(10):1808-17.

Patel NN, Lin H, Jones C, Walkden G, Ray P, Sleeman PA, Angelini GD, Murphy GJ. Interactions of Cardiopulmonary Bypass and Erythrocyte Transfusion in the Pathogenesis of Pulmonary Dysfunction in Swine. Anesthesiology. 2013 Aug;119(2):365-78.

Huang WC, Newby GB, Lewis AL, Stratford PW, Rogers CA, Newby AC, Murphy GJ. Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts. J Surg Res. 2013 Jul;183(1):33-9.

Hickey GL, Grant SW, Murphy GJ, Bhabra M, Pagano D, McAllister K, Buchan I, Bridgewater B. Dynamic trends in cardiac surgery: why the logistic EuroSCORE is no longer suitable for contemporary cardiac surgery and implications for future risk models. Eur J Cardiothorac Surg. 2013 Jun;43(6):1146-52.

Menkis AH, Martin J, Cheng DC, Fitzgerald DC, Freedman JJ, Gao C, Koster A, Mackenzie GS, Murphy GJ, Spiess B, Ad N. Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. Innovations (Phila). 2012 Jul-Aug;7(4):229-41.

Rogers CA, Pike K, Kounali D, Reeves BC, Culliford C, Tomkins S, Angelini GD, Murphy GJ. A randomised controlled trial of median sternotomy vs. anterolateral left thoracotomy on morbidity and healthcare resource use in patients having off-pump coronary artery bypass surgery (SteT). J Thorac Cardiovasc Surg. 2013 Aug;146(2):306-16.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Phosphodiesterase Type 5 inhibition prevents post cardiopulmonary bypass acute kidney injury. Annals of Thoracic Surgery 2011;92(6):2168-76.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Reversal of anaemia with allogenic RBC transfusion prevents post cardiopulmonary bypass acute kidney injury in swine. Am J Physiol Renal Physiol 2011;301(3):F605-14.

Patel NN, Rogers CS, Angelini GD, Murphy GJ. Pharmacological therapies for the prevention of acute kidney injury following cardiac surgery: A systematic review. Heart Failure Reviews 2011;16(6):553-67.

Ranucci M, Aronson S, Dietrich W, Dyke CM, Hofmann A, Karkouti K, Levi M, Murphy GJ, Sellke FW, Shore-Lesserson L, von Heymann C; European Association of Cardiothoracic Anaesthesiologists. Patient blood management during cardiac surgery: do we have enough evidence for clinical practice? J Thorac Cardiovasc Surg. 2011 Aug;142(2):249.e1-32.

Narayan P, Wong A, Davies I, Angelini GD, Bryan AJ, Wilde P, Murphy GJ. Thoracic endovascular repair versus open surgical repair - which is the more cost-effective intervention for descending thoracic aortic pathologies? Eur J Cardiothorac Surg. 2011 Oct;40(4):869-74. Epub 2011 Feb 25.

Shander A, Fink  A, Javidroozi M, Erhard J, Farmer SL, Corwin H, Goodnough LT, Hofmann A, Isbister J, Ozawa S, Spahn D for the International Consensus Conference on Transfusion Outcomes group. Appropriateness of allogeneic red blood cell transfusion: The International Consensus Conference on Transfusion Outcomes (ICCTO). Trans Med Rev 2011;25(3):232-246.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, George SJ, Murphy GJ. Prevention of post cardiopulmonary bypass acute kidney injury by endothelin-A receptor blockade. Critical Care Medicine 2011;39:793-802.

Rajathurai T, Rizvi SI, Lin H, Angelini GD, Newby AC, Murphy GJ. Peri-adventitial rapamycin eluting microbeads promote vein graft disease in long-term pig vein-into-artery interposition grafts. Circulation: Cardiovascular Interventions 2010;3:157-65.

Murphy GJ, Lin H, Coward RJ, Toth T, Hall D, Holmes RB, Angelini GD. An initial evaluation of post-cardiopulmonary bypass acute kidney injury in swine. Eur J Cardiothorac Surg 2009;36:849-55.

Angelini GD, Culliford L, Smith DK, Hamilton MC, Murphy GJ, Ascione R, Baumbach A, Reeves BC. Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: long-term follow-up of 2 randomized controlled trials. J Thorac Cardiovasc Surg 2009;137:295-303.

Murphy GJ, Reeves BC, Rogers CA, Rizvi SIA, Culliford L, Angelini GD. Increased mortality, post-operative morbidity and cost following red blood cell transfusion in patients having cardiac surgery. Circulation 2007;116:2544-52.

 Murphy GJ, Johnson TW, Chamberlain MH, Rizvi SI, Wyatt M, George SJ, Angelini GD, Karsch KR, Oberhoff M, Newby AC. Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts. Cardiovasc Res 2007;73:607-17.

Murphy GJ, Newby AC, Jeremy JY, Baumbach A, Angelini GD. A randomized trial of an external Dacron sheath for the prevention of vein graft disease: the Extent study. J Thorac Cardiovasc Surg 2007;134:504-5.

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