Professor Gerry McCann

Personal details

  • NIHR Research Professor (Experimental Medicine)
  • Professor of Cardiac Imaging, Honorary Consultant Cardiologist, University of Leicester
  • +44 (0)116 258 3038
  • gpm12@le.ac.uk

 

  • Sally Utton (Imaging Research Manager)
  • Alison Watson (PA & Research Coordinator)

 

Professor McCann has established a national and growing international reputation as an expert in Cardiac MRI (CMR) and clinical trials. His research interests include the use of novel CMR sequences in the study of cardiovascular diseases, with a particular focus on coronary disease, diabetic cardiomyopathy and aortic stenosis. He has multiple collaborators locally, nationally and internationally.

Professor McCann is the Cardiovascular theme lead and heads a growing and dynamic multidisciplinary research group. He is also NIHR Cardiovascular lead for the East Midlands, sits on the NIHR doctoral panel and was on the BHF Fellowships Committee (2015-18). He leads the imaging biomarker discovery research and evaluations of novel cardiovascular interventions and the mentorship programme for the Department and BHF Accelerator Award.

 

Qualifications

  • University of Glasgow, MB ChB Medicine July 1992, 1985-1992
  • BSc (Hons 2:1) Physiology/Sports Science 1989
  • MRCP (UK), February 1995
  • Dip Sp Med Scottish Royal Colleges, April 1997
  • MD University of Glasgow, April 2002

 

Teaching

Professor McCann’s main teaching contribution is through the supervision of undergraduate and postgraduate students.  He has an excellent track record in all domains and a major focus is the development of individuals within the Cardiovascular Imaging Research group.

In addition Gerry delivers occasional lectures to undergraduate medical students, post-graduate trainees and hands-on clinical training in CMR. He lectures widely on CMR, aortic stenosis and diabetic heart disease and is a regular speaker at national and international conferences.

 

Research

Professor McCann’s research is focused on clinical imaging and conducting randomized controlled trials.  His work has been quoted in multiple International guidelines and the CvLPRIt trial helped change the guidelines on patients presenting with STEMI and multivessel disease. The recently published CEMARC-2 and MR-INFORM trials will influence future guidance on the assessment of patients with chest pain of suspected cardiac origin.

 

Publications

Professor McCann has published over 190 peer-reviewed articles, 120 of which have been in the last 5 years and he is senior or first author on over half of these publications.  Current H-Index is 38 (i10 99/Google Scholar, April 2021) and has over 5,000 citations.

https://www.ncbi.nlm.nih.gov/pubmed/?term=mccann+gp

 

Top ten Papers in last 5 years

  1. Gulsin GS, Swarbrick DJ, Athithan L, …..McCann GP. Effects of Low-Energy Diet or Exercise on Cardiovascular Function in Working-Age Adults With Type 2 Diabetes: A Prospective, Randomized, Open-Label, Blinded End Point Trial. Diabetes care. 2020;43:1300-1310.
  2. Everett RJ, Treibel TA, …, McCann GP, Greenwood JP, Moon JC and Dweck MR. Extracellular Myocardial Volume in Patients With Aortic Stenosis. JACC. 2020;75:304-316 DOI: 10.1016/j.jacc.2019.11.032
  3. Nagel E, Greenwood JP, McCann GP, et al Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease. NEJM 2019; 380(25): 2418-28.
  4. Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL and McCann GP. Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction. JACC Cardiovascular imaging. 2019;12:2291-2301.
  5. Musa, T.A., …. McCann GP, Moon J, Greenwood JP, Myocardial Scar and Mortality in Severe Aortic Stenosis:. Circulation, 2018; 138:1935-47
  6. Singh A, Greenwood JP, Berry C, …… and McCann GP. Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study. European heart journal. 2017;38:1222-1229.
  7. Greenwood JP, Ripley DP, Berry C, McCann GP et al. Effect of Care Guided by Cardiovascular Magnetic Resonance, Myocardial Perfusion Scintigraphy, or NICE Guidelines on Subsequent Unnecessary Angiography Rates: The CE-MARC 2 Randomized Clinical Trial. JAMA 2016; 316(10): 1051-60.
  8. Nazir SA, McCann GP, Greenwood JP, … Gershlick AH. Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial. European heart journal. 2016;37:1910-9.
  9. McCann GP, Khan JN, Greenwood JP,… Gershlick AH. Complete Versus Lesion-Only Primary PCI: The Randomized Cardiovascular MR CvLPRIT Substudy. Journal of the American College of Cardiology. 2015;66:2713-24.
  10. Gershlick AH, Khan JN, Kelly DJ, …. McCann GP. Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial. Journal of the American College of Cardiology. 2015;65:963-72.

Current Grants

Professor McCann has secured over £35m in grants (over £10m as PI).

  • BHF Travel Fellowship.  University of British Columbia Advanced Cardiac Imaging Fellowship: 1. Understanding Bioprosthetic Leaflet Degeneration in Patients with and without type 2 diabetes - a pilot study, and 2. Coronary Artery Plaque Characteristics and their Association with Outcomes - analyses from the ISCHEMIA trial. £48,837. Co-applicant (Gaurav Gulsin).
  • BHF PhD Studentship Programme. Sep 21 – Aug 28. £1,775,000. Co-CI
  • BHF CRTF.  A novel cardiac magnetic resonance technique to quantify altered myocardial calcium handling in diabetic cardiomyopathy and the response to lifestyle intervention (Dr Abhishek Dattani). 10/05/2021 - 09/05/2025.  £298,000.  PI
  • BHF.  Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study. 01/08/2020. £750,000. Co-CI
  • NIHR RfPB. Accelerated Cardiovascular Magnetic Resonance in Coronary Artery Disease. 01/07/2020. £247,938. Co-CI.
  • BHF. Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes (PHOSP-COVID). 01/04/2020 £8,400,000. Named collaborator
  • UK-Canada Diabetes Partnership. REmission of diabetes and improved diastolic function by combining Structured Exercise with meal replacemenT and food reintroduction. 01/04/2020. £338,693. Co-CI.

 

Awards and Nominations

  • Awards - for student supervision (2015, 2016). BJCA trainer of the year 2016 - runner up.
  • ACC 2015: Best abstract from the UK (CvLPRIt CMR)
  • East Midlands CRN Finalist: Exemplary investigator contribution 2017.

 

Student awards

  • Presidents Cardiology Section of the Royal Society, finalists, Alastair Moss & Gaurav Gulsin, Oct 2020
  • Royal College of Physicians, Turner-Warwick Lecturer, Matt Graham-Brown, March 2020
    https://www.rcplondon.ac.uk/education-practice/funding-awards/turner-warwick-lectures
  • British Society for Heart Failure Annual Autumn Meeting - Early Career Investigator Award Winner – G Gulsin, November 2019
  • Images of Research, short-listed, Aseel Alfuhied, November 2019
  • AHA Lifestyle and Cardiometabolic Health Samuel Levine Early Career Investigator Award, DIASTOLIC study team, G Gulsin November 2019
  • 'The Raine Award', UK Renal Association, M Graham-Brown, October 2019
  • BIHS meeting, Dr Robert Grayson Award, Best abstract in vascular disease, Dr G Gulsin, September 2019
  • Renal Association SpR Club best medical student abstract Federica Poli, Matthew Graham-Brown, 2019
  • Winning team for Best MPHrp (Making People Healthier research programme) Research Proposal at the 10th NIHR Infrastructure Doctoral Research Training Camp, Lavanya Athithan, 2019
  • University of Leicester Research Bytes Competition - Postgraduate Student 1st Prize Winner, G Gulsin, 2019
  • EuroCMR, Best poster, Ahmed Khedr Abdelaty, April 2019
  • Society of Cardiovascular MR Early Career Award: Winner A Singh (2016); Finalists C Steadman (2011), P Kanagala (2018)
  • British/Irish Hypertension Society 2017 Young Investigator Award Winner (W Hunt). Best Presentation Dr Gaurav Gulsin 2019
  • British Heart Valve Society 2015 – Young Investigator Award Winner  (A Singh)
  • BMA student research award 2017 (Runner-up S Ardenwalla)
  • Royal College of Physicians NHS Trainee Research 2017 Award Winner (G Gulsin)

 

External Roles

  • Wellcome Trust Expert Review Group- Physiology in Health and Disease- 2020- present
  • NIHR Doctoral Fellowships Committee 2018-2020
  • BHF fellowships Committee- 2015-2018
  • BSCMR Board member 2008-2014
  • BSCMR Research Group Chair 2018- present; 2012-present. Co-chair 2012-18
  • NIHR CRN CV Deputy Lead East Midlands 2014-17
  • NIHR CLRN CV Deputy Lead Leicester, Northampton and Rutland 2012-2014

 

Editorial Board and Reviewer Experience

Professor McCann is a reviewer for all the major cardiovascular funders in the UK and has also reviewed for several international funders.

 

Periodic Reviewer and External Examiner Experience

JACC and CV Imaging; European Heart Journal and Imaging and Heart failure sub journals; Circulation Cardiovascular Imaging; Heart, The Journal of Cardiovascular Magnetic Resonance; European Radiology and the BMJ.

Professor McCann has been external examiner for a large number of PhDs including at Oxford, London, Birmingham and Edinburgh.

 

Research Supervision

Prof McCann has an excellent record in developing junior researchers. He has been the principal supervisor for five doctorates, one of whom has progressed to a NIHR Academic Clinical Lecturer. His post-doctoral fellows and lecturers have been successful in attracting external funding from the Wellcome Trust, BHF, the Academy of Medical Sciences and garnering industry support for their research projects.   Most recently his post-doctoral fellow secured his own NIHR Clinician Scientist Award (2019-2024).  Two of his PhD students have been appointed as NIHR Academic Clinical Lecturers (ACL) and another NIHR ACL has recently secured a five-year senior lecturer position at the University of Leeds.

 

Previous and Current Doctoral students

  • Chris Steadman 2008-12 MD Relation of LVH and diastolic dysfunction to exercise capacity in AS.  Consultant Cardiologist.
  • Jamal Khan- 2010-2014. PhD. (shortlisted best in College). Cardiovascular Magnetic Resonance Imaging in the Assessment of the Management of Multivessel Coronary Artery Disease in Acute St-Segment Elevation Myocardial Infarction. Consultant Cardiologist.
  • Anvesha Singh 2011-2014 PhD. Relation of myocardial perfusion to symptom onset in aortic stenosis.  Associate Professor.
  • Sheraz Nazir- 2011-2020.
  • Prathap Kanagala 2011-2015. PhD Awarded 2018. Characterising Heart Failure with Preserved Ejection Fraction. Awarded prize for best in College.
  • Gaurav Gulsin- 2017-2020.  Prevalence and Determinants of subclinical cardiac dysfunction in Type 2 diabetes.
  • Lavanya Athithan Aug 2017-present. Rest and stress metabolism in type 2 diabetes.
  • Loai Althagafi- Aug 2018- present. Visceral adiposity and relation to subclinical cardiovascular dysfunction in type 2 diabetes.
  • Secondary supervisor for a further 3 PhD students undertaking cardiac MRI projects.
  • Grace Walters - Sep 2019-ongoing. A low-energy meal replacement plan for the treatment of heart failure with preserved ejection fraction and type 2 diabetes: a feasibility study.

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