Dr Dave Lodwick

Dr Dave Lodwick

Honorary Lecturer in Molecular Biology

B.Sc Biochemistry with Chemistry, 1982, University of Southampton
Ph.D Molecular Genetics, 1989, University of Liverpool
FHEA, 2001

Tel: 0116 204 4760
Email: lod@le.ac.uk    

Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP

Research Interests

  • Molecular biology of ATP-sensitive potassium channels

  • RNA interference 

Membership of Learned Societies

The Society for General Microbiology 1986-

The Biochemical Society 1992-

The British Hypertension Society 1994-

The Physiological Society 2010-

The British Society for Cardiovascular Research 2014-

The Medical Research Society 1994-2008

The International Society for Hypertension 1998-2008

Recent Publications

Brennan S, Jackson R, Patel M, Sims MW, Hudman D, Norman RI, Lodwick D, Rainbow RD. Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection. J. Mol. Cell. Cardiol. 2015 Feb;79:42-53

Lodwick D, Rainbow RD, Rubaiy HN, Al Johi M, Vuister GW, Norman RI. Sulphonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an inter-subunit salt bridge. Biochemical Journal 2014.

Storey NM, Stratton RC, Rainbow RD, Standen NB, Lodwick D. Kir6.2 limits calcium overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress. Am. J. Physiol. Heart and Circulatory Physiology 2013; 305:H1508-H1518.

Bhagatte Y, Lodwick D and Storey N. Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes. Cell Death and Disease 2012; 3:e345

Pawluczyk IZA, Tan EKC, Lodwick D, Harris KPG. Kallikrein gene knock-down by siRNA transfection induces a pro-fibrotic phenotype in rat mesangial cells. J. Hypertens 2008; 26:93-101.

Kang Y, Ng B, He Y, Leung Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, Gaisano HY. Syntaxin-1a actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac KATP channel activation. JBC 2006;281:19019-19028.

Hetherington SL, Singh RK, Lodwick D, Thompson JR, Goodall AH, Samani NJ. A dimorphism in the P2RY1 receptor gene is associated with increased platelet activation response to ADP. ATVB 2005; 25:252-257.

Rainbow RD, Lodwick D, Hudman D, Davies NW, Norman RI, Standen NB. SUR2A C-terminal fragments reduce KATP currents and ischaemic tolerance of rat cardiac myocytes. J. Physiol. 2004; 557:785-794.

Kovalev H, Quayle JM, Kamishima T, Lodwick D. Molecular analysis of the sub-type selective inhibition of cloned KATP channels by PNU-37883A. Brit. J. Pharmacol. 2004;141:867-873.

Rainbow RD, James M, Hudman D, Al Johi M, Singh H, Watson PJ, Ashmole I,Davies NW, Lodwick D, Norman RI. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with the pore-forming Kir6.0 subunits in KATP channels. Biochem. J. 2004;379:173-181.

Singh H, Hudman D, Lawrence CL, Rainbow RD, Lodwick D, Norman RI. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated cardiac myocytes. J. Mol. Cell. Cardiol. 2003;35:445-459.

Mahadeva H, Brooks G, Lodwick D, Chong NW, Samani NJ. ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy. FEBS Lett. 2002;521:100-104.

Reviews

Lodwick D. Receptor double-trouble in preeclampsia (News and Views). Nature Medicine 2001;7:999-1000.

Books

Norman RI and Lodwick D. Medical Cell Biology Made Memorable. Churchill Livingstone (1999) 195 pages.

Norman RI and Lodwick D. Flesh and Bones of Medical Cell Biology. Mosby (2007) 124 pages. Award winner at Royal Society of Medicine Book Awards, 2008

Flesh & Bones of Medical Cell Biology
Flesh and Bones of Medical Cell Biology. Winner at Royal Society of Medicine Book Awards, 2008.
Drs Lodwick & Norman
Drs Norman and Lodwick receiving their award from Alexander MacCall Smith. (Photo: Matt Crossick)
 

Links

Ion Channels Group

Department of Cardiovascular Sciences

Share this page: